Relaxed substrate specificity leads to extensive tRNA mischarging by Streptococcus pneumoniae class I and class II aminoacyl-tRNA synthetases

mBio

Volumn 5, Issue 5, 2014, Pages

  Shepherd, Jennifer ^a   Ibba, Michael ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID TRANSFER RNA LIGASE; CLASS I ISOLEUCYL TRANSFER RNA SYNTHETASE; CLASS II LYSYL TANSFER RNA SYNTHETASE; LEUCINE; LYSINE; PEPTIDOGLYCAN; SERINE; UNCLASSIFIED DRUG; VALINE; BACTERIAL DNA; BACTERIAL PROTEIN; PENICILLIN DERIVATIVE; TRANSFER RNA;

AMINO ACID ANALYSIS; AMINOACYLATION; ARTICLE; BIOGENESIS; CELL WALL; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE ACTIVITY; NONHUMAN; PROTEIN SYNTHESIS; RNA MISCHARGING; RNA SEQUENCE; RNA TRANSLATION; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIA; ANTIBIOTIC RESISTANCE; BACTERIAL CHROMOSOME; BIOSYNTHESIS; CLASSIFICATION; CONFORMATION; DNA SEQUENCE; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; METABOLISM; PLASMID; STREPTOCOCCUS PNEUMONIAE;

STREPTOCOCCUS PNEUMONIAE;

AMINO ACYL-TRNA SYNTHETASES; BACTERIAL PROTEINS; CHROMOSOMES, BACTERIAL; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; NUCLEIC ACID CONFORMATION; PENICILLINS; PEPTIDOGLYCAN; PLASMIDS; PROTEIN BIOSYNTHESIS; RNA, TRANSFER; SEQUENCE ANALYSIS, DNA; STREPTOCOCCUS PNEUMONIAE; SUBSTRATE SPECIFICITY;

EID: 84908439733     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01656-14     Document Type: Article

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