메뉴 건너뛰기




Volumn 351, Issue 3, 2014, Pages 585-595

Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: An in vivo electrophysiologic characterization

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL]AMIDE METHYL ESTER; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; APOMORPHINE; ARIPIPRAZOLE; BREXPIPRAZOLE; CLONIDINE; DOPAMINE; DOPAMINE 2 RECEPTOR; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NORADRENALIN; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; 7-(4-(4-(1-BENZOTHIOPHEN-4-YL)PIPERAZIN-1-YL)BUTOXY)QUINOLIN-2(1H)-ONE; QUINOLONE DERIVATIVE; THIOPHENE DERIVATIVE;

EID: 84908428543     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.218578     Document Type: Article
Times cited : (40)

References (59)
  • 2
    • 3142739323 scopus 로고    scopus 로고
    • Adrenergic targets for the treatment of cognitive deficits in schizophrenia
    • Arnsten AF (2004) Adrenergic targets for the treatment of cognitive deficits in schizophrenia. Psychopharmacology (Berl) 174:25-31.
    • (2004) Psychopharmacology (Berl) , vol.174 , pp. 25-31
    • Arnsten, A.F.1
  • 3
    • 84883885115 scopus 로고    scopus 로고
    • Serotonin and beyond: Therapeutics for major depression
    • Blier P and El Mansari M (2013) Serotonin and beyond: therapeutics for major depression. Philos Trans R Soc Lond B Biol Sci 368:20120536.
    • (2013) Philos Trans R Soc Lond B Biol Sci , vol.368 , pp. 20120536
    • Blier, P.1    El Mansari, M.2
  • 4
    • 0024571452 scopus 로고
    • Frequency-dependence of serotonin autoreceptor but not alpha 2-adrenoceptor inhibition of [3H]-serotonin release in rat hypothalamic slices
    • Blier P, Ramdine R, Galzin AM, and Langer SZ (1989) Frequency-dependence of serotonin autoreceptor but not alpha 2-adrenoceptor inhibition of [3H]-serotonin release in rat hypothalamic slices. Naunyn Schmiedebergs Arch Pharmacol 339:60-64.
    • (1989) Naunyn Schmiedebergs Arch Pharmacol , vol.339 , pp. 60-64
    • Blier, P.1    Ramdine, R.2    Galzin, A.M.3    Langer, S.Z.4
  • 5
    • 29344438343 scopus 로고    scopus 로고
    • Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety
    • Blier P and Szabo ST (2005) Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety. J Clin Psychiatry 66 (Suppl 8):30-40.
    • (2005) J Clin Psychiatry , vol.66 , pp. 30-40
    • Blier, P.1    Szabo, S.T.2
  • 6
    • 0037304917 scopus 로고    scopus 로고
    • Is there a role for 5-HT1A agonists in the treatment of depression?
    • Blier P and Ward NM (2003) Is there a role for 5-HT1A agonists in the treatment of depression? Biol Psychiatry 53:193-203.
    • (2003) Biol Psychiatry , vol.53 , pp. 193-203
    • Blier, P.1    Ward, N.M.2
  • 8
    • 0022503862 scopus 로고
    • In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals
    • Chaput Y, Blier P, and de Montigny C (1986) In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. J Neurosci 6:2796-2801.
    • (1986) J Neurosci , vol.6 , pp. 2796-2801
    • Chaput, Y.1    Blier, P.2    De Montigny, C.3
  • 9
    • 69549105678 scopus 로고    scopus 로고
    • Electrophysiological studies in the rat brain on the basis for aripiprazole augmentation of antidepressants in major depressive disorder
    • Chernoloz O, El Mansari M, and Blier P (2009) Electrophysiological studies in the rat brain on the basis for aripiprazole augmentation of antidepressants in major depressive disorder. Psychopharmacology (Berl) 206:335-344.
    • (2009) Psychopharmacology (Berl) , vol.206 , pp. 335-344
    • Chernoloz, O.1    El Mansari, M.2    Blier, P.3
  • 10
    • 84861182426 scopus 로고    scopus 로고
    • Effects of sustained administration of quetiapine alone and in combination with a serotonin reuptake inhibitor on norepinephrine and serotonin transmission
    • Chernoloz O, El Mansari M, and Blier P (2012) Effects of sustained administration of quetiapine alone and in combination with a serotonin reuptake inhibitor on norepinephrine and serotonin transmission. Neuropsychopharmacology 37:1717-1728.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1717-1728
    • Chernoloz, O.1    El Mansari, M.2    Blier, P.3
  • 11
    • 0023754346 scopus 로고
    • Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. I. Receptors mediating the effect of microiontophoretically applied norepinephrine
    • Curet O and De Montigny C (1988) Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. I. Receptors mediating the effect of microiontophoretically applied norepinephrine. Brain Res 475:35-46.
    • (1988) Brain Res , vol.475 , pp. 35-46
    • Curet, O.1    De Montigny, C.2
  • 12
    • 62149121073 scopus 로고    scopus 로고
    • Effects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviour
    • Dahan L, Husum H, Mnie-Filali O, Arnt J, Hertel P, and Haddjeri N (2009) Effects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviour. J Psychopharmacol 23:177-189.
    • (2009) J Psychopharmacol , vol.23 , pp. 177-189
    • Dahan, L.1    Husum, H.2    Mnie-Filali, O.3    Arnt, J.4    Hertel, P.5    Haddjeri, N.6
  • 13
    • 0030804657 scopus 로고    scopus 로고
    • Distribution of α 1a-, α 1b- and α 1d-adrenergic receptor mRNA in the rat brain and spinal cord
    • Day HE, Campeau S, Watson SJ, Jr, and Akil H (1997) Distribution of α 1a-, α 1b- and α 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat 13:115-139.
    • (1997) J Chem Neuroanat , vol.13 , pp. 115-139
    • Day, H.E.1    Campeau, S.2    Watson, S.J.3    Akil, H.4
  • 14
    • 0018966077 scopus 로고
    • Monoaminergic denervation of the rat hippocampus: Microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin
    • De Montigny C, Wang RY, Reader TA, and Aghajanian GK (1980) Monoaminergic denervation of the rat hippocampus: microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin. Brain Res 200:363-376.
    • (1980) Brain Res , vol.200 , pp. 363-376
    • De Montigny, C.1    Wang, R.Y.2    Reader, T.A.3    Aghajanian, G.K.4
  • 15
    • 28044469011 scopus 로고    scopus 로고
    • Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: Role in atypical antipsychotic action
    • Díaz-Mataix L, Scorza MC, Bortolozzi A, Toth M, Celada P, and Artigas F (2005) Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action. J Neurosci 25:10831-10843.
    • (2005) J Neurosci , vol.25 , pp. 10831-10843
    • Díaz-Mataix, L.1    Scorza, M.C.2    Bortolozzi, A.3    Toth, M.4    Celada, P.5    Artigas, F.6
  • 16
    • 0032160077 scopus 로고    scopus 로고
    • Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe
    • Dong J, De Montigny C, and Blier P (1998) Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe. J Pharmacol Exp Ther 286:1239-1247.
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 1239-1247
    • Dong, J.1    De Montigny, C.2    Blier, P.3
  • 17
    • 33847275575 scopus 로고    scopus 로고
    • Noradrenergic augmentation of escitalopram response by risperidone: Electrophysiologic studies in the rat brain
    • Dremencov E, El Mansari M, and Blier P (2007) Noradrenergic augmentation of escitalopram response by risperidone: electrophysiologic studies in the rat brain. Biol Psychiatry 61:671-678.
    • (2007) Biol Psychiatry , vol.61 , pp. 671-678
    • Dremencov, E.1    El Mansari, M.2    Blier, P.3
  • 18
    • 20544472658 scopus 로고    scopus 로고
    • Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: An in vivo electrophysiological study in rat brain
    • El Mansari M, Sánchez C, Chouvet G, Renaud B, and Haddjeri N (2005) Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brain. Neuropsychopharmacology 30:1269-1277.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1269-1277
    • El Mansari, M.1    Sánchez, C.2    Chouvet, G.3    Renaud, B.4    Haddjeri, N.5
  • 19
    • 0032414602 scopus 로고    scopus 로고
    • Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression
    • Fawcett J and Barkin RL (1998) Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression. J Affect Disord 51:267-285.
    • (1998) J Affect Disord , vol.51 , pp. 267-285
    • Fawcett, J.1    Barkin, R.L.2
  • 20
    • 77957235566 scopus 로고    scopus 로고
    • Sustained administration of trazodone enhances serotonergic neurotransmission: In vivo electrophysiological study in the rat brain
    • Ghanbari R, El Mansari M, and Blier P (2010) Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain. J Pharmacol Exp Ther 335:197-206.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 197-206
    • Ghanbari, R.1    El Mansari, M.2    Blier, P.3
  • 21
    • 82955235619 scopus 로고    scopus 로고
    • Enhancement of serotonergic and noradrenergic neurotransmission in the rat hippocampus by sustained administration of bupropion
    • Ghanbari R, El Mansari M, and Blier P (2011) Enhancement of serotonergic and noradrenergic neurotransmission in the rat hippocampus by sustained administration of bupropion. Psychopharmacology (Berl) 217:61-73.
    • (2011) Psychopharmacology (Berl) , vol.217 , pp. 61-73
    • Ghanbari, R.1    El Mansari, M.2    Blier, P.3
  • 22
    • 58949100862 scopus 로고    scopus 로고
    • Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain
    • Ghanbari R, El Mansari M, Shahid M, and Blier P (2009) Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain. Eur Neuropsychopharmacol 19:177-187.
    • (2009) Eur Neuropsychopharmacol , vol.19 , pp. 177-187
    • Ghanbari, R.1    El Mansari, M.2    Shahid, M.3    Blier, P.4
  • 23
    • 0034016037 scopus 로고    scopus 로고
    • Extrapyramidal side effects, tardive dyskinesia, and the concept of atypicality
    • Glazer WM(2000) Extrapyramidal side effects, tardive dyskinesia, and the concept of atypicality. J Clin Psychiatry 61 (Suppl 3):16-21.
    • (2000) J Clin Psychiatry , vol.61 , pp. 16-21
    • Glazer, W.M.1
  • 24
    • 0020558538 scopus 로고
    • Intracellular and extracellular electrophysiology of nigral dopaminergic neurons - 1. Identification and characterization
    • Grace AA and Bunney BS (1983) Intracellular and extracellular electrophysiology of nigral dopaminergic neurons - 1. Identification and characterization. Neuroscience 10:301-315.
    • (1983) Neuroscience , vol.10 , pp. 301-315
    • Grace, A.A.1    Bunney, B.S.2
  • 25
    • 0021718376 scopus 로고
    • The control of firing pattern in nigral dopamine neurons: Burst firing
    • Grace AA and Bunney BS (1984) The control of firing pattern in nigral dopamine neurons: burst firing. J Neurosci 4:2877-2890.
    • (1984) J Neurosci , vol.4 , pp. 2877-2890
    • Grace, A.A.1    Bunney, B.S.2
  • 26
    • 53949115267 scopus 로고    scopus 로고
    • Involvement of glutamate neurotransmission and N-methyl-daspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: An electrophysiological study in the rat
    • Gronier B (2008) Involvement of glutamate neurotransmission and N-methyl-daspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat. Neuroscience 156:995-1004.
    • (2008) Neuroscience , vol.156 , pp. 995-1004
    • Gronier, B.1
  • 27
    • 0030431697 scopus 로고    scopus 로고
    • Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain
    • Haddjeri N, Blier P, and de Montigny C (1996) Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain. J Pharmacol Exp Ther 277:861-871.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 861-871
    • Haddjeri, N.1    Blier, P.2    De Montigny, C.3
  • 28
    • 0032440172 scopus 로고    scopus 로고
    • Acute and long-term actions of the antidepressant drug mirtazapine on central 5-HT neurotransmission
    • Haddjeri N, Blier P, and de Montigny C (1998) Acute and long-term actions of the antidepressant drug mirtazapine on central 5-HT neurotransmission. J Affect Disord 51:255-266.
    • (1998) J Affect Disord , vol.51 , pp. 255-266
    • Haddjeri, N.1    Blier, P.2    De Montigny, C.3
  • 29
    • 0029998737 scopus 로고    scopus 로고
    • Partial agonistic activity of R- and S-enantiomers of 8-OH-DPAT at 5-HT1A receptors
    • Hadrava V, Blier P, and de Montigny C (1996) Partial agonistic activity of R- and S-enantiomers of 8-OH-DPAT at 5-HT1A receptors. J Psychiatry Neurosci 21:101-108.
    • (1996) J Psychiatry Neurosci , vol.21 , pp. 101-108
    • Hadrava, V.1    Blier, P.2    De Montigny, C.3
  • 30
    • 0028972481 scopus 로고
    • Characterization of 5-hydroxytryptamine1A properties of flesinoxan: In vivo electrophysiology and hypothermia study
    • Hadrava V, Blier P, Dennis T, Ortemann C, and de Montigny C (1995) Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology 34:1311-1326.
    • (1995) Neuropharmacology , vol.34 , pp. 1311-1326
    • Hadrava, V.1    Blier, P.2    Dennis, T.3    Ortemann, C.4    De Montigny, C.5
  • 31
    • 0023233950 scopus 로고
    • Differential effects of acute clozapine and haloperidol on the activity of ventral tegmental (A10) and nigrostriatal (A9) dopamine neurons
    • Hand TH, Hu X-T, and Wang RY (1987) Differential effects of acute clozapine and haloperidol on the activity of ventral tegmental (A10) and nigrostriatal (A9) dopamine neurons. Brain Res 415:257-269.
    • (1987) Brain Res , vol.415 , pp. 257-269
    • Hand, T.H.1    Hu, X.-T.2    Wang, R.Y.3
  • 32
    • 84908404758 scopus 로고    scopus 로고
    • Synergistic effects of brexpiprazole with SSRI/SNRI/diazepam on forced swim test and marble burying behavior in mice
    • Hirose T, Maeda K, Stensbøl TB, and Kikuchi T (2014) Synergistic effects of brexpiprazole with SSRI/SNRI/diazepam on forced swim test and marble burying behavior in mice. Biol Psychiatry 75 (Suppl 9):132S.
    • (2014) Biol Psychiatry , vol.75 , pp. 132S
    • Hirose, T.1    Maeda, K.2    Stensbøl, T.B.3    Kikuchi, T.4
  • 33
    • 0034025771 scopus 로고    scopus 로고
    • Relationship between dopamine D(2) occupancy, clinical response, and side effects: A double-blind PET study of first-episode schizophrenia
    • Kapur S, Zipursky R, Jones C, Remington G, and Houle S (2000) Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am J Psychiatry 157:514-520.
    • (2000) Am J Psychiatry , vol.157 , pp. 514-520
    • Kapur, S.1    Zipursky, R.2    Jones, C.3    Remington, G.4    Houle, S.5
  • 34
    • 50349086333 scopus 로고    scopus 로고
    • Neuropharmacology of second-generation antipsychotic drugs: A validity of the serotonin-dopamine hypothesis
    • Kuroki T, Nagao N, and Nakahara T (2008) Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis. Prog Brain Res 172:199-212.
    • (2008) Prog Brain Res , vol.172 , pp. 199-212
    • Kuroki, T.1    Nagao, N.2    Nakahara, T.3
  • 37
    • 77957241598 scopus 로고    scopus 로고
    • Adjunctive alpha2-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission
    • Cambridge University Press
    • Marcus MM, Wiker C, Fra˚nberg O, Konradsson-Geuken A, Langlois X, Jardemark K, and Svensson TH (2010) Adjunctive alpha2-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission. Int J Neuropsychopharmacol 13:891-903 Cambridge University Press.
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 891-903
    • Marcus, M.M.1    Wiker, C.2    Fra˚nberg, O.3    Konradsson-Geuken, A.4    Langlois, X.5    Jardemark, K.6    Svensson, T.H.7
  • 38
    • 0019415337 scopus 로고
    • Prazosin selectively antagonizes neuronal responses mediated by alpha1-adrenoceptors in brain
    • Menkes DB, Baraban JM, and Aghajanian GK (1981) Prazosin selectively antagonizes neuronal responses mediated by alpha1-adrenoceptors in brain. Naunyn Schmiedebergs Arch Pharmacol 317:273-275.
    • (1981) Naunyn Schmiedebergs Arch Pharmacol , vol.317 , pp. 273-275
    • Menkes, D.B.1    Baraban, J.M.2    Aghajanian, G.K.3
  • 39
    • 0027446907 scopus 로고
    • In vivo electrophysiological evidence for tonic activation by endogenous noradrenaline of alpha 2-adrenoceptors on 5-hydroxytryptamine terminals in the rat hippocampus
    • Mongeau R, Blier P, and de Montigny C (1993) In vivo electrophysiological evidence for tonic activation by endogenous noradrenaline of alpha 2-adrenoceptors on 5-hydroxytryptamine terminals in the rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol 347:266-272.
    • (1993) Naunyn Schmiedebergs Arch Pharmacol , vol.347 , pp. 266-272
    • Mongeau, R.1    Blier, P.2    De Montigny, C.3
  • 40
    • 0028328482 scopus 로고
    • Electrophysiologic evidence for desensitization of alpha 2-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration
    • Mongeau R, de Montigny C, and Blier P (1994) Electrophysiologic evidence for desensitization of alpha 2-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration. Neuropsychopharmacology 10:41-51.
    • (1994) Neuropsychopharmacology , vol.10 , pp. 41-51
    • Mongeau, R.1    De Montigny, C.2    Blier, P.3
  • 41
    • 69949087539 scopus 로고    scopus 로고
    • Atypical antipsychotic augmentation in major depressive disorder: A meta-analysis of placebo-controlled randomized trials
    • Nelson JC and Papakostas GI (2009) Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials. Am J Psychiatry 166:980-991.
    • (2009) Am J Psychiatry , vol.166 , pp. 980-991
    • Nelson, J.C.1    Papakostas, G.I.2
  • 42
    • 77954122304 scopus 로고    scopus 로고
    • The importance of 5-HT1A receptor agonism in antipsychotic drug action: Rationale and perspectives
    • Newman-Tancredi A (2010) The importance of 5-HT1A receptor agonism in antipsychotic drug action: rationale and perspectives. Curr Opin Investig Drugs 11:802-812.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 802-812
    • Newman-Tancredi, A.1
  • 43
    • 0028220927 scopus 로고
    • Desensitization of the neuronal 5-HT carrier following its long-term blockade
    • Piñeyro G, Blier P, Dennis T, and de Montigny C (1994) Desensitization of the neuronal 5-HT carrier following its long-term blockade. J Neurosci 14:3036-3047.
    • (1994) J Neurosci , vol.14 , pp. 3036-3047
    • Piñeyro, G.1    Blier, P.2    Dennis, T.3    De Montigny, C.4
  • 44
    • 0027939061 scopus 로고
    • Evidence that systemically administered dopamine antagonists activate dopamine neuron firing primarily by blockade of somatodendritic autoreceptors
    • Pucak ML and Grace AA (1994) Evidence that systemically administered dopamine antagonists activate dopamine neuron firing primarily by blockade of somatodendritic autoreceptors. J Pharmacol Exp Ther 271:1181-1192.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1181-1192
    • Pucak, M.L.1    Grace, A.A.2
  • 45
    • 0015803670 scopus 로고
    • Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats. I. Behavioral correlates and firing repertoires
    • Ranck JB, Jr (1973) Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats. I. Behavioral correlates and firing repertoires. Exp Neurol 41:461-531.
    • (1973) Exp Neurol , vol.41 , pp. 461-531
    • Ranck, J.B.1
  • 46
    • 84879116622 scopus 로고    scopus 로고
    • Investigational drugs for schizophrenia targeting the dopamine receptor: Phase II trials
    • Rao NP and Remington G (2013) Investigational drugs for schizophrenia targeting the dopamine receptor: phase II trials. Expert Opin Investig Drugs 22:881-894.
    • (2013) Expert Opin Investig Drugs , vol.22 , pp. 881-894
    • Rao, N.P.1    Remington, G.2
  • 47
    • 0018833733 scopus 로고
    • Activation of lateral geniculate neurons by norepinephrine: Mediation by an alpha-adrenergic receptor
    • Rogawski MA and Aghajanian GK (1980) Activation of lateral geniculate neurons by norepinephrine: mediation by an alpha-adrenergic receptor. Brain Res 182:345-359.
    • (1980) Brain Res , vol.182 , pp. 345-359
    • Rogawski, M.A.1    Aghajanian, G.K.2
  • 48
    • 0019917851 scopus 로고
    • Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: Selective blockade by the alpha 1-adrenoceptor antagonist prazosin
    • Rogawski MA and Aghajanian GK (1982) Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: selective blockade by the alpha 1-adrenoceptor antagonist prazosin. Brain Res 250:31-39.
    • (1982) Brain Res , vol.250 , pp. 31-39
    • Rogawski, M.A.1    Aghajanian, G.K.2
  • 49
    • 0016592484 scopus 로고
    • Antipsychotic drugs: Direct correlation between clinical potency and presynaptic action on dopamine neurons
    • Seeman P and Lee T (1975) Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. Science 188:1217-1219.
    • (1975) Science , vol.188 , pp. 1217-1219
    • Seeman, P.1    Lee, T.2
  • 50
    • 58649100010 scopus 로고    scopus 로고
    • Asenapine: A novel psychopharmacologic agent with a unique human receptor signature
    • Shahid M, Walker GB, Zorn SH, and Wong EHF (2009) Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol 23:65-73.
    • (2009) J Psychopharmacol , vol.23 , pp. 65-73
    • Shahid, M.1    Walker, G.B.2    Zorn, S.H.3    Wong, E.H.F.4
  • 53
    • 0027887319 scopus 로고
    • Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors
    • Stockmeier CA, DiCarlo JJ, Zhang Y, Thompson P, and Meltzer HY (1993) Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors. J Pharmacol Exp Ther 266:1374-1384.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 1374-1384
    • Stockmeier, C.A.1    DiCarlo, J.J.2    Zhang, Y.3    Thompson, P.4    Meltzer, H.Y.5
  • 54
    • 0035856882 scopus 로고    scopus 로고
    • Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons
    • Szabo ST and Blier P (2001) Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons. Brain Res 922:9-20.
    • (2001) Brain Res , vol.922 , pp. 9-20
    • Szabo, S.T.1    Blier, P.2
  • 56
    • 0021023465 scopus 로고
    • Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
    • Vandermaelen CP and Aghajanian GK (1983) Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res 289:109-119.
    • (1983) Brain Res , vol.289 , pp. 109-119
    • Vandermaelen, C.P.1    Aghajanian, G.K.2
  • 57
    • 0019849229 scopus 로고
    • Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization
    • Wang RY (1981) Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization. Brain Res Rev 3:123-140.
    • (1981) Brain Res Rev , vol.3 , pp. 123-140
    • Wang, R.Y.1
  • 58
    • 0029065459 scopus 로고
    • Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine
    • Wetzel JM, Miao SW, Forray C, Borden LA, Branchek TA, and Gluchowski C (1995) Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J Med Chem 38:1579-1581.
    • (1995) J Med Chem , vol.38 , pp. 1579-1581
    • Wetzel, J.M.1    Miao, S.W.2    Forray, C.3    Borden, L.A.4    Branchek, T.A.5    Gluchowski, C.6
  • 59
    • 84903988963 scopus 로고    scopus 로고
    • Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: A role for serotonin 5-HT1A receptors
    • Yoshimi N, Fujita Y, Ohgi Y, Futamura T, Kikuchi T, and Hashimoto K (2014) Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: A role for serotonin 5-HT1A receptors. Pharmacol Biochem Behav 124:245-249.
    • (2014) Pharmacol Biochem Behav , vol.124 , pp. 245-249
    • Yoshimi, N.1    Fujita, Y.2    Ohgi, Y.3    Futamura, T.4    Kikuchi, T.5    Hashimoto, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.