Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: Role in atypical antipsychotic action

Journal of Neuroscience

Volumn 25, Issue 47, 2005, Pages 10831-10843

  Díaz Mataix, Llorenç ^a   Scorza, M Cecilia ^a,c   Bortolozzi, Analía ^a   Toth, Miklos ^b   Celada, Pau ^a   Artigas, Francesc ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

Author keywords

Antipsychotic; Dopamine; Prefrontal cortex; Schizophrenia; Serotonergic 1A receptor; Ventral tegmental area

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; BICUCULLINE; CLOZAPINE; HALOPERIDOL; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NOMIFENSINE; OLANZAPINE; REPINOTAN; SEROTONIN 1A RECEPTOR; ZIPRASIDONE; BENZOPYRAN DERIVATIVE; DOPAMINE; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; SEROTONIN AGONIST; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; DRUG EFFECT; DRUG MECHANISM; HYPERPOLARIZATION; MALE; NEGATIVE SYNDROME; NERVE CONDUCTION; NERVE EXCITABILITY; NERVE TRANSECTION; NONHUMAN; PHYSICAL ACTIVITY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOSIS; RAT; SCHIZOPHRENIA; VENTRAL TEGMENTUM; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG POTENTIATION; ELECTROPHYSIOLOGY; EXTRACELLULAR FLUID; METABOLISM; MOUSE; MOUSE MUTANT; NERVE CELL; NERVE TRACT; OSMOLARITY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZOPYRANS; DOPAMINE; ELECTROPHYSIOLOGY; EXTRACELLULAR FLUID; HALOPERIDOL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAL PATHWAYS; NEURONS; OSMOLAR CONCENTRATION; PIPERAZINES; PREFRONTAL CORTEX; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; THIAZOLES; VENTRAL TEGMENTAL AREA;

EID: 28044469011     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2999-05.2005     Document Type: Article

References (87)

1. Abi-Dargham A, Rodenhiser J, Printz D, Zea-Ponce Y, Gil R, Kegeles LS, Weiss R, Cooper TB, Mann JJ, Van Heertum RL, Gorman JM, Laruelle M (2000) Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc Natl Acad Sci USA 97:8104-8109.
2. Adell A, Artigas F (2004) The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems. Neurosci Biobehav Rev 28:415-431.
3. Adell A, Carceller A, Artigas F (1993) In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat. Effects of 8-hydroxy-2-(di-N-propylamino)tetralin. J Neurochem 60:1673-1681.
4. Aghajanian GK, Wang RY (1977) Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique. Brain Res 122:229-242.
5. 2A receptors in pyramidal neurons of prefrontal cortex. Cereb Cortex 14:281-299.
6. 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience 40:399-412.
7. 1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons. Naunyn Schmiedebergs Arch Pharmacol 347:353-362.
8. Arborelius L, Nokimos GG, Hacksell U, Svensson TH (1993b) (R)-S-OH-DPAT preferentially increases dopamine release in rat medial prefrontal cortex. Acta Physiol Scand 148:465-466.
9. Arnt J, Skarsfeldt T (1998) Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology 18:63-101.
10. 2A receptors in the rat medial prefrontal cortex: an iontophoretic study. Synapse 17:173-181.
11. 1A receptor in primate brain neurons and glial cells. Neuropsychopharmacology 14:35-46.
12. 1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells. J Pharmacol ExpTher 263:350-359.
13. 2A receptor antagonist directly activates postsynaptic 5-HT inhibitory responses in the rat cerebral cortex. Naunyn Schmiederbergs Arch Pharmacol 352:283-290.
14. 2A receptors. Effect of antipsychotic drugs. Eur J Neurosci 18:1235-1246.
15. 2A receptors in prefrontal cortex enhances dopaminergic activity. J Neurochem, in press.
16. Carlsson A (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1:179-186.
17. Carr DB, Sesack SR (2000a) Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons. J Neurosci 20:3864-3873.
18. Carr DB, Sesack SR (2000b) GABA-containing neurons in the rat ventral tegmental area project to the prefrontal cortex. Synapse 38:114-123.
19. 1A receptors control 5-HT release in the rat medial prefrontal cortex. NeuroReport 10:1441-1445.
20. 1A receptor agonist BAY × 3702 on serotonergic cell firing and release. Naunyn Schmiedebergs Arch Pharmacol 362:248-254.
21. Ceci A, Baschirotto A, Borsini F (1994) The inhibitori effect of 8-OH-DPAT on the firing activity of dorsal raphe neurons in rats is attenuated by lesion of the frontal cortex. Neuropharmacology 33:709-713.
22. Celada P, Paladini CA, Tepper JM (1999) GABAergic control of rat substantia nigra dopaminergic neurons: role of globus pallidus and substantia nigra pars reticulata. Neuroscience 89:813-825.
23. A, and glutamate receptors. J Neurosci 21:9917-9929.
24. Chergui K, Suaud-Chagny MF, Gonon F (1994) Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brain in vivo. Neuroscience 62:641-645.
25. 1A receptors by clozapine in the primate brain: a PET study. Psychopharmacology 166:234-240.
26. Creese I, Burt DR, Snyder SH (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192:481-483.
27. 1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex. Brain Res 989:42-51.
28. De Felipe J, Arellano JI, Gomez A, Azmitia EC, Muñoz A (2001) Pyramidal cell axons show a local specialization for GABA and 5-HT inputs in monkey and human cerebral cortex. J Comp Neurol433:148-155.
29. 1A receptor agonist. J Pharmacol Exp Ther 284:1082-1094.
30. 1A receptor agonist. Eur Neuropsychopharmacol, in press.
31. 2C receptors in the control of central dopamine function. Trends Pharmacol Sci 22:229-232.
32. Fa M, Mereu G, Ghiglieri V, Meloni A, Salis P, Gessa GL (2003) Electrophysiological and pharmacological characteristics of nigral dopaminergic neurons in the conscious, head-restrained rat. Synapse 48:1-9.
33. Ferré S, Cortés R, Artigas F (1994) Dopaminergic regulation of the serotonergic raphe-striatal pathway: microdialysis studies in freely moving rats. J Neurosci 14:4839-4846.
34. Floresco SB, West AR, Ash B, Moore H, Grace AA (2003) Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nat Neurosci 6:968-973.
35. 1A receptor antagonist, WAY-100635. Eur J Pharmacol 281:81-88.
36. Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. San Diego: Academic.
37. Gariano RF, Groves PM (1988) Burst firing induced in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices. Brain Res 462:194-198.
38. Gessa GL, Devoto P, Diana M, Flore G, Melis M, Pistis M (2000) Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex. Neuropsychopharmacology 22:642-649.
39. Glowinski J, Tassin JP, Thierry AM (1984) The mesocortico-prefrontal dopaminergic neurons. Trends Neurosci 7:415-418.
40. Grace AA, Bunney BS (1984) The control of firing pattern in nigral dopamine neurons: burst firing. J Neurosci 4:2877-2890.
41. Hajós M, Richards CD, Szekely AD, Sharp T (1998) An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience 87:95-108.
42. 1A receptor- induced inhibition of 5-HT neuronal activity in the rat. Br J Pharmacol 126:1741-1750.
43. Hoyer D, Boddeke WGM (1993) Partial agonists, full agonists, antagonists: dilemmas of definition. Trends Pharmacol Sci 14:270-275.
44. 1A receptor agonist, inhibits amphetamine- induced dopamine release in rat striatum and nucleus accumbens. Eur J Pharmacol 287:179-184.
45. 1A receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. J Neurochem 76:1521-1531.
46. 2A/2C receptor agonist, attenuates clozapine-induced cortical dopamine release. Brain Res 907:151-155.
47. 1A receptors in the rat central nervous system. J Comp Neurol 365:289-305.
48. 1A receptor agonist, inhibits amphetamine-induced serotonin and dopamine release in rat medial prefrontal cortex. Brain Res 743:357-361.
49. Kuroki T, Meltzer HY, Ichikawa J (1999) Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens. J Pharmacol Exp Ther 288:774-781.
50. Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, McCance E, Rosenblatt W, Fingado C, Zoghbi SS, Baldwin RM, Seibyl JP, Krystal JH, Charney DS, Innis RB (1996) Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA 93:9235-9240.
51. 1A) receptors: WAY 100, 635-reversible actions of the highly selective ligands, flesinoxan and S-15535. Synapse 30:172-180.
52. 4 receptors exert a state-dependent facilitatory control in vivo on nigrostriatal, but not mesoaccumbal, dopaminergic function. Eur J Neurosci 13:889-898.
53. Martín-Ruiz R, Puig MV, Celada P, Shapiro DA, Roth BL, Mengod G, Artigas F (2001) Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. J Neurosci 21:9856-9866.
54. Meltzer HY (1999) The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 21:5106-5115.
55. 1A) receptors. J Pharmacol Exp Ther 295:853-861.
56. Murase S, Grenhoff J, Chouvet G, Gonon FG, Svensson TH (1993) Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo. Neurosci Lett 157:53-56.
57. Omelchenko N, Sesack SR (2005) Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area, J Comp Neurol 483:217-235.
58. 1A receptor. Proc Natl Acad Sci USA 95:10734-10739.
59. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Sydney: Academic.
60. Pazos A, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res 346:205-230.
61. Peyron C, Petit JM, Rampon C, Jouvet M, Luppi PH (1998) Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods. Neuroscience 82:443-468.
62. 1A receptor in the rat brain: correlation with receptor binding. J Neurosci 12:440-453.
63. 2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 26:311-324.
64. Prisco S, Pagannone S, Esposito E (1994) Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo. J Pharmacol Exp Ther 271:83-90.
65. Puig MV, Artigas F, Celada P (2005) Modulation of the activity of pyramidal neurons in rat prefrontal cortex by raphe stimulation in vivo: involvement of serotonin and GABA. Cereb Cortex 15:1-14.
66. 1B serotonin receptors in adult rat brain. J Comp Neurol 417:181-194.
67. Robbins TW (2000) Chemical neuromodulation of frontal-executive functions in humans and other animals. Exp Brain Res 133:130-138.
68. 1A receptor activation. Eur J Pharmacol 338:R3-R5.
69. 1A receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biol Psychiatry 48:229-237.
70. Roth BL, Scheffler D, Potkin SG (2005) Atypical antipsychotic drug actions: unitary or multiple mechanisms for "atypicality"? Clin Neurosci Res 3:108-117.
71. 1A receptor activation increases in vivo dopaminerelease in rat prefrontal cortex. Br J Pharmacol 129:1028-1034.
72. 2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex. Cereb Cortex 14:1100-1109.
73. Schultz W (2004) Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology. Curr Opin Neurobiol 14:139-147.
74. Seeman P, Lee T (1975) Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. Science 188:1217-1219.
75. Sesack SR, Hawrylak VA, Matus C, Guido MA, Levey AI (1998) Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 18:2697-2708.
76. Sesack SR, Carr DB, Omelchenko N, Pinto A (2003) Anatomical substrates for glutamate-dopamine interactions: evidence for specificity of connections and extrasynaptic actions. Ann NY Acad Sci 1003:36-52.
77. 1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br J Pharmacol 96:283-290.
78. 1A selective agonists. Eur J Pharmacol 128:295-298.
79. 1B agonists. Synapse 1:3-9.
80. Thierry AM, Deniau JM, Feger J (1979) Effects of stimulation of the frontal cortex on identified output VMT cells in the rat. Neurosci Lett 15:103-107.
81. Thierry AM, Chevalier G, Perron A, Glowinski J (1983) Diencephalic and mesencephalic efferents of the medial prefrontal cortex in the rat: electrophysiological evidence for the existence of branched axons. Exp Brain Res 50:275-282.
82. Tierney PL, Degenetais E, Thierry AM, Glowinski J, Gioanni Y (2004) Influence of the hippocampus on interneurons of the rat prefrontal cortex. Eur J Neurosci 20:514-524.
83. Tong ZY, Overton PG, Clark D (1996) Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events. Synapse 22:195-208.
84. Tong ZY, Overton PG, Martinez-Cue C, Clark D (1998) Do non-dopaminergic neurons in the ventral tegmental area play a role in the responses elicited in A10 dopaminergic neurons by electrical stimulation of the prefrontal cortex? Exp Brain Res 118:466-476.
85. Tzschentke TM, Schmidt WJ (2000) Functional relationship among medial prefrontal cortex, nucleus accumbens, and ventral tegmental area in locomotion and reward. Crit RevNeurobiol 14:131-142.
86. Weinberger DR, Aloia MS, Goldberg TE, Berman KF (1994) The frontal lobes and schizophrenia. J Neuropsychiatry Clin Neurosci 6:419-427.
87. Williams GV, Goldman-Rakic PS (1995) Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 376:572-575.