Unmethylation of the CHRNB4 gene is an unfavorable prognostic factor in non-small cell lung cancer

Lung Cancer

Volumn 86, Issue 1, 2014, Pages 85-90

  Yoo, Seung Soo ^a   Lee, Su Man ^a   Do, Sook Kyung ^a   Lee, Won Kee ^a   Kim, Dong Sun ^a   Park, Jae Yong ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

CHRNB4; Methylation specific polymerase chain reaction; Nicotinic acetylcholine receptors; Non small cell lung cancer; Prognosis; Unmethylation

Indexed keywords

MESSENGER RNA; NICOTINIC ACETYLCHOLINE RECEPTOR BETA 4; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG; CHRNB4 PROTEIN, HUMAN; NERVE PROTEIN;

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL PROLIFERATION; CLINICAL FEATURE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG ALVEOLUS EPITHELIUM; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE; TUMOR GROWTH; UBIQUITINATION; UPREGULATION; AGED; CPG ISLAND; GENETICS; LUNG TUMOR; MIDDLE AGED; MORTALITY; OUTCOME ASSESSMENT; PATHOLOGY; PROGNOSIS; RISK FACTOR; TUMOR CELL LINE;

ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NERVE TISSUE PROTEINS; PATIENT OUTCOME ASSESSMENT; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RECEPTORS, NICOTINIC; RISK FACTORS;

EID: 84908398982     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2014.08.002     Document Type: Article

References (31)

1. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60:277-300.
2. Sun S., Schiller J.H., Spinora M., Minna J.D. New molecular targeted therapies for lung cancer. J Clin Invest 2007, 117:2740-2750.
3. Minna J.D., Roth J.A., Gazdar A.F. Focus on lung cancer. Cancer Cell 2002, 1:49-52.
4. Xu H., Spitz M.R., Amos C.I., Shete S. Complex segregation analysis reveals a multigene model for lung cancer. Hum Genet 2005, 116:121-127.
5. Hou L., Zhang X., Wang D., Baccarelli A. Environmental chemical exposures and human epigenetics. Int J Epidemiol 2012, 41:79-109.
6. Brzezianska E., Dutkowaska A., Antczak A. The significance of epigenetic alterations in lung carcinogenesis. Mol Biol Rep 2013, 40:309-325.
7. Lu F., Zhang H.T. DNA methylation and nonsmall cell lung cancer. Anat Rec 2011, 294:1787-1795.
8. Wilson A.S., Power B.E., Molloy P.L. DNA hypomethylation and human disease. Biochim Biophys Acta 2007, 1775:138-162.
9. Ehrlich M. DNA hypomethylation in cancer cells. Epigenomics 2009, 1:239-259.
10. Selamat S.A., Chung B.S., Girard L., Zhang W., Zhang Y., Campan M., et al. Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res 2012, 22:1197-1211.
11. Lokk K., Vooder T., Kolde R., Valk K., Vosa U., Roosipuu R., et al. Mehtylation markers of early-stage non-small cell lung cancer. PLoS ONE 2012, 7:e39813.
12. Catassi A., Servent D., Paleari L., Cesario A., Russo P. Multiple role of nicotine on cell proliferation and inhibition of apoptosis: implication on lung carcinogenesis. Mutat Res 2008, 659:221-231.
13. Improgo M.R., Tapper A.R., Gardner P.D. Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer. Biochem Pharmacol 2011, 82:1015-1021.
14. Lukas R.J., Changeux J.P., Le Novère N., Albuquerque E.X., Balfour D.J., Berg D.K., et al. International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 1999, 51:397-401.
15. West K.A., Brognard J., Clark A.S., Linnolia I.R., Yang X., Swain S.M., et al. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest 2003, 11:81-90.
16. Aldea M., Castillo M., Mulet J., Sala S., Criado M., Sala F. Role of the extracellular transmembrane domain interface in gating and pharmacology of a heteromeric neuronal nicotinic receptor. J Neurochem 2010, 113:1036-1045.
17. Hung R.J., McKay J.D., Gaborieau V., Boffetta P., Hashibe M., Zaridze D., et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholin receptor subunit genes on 15q25. Nature 2008, 452:633-638.
18. Improgo M.R.D., Scofield M.D., Tapper A.R., Garder P.D. From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene 2010, 29:4874-4884.
19. Paliwal A., Vaissiere T., Krais A., Cuenin C., Cros M.P., Zaridze D., et al. Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer. Cancer Res 2010, 70:2779-2788.
20. Scherf D.B., Sarkisyan N., Jacobsson H., Claus R., Bermejo J.L., Peil B., et al. Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4. Oncogene 2013, 32:3329-3338.
21. Herman J.G., Graff J.R., Myohanen S., Nelkin B.D., Baylin S.B., Baylin S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996, 93:9821-9826.
22. Sotamaa K., Liyanarachchi S., Mecklin J.P., Jarvinen H., Aaltonen L.A., Peltomaki P., et al. p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. Clin Cancer Res 2005, 11:6840-6844.
23. Claus R., Wilop S., Hielscher T., Sonnet M., Dahl E., Galm O., et al. A systematic comparison of quantitative high-resolution DNA methylation analysis and methylation-specific PCR. Epigenetics 2012, 7:772-780.
24. Toyook S., Maruyama R., Toyook K.O., McLerran D., Feng Z., Fukuyama Y., et al. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer 2003, 103:153-160.
25. Luetje C.W., Patrick J. Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J Neurosci 1991, 11:837-845.
26. Schuller H.M. Is cancer triggered by altered signaling of nicotinic acetylcholine receptors. Nat Rev Cancer 2009, 9:195-205.
27. Lam D.C., Girard L., Ramirez R., Chau W.S., Suen W.S., Sheridan S., et al. Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res 2007, 67:4638-4647.
28. Improgo M.R.D., Schlichting N.A., Cortes R.Y., Zhao-Shea R., Tapper A.R., Garder P.D. ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Mol Cancer Res 2010, 8:194-203.
29. Rose J.E. Multiple brain pathways and receptors underlying tobacco addiction. Biochem Pharmacol 2007, 74:1263-1270.
30. Gallego X., Molas S., Amador-Arjona A., Marks M.J., Robles N., Murtra P., et al. Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. Amino Acids 2012, 43:897-909.
31. Schuller H.M. Nitrosamines as nicotinic receptor ligands. Life Sci 2007, 80:2274-2280.