Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 22, 2014, Pages 6453-6458

  Zhao, Xiao Bo ^a   Wu, Dan ^a   Wang, Mei Juan ^a   Goto, Masuo ^b   Morris Natschke, Susan L ^b   Liu, Ying Qian ^a   Wu, Xiao Bing ^a   Song, Zi Long ^a   Zhu, Gao Xiang ^a   Lee, Kuo Hsiung ^b,c  

^a LANZHOU UNIVERSITY   (China)

^b UNC Hamner Institute for Drug Safety Sciences   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

C 20 position; Camptothecin; Cytotoxic activity; Spin labeled

Indexed keywords

CAMPTOTHECIN DERIVATIVE; COPPER; CYTOTOXIC AGENT; TOPOTECAN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; SPIN LABELING;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CATALYSIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; KB CELL LINE; KBVIN CELL LINE; MDA MB 231 CELL LINE; MULTIDRUG RESISTANCE; ONE POT SYNTHESIS; PHENOTYPE; SPIN LABELING; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KB CELLS; SPIN LABELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908390465     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.09.035     Document Type: Article

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