Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7530-7533

  Liu, Yingqian ^a,d   Qian, Keduo ^a   Wang, Chih Ya ^a   Chen, Chin Ho ^b   Yang, Xiaoming ^a   Lee, Kuo Hsiung ^a,c  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d LANZHOU UNIVERSITY   (China)

Author keywords

18 Glycyrrhetinic acid; 20S proteasome inhibitors; Cytotoxicity; Nitroxide; Spin labeled

Indexed keywords

18BETA GLYCYRRHETINIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; GLYCYRRHETINIC ACID DERIVATIVE; LACTACYSTIN; PIPERIDINE DERIVATIVE; PROTEASOME INHIBITOR; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCYRRHETINIC ACID; HUMANS; MOLECULAR CONFORMATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870236278     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.041     Document Type: Article

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