Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions

Biochemical Journal

Volumn 464, Issue 1, 2014, Pages 123-133

  Harmer, Jenny E ^a   Hiscox, Martyn J ^a   Dinis, Pedro C ^a   Fox, Stephen J ^a   Iliopoulos, Andreas ^a   Hussey, James E ^a   Sandy, James ^b   Van Beek, Florian T ^a   Essex, Jonathan W ^a   Roach, Peter L ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b DIAMOND LIGHT SOURCE LTD   (United Kingdom)

Author keywords

Cofactor; Crystal structure; Enzyme catalysis; Lipoyl synthase; Radical s adenosylmethionine (SAM); Sulfur; Thermosynechococcus elongatus

Indexed keywords

5' METHYLTHIOADENOSINE; LIGAND; LIPOYL SYNTHASE; RADICAL; S ADENOSYLMETHIONINE; SERINE; SULFIDE; SULFUR; SYNTHETASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; LIPOIC ACID SYNTHASE; SULFURTRANSFERASE;

ARTICLE; CHEMICAL REACTION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; BINDING SITE; CHEMISTRY; METABOLISM; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

THERMOSYNECHOCOCCUS ELONGATUS;

BACTERIAL PROTEINS; BINDING SITES; CRYSTALLIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SULFUR; SULFURTRANSFERASES;

EID: 84908387322     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140895     Document Type: Article

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