Cecropin A-melittin mutant with improved proteolytic stability and enhanced antimicrobial activity against bacteria and fungi associated with gastroenteritis in vitro

Biochemical and Biophysical Research Communications

Volumn 451, Issue 4, 2014, Pages 650-655

  Ji, Shengyue ^a   Li, Weili ^b   Zhang, Lei ^a   Zhang, Yue ^a   Cao, Binyun ^a  

^a NORTHWEST A F UNIVERSITY   (China)

^b Beijing Hoyateq Science AndTechnology Co Ltd   (China)

Author keywords

Antimicrobial peptide; Biological potency; Pharmaceutical index; Proteolytic stability

Indexed keywords

ADENOSINE PHOSPHATE; CECROPIN A; CECROPIN A MELITTIN; CECROPIN A MELITTIN W; ELASTASE; LEUKOCYTE ELASTASE; LIPOSOME; MELITTIN; PEPSIN A; PROTEINASE; TRYPSIN; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; PEPTIDE HYDROLASE; POLYPEPTIDE ANTIBIOTIC AGENT;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIUM; BIOTECHNOLOGY; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; DRUG POTENCY; FUNGUS; GASTROENTERITIS; GASTROINTESTINAL TRACT; HEAT TOLERANCE; HEMOLYSIS; HUMAN; HUMAN TISSUE; IC50; IN VITRO STUDY; NONHUMAN; PH; PROTEIN DEGRADATION; PROTEIN STABILITY; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; BIOLOGICAL POTENCY; DRUG EFFECT; DRUG STABILITY; GENETICS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PHARMACEUTICAL INDEX; PROTEOLYTIC STABILITY; TEMPERATURE;

ANTIMICROBIAL PEPTIDE; BIOLOGICAL POTENCY; PHARMACEUTICAL INDEX; PROTEOLYTIC STABILITY;

ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; DRUG STABILITY; FUNGI; GASTROENTERITIS; HUMANS; HYDROGEN-ION CONCENTRATION; MELITTEN; MICROBIAL SENSITIVITY TESTS; PEPTIDE HYDROLASES; PROTEOLYSIS; TEMPERATURE;

EID: 84908371144     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.08.044     Document Type: Article

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