Rational Design of Tryptophan-Rich Antimicrobial Peptides with Enhanced Antimicrobial Activities and Specificities

ChemBioChem

Volumn 11, Issue 16, 2010, Pages 2273-2282

  Yu , Hui Yuan ^a   Huang , Kuo Chun ^a   Yip , Bak Sau ^a,b   Tu, Chih Hsiang ^a   Chen, Heng Li ^a   Cheng, Hsi Tsung ^a   Cheng, Jya Wei ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b Hsinchu General Hospital   (Taiwan)

Author keywords

Antibiotics; Drug design; Membranes; Peptides; Structure activity relationships

Indexed keywords

ALANINE; CALCEIN; DODECYLPHOSPHORYLCHOLINE; LEUCINE; LYSYLLYSYLTRYPTOPHYLARGINYLALANYLTRYPTOPHYLLEUCYLLYSYLTRYPTOPHYLLEUCYLALANYLLYSYLLYSINE; LYSYLLYSYLTRYPTOPHYLARGINYLLYSYLTRYPTOPHYLLEUCYLLYSYLTRYPTOPHYLLEUCYLALANYLLYSYLLYSINE; LYSYLLYSYLTRYPTOPHYLARGINYLTRYPTOPHYLTRYPTOPHYLLEUCYLLYSYLALANYLLEUCYLALANYLLYSYLLYSINE; POLYPEPTIDE ANTIBIOTIC AGENT; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALPHA HELIX; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG BINDING; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; ELECTRICITY; FLUORESCENCE SPECTROSCOPY; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MICELLE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CALORIMETRY; CIRCULAR DICHROISM; DRUG DESIGN; ERYTHROCYTES; HEMOLYSIS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MICROBIAL SENSITIVITY TESTS; PHOSPHORYLCHOLINE; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

ANIMALIA; BACTERIA (MICROORGANISMS); BOTHROPS ASPER; NEGIBACTERIA; POSIBACTERIA;

EID: 78049317400     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000372     Document Type: Article

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