PPARgamma agonist pioglitazone does not enhance performance in mice

Drug Testing and Analysis

Volumn 6, Issue 9, 2014, Pages 922-929

  Sanchis Gomar, Fabian ^a   Pareja Galeano, Helios ^a   Martinez Bello, Vladimir E ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Endurance capacity; Maximal aerobic velocity; Mitochondrial biogenesis; Performance; PGC 1 ; Thiazolidinediones

Indexed keywords

BIOSYNTHESIS; CYTOLOGY; ENZYME ACTIVITY; MAMMALS; METABOLISM; TRANSCRIPTION;

AMP-ACTIVATED PROTEIN KINASE; CITRATE SYNTHASE; ENDURANCE CAPACITY; MAXIMAL AEROBIC VELOCITY; MITOCHONDRIAL BIOGENESIS; PERFORMANCE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PGC-1Α; PIOGLITAZONE; THIAZOLIDINEDIONES;

MUSCLE;

CITRATE SYNTHASE; CYTOCHROME C; GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PIOGLITAZONE; TRANSCRIPTION FACTOR NRF1; 2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUCOSE BLOOD LEVEL; PERFORMANCE ENHANCING SUBSTANCE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

AEROBIC CAPACITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDURANCE; ENZYME ACTIVITY; GASTROCNEMIUS MUSCLE; GLUCOSE BLOOD LEVEL; GRIP STRENGTH; MALE; MITOCHONDRIAL BIOGENESIS; MOUSE; NONHUMAN; PROTEIN CONTENT; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SOLEUS MUSCLE; AGONISTS; ANIMAL; DRUG EFFECTS; HAND STRENGTH; LUNG VENTILATION; METABOLISM; MITOCHONDRIAL DYNAMICS; SKELETAL MUSCLE;

ANIMALS; BLOOD GLUCOSE; HAND STRENGTH; MAXIMAL VOLUNTARY VENTILATION; MICE; MITOCHONDRIAL TURNOVER; MUSCLE, SKELETAL; PERFORMANCE-ENHANCING SUBSTANCES; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; PPAR GAMMA; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES;

EID: 84908340899     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1587     Document Type: Article

References (37)

1. M. Thevis, I. Moller, A. Thomas, S. Beuck, G. Rodchenkov, W. Bornatsch, H. Geyer, W. Schanzer . Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Anal. Bioanal. Chem. 2009, 396, 2479.
2. A. Thomas, S. Beuck, J.C. Eickhoff, S. Guddat, O. Krug, M. Kamber, W. Schanzer, M. Thevis . Quantification of urinary AICAR concentrations as a matter of doping controls. Anal. Bioanal. Chem. 2010, 396, 2899.
3. V.A. Lira, C.R. Benton, Z. Yan, A. Bonen . PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 2010, 299, E145.
4. V.A. Narkar, M. Downes, R.T. Yu, E. Embler, Y.X. Wang, E. Banayo, M.M. Mihaylova, M.C. Nelson, Y. Zou, H. Juguilon, H. Kang, R.J. Shaw, R.M. Evans . AMPK and PPARdelta agonists are exercise mimetics. Cell 2008, 134, 405.
5. L.J. Goodyear . The exercise pill--too good to be true? New Engl. J. Med. 2008, 359, 1842.
6. Y. Shi, M. Hon, R.M. Evans . The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 2613.
7. M.C. Gomez-Cabrera, E. Domenech, M. Romagnoli, A. Arduini, C. Borras, F.V. Pallardo, J. Sastre, J. Vina . Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am. J. Clin. Nutr. 2008, 87, 142.
8. P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, B.M. Spiegelman . A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92, 829.
9. J. St-Pierre, S. Drori, M. Uldry, J.M. Silvaggi, J. Rhee, S. Jager, C. Handschin, K. Zheng, J. Lin, W. Yang, D.K. Simon, R. Bachoo, B.M. Spiegelman . Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006, 127, 397.
10. C. Handschin, S. Chin, P. Li, F. Liu, E. Maratos-Flier, N.K. Lebrasseur, Z. Yan, B.M. Spiegelman . Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J. Biol. Chem. 2007, 282, 30014.
11. Y.X. Wang, C.L. Zhang, R.T. Yu, H.K. Cho, M.C. Nelson, C.R. Bayuga-Ocampo, J. Ham, H. Kang, R.M. Evans . Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004, 2, e294.
12. A.E. Civitarese, B. Ukropcova, S. Carling, M. Hulver, R.A. DeFronzo, L. Mandarino, E. Ravussin, S.R. Smith . Role of adiponectin in human skeletal muscle bioenergetics. Cell Metab. 2006, 4, 75.
13. S. Jager, C. Handschin, J. St-Pierre, B.M. Spiegelman . AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 12017.
14. Q. Long, T. Lei, B. Feng, C. Yin, D. Jin, Y. Wu, X. Zhu, X. Chen, L. Gan, Z. Yang . Peroxisome proliferator-activated receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44. Endocrinology 2010, 151, 3195.
15. R.H. Amin, S.T. Mathews, H.S. Camp, L. Ding, T. Leff . Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2010, 298 E28.
16. C. Handschin, B.M. Spiegelman . Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 2006, 27, 728.
17. S.J. Lessard, Z.P. Chen, M.J. Watt, M. Hashem, J.J. Reid, M.A. Febbraio, B.E. Kemp, J.A. Hawley . Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 2006, 290, E251.
18. I. Pagel-Langenickel, J. Bao, J.J. Joseph, D.R. Schwartz, B.S. Mantell, X. Xu, N. Raghavachari, M.N. Sack . PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle. J. Biol. Chem. 2008, 283, 22464.
19. V. Skov, D. Glintborg, S. Knudsen, Q. Tan, T. Jensen, T.A. Kruse, H. Beck-Nielsen, K. Hojlund . Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome. PLoS One 2008, 3, e2466.
20. Y. Higashi, K. Holder, P. Delafontaine . Thiazolidinediones upregulate insulin-like growth factor-1 receptor via a peroxisome proliferator-activated receptor {gamma}-independent pathway. J. Biol. Chem. 2010, 285, 36361.
21. J.A. Lack, M.E. Stuart-Taylor . Calculation of drug dosage and body surface area of children. Brit. J. Anaesth. 1997, 78, 601.
22. S. Reagan-Shaw, M. Nihal, N. Ahmad . Dose translation from animal to human studies revisited. FASEB J. 2008, 22, 659.
23. F. Sanchis-Gomar, G. Lippi . Telmisartan as metabolic modulator: A new perspective in sports doping? J. Strength Cond. Res. 2012, 26, 608.
24. K.J. Davies, L. Packer, G.A. Brooks . Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training. Arch. Biochem. Biophys. 1981, 209, 539.
25. K.J. Davies, L. Packer, G.A. Brooks . Exercise bioenergetics following sprint training. Arch. Biochem. Biophys. 1982, 215, 260.
26. V.E. Martinez-Bello, F. Sanchis-Gomar, A.L. Nascimento, F.V. Pallardo, S. Ibanez-Sania, G. Olaso-Gonzalez, J.A. Calbet, M.C. Gomez-Cabrera, J. Vina . Living at high altitude in combination with sea-level sprint training increases hematological parameters but does not improve performance in rats. Eur. J. Appl. Physiol. 2011, 111, 1147.
27. G.A. Brooks, T.P. White . Determination of metabolic and heart rate responses of rats to treadmill exercise. J. Appl. Physiol. 1978, 45, 1009.
28. J.C. Crabbe, C.J. Cotnam, A.J. Cameron, J.P. Schlumbohm, J.S. Rhodes, P. Metten, D. Wahlsten . Strain differences in three measures of ethanol intoxication in mice: The screen, dowel and grip strength tests. Genes Brain Behav. 2003, 2, 201.
29. O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall . Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193, 265.
30. M. Nakamoto, Y. Ohya, T. Shinzato, R. Mano, M. Yamazato, A. Sakima, S. Takishita . Pioglitazone, a thiazolidinedione derivative, attenuates left ventricular hypertrophy and fibrosis in salt-sensitive hypertension. Hypertens. Res. 2008, 31, 353.
31. M. Anjaneyulu, P. Ramarao . Protective effect of pioglitazone against multiple low-dose streptozotocin-induced diabetes in rats. Methods Find. Exp. Clin. Pharmacol. 2003, 25, 205.
32. C.R. Bueno Junior, L.C. Pantaleao, V.A. Voltarelli, L.H. Bozi, P.C. Brum, M. Zatz . Combined effect of AMPK/PPAR agonists and exercise training in mdx mice functional performance. PLoS One 2012, 7, e45699.
33. S. Terada, M. Goto, M. Kato, K. Kawanaka, T. Shimokawa, I. Tabata . Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Biochem. Biophys. Res. Commun. 2002, 296, 350.
34. T. Tanaka, J. Yamamoto, S. Iwasaki, H. Asaba, H. Hamura, Y. Ikeda, M. Watanabe, K. Magoori, R.X. Ioka, K. Tachibana, Y. Watanabe, Y. Uchiyama, K. Sumi, H. Iguchi, S. Ito, T. Doi, T. Hamakubo, M. Naito, J. Auwerx, M. Yanagisawa, T. Kodama, J. Sakai . Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 15924.
35. W.W. Winder, B.F. Holmes, D.S. Rubink, E.B. Jensen, M. Chen, J.O. Holloszy . Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J. Appl. Physiol. 2000, 88, 2219.
36. K. Baar, Z. Song, C.F. Semenkovich, T.E. Jones, D.H. Han, L.A. Nolte, E.O. Ojuka, M. Chen, J.O. Holloszy . Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity. Faseb. J. 2003, 17, 1666.
37. A.P. Marsh, M. Kyla Shea, R.M. Vance Locke, M.E. Miller, S. Isom, G.D. Miller, B.J. Nicklas, M.F. Lyles, J.J. Carr, S.B. Kritchevsky . Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight Loss in older adults. J. Gerontol. A Biol. Sci. Med. Sci. 2013, 68, 828.