Strain differences in three measures of ethanol intoxication in mice: The screen, dowel and grip strength tests

Genes, Brain and Behavior

Volumn 2, Issue 4, 2003, Pages 201-213

  Crabbe, J C ^a,c   Cotnam, C J ^a   Cameron, A J ^a   Schlumbohm, J P ^a   Rhodes, J S ^a   Metten, P ^a   Wahlsten, D ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Ataxia; Balance; Dowel test; Ethanol; Grip strength; Inbred mouse strains; Pharmacogenetics; Screen test

Indexed keywords

ALCOHOL INTOXICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; CONTROLLED STUDY; GENOTYPE; GRIP STRENGTH; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SCREENING TEST;

ALCOHOLIC INTOXICATION; ANIMALS; ATAXIA; BEHAVIOR, ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; GENOTYPE; MICE; MICE, INBRED STRAINS; SPECIES SPECIFICITY;

ANIMALIA;

EID: 0041466270     PISSN: 16011848     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1601-183X.2003.00023.x     Document Type: Article

References (42)

1. Beck, J.A., Lloyd, S., Hafezparast, M., Lennon-Pierce, M., Eppig, J.T., Festing, M.F.W. & Fisher, E.M.C. (2000) Genealogies of mouse inbred strains. Nat Genet 24, 23-25.
2. Boehm, S.L., II, Schafer, G.L., Phillips, T.J., Browman, K.E. & Crabbe, J.C. (2000) Sensitivity to ethanol-induced motor incoordination in 5-HT (1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice. Behav Neurosci 114, 401-409.
3. Bogo, V., Hill, T.A. & Young, R.W. (1981) Comparison of accelerod and rotarod sensitivity in detecting ethanol- and acrylamide-induced performance decrement in rats: review of experimental considerations of rotating rod systems. Neurotoxicology 2, 765-787.
4. Browman, K.E. & Crabbe, J.C. (2000) Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice. Alcohol Clin Exp Res 24, 17-23.
5. Cohen, J. (1988) Statistical Power Analysis for the Behavioral Sciences. Erlbaum, Hillsdale, NJ.
6. Contet, C., Rawlins, J.N. & Deacon, R.M. (2001) A comparison of 129S2/SvHsd and C57BL/6JOIaHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice. Behav Brain Res 124, 33-46.
7. Crabbe, J.C. (1983) Sensitivity to ethanol in inbred mice: genotypic correlations among several behavioral responses. Behav Neurosci 97, 280-289.
8. Crabbe, J.C., Gallaher, E.J., Phillips, T.J. & Belknap, J.K. (1994) Genetic determinants of sensitivity to ethanol in inbred mice. Behav Neurosci 108, 186-195.
9. Crabbe, J.C., Janowsky, J.S., Young, E.R., Kosobud, A., Stack, J. & Rigter, H. (1982) Tolerance to ethanol hypothermia in inbred mice: genotypic correlations with behavioral responses. Alcohol Clin Exp Res 6, 446-458.
10. Crabbe, J.C., Metten, P., Yu, C.-H., Schlumbohm, J.P., Cameron, A.J. & Wahlsten, D. Genotypic differences in ethanol sensitivity in two tests of motor incoordination. J Appl Physiol in press.
11. Crabbe, J.C., Wahlsten, D. & Dudek, B.C. (1999) Genetics of mouse behavior: interactions with laboratory environment. Science 284, 1670-1672.
12. Crabbe, J.C., Young, E.R. & Kosobud, A. (1983) Genetic correlations with ethanol withdrawal severity. Pharmacol Biochem Behav 18, 541-547.
13. Damjanovich, R.P. & Maclnnes, J.W. (1973) Factors involved in ethanol narcosis: analysis in mice of three inbred strains. Life Sci 13, 55-65.
14. Deitrich, R.A., Bludeau, P. & Erwin, V.G. (2000) Phenotypic and genotypic relationships between ethanol tolerance and sensitivity in mice selectively bred for initial sensitivity to ethanol (SS and LS) or development of acute tolerance (HAFT and LAFT). Alcohol Clin Exp Res 24, 595-604.
15. Dunham, N.W. & Miya, T.S. (1957) A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharmaceut Assoc 46, 208-209.
16. Erwin, V.G. & Deitrich, R.A. (1996) Genetic selection and characterization of mouse lines for acute functional tolerance to ethanol. J Pharmacol Exp Ther 279, 1310-1317.
17. Erwin, V.G., Gehle, V.M. & Deitrich, R.A. (2000) Selectively bred lines of mice show response and drug specificity for genetic regulation of acute functional tolerance to ethanol and pentobarbital. J Pharmacol Exp Ther 293, 188-195.
18. Gallaher, E.J., Parsons, L.M. & Goldstein, D.B. (1982) The rapid onset of tolerance to ataxic effects of ethanol in mice. Psychopharmacology 78, 67-70.
19. Gehle, V.M. & Erwin, V.G. (2000) The genetics of acute functional tolerance and initial sensitivity to ethanol for an ataxia test in the LSxSS RI strains. Alcohol Clin Exp Res 24, 579-587.
20. Grisel, J.E., Metten, P., Wenger, C.D., Merrill, C.M. & Crabbe, J.C. (2002) Quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains. Alcohol Clin Exp Res 26, 610-616.
21. Hegmann, J.P. & Possidente, B. (1981) Estimating genetic correlations from inbred strains. Behav Genet 11, 103-114.
22. Jones, B.J. & Roberts, D.J. (1968) The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod. J Pharm Pharmacol 20, 302-304.
23. Kiernan, B.W., Garcion, E., Ferguson, J., Frost, E.E., Torres, E.M., Dunnett, S.B., Saga, Y., Aizawa, S., Faissner, A., Kaur, R., Franklin, R.J. & ffrench-Constant, C. (1999) Myelination and behaviour of tenascin-C null transgenic mice. Eur J Neurosci 11, 3082-3092.
24. Kirstein, S.L., Davidson, K.L., Ehringer, M.A., Sikela, J.M., Erwin, V.G. & Tabakoff, B. (2002) Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice. J Pharmacol Exp Ther 302, 1238-1245.
25. Kirstein, S.L. & Tabakoff, B. (2001) Genetic correlations between initial sensitivity to ethanol and brain cAMP signaling in inbred and selectively bred mice. Alcohol Clin Exp Res 25, 791-799.
26. Le Marec, N. & Lalonde, R. (1997) Sensorimotor learning and retention during equilibrium tests in Purkinje cell degeneration mutant mice. Brain Res 768, 310-316.
27. McClearn, G.E., Wilson, J.R. & Meredith, W. (1970) The use of isogenic and heterogenic mouse stocks in behavioral research. In Lindzey, G. & Thiessen, D.D. (eds), Contributions to Behavior-Genetic Analysis: the Mouse as a Prototype. Appleton-Century-Crofts, New York, pp. 3-22.
28. Nevins, M.E., Nash, S.A. & Beardsley, P.M. (1993) Quantitative grip strength assessment as a means of evaluating muscle relaxation in mice. Psychopharmacology 110, 92-96.
29. Paigen, K. & Eppig, J.T. (2000) A mouse phenome project. Mamm Genome 11, 715-717.
30. Palmer, M.R., Wang, Y., Fossom, L.H. & Spuhler, K.P. (1987) Genetic correlation of ethanol-induced ataxia and cerebellar purkinje neuron depression among inbred strains and selected lines of rats. Alcohol Clin Exp Res 11, 494-501.
31. Perlman, B.J. & Goldstein, D.B. (1984) Genetic influences on the central nervous system depressant and membrane-disordering actions of ethanol and sodium valproate. Mol Pharmacol 26, 547-552.
32. Ponomarev, I. & Crabbe, J.C. (2002) A novel method to assess initial sensitivity and acute functional tolerance to hypnotic effects of ethanol. J Pharmacol Exper Ther 302, 257-263.
33. Rowe, D.C. (2002) Assessing genotype-environment interactions and correlations in the postgenomic era. In Plomin, R., DeFries, J.C., Craig, I.W. & McGuffin, P. (eds), Behavioral Genetics in the Postgenomic Era. American Psychological Association, New York, pp. 71-86.
34. Rustay, N.R., Wahlsten, D. & Crabbe, J.C. (2003a) Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Nat Acad Sci USA 100, 2917-2922.
35. Rustay, N.R., Wahlsten, D. & Crabbe, J.C. (2003b) Influence of task parameters on rotarod performance and sensitivity to ethanol in mice. Behav Brain Res 141, 237-249.
36. Schafer, G.L. & Crabbe, J.C. (1996) Sensitivity to ethanol-induced ataxia in HOT and COLD selected lines of mice. Alcohol Clin Exp Res 20, 1604-1612.
37. Smith, J.P., Hicks, P.S., Ortiz, L.R., Martinez, M.J. & Mandler, R.N. (1995) Quantitative measurements of muscle strength in the mouse. J Neurosci Meth 62, 15-19.
38. Voikar, V., Rauvala, H. & Ikonen, E. (2002) Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease. Behav Brain Res 132, 1-10.
39. Wahlsten, D. (1990) Insensitivity of the analysis of variance to hereditary-environment interaction. Behav Brain Sci 13, 109-120.
40. Wahlsten, D., Metten, P. & Crabbe, J.C. (2003a) A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2, 71-79.
41. Wahlsten, D., Metten, P., Phillips, T.J., Boehm, S.L., II, Burkhart-Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd-Henricks, K., Hen, R., McKinnon, C.S., Merrill, C.M., Nolte, C., Schalomon, M., Schlumbohm, J.P., Sibert, J.R., Wenger, C.D., Dudek, B.C. & Crabbe, J.C. (2003b) Different data from different labs: lessons from studies of gene-environment interaction. J Neurobiol 54, 283-311.
42. Wahlsten, D., Rustay, N.R., Metten, P. & Crabbe, J.C. (2003c) In search of a better mouse test. Trends Neurosci 26, 132-136.