Maternal stress during pregnancy, ADHD symptomatology in children and genotype: Gene-environment interaction

Journal of the Canadian Academy of Child and Adolescent Psychiatry

Volumn 21, Issue 1, 2012, Pages 9-15

  Grizenko, Natalie ^a,b   Fortier, Marie Eve ^b   Zadorozny, Christin ^c   Thakur, Geeta ^a,b   Schmitz, Norbert ^a   Duval, Renaud ^d   Joober, Ridha ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

ADHD; DRD4; Pregnancy; Prenatal stress

Indexed keywords

ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CHILD BEHAVIOR CHECKLIST; CONNERS GLOBAL INDEX FOR PARENTS; CONTROLLED STUDY; DISEASE SEVERITY; DOPAMINE RECEPTOR 4 GENE; DOPAMINE TRANSPORTER 1 GENE; FEMALE; GENE; GENETIC RISK; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; KINNEY MEDICAL AND GYNECOLOGICAL QUESTIONNAIRE; MAJOR CLINICAL STUDY; MALE; MATERNAL STRESS; PREGNANT WOMAN; PRENATAL STRESS; PRESCHOOL CHILD; QUESTIONNAIRE; SCHOOL CHILD; SIBLING;

EID: 84856195962     PISSN: 17198429     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Achenbach, T. M. (1991). The Child Behavioral Checklist/4-18. University of Vermont, Burlington, VT.
2. Biederman, J., & Faraone, S. V. (2005). Attention-deficit hyperactivity disorder. Lancet, 366, 237-248.
3. Brookes, K. J., Mill, J., Guindalini, C., Curran, S., Xu, X., Knight, J.,... Asherson, P. (2006). A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Archives of General Psychiatry, 63, 74-81.
4. Conners, C. K. (2003). Conners' Global Index- Parents. Multihealth Systems, North Noranda, NY.
5. Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005). Molecular genetics of attentiondeficit/hyperactivity disorder. Biological Psychiatry, 57, 1313-1323.
6. Gizer, I. R., Ficks, C., & Waldman, I. D. (2009). Candidate gene studies of ADHD: A meta-analytic review. Human Genetics, 126, 51-90.
7. Grizenko, N., Shayan, Y. R., Polotskaia, A., Ter-Stepanian, M., & Joober, R. (2008). Relation of maternal stress during pregnancy to symptom severity and response to treatment in children with ADHD. Journal of Psychiatry and Neuroscience, 33, 10-16.
8. Hedegaard, M., Henriksen, T. B., Secher, N. J., Hatch, M. C., & Sabroe, S. (1996). Do stressful life events affect duration of gestation and risk of preterm delivery? Epidemiology, 7, 339-345.
9. Langley, K., Holmans, P. A., van den Bree, M. B., & Thapar, A. (2007). Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: Investigation in a clinical sample. BMC Psychiatry, 7, 26.
10. Laplante, D. P., Barr, R. G., Brunet, A., Galbaud du, F. G., Meaney, M. L., Saucier, J. F.,...King, S. (2004). Stress during pregnancy affectsgeneral intellectual and language functioning in human toddlers. Pediatric Reaserch, 56, 400-410.
11. Laucht, M., Esser, G., Baving, L., Gerhold, M., Hoesch, I., Ihle, W.,... Schmidt, M. H. (2000). Behavioral sequelae of perinatal insults and early family adversity at 8 years of age. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 1229-1237.
12. Li, D., Sham, P. C., Owen, M. J., & He, L. (2006). Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Human Molecular Genetics, 15, 2276-2284.
13. Li, J., Olsen, J., Vestergaard, M., & Obel, C. (2010). Attention-deficit/ hyperactivity disorder in the offspring following prenatal maternal bereavement: A nationwide follow-up study in Denmark. European Child & Adolescent Psychiatry, 19, 747-753.
14. Lichter, J. B., Barr, C. L., Kennedy, J. L., Van Tol, H. H., Kidd, K. K., & Livak, K. J. (1993). A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics, 2, 767-773.
15. Linnet, K. M., Dalsgaard, S., Obel, C., Wisborg, K., Henriksen, T. B., Rodriguez, A.,...Jarvelin, M. R. (2003). Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: Review of the current evidence. American Journal of Psychiatry, 160, 1028-1040.
16. McNeil, T. F., Cantor-Graae, E., & Sjostrom, K. (1994). Obstetric complications as antecedents of schizophrenia: Empirical effects of using different obstetric complication scales. Journal of Psychiatric Research, 28, 519-530.
17. Neuman, R. J., Lobos, E., Reich, W., Henderson, C. A., Sun, L. W., & Todd, R. D. (2007). Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biological Psychiatry, 61, 1320-1328.
18. O'Connor, T. G., Heron, J., Golding, J., & Glover, V. (2003). Maternal antenatal anxiety and behavioural/emotional problems in children: A test of a programming hypothesis. Journal of Child Psychology and Psychiatry, 44, 1025-1036.
19. Rodriguez, A., & Bohlin, G. (2005). Are maternal smoking and stress during pregnancy related to ADHD symptoms in children? Journal of Child Psychology and Psychiatry, 46, 246-254.
20. Seckl, J. R., & Holmes, M. C. (2007). Mechanisms of disease: Glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology. Nature Clinical Practice Endocrinology & Metabolism, 3, 479-488.
21. Shaffer, D., Fisher, P., Lucas, C. P., Dulcan, M. K., & Schwab-Stone, M. E. (2000). NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 28-38.
22. Teixeira, J. M., Fisk, N. M., & Glover, V. (1999). Association between maternal anxiety in pregnancy and increased uterine artery resistance index: Cohort based study. British Medical Journal, 318, 153-157.
23. van den Bergh, B. R., & Marcoen, A. (2004). High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds. Child Development, 75, 1085-1097.
24. Vandenbergh, D.J., Persico, A. M., Hawkins, A.L., Griffin, C. A., Li, X., Jabs, E. W., & Uhl, G. R. (1992). Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics, 14, 1104-1106.