Methylnitrosourea (MNU)-induced retinal degeneration and regeneration in the zebrafish: Histological and functional characteristics

Journal of Visualized Experiments

Volumn , Issue 92, 2014, Pages

  Maurer, Ellinor ^a   Enzmann, Volker ^a   Tappeiner, Christoph ^a   Tschopp, Markus ^a,b   Sallin, Pauline ^c   Jazwinska, Anna ^c  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Cellular biology; Degeneration; Issue 92; M ller cells; N methyl N nitrosourea (MNU); Photoreceptors; Regeneration; Retina; Visual function; Zebrafish

Indexed keywords

METHYLNITROSOUREA;

ANIMAL; APOPTOSIS; CHEMICALLY INDUCED; DRUG EFFECTS; PATHOLOGY; PHOTORECEPTOR CELL; PHYSIOLOGY; REGENERATION; RETINA; RETINA DEGENERATION; ZEBRA FISH;

ANIMALS; APOPTOSIS; METHYLNITROSOUREA; PHOTORECEPTOR CELLS; REGENERATION; RETINA; RETINAL DEGENERATION; ZEBRAFISH;

EID: 84908320683     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/51909     Document Type: Article

References (23)

1. Haddad, S., Chen, C.A., Santangelo, S.L., & Seddon, J.M. The genetics of age-related macular degeneration: a review of progress to date. Surv. Ophthalmol. 51 (4), 316-63, doi:10:1016/j.survophthal.2006.05.001, (2006).
2. Bhatti, M.T. Retinitis pigmentosa, pigmentary retinopathies, and neurologic diseases. Curr. Neurol. Neurosci. Rep. 6 (5), 403-13, (2006).
3. Hartong, D.T., Berson, E.L., & Dryja, T.P. Retinitis pigmentosa. Lancet. 368, 1795-1809, doi: 10.1016/S0140-6736(06)69740-7, (2006).
4. Tsubura, A., Yoshizawa, K., Kuwata, M., & Uehara, N. Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials. Histol. Histopathol. 25, 233-248, (2010).
5. Machida, K., Urano, K., Yoshimura, M., Tsutsumi, H., Nomura, & Usui, T. Carcinogenic comparative study on rasH2 mice produced by two breeding facilities. J. Toxicol. Sci. 33, 493-501, doi: 10.2131/jts.33.493 (2008).
6. Morton, D., et al. N-Methyl-N-Nitrosourea (MNU): A positive control chemical for p53+/-mouse carcinogenicity studies. Toxicol. Pathol. 36, 926-931, doi: 10.1177/0192623308324959, (2008).
7. Terracini, B., & Testa, M.C. Carcinogenicity of a single administration of N-nitrosomethylurea: a comparison between newborn and 5-week-old mice and rats. Br. J. Cancer. 24, 588-598, (1970).
8. Zulliger, R., Lecaudé, S., Eigeldinger-Berthou, S., Wolf-Schnurrbusch, U.E.K., & Enzmann, V. Caspase-3-independent photoreceptor degeneration by N-methyl-N-nitrosourea (MNU) induces morphological and functional changes in the mouse retina. Graefes Arch. Clin. Exp. Ophthalmol. 249, 859-869, doi: 10.1007/s00417-010-1584-6, (2011).
9. Tappeiner, C., et al. Characteristics of rod regeneration in a novel zebrafish retinal degeneration model using N-methyl-N-nitrosourea (MNU). PLOS One. 12, e71064, doi: 10.1371/journal.pone.0071064, (2013).
10. Bilotta, J., & Saszik, S. The zebrafish as a model visual system. Int. J. Dev. Neurosci. 19, 621-629, doi: 10.1016/S0736-5748(01)00050-8, (2001).
11. Fleisch, C. and Neuhauss, S. Visual Behavior in Zebrafish. Zebrafish. 3, 191-201, doi: 10.1089/zeb.2006.3.191., (2006).
12. Hodel, C., Neuhauss, S.C.F., & Biehmaier, O. Time course and development of light adaptation processes in the outer zebrafish retina. InterScience. 288A, 653-662, doi: 10.1002/ar.a.20329, (2006).
13. Gemberling, M., Bailey, T.J., Hyde, D.R., & Poss, K.D. The zebrafish as a model for complex tissue regeneration. Trends Genet. 29 (11), 611-20, doi: 10.1016/j.tig.2013.07.003, (2013).
14. Brockerhoff, S.E., & Fadool, J.M. Genetics of photoreceptor degeneration and regeneration in zebrafish. Cell Mol. Life Sci. 68, 651-659, doi: 10.1007/s00018-010-0563-8, (2011).
15. Brand, M., Granato, M., & Nüsslein-Volhard, C. Keeping and raising zebrafish. In: Zebrafish: A Practical Approach. Nüsslein-Volhard, C., & Dahm, R., eds., IRL Press, 7-38 (2002).
16. Tappeiner, C., Gerber S., Enzmann V., Balmer J., Jazwinska A., & Tschopp, M. Visual acuity and contrast sensitivity of adult zebrafish. Front. Zool. 9 (1), 10, doi:10.1186/1742-9994-9-10, (2012).
17. Bailey, T.J., Fossum, S.L., Fimbel, S.M., Montgomery, J.E., & Hyde, D.R. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp. Eye Res. 91, 601-612, doi: 10.1016/j.exer.2010.07.017, (2010).
18. Nelson, C.M., & Hyde, D.R. Müller glia as a source of neuronal progenitor cells to regenerate the damaged zebrafish retina. Adv. Exp. Med. Biol. 723, 425-430, doi: 10.1007/978-1-4614-0631-0_54, (2012).
19. Prusky, G.T., Alam, N.M., Beekman, S., & Douglas, R.M. Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. Invest. Ophthalmol Vis. Sci. 45 (12), 4611-4616, doi: 10.1167/iovs.04-0541, (2004).
20. Beck, J.C., Gilland, E., Tank, D.W., & Baker R. Quantifying the ontogeny of optokinetic and vestibulo-ocular behaviors in zebrafish, medaka, and goldfish. J. Neurophysiol. 92(6), 3546-61, (2004).
21. Fimbel, S.M., Montgomery, J.E., Burket, C.T., & Hyde, D.R. Regeneration of Inner Retinal Neurons after Intravitreal Injection of Ouabain in Zebrafish. J. Neurosci. 27, 1712-1724, doi: 10.1523/JNEUROSCI.5317-06.2007, (2007).
22. Sherpa, T., et al. Ganglion cell regeneration following whole-retina destruction in zebrafish. Dev. Neurobiol. 68: 166-181, doi:10.1002/dneu.20568, (2008).
23. Yurco, P., & Cameron, D.A. Responses of Müller glia to retinal injury in adult zebrafish. Vision Res. 45, 991-1002, doi: 10.1016/j.visres.2004.10.022, (2005).