Carcinogenic comparative study on rasH2 mice produced by two breeding facilities

Journal of Toxicological Sciences

Volumn 33, Issue 4, 2008, Pages 493-501

  Machida, Kazuhiko ^a   Urano, Koji ^a   Yoshimura, Masumi ^a   Tsutsumi, Hideki ^a   Nomura, Tatsuji ^a   Usui, Toshimi ^a  

^a CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

Author keywords

Alternative; Carcinogenicity; rasH2 mice; Reproducibility; Short term test

Indexed keywords

METHYLNITROSOUREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREEDING METHOD; CARCINOGENICITY; CONTROLLED STUDY; HISTOPATHOLOGY; LYMPHOMA; MOUSE; NONHUMAN; SQUAMOUS CELL CARCINOMA; TUMOR;

MUS;

EID: 55949119911     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.33.493     Document Type: Article

References (19)

1. Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A.J., Butel, J.S. and Bradley, A. (1992): Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature, 356, 215-221.
2. Festing, M.F.W. (2003): Laboratory animal genetics and genetic quality control. In Handbook of Laboratory Animal Science. 2nd ed. (Hau J. and Van Hoosier G.L. ed.), pp. 173-203, CRC Press LLC, London, New York.
3. Flaherty, L. (1981): Congenic strains. In The Mouse in Biomedical Research, Vol. 1 (Foster, H.L. Small, J.D. and Fox, J.G. ed.), pp. 215-222. Academic Press, New York.
4. French, J., Storer, R.D. and Donehower, L.A. (2001): The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens. Toxicol. Pathol., 29 (Suppl.), 24-29.
5. Green, E.L. (1981): Genetics and probability in animal breeding experiments. Oxford University Press, New York.
6. Honchel, R., Rosenzweig, B.A., Thompson, K.L., Blanchard, K.T., Furst, S.M., Stoll, R.E. and Sistare, F.D. (2001): Loss of palindromic symmetry in Tg.AC mice with a nonresponder phenotype. Mol. Carcinog., 30, 99-110.
7. Leder, A., Kuo, A., Cardiff, R.D., Sinn, E. and Leder, P. (1990): v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid. PNAS, 87, 9178-9182.
8. MacDonald, J., French, J.E., Gerson, R.J., Goodman, J., Inoue, T., Jacobs, A., Kasper, P., Keller, D., Lavin, A., Long, G., McCullough, B., Sistare, F.D., Storer, R. and Van der Laan, J.W. (2004): The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. Toxicol. Sci., 77, 188-194.
9. Robinson, D.E. and MacDonald, J.S. (2001): Background and framework for ILSI's collaborative evaluation program on alternative models for carcinogenicity assessment. Toxicol. Pathol., 29 (Suppl.), 13-19.
10. Saitoh, A., Kimura, M., Takahashi, R., Yokoyama, M., Nomura, T., Izawa, M., Sekiya, T., Nishimura, S. and Katsuki, M. (1990): Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene, 5, 1195-1200.
11. Suemizu, H., Muguruma, K., Maruyama, C., Tomisawa, M., Kimura, M., Hioki, K., Shimozawa, N., Ohnishi, Y., Tamaoki, N. and Nomura, T. (2002): Transgene stability and features of rasH2 mice as an animal model for short-term carcinogenicity testing. Mol. Carcinog., 34, 1-9.
12. Suemizu, H., Kito-Maruyama, C., Sotomaru, Y., Ogura, T., Hioki, K., Ohnishi, Y. and Tamaoki, N. (2004): PCR method for genotyping and zygosity-testing of rasH2 transgenic mice. Exp. Anim., 53, 463-466.
13. Tanioka, Y., Esaki, K., Yamauchi, C. and Nomura, T. (1971): Effect of the change in environmental temperature on the incidence of malformations in the mouse fetuses induced by ethylurethane injection. Cong. Anom., 11, 19-23.
14. Takaoka, M., Sehata, S., Maejima, T., Imai, T., Torii, M., Satoh, H., Toyosawa, K., Tanakamaru, Z., Adachi, T., Hisada, S., Ueda, M., Ogasawara, H., Matsumoto, M., Kobayashi, K., Mutai, M. and Usui, T. (2003): Interlaboratory comparison of short-term carcinogenicity studies using CB6F1-rasH2 transgenic mice. Toxicol. Pathol., 31, 191-199.
15. Tamaoki, N. (2001): The rasH2 transgenic mouse: Nature of the model and mechanistic studies on tumorigenesis. Toxicol. Pathol., 29 (Suppl.), 81-89.
16. Thompson, K.L., Rosenzweig, B.A. and Sistare, F.D. (1998): An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness. Toxicol. Pathol., 26, 548-555.
17. Usui, T., Mutai, M., Hisada, S., Takaoka, M., Soper, K.A., McCullough, B. and Alden, C. (2001): CB6F1-rasH2 mouse: overview of available data. Toxicol. Pathol., 29 (Suppl.), 90-108.
18. Yamamoto, S., Urano, K., Koizumi, H., Wakana, S., Hioki, K., Mitsumori, K., Kurokawa, Y., Hayashi, Y. and Nomura, T. (1998): Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Environ. Health Perspect., 106 (Supple. 1), 57-69.
19. Yamauchi, C., Takahashi, H. and Nomura, T. (1966): Influence of environmental temperature on circulatory and respiratory functions in the laboratory mouse. Fed. Proc., 25, 1310-1311.