N-Methyl-N-Nitrosourea (MNU): A positive control chemical for p53+/- mouse carcinogenicity studies

Toxicologic Pathology

Volumn 36, Issue 7, 2008, Pages 926-931

  Morton, Daniel ^a   Bailey, Keith L ^a,b   Stout, Cheryl L ^a   Weaver, R John ^a   White, Kathleen A ^a   Lorenzen, Marianne J ^a   Ball, Douglas J ^a  

^a PFIZER INC   (United States)

^b AMGEN INC   (United States)

Author keywords

Carcinogenicity; Intestinal adenoma adenocarcinoma; Lymphoma; N methyl N nitrosourea; P53+ mouse; Thymus

Indexed keywords

CD3 ANTIGEN; CITRIC ACID; METHYLNITROSOUREA; CARCINOGEN;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BODY WEIGHT; CANCER GROWTH; CARCINOGENESIS; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; LYMPHOBLAST; MALE; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; THYMUS LYMPHOMA; ADENOMA; ANIMAL; CARCINOGEN TESTING; CHEMICALLY INDUCED DISORDER; DUODENUM TUMOR; HETEROZYGOTE; INTRAPERITONEAL DRUG ADMINISTRATION; JEJUNUM TUMOR; LYMPHOMA; METABOLISM; METHODOLOGY; MOUSE MUTANT; NEOPLASM; PATHOLOGY; SMALL INTESTINE; THYMOMA; THYMUS; TUMOR SUPPRESSOR GENE;

MUS;

ADENOCARCINOMA; ADENOMA; ANIMALS; ANTIGENS, CD3; CARCINOGENICITY TESTS; CARCINOGENS; DUODENAL NEOPLASMS; FEMALE; GENES, P53; HETEROZYGOTE; INJECTIONS, INTRAPERITONEAL; INTESTINE, SMALL; JEJUNAL NEOPLASMS; LYMPHOMA; MALE; METHYLNITROSOUREA; MICE; MICE, KNOCKOUT; NEOPLASMS; THYMUS GLAND; THYMUS NEOPLASMS;

EID: 68149100941     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623308324959     Document Type: Article

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