Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer

Journal of Pharmacology and Experimental Therapeutics

Volumn 351, Issue 3, 2014, Pages 559-567

  Cheng, Jie ^a   Fang, Zhong Ze ^a,b   Nagaoka, Kenjiro ^a   Okamoto, Minoru ^a   Qu, Aijuan ^a   Tanaka, Naoki ^a   Kimura, Shioko ^a   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PREGNANE X RECEPTOR; RIFAXIMIN; PROTECTIVE AGENT; RIFAMYCIN; STEROID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER REGRESSION; CANCER SURVIVAL; CELL CYCLE REGULATION; CELL PROLIFERATION; CHEMOPROPHYLAXIS; COLON CANCER; CONTROLLED STUDY; DRUG TARGETING; IN VITRO STUDY; INFLAMMATION; MALE; MOUSE; MOUSE MODEL; NONHUMAN; NULL ALLELE; PHARMACEUTICAL EQUIVALENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSCRIPTION REGULATION; UPREGULATION; WILD TYPE; AGONISTS; ANIMAL; CHEMICALLY INDUCED; COLONIC NEOPLASMS; HT 29 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM;

ANIMALS; AZOXYMETHANE; COLONIC NEOPLASMS; DEXTRAN SULFATE; HT29 CELLS; HUMANS; MALE; MICE; MICE, KNOCKOUT; PROTECTIVE AGENTS; RECEPTORS, STEROID; RIFAMYCINS;

EID: 84908296747     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.215913     Document Type: Article

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