β-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet

Cancer Science

Volumn 99, Issue 9, 2008, Pages 1754-1759

  Wang, Rong ^a   Dashwood, W Mohaiza ^a   Löhr, Christiane V ^b   Fischer, Kay A ^b   Nakagama, Hitoshi ^c   Williams, David E ^a,b   Dashwood, Roderick H ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; BETA CATENIN; BROXURIDINE; CASPASE 3; MYC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASCENDING COLON; CANCER GROWTH; CANCER INHIBITION; CARCINOGENIC ACTIVITY; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; DESCENDING COLON; FISCHER 344 RAT; GENE OVEREXPRESSION; HOMEOSTASIS; IMMUNOBLOTTING; IMMUNOLOCALIZATION; IMMUNOPATHOLOGY; INTESTINE CRYPT; LABELING INDEX; LIPID DIET; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; BETA CATENIN; CARCINOGENS; COLON; DIETARY FATS; GENES, MYC; IMIDAZOLES; INTESTINAL MUCOSA; MALE; RATS; RATS, INBRED F344; TIME FACTORS;

EID: 50149119030     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00887.x     Document Type: Article

References (15)

1. Sugimura T, Wakabayashi K, Nakagama H, Nagao M. Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci 2004; 95: 290-9.
2. Knize MG, Felton JS. Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat. Nutr Rev 2005; 63: 158-65.
3. Ito N, Hasegawa R, Imaida K et al. Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-#1b] pyridine (PhIP) in the rat. Mutat Res 1997; 376: 107-14.
4. Dashwood RH, Suzui M, Nakagama H, Sugimura T, Nagao M. High frequency of β-catenin (Ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Res 1998; 58: 1127-9.
5. Wang R, Dashwood WM, Bailey GS, Williams DE, Dashwood RH. Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in β-catenin that are independent of β-catenin mutation status. Mutat Res 2006; 601: 11-18.
6. Blum CA, Tanaka T, Zhong X et al. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5- f] quinoline: Mutational 'hotspots'and the relative expression of β-catenin and c-jun. Mol Carcinogen 2003; 36: 195-203.
7. Blum CA, Xu M, Orner GA et al. β-Catenin mutation in rat colon tumors initiated with 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5- f] quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. Carcinogenesis 2001; 22: 315-20.
8. Segditsas S, Tomlinson I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene 2006; 25: 7531-7.
9. Gavert N, Ben-Ze'ev A. beta-Catenin signaling in biological control and cancer. J Cell Biochem 2007; 102: 820-8.
10. Wood LD, Parsons DW, Jones S et al. The genomic landscapes of human breast and colorectal cancers. Science 2007; 318: 1108-13.
11. Ubagai T, Ochiai M, Kawamori T et al. Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-#1b] pyridine in combination with a high-fat diet. Carcinogenesis 2002; 23: 197-200.
12. Wang R, Dashwood WM, Löhr CV et al. Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and β-catenin expression in the rat. Carcinogenesis 2008; 29: 834-9.
13. Ochiai M, Watanabe M, Kushida H, Wakabayashi K, Sugimura T, Nagao M. DNA adduct formation, cell proliferation, and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis. Carcinogenesis 1996; 17: 95-8.
14. Mann B, Gelos M, Siedow A et al. Target genes of β-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci USA 1999; 96: 1603-8.
15. Yekkala K, Baudino TA. Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression. Mol Cancer Res 2007; 5: 1296-303.