Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle at G2-M and induces ROS-independent apoptosis in A549 cells, targeting nuclear DNA

Cell Proliferation

Volumn 47, Issue 1, 2014, Pages 56-71

  Mukherjee, A ^a   Sikdar, S ^a   Bishayee, K ^a   Boujedaini, N ^b   Khuda Bukhsh, A R ^a  

^a UNIVERSITY OF KALYANI   (India)

^b Boiron Laboratory   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CEDAR LEAF OIL; CELL NUCLEUS DNA; CISPLATIN; CYTOCHROME C; FLAVONOL; K RAS PROTEIN; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

A549 CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL VIABILITY; CHEMOPROPHYLAXIS; CIRCULAR DICHROISM; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ISOLATION; DRUG SCREENING; DRUG TARGETING; FLUORESCENCE ACTIVATED CELL SORTING; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NICK END LABELING; NONHUMAN; PLANT LEAF;

MUS; THUJA OCCIDENTALIS;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE CHECKPOINTS; CELL DIVISION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOLS; G2 PHASE; HUMANS; LUNG NEOPLASMS; MICE; PLANT EXTRACTS; PLANT LEAVES; REACTIVE OXYGEN SPECIES; THUJA;

EID: 84892784149     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/cpr.12079     Document Type: Article

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