SPAK and OSR1 dependent down-regulation of murine renal outer medullary K+ channel ROMK1

Kidney and Blood Pressure Research

Volumn 39, Issue 4, 2014, Pages 353-360

  Elvira, Bernat ^a   Munoz, Carlos ^b   Borras, Jose ^a   Chen, Hong ^a   Warsi, Jamshed ^a   Ajay, Sumant Singh ^a   Shumilina, Ekaterina ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

K+ channel; Oxidative stress responsive kinase 1; Renal tubule; SPS1 related proline alaninerich kinase; WNK

Indexed keywords

HEMAGGLUTININ; OXIDATIVE STRESS RESPONSIVE KINASE 1; PHOSPHOTRANSFERASE; POTASSIUM CHANNEL; POTASSIUM CHANNEL ROMK1; SPS1 RELATED PROLINE ALANINE RICH KINASE; UNCLASSIFIED DRUG; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ1 PROTEIN, MOUSE; OSR1 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; STK39 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; CELL MEMBRANE; CELL SURFACE; CHEMOLUMINESCENCE; DOWN REGULATION; KIDNEY TUBULE; MALE; MOUSE; NONHUMAN; OOCYTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; VOLTAGE CLAMP TECHNIQUE; XENOPUS; ANIMAL; GENETICS; KIDNEY MEDULLA; METABOLISM; PATCH CLAMP TECHNIQUE; XENOPUS LAEVIS;

ANIMALS; KIDNEY MEDULLA; MICE; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; XENOPUS LAEVIS;

EID: 84908288140     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000355812     Document Type: Article

References (40)

1. Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanovic S, Jovanovic A, O'Shaughnessy KM, Alessi DR: Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med 2010;2:63-75.
2. Castaneda-Bueno M, Gamba G: SPAKling insight into blood pressure regulation. EMBO Mol Med 2010;2:39-41.
3. Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH: SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol 2010;21:1868-1877.
4. Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS: Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci USA 2011;108:17538-17543.
5. Villa F, Deak M, Alessi DR, van Aalten DM: Structure of the OSR1 kinase, a hypertension drug target. Proteins 2008;73:1082-1087.
6. Vitari AC, Deak M, Morrice NA, Alessi DR: The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 2005;391:17-24.
7. Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR: Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem J 2006;397:223-231.
8. Glover M, Zuber AM, O'Shaughnessy KM: Hypertension, dietary salt intake, and the role of the thiazidesensitive sodium chloride transporter NCCT. Cardiovasc Ther 2011;29:68-76.
9. O'Reilly M, Marshall E, Speirs HJ, Brown RW: WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol 2003;14:2447-2456.
10. Kahle KT, Rinehart J, Lifton RP: Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Biochim Biophys Acta 2010;1802:1150-1158.
11. Flatman PW: Cotransporters, WNKs and hypertension: an update. Curr Opin Nephrol Hypertens 2008;17:186-192.
12. Furgeson SB, Linas S: Mechanisms of type I and type II pseudohypoaldosteronism. J Am Soc Nephrol 2010;21:1842-1845.
13. Uchida S: Pathophysiological roles of WNK kinases in the kidney. Pflugers Arch 2010;460:695-702.
14. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP: Human hypertension caused by mutations in WNK kinases. Science 2001;293:1107-1112.
15. Delpire E, Gagnon KB: SPAK and OSR1, key kinases involved in the regulation of chloride transport. Acta Physiol (Oxf) 2006;187:103-113.
16. Delpire E, Gagnon KB: SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem J 2008;409:321-331.
17. Gimenez I: Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters. Curr Opin Nephrol Hypertens 2006;15:517-523.
18. Richardson C, Sakamoto K, de los HP, Deak M, Campbell DG, Prescott AR, Alessi DR: Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci 2011;124:789-800.
19. Gagnon KB, Delpire E: On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity. Am J Physiol Cell Physiol 2010;299:C614-C620.
20. Glover M, O'Shaughnessy KM: SPAK and WNK kinases: a new target for blood pressure treatment? Curr Opin Nephrol Hypertens 2011;20:16-22.
21. Huang CL, Yang SS, Lin SH: Mechanism of regulation of renal ion transport by WNK kinases. Curr Opin Nephrol Hypertens 2008;17:519-525.
22. Mercier-Zuber A, O'Shaughnessy KM: Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters. Curr Opin Nephrol Hypertens 2011;20:534-540.
23. Richardson C, Alessi DR: The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. J Cell Sci 2008;121:3293-3304.
24. Achard JM, Disse-Nicodeme S, Fiquet-Kempf B, Jeunemaitre X: Phenotypic and genetic heterogeneity of familial hyperkalaemic hypertension (Gordon syndrome). Clin Exp Pharmacol Physiol 2001;28:1048-1052.
25. Capasso G, Cantone A, Evangelista C, Zacchia M, Trepiccione F, Acone D, Rizzo M: Channels, carriers, and pumps in the pathogenesis of sodium-sensitive hypertension. Semin Nephrol 2005;25:419-424.
26. He G, Wang HR, Huang SK, Huang CL: Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest 2007;117:1078-1087.
27. Hoorn EJ, Nelson JH, McCormick JA, Ellison DH: The WNK kinase network regulating sodium, potassium, and blood pressure. J Am Soc Nephrol 2011;22:605-614.
28. Fang L, Garuti R, Kim BY, Wade JB, Welling PA: The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney. J Clin Invest 2009;119:3278-3289.
29. Palmada M, Embark HM, Wyatt AW, Bohmer C, Lang F: Negative charge at the consensus sequence for the serum- and glucocorticoid-inducible kinase, SGK1, determines pH sensitivity of the renal outer medullary K+ channel, ROMK1. Biochem Biophys Res Commun 2003;307:967-972.
30. Pathare G, Foller M, Michael D, Walker B, Hierlmeier M, Mannheim JG, Pichler BJ, Lang F: Enhanced FGF23 serum concentrations and phosphaturia in gene targeted mice expressing WNK-resistant SPAK. Kidney Blood Press Res 2012;36:355-364.
31. Pathare G, Foller M, Daryadel A, Mutig K, Bogatikov E, Fajol A, Almilaji A, Michael D, Stange G, Voelkl J, Wagner CA, Bachmann S, Lang F: OSR1-Sensitive Renal Tubular Phosphate Reabsorption. Kidney Blood Press Res 2012;36:149-161.
32. Hosseinzadeh Z, Dong L, Bhavsar SK, Warsi J, Almilaji A, Lang F: Upregulation of peptide transporters PEPT1 and PEPT2 by Janus kinase JAK2. Cell Physiol Biochem 2013;31:673-682.
33. Alesutan I, Sopjani M, Dermaku-Sopjani M, Munoz C, Voelkl J, Lang F: Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2. Cell Physiol Biochem 2012;30:458-465.
34. Henrion U, Zumhagen S, Steinke K, Strutz-Seebohm N, Stallmeyer B, Lang F, Schulze-Bahr E, Seebohm G: Overlapping cardiac phenotype associated with a familial mutation in the voltage sensor of the KCNQ1 channel. Cell Physiol Biochem 2012;29:809-818.
35. Hosseinzadeh Z, Bhavsar SK, Lang F: Downregulation of ClC-2 by JAK2. Cell Physiol Biochem 2012;29:737-742.
36. Bogatikov E, Munoz C, Pakladok T, Alesutan I, Shojaiefard M, Seebohm G, Foller M, Palmada M, Bohmer C, Broer S, Lang F: Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve. Cell Physiol Biochem 2012;30:1538-1546.
37. Mia S, Munoz C, Pakladok T, Siraskar G, Voelkl J, Alesutan I, Lang F: Downregulation of Kv1.5 K channels by the AMP-activated protein kinase. Cell Physiol Biochem 2012;30:1039-1050.
38. Pakladok T, Almilaji A, Munoz C, Alesutan I, Lang F: PIKfyve sensitivity of hERG channels. Cell Physiol Biochem 2013;31:785-794.
39. Giebisch G, Wang W: Potassium transport: from clearance to channels and pumps. Kidney Int 1996;49:1624-1631.
40. Wang WH, Giebisch G: Regulation of potassium (K) handling in the renal collecting duct. Pflugers Arch 2009;458:157-168.