Impaired phosphorylation of Na +-K +-2Cl - cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 42, 2011, Pages 17538-17543

  Lin, Shih Hua ^a,b   Yu, I Shing ^c   Jiang, Si Tse ^d   Lin, Shu Wha ^c   Chu, Pauling ^a   Chen, Ann ^b   Sytwu, Huey Kang ^b   Sohara, Eisei ^e   Uchida, Shinichi ^e   Sasaki, Sei ^e   Yang, Sung Sen ^a,b  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL APPLIED RESEARCH LABORATORIES   (Taiwan)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Bartter syndrome; Electrolytes; Hormone; Knockout mice; Volume

Indexed keywords

FUROSEMIDE; OXIDATIVE STRESS RESPONSIVE KINASE 1; PROTEIN SERINE THREONINE KINASE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

AORTA; ARTICLE; BARTTER SYNDROME; BLOOD PRESSURE; CONTROLLED STUDY; HYPERCALCIURIA; HYPOKALEMIA; HYPOTENSION; IN VIVO STUDY; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; POTASSIUM RESTRICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SODIUM RESTRICTION;

ANIMALS; AORTA; BARTTER SYNDROME; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; HYPOTENSION; KIDNEY TUBULES; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; POTASSIUM; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, DRUG; SODIUM; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; SYMPORTERS; WATER-ELECTROLYTE BALANCE;

MUS;

EID: 80054817968     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1107452108     Document Type: Article

References (37)

1. Meyer JW, et al. (2002) Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter. Am J Physiol Heart Circ Physiol 283:H1846-H1855. (Pubitemid 35217018)
2. Garg P, et al. (2007) Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone. Am J Physiol Heart Circ Physiol 292:H2100-H2105. (Pubitemid 47084588)
3. Wall SM, et al. (2006) Hypotension in NKCC1 null mice: Role of the kidneys. Am J Physiol Renal Physiol 290:F409-F416. (Pubitemid 43724994)
4. Kim SM, et al. (2008) Salt sensitivity of blood pressure in NKCC1-deficient mice. Am J Physiol Renal Physiol 295:F1230-F1238.
5. Gamba G (2005) Molecular physiology and pathophysiology of electroneutral cationchloride cotransporters. Physiol Rev 85:423-493.
6. Orlov SN, Adragna NC, Adarichev VA, Hamet P (1999) Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension. Am J Physiol 276:C511-C536. (Pubitemid 29157367)
7. Orlov SN, Tremblay J, Hamet P (2010) NKCC1 and hypertension: A novel therapeutic target involved in the regulation of vascular tone and renal function. Curr Opin Nephrol Hypertens 19:163-168.
8. Wilson FH, et al. (2001) Human hypertension caused by mutations in WNK kinases. Science 293:1107-1112. (Pubitemid 32758085)
9. Simon DB, et al. (1996) Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet 13:183-188.
10. Simon DB, et al. (1996) Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 12:24-30. (Pubitemid 26011315)
11. Tamari M, Daigo Y, Nakamura Y (1999) Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p2. 3. J Hum Genet 44:2-116-21120.
12. Johnston AM, et al. (2000) SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene 19:4290-4297.
13. Piechotta K, Lu J, Delpire E (2002) Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J Biol Chem 277:50812-50819. (Pubitemid 36042246)
14. Moriguchi T, et al. (2005) WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280: 42685-42693. (Pubitemid 43049227)
15. Vitari AC, Deak M, Morrice NA, Alessi DR (2005) The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391:17-24. (Pubitemid 41445471)
16. Huang CL, Yang SS, Lin SH (2008) Mechanism of regulation of renal ion transport by WNK kinases. Curr Opin Nephrol Hypertens 17:519-525.
17. Yang SS, et al. (2007) Molecular pathogenesis of pseudohypoaldosteronism type II: Generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab 5:331-344.
18. Ohta A, et al. (2009) Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet 18:3978-3986.
19. Yang SS, et al. (2010) SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol 21:1868-1877.
20. Cheng CJ, Shiang JC, Hsu YJ, Yang SS, Lin SH (2007) Hypocalciuria in patients with Gitelman syndrome: Role of blood volume. Am J Kidney Dis 49:693-700.
21. Delpire E, Gagnon KB (2008) SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem J 409:321-331. (Pubitemid 351184951)
22. Rafiqi FH, et al. (2010) Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med 2:63-75.
23. Orlov SN, Mongin AA (2007) Salt-sensing mechanisms in blood pressure regulation and hypertension. Am J Physiol Heart Circ Physiol 293:H2039-H2053. (Pubitemid 47605848)
24. Kaplan MR, Plotkin MD, Brown D, Hebert SC, Delpire E (1996) Expression of the mouse Na-K-2Cl cotransporter, mBSC2, in the terminal inner medullary collecting duct, the glomerular and extraglomerular mesangium, and the glomerular afferent arteriole. J Clin Invest 98:723-730. (Pubitemid 26349177)
25. Guyton AC (1989) Roles of the kidneys and fluid volumes in arterial pressure regulation and hypertension. Chin J Physiol 32:49-57.
26. Oppermann M, et al. (2006) Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter. J Am Soc Nephrol 17:2143-2152. (Pubitemid 44141904)
27. Oppermann M, et al. (2007) Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter. J Am Soc Nephrol 18:440-448. (Pubitemid 46193310)
28. Bartter FC, Pronove P, Gill JR, Jr., MacCardle RC (1962) Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. Am J Med 33:811-828.
29. Kurtz I (1998) Molecular pathogenesis of Bartter's and Gitelman's syndromes. Kidney Int 54:1396-1410.
30. Takahashi N, et al. (2000) Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci USA 97:5434-5439. (Pubitemid 30313736)
31. Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA (2009) WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J Biol Chem 284:18471-18480.
32. Richardson C, et al. (2011) Regulation of the NKCC2 ion cotransporter by SPAK-OSR1- dependent and -independent pathways. J Cell Sci 124:789-800.
33. Yang SS, et al. (2010) Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. Hum Mutat 31:1304-1315.
34. Liu Z, et al. (2011) Downregulation of NCC and NKCC2 cotransporters by kidneyspecific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet 20:855-866.
35. Chiga M, et al. (2008) Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int 74:1403-1409.
36. Wang Y, et al. (2009) From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci USA 106:226-231.
37. Lytle C, Xu JC, Biemesderfer D, Forbush B, 3rd (1995) Distribution and diversity of Na-K-Cl cotransport proteins: A study with monoclonal antibodies. Am J Physiol 269:C1496-C1505.