Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking

Biochemistry

Volumn 53, Issue 42, 2014, Pages 6706-6716

  Ferguson, Fleur M ^a   Dias, David M ^a   Rodrigues, João P G L M ^b   Wienk, Hans ^b   Boelens, Rolf ^b   Bonvin, Alexandre M J J ^b   Abell, Chris ^a   Ciulli, Alessio ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CHEMICAL SHIFT; MOLECULES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CHEMICAL EXCHANGE; CHEMICAL SHIFT PERTURBATIONS; DATA-DRIVEN MODEL; PHARMACEUTICAL RESEARCH; SELECTIVE INHIBITORS; SMALL MOLECULE INHIBITOR; STRUCTURAL INFORMATION; STRUCTURE AND DYNAMICS;

PROTEINS;

BAZ2B BROMODOMAIN; HISTONE; HISTONE H3; PROTEIN; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; PEPTIDE; PROTEIN BINDING; SOLUTION AND SOLUBILITY;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SITE DIRECTED MUTAGENESIS; ACETYLATION; CHEMISTRY; HUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE; SOLUTION AND SOLUBILITY;

ACETYLATION; HISTONES; HUMANS; MOLECULAR DOCKING SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEAR PROTEINS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SOLUTIONS;

EID: 84908278490     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500909d     Document Type: Article

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