Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4

Biochemical and Biophysical Research Communications

Volumn 358, Issue 2, 2007, Pages 435-441

  Sun, Hongbin ^a   Liu, Jiangxin ^a   Zhang, Jiahai ^a   Shen, Weiqun ^a   Huang, Hongda ^a   Xu, Chao ^a   Dai, Haiming ^a   Wu, Jihui ^a   Shi, Yunyu ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

BRD7; Bromodomain; Dissociation constant; Histone; Lysine acetylated; NMR spectroscopy; Solution structure; Titration

Indexed keywords

BRD7 PROTEIN; HISTONE H3; HISTONE H4; LYSINE; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; TITRIMETRY;

ACETYLATION; AMINO ACID SEQUENCE; BINDING SITES; CHROMOSOMAL PROTEINS, NON-HISTONE; COMPUTER SIMULATION; HISTONES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY;

EID: 34248512282     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.04.139     Document Type: Article

References (24)

1. Yu S.G.Z.Y., Zhang B.C., Zhou M., Xiang J.J., and Li G.Y. Growth suppression of nasopharyngeal carcinoma cell through transfection of BRD7 gene. Chin. J. Cancer 20 (2001) 569-574
2. Zhou J., Ma J., Zhang B.C., Li X.L., Shen S.R., Zhu S.G., Xiong W., Liu H.Y., Huang H., Zhou M., and Li G.Y. BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways. J. Cell. Physiol. 200 (2004) 89-98
3. Staal A., Enserink J.M., Stein J.L., Stein G.S., and van Wijnen A.J. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. J. Cell. Physiol. 185 (2000) 269-279
4. Kzhyshkowska J., Rusch A., Wolf H., and Dobner T. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. Biochem. J. 371 (2003) 385-393
5. Haynes S.R., Dollard C., Winston F., Beck S., Trowsdale J., and Dawid I.B. The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins. Nucleic Acids Res. 20 (1992) 2603
6. Tamkun J.W., Deuring R., Scott M.P., Kissinger M., Pattatucci A.M., Kaufman T.C., and Kennison J.A. brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell 68 (1992) 561-572
7. Jeanmougin F., Wurtz J.M., Le Douarin B., Chambon P., and Losson R. The bromodomain revisited. Trends Biochem. Sci. 22 (1997) 151-153
8. Dyson M.H., Rose S., and Mahadevan L.C. Acetyllysine-binding and function of bromodomain-containing proteins in chromatin. Front. Biosci. 6 (2001) D853-D865
9. Winston F., and Allis C.D. The bromodomain: a chromatin-targeting module?. Nat. Struct. Biol. 6 (1999) 601-604
10. Kouzarides T. Acetylation: a regulatory modification to rival phosphorylation?. EMBO J. 19 (2000) 1176-1179
11. Zeng L., and Zhou M.M. Bromodomain: an acetyl-lysine binding domain. FEBS Lett. 513 (2002) 124-128
12. Peng C., Zhou J., Liu H.Y., Zhou M., Wang L.L., Zhang Q.H., Yang Y.X., Xiong W., Shen S.R., Li X.L., and Li G.Y. The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. J. Cell. Biochem. 97 (2006) 882-892
13. Dhalluin C., Carlson J.E., Zeng L., He C., Aggarwal A.K., and Zhou M.M. Structure and ligand of a histone acetyltransferase bromodomain. Nature 399 (1999) 491-496
14. Jacobson R.H., Ladurner A.G., King D.S., and Tjian R. Structure and function of a human TAFII250 double bromodomain module. Science 288 (2000) 1422-1425
15. Hudson B.P., Martinez-Yamout M.A., Dyson H.J., and Wright P.E. Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. J. Mol. Biol. 304 (2000) 355-370
16. Owen D.J., Ornaghi P., Yang J.C., Lowe N., Evans P.R., Ballario P., Neuhaus D., Filetici P., and Travers A.A. The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p. EMBO J. 19 (2000) 6141-6149
17. Mujtaba S., He Y., Zeng L., Farooq A., Carlson J.E., Ott M., Verdin E., and Zhou M.M. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol. Cell 9 (2002) 575-586
18. Mujtaba S., He Y., Zeng L., Yan S., Plotnikova O., Sachchidanand, Sanchez R., Zeleznik-Le N.J., Ronai Z., and Zhou M.M. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol. Cell 13 (2004) 251-263
19. Delaglio F., Grzesiek S., Vuister G.W., Zhu G., Pfeifer J., and Bax A. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6 (1995) 277-293
20. Cornilescu G., Delaglio F., and Bax A. Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J. Biomol. NMR 13 (1999) 289-302
21. Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S., Read R.J., Rice L.M., Simonson T., and Warren G.L. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54 (1998) 905-921
22. Shen W., Xu C., Huang W., Zhang J., Carlson J.E., Tu X., Wu J., and Shi Y. Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails. Biochemistry 46 (2007) 2100-2110
23. Loyola A., and Almouzni G. Bromodomains in living cells participate in deciphering the histone code. Trends Cell Biol. 14 (2004) 279-281
24. Shindyalov I.N., and Bourne P.E. Protein structure alignment by incremental combinatorial extension (CE) of the optimal path. Protein Eng. 11 (1998) 739-747