-
1
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
M.F. Krummel, and J.P. Allison CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation J Exp Med 182 1995 459 465
-
(1995)
J Exp Med
, vol.182
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
2
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
D.R. Leach, M.F. Krummel, and J.P. Allison Enhancement of antitumor immunity by CTLA-4 blockade Science 271 1996 1734 1736
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
3
-
-
84880511594
-
Development of ipilimumab: A novel immunotherapeutic approach for the treatment of advanced melanoma
-
J.D. Wolchok, F.S. Hodi, J.S. Weber, J.P. Allison, W.J. Urba, and C. Robert Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma Ann N Y Acad Sci 1291 2013 1 13
-
(2013)
Ann N y Acad Sci
, vol.1291
, pp. 1-13
-
-
Wolchok, J.D.1
Hodi, F.S.2
Weber, J.S.3
Allison, J.P.4
Urba, W.J.5
Robert, C.6
-
5
-
-
80054875641
-
Novel cancer immunotherapy agents with survival benefit: Recent successes and next steps
-
P. Sharma, K. Wagner, J.D. Wolchok, and J.P. Allison Novel cancer immunotherapy agents with survival benefit: recent successes and next steps Nat Rev Cancer 11 2011 805 812
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 805-812
-
-
Sharma, P.1
Wagner, K.2
Wolchok, J.D.3
Allison, J.P.4
-
6
-
-
34250223096
-
A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
-
E.J. Small, N.S. Tchekmedyian, B.I. Rini, L. Fong, I. Lowy, and J.P. Allison A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer Clin Cancer Res 13 2007 1810 1815
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1810-1815
-
-
Small, E.J.1
Tchekmedyian, N.S.2
Rini, B.I.3
Fong, L.4
Lowy, I.5
Allison, J.P.6
-
7
-
-
84880508629
-
Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: Results from an open-label, multicenter phase I/II study
-
S.F. Slovin, C.S. Higano, O. Hamid, S. Tejwani, A. Harzstark, and J.J. Alumkal Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study Ann Oncol 24 2013 1813 1821
-
(2013)
Ann Oncol
, vol.24
, pp. 1813-1821
-
-
Slovin, S.F.1
Higano, C.S.2
Hamid, O.3
Tejwani, S.4
Harzstark, A.5
Alumkal, J.J.6
-
8
-
-
84871532643
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
-
M. Reck, I. Bondarenko, A. Luft, P. Serwatowski, F. Barlesi, and R. Chacko Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial Ann Oncol 24 2013 75 83
-
(2013)
Ann Oncol
, vol.24
, pp. 75-83
-
-
Reck, M.1
Bondarenko, I.2
Luft, A.3
Serwatowski, P.4
Barlesi, F.5
Chacko, R.6
-
9
-
-
84863911486
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
-
T.J. Lynch, I. Bondarenko, A. Luft, P. Serwatowski, F. Barlesi, and R. Chacko Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study J Clin Oncol 30 2012 2046 2054
-
(2012)
J Clin Oncol
, vol.30
, pp. 2046-2054
-
-
Lynch, T.J.1
Bondarenko, I.2
Luft, A.3
Serwatowski, P.4
Barlesi, F.5
Chacko, R.6
-
10
-
-
37349072460
-
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
J.C. Yang, M. Hughes, U. Kammula, R. Royal, R.M. Sherry, and S.L. Topalian Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis J Immunother 30 2007 825 830
-
(2007)
J Immunother
, vol.30
, pp. 825-830
-
-
Yang, J.C.1
Hughes, M.2
Kammula, U.3
Royal, R.4
Sherry, R.M.5
Topalian, S.L.6
-
11
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
F.S. Hodi, S.J. ODay, D.F. McDermott, R.W. Weber, J.A. Sosman, and J.B. Haanen Improved survival with ipilimumab in patients with metastatic melanoma N Engl J Med 363 2010 711 723
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
Oday, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
12
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
C. Robert, L. Thomas, I. Bondarenko, S. O'Day, J. Weber, and C. Garbe Ipilimumab plus dacarbazine for previously untreated metastatic melanoma N Engl J Med 364 2011 2517 2526
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
O'Day, S.4
Weber, J.5
Garbe, C.6
-
13
-
-
84907521156
-
Ipilimumab versus placebo after complete resection of stage III melanoma: Initial efficacy and safety results from the EORTC 18071 phase III trial [abstract]
-
A.M. Eggermont, V. Chiarion-Sileni, J.J. Grob, R. Dummer, J.D. Wolchok, and H. Schmidt Ipilimumab versus placebo after complete resection of stage III melanoma: Initial efficacy and safety results from the EORTC 18071 phase III trial [abstract] J Clin Oncol (Meeting Abstracts) 32 5s 2014 LBA9008
-
(2014)
J Clin Oncol (Meeting Abstracts)
, vol.32
, Issue.5 S
, pp. 9008
-
-
Eggermont, A.M.1
Chiarion-Sileni, V.2
Grob, J.J.3
Dummer, R.4
Wolchok, J.D.5
Schmidt, H.6
-
14
-
-
84879141840
-
A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
-
B. Sangro, C. Gomez-Martin, M. de la Mata, M. Iñarrairaegui, E. Garralda, and P. Barrera A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C J Hepatol 59 2013 81 88
-
(2013)
J Hepatol
, vol.59
, pp. 81-88
-
-
Sangro, B.1
Gomez-Martin, C.2
De La Mata, M.3
Iñarrairaegui, M.4
Garralda, E.5
Barrera, P.6
-
15
-
-
61449090474
-
Phase I/II trial of tremelimumab in patients with metastatic melanoma
-
L.H. Camacho, S. Antonia, J. Sosman, J.M. Kirkwood, T.F. Gajewski, and B. Redman Phase I/II trial of tremelimumab in patients with metastatic melanoma J Clin Oncol 27 2009 1075 1081
-
(2009)
J Clin Oncol
, vol.27
, pp. 1075-1081
-
-
Camacho, L.H.1
Antonia, S.2
Sosman, J.3
Kirkwood, J.M.4
Gajewski, T.F.5
Redman, B.6
-
16
-
-
77955292303
-
Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
-
K.Y. Chung, I. Gore, L. Fong, A. Venook, S.B. Beck, and P. Dorazio Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer J Clin Oncol 28 2010 3485 3490
-
(2010)
J Clin Oncol
, vol.28
, pp. 3485-3490
-
-
Chung, K.Y.1
Gore, I.2
Fong, L.3
Venook, A.4
Beck, S.B.5
Dorazio, P.6
-
17
-
-
76049092889
-
Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma
-
J.M. Kirkwood, P. Lorigan, P. Hersey, A. Hauschild, C. Robert, and D. McDermott Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma Clin Cancer Res 16 2010 1042 1048
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1042-1048
-
-
Kirkwood, J.M.1
Lorigan, P.2
Hersey, P.3
Hauschild, A.4
Robert, C.5
McDermott, D.6
-
18
-
-
84884703526
-
Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: An open-label, single-arm, phase 2 trial
-
L. Calabro, A. Morra, E. Fonsatti, O. Cutaia, G. Amato, and D. Giannarelli Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial Lancet Oncol 14 2013 1104 1111
-
(2013)
Lancet Oncol
, vol.14
, pp. 1104-1111
-
-
Calabro, L.1
Morra, A.2
Fonsatti, E.3
Cutaia, O.4
Amato, G.5
Giannarelli, D.6
-
19
-
-
84874605864
-
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
A. Ribas, R. Kefford, M.A. Marshall, C.J. Punt, J.B. Haanen, and M. Marmol Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma J Clin Oncol 31 2013 616 622
-
(2013)
J Clin Oncol
, vol.31
, pp. 616-622
-
-
Ribas, A.1
Kefford, R.2
Marshall, M.A.3
Punt, C.J.4
Haanen, J.B.5
Marmol, M.6
-
20
-
-
84886443514
-
CTLA-4 and PD-1/PD-L1 blockade: New immunotherapeutic modalities with durable clinical benefit in melanoma patients
-
P.A. Ott, F.S. Hodi, and C. Robert CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients Clin Cancer Res 19 2013 5300 5309
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5300-5309
-
-
Ott, P.A.1
Hodi, F.S.2
Robert, C.3
-
21
-
-
84864052441
-
Management of immune-related adverse events and kinetics of response with ipilimumab
-
J.S. Weber, K.C. Kähler, and A. Hauschild Management of immune-related adverse events and kinetics of response with ipilimumab J Clin Oncol 30 2012 2691 2697
-
(2012)
J Clin Oncol
, vol.30
, pp. 2691-2697
-
-
Weber, J.S.1
Kähler, K.C.2
Hauschild, A.3
-
22
-
-
78449256966
-
Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: Identification of clinical and biological response patterns, immune-related adverse events, and their management
-
K.C. Kaehler, S. Piel, E. Livingstone, B. Schilling, A. Hauschild, and D. Schadendorf Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: identification of clinical and biological response patterns, immune-related adverse events, and their management Semin Oncol 37 2010 485 498
-
(2010)
Semin Oncol
, vol.37
, pp. 485-498
-
-
Kaehler, K.C.1
Piel, S.2
Livingstone, E.3
Schilling, B.4
Hauschild, A.5
Schadendorf, D.6
-
23
-
-
57849117384
-
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
-
E.A. Eisenhauer, P. Therasse, J. Bogaerts, L.H. Schwartz, D. Sargent, and R. Ford New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) Eur J Cancer 45 2009 228 247
-
(2009)
Eur J Cancer
, vol.45
, pp. 228-247
-
-
Eisenhauer, E.A.1
Therasse, P.2
Bogaerts, J.3
Schwartz, L.H.4
Sargent, D.5
Ford, R.6
-
24
-
-
84870255287
-
Patient responses to ipilimumab, a novel immunopotentiator for metastatic melanoma: How different are these from conventional treatment responses?
-
G.K. Pennock, W. Waterfield, and J.D. Wolchok Patient responses to ipilimumab, a novel immunopotentiator for metastatic melanoma: how different are these from conventional treatment responses? Am J Clin Oncol 35 2012 606 611
-
(2012)
Am J Clin Oncol
, vol.35
, pp. 606-611
-
-
Pennock, G.K.1
Waterfield, W.2
Wolchok, J.D.3
-
25
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
J.D. Wolchok, A. Hoos, S. ODay, J.S. Weber, O. Hamid, and C. Lebbé Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria Clin Cancer Res 15 2009 7412 7420
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
Oday, S.3
Weber, J.S.4
Hamid, O.5
Lebbé, C.6
-
26
-
-
84881128653
-
Developing a common language for tumor response to immunotherapy: Immune-related response criteria using unidimensional measurements
-
M. Nishino, A. Giobbie-Hurder, M. Gargano, M. Suda, N.H. Ramaiya, and F.S. Hodi Developing a common language for tumor response to immunotherapy: immune-related response criteria using unidimensional measurements Clin Cancer Res 19 2013 3936 3943
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3936-3943
-
-
Nishino, M.1
Giobbie-Hurder, A.2
Gargano, M.3
Suda, M.4
Ramaiya, N.H.5
Hodi, F.S.6
-
27
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
H. Dong, S.E. Strome, D.R. Salomao, H. Tamura, F. Hirano, and D.B. Flies Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion Nat Med 8 2002 793 800
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
Tamura, H.4
Hirano, F.5
Flies, D.B.6
-
28
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
G.J. Freeman, A.J. Long, Y. Iwai, K. Bourque, T. Chernova, and H. Nishimura Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation J Exp Med 192 2000 1027 1034
-
(2000)
J Exp Med
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
Bourque, K.4
Chernova, T.5
Nishimura, H.6
-
29
-
-
0026700235
-
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
-
Y. Ishida, Y. Agata, K. Shibahara, and T. Honjo Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death EMBO J 11 1992 3887 3895
-
(1992)
EMBO J
, vol.11
, pp. 3887-3895
-
-
Ishida, Y.1
Agata, Y.2
Shibahara, K.3
Honjo, T.4
-
31
-
-
33645846313
-
Tissue expression of PD-L1 mediates peripheral T cell tolerance
-
M.E. Keir, S.C. Liang, I. Guleria, Y.E. Latchman, A. Qipo, and L.A. Albacker Tissue expression of PD-L1 mediates peripheral T cell tolerance J Exp Med 203 2006 883 895
-
(2006)
J Exp Med
, vol.203
, pp. 883-895
-
-
Keir, M.E.1
Liang, S.C.2
Guleria, I.3
Latchman, Y.E.4
Qipo, A.5
Albacker, L.A.6
-
32
-
-
0033180181
-
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
-
H. Nishimura, M. Nose, H. Hiai, N. Minato, and T. Honjo Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor Immunity 11 1999 141 151
-
(1999)
Immunity
, vol.11
, pp. 141-151
-
-
Nishimura, H.1
Nose, M.2
Hiai, H.3
Minato, N.4
Honjo, T.5
-
33
-
-
0035846991
-
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
-
H. Nishimura, T. Okazaki, Y. Tanaka, K. Nakatani, M. Hara, and A. Matsumori Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice Science 291 2001 319 322
-
(2001)
Science
, vol.291
, pp. 319-322
-
-
Nishimura, H.1
Okazaki, T.2
Tanaka, Y.3
Nakatani, K.4
Hara, M.5
Matsumori, A.6
-
34
-
-
34547794178
-
PD-1 and PD-1 ligands: From discovery to clinical application
-
T. Okazaki, and T. Honjo PD-1 and PD-1 ligands: from discovery to clinical application Int Immunol 19 2007 813 824
-
(2007)
Int Immunol
, vol.19
, pp. 813-824
-
-
Okazaki, T.1
Honjo, T.2
-
35
-
-
33846118474
-
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
-
A.T. Parsa, J.S. Waldron, A. Panner, C.A. Crane, I.F. Parney, and J.J. Barry Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma Nat Med 13 2007 84 88
-
(2007)
Nat Med
, vol.13
, pp. 84-88
-
-
Parsa, A.T.1
Waldron, J.S.2
Panner, A.3
Crane, C.A.4
Parney, I.F.5
Barry, J.J.6
-
36
-
-
84883050318
-
Drug of the year: Programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies
-
C. Robert, J.C. Soria, and A.M. Eggermont Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies Eur J Cancer 49 2013 2968 2971
-
(2013)
Eur J Cancer
, vol.49
, pp. 2968-2971
-
-
Robert, C.1
Soria, J.C.2
Eggermont, A.M.3
-
37
-
-
84880732199
-
Survival and long-term follow-up of safety and response in patients (pts) with advanced melanoma (MEL) in a phase i trial of nivolumab (anti-PD-1; BMS-936558; ONO-4538) [abstract]
-
M. Sznol, H.M. Kluger, F.S. Hodi, D.F. McDermott, R.D. Carvajal, and D.P. Lawrence Survival and long-term follow-up of safety and response in patients (pts) with advanced melanoma (MEL) in a phase I trial of nivolumab (anti-PD-1; BMS-936558; ONO-4538) [abstract] J Clin Oncol (Meeting Abstracts) 31 2013 CRA9006
-
(2013)
J Clin Oncol (Meeting Abstracts)
, vol.31
, pp. 9006
-
-
Sznol, M.1
Kluger, H.M.2
Hodi, F.S.3
McDermott, D.F.4
Carvajal, R.D.5
Lawrence, D.P.6
-
38
-
-
84880710451
-
Nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients with advanced solid tumors: Survival and long-term safety in a phase i trial [abstract]
-
S.L. Topalian, M. Sznol, J.R. Brahmer, D.F. McDermott, D.C. Smith, and S.N. Gettinger Nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients with advanced solid tumors: Survival and long-term safety in a phase I trial [abstract] J Clin Oncol (Meeting Abstracts) 31 2013 3002
-
(2013)
J Clin Oncol (Meeting Abstracts)
, vol.31
, pp. 3002
-
-
Topalian, S.L.1
Sznol, M.2
Brahmer, J.R.3
McDermott, D.F.4
Smith, D.C.5
Gettinger, S.N.6
-
39
-
-
84907558390
-
Long-term survival of ipilimumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) in a phase i trial [abstract]
-
F.S. Hodi, M. Sznol, H.M. Kluger, D.F. McDermott, R.D. Carvajal, and D.P. Lawrence Long-term survival of ipilimumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) in a phase I trial [abstract] J Clin Oncol (Meeting Abstracts) 32 5s 2014 9002
-
(2014)
J Clin Oncol (Meeting Abstracts)
, vol.32
, Issue.5 S
, pp. 9002
-
-
Hodi, F.S.1
Sznol, M.2
Kluger, H.M.3
McDermott, D.F.4
Carvajal, R.D.5
Lawrence, D.P.6
-
40
-
-
84908299923
-
Updated survival, toxicity, and biomarkers of nivolumab with/without peptide vaccine in patients naive to, or progressed on, ipilimumab (IPI) [abstract]
-
J.S. Weber, R.R. Kudchadkar, G.T. Gibney, B. Yu, P.Y. Cheng, and A. Martinez Updated survival, toxicity, and biomarkers of nivolumab with/without peptide vaccine in patients naive to, or progressed on, ipilimumab (IPI) [abstract] J Clin Oncol (Meeting Abstracts) 32 5s 2014 3009
-
(2014)
J Clin Oncol (Meeting Abstracts)
, vol.32
, Issue.5 S
, pp. 3009
-
-
Weber, J.S.1
Kudchadkar, R.R.2
Gibney, G.T.3
Yu, B.4
Cheng, P.Y.5
Martinez, A.6
-
41
-
-
84880715077
-
Survival and long-term follow-up of the phase i trial of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with previously treated advanced non-small cell lung cancer (NSCLC) [abstract]
-
J.R. Brahmer, L. Horn, S.J. Antonia, D.R. Spigel, L. Gandhi, and L.V. Sequist Survival and long-term follow-up of the phase I trial of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with previously treated advanced non-small cell lung cancer (NSCLC) [abstract] J Clin Oncol (Meeting Abstracts) 31 2013 8030
-
(2013)
J Clin Oncol (Meeting Abstracts)
, vol.31
, pp. 8030
-
-
Brahmer, J.R.1
Horn, L.2
Antonia, S.J.3
Spigel, D.R.4
Gandhi, L.5
Sequist, L.V.6
-
42
-
-
84880706331
-
Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase i trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up [abstract]
-
C.G. Drake, D.F. McDermott, M. Sznol, T.K. Choueiri, H.M. Kluger, and J.D. Powderly Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up [abstract] J Clin Oncol (Meeting Abstracts) 31 2013 4514
-
(2013)
J Clin Oncol (Meeting Abstracts)
, vol.31
, pp. 4514
-
-
Drake, C.G.1
McDermott, D.F.2
Sznol, M.3
Choueiri, T.K.4
Kluger, H.M.5
Powderly, J.D.6
-
43
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
O. Hamid, C. Robert, A. Daud, F.S. Hodi, W.J. Hwu, and R. Kefford Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma N Engl J Med 369 2013 134 144
-
(2013)
N Engl J Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.J.5
Kefford, R.6
-
44
-
-
84907543029
-
Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL) [abstract]
-
A. Ribas, F.S. Hodi, R. Kefford, O. Hamid, A. Daud, and J.D. Wolchok Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL) [abstract] J Clin Oncol (Meeting Abstracts) 32 5s 2014 LBA9000
-
(2014)
J Clin Oncol (Meeting Abstracts)
, vol.32
, Issue.5 S
, pp. 9000
-
-
Ribas, A.1
Hodi, F.S.2
Kefford, R.3
Hamid, O.4
Daud, A.5
Wolchok, J.D.6
-
45
-
-
84907498839
-
Randomized comparison of two doses of the anti-PD-1 monoclonal antibody MK-3475 for ipilimumabrefractory (IPI-R) and IPI-naive (IPI-N) melanoma (MEL) [abstract]
-
O. Hamid, C. Robert, A. Ribas, J.D. Wolchok, F.S. Hodi, and R. Kefford Randomized comparison of two doses of the anti-PD-1 monoclonal antibody MK-3475 for ipilimumabrefractory (IPI-R) and IPI-naive (IPI-N) melanoma (MEL) [abstract] J Clin Oncol (Meeting Abstracts) 32 5s 2014 3000
-
(2014)
J Clin Oncol (Meeting Abstracts)
, vol.32
, Issue.5 S
, pp. 3000
-
-
Hamid, O.1
Robert, C.2
Ribas, A.3
Wolchok, J.D.4
Hodi, F.S.5
Kefford, R.6
-
46
-
-
84907973066
-
Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475 [abstract]
-
R. Kefford, A. Ribas, O. Hamid, C. Robert, A. Daud, and J.D. Wolchok Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475 [abstract] J Clin Oncol (Meeting Abstracts) 32 5s 2014 3005
-
(2014)
J Clin Oncol (Meeting Abstracts)
, vol.32
, Issue.5 S
, pp. 3005
-
-
Kefford, R.1
Ribas, A.2
Hamid, O.3
Robert, C.4
Daud, A.5
Wolchok, J.D.6
-
47
-
-
49649114804
-
Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
R. Berger, R. Rotem-Yehudar, G. Slama, S. Landes, A. Kneller, and M. Leiba Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies Clin Cancer Res 14 2008 3044 3051
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
Landes, S.4
Kneller, A.5
Leiba, M.6
-
48
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
J.R. Brahmer, S.S. Tykodi, L.Q. Chow, W.J. Hwu, S.L. Topalian, and P. Hwu Safety and activity of anti-PD-L1 antibody in patients with advanced cancer N Engl J Med 366 2012 2455 2465
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
-
49
-
-
84887262315
-
A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors [abstract]
-
R.S. Herbst, M.S. Gordon, G.D. Fine, J.A. Sosman, J.-C. Soria, and O. Hamid A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors [abstract] J Clin Oncol (Meeting Abstracts) 31 2013 3000
-
(2013)
J Clin Oncol (Meeting Abstracts)
, vol.31
, pp. 3000
-
-
Herbst, R.S.1
Gordon, M.S.2
Fine, G.D.3
Sosman, J.A.4
Soria, J.-C.5
Hamid, O.6
-
50
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
S.L. Topalian, F.S. Hodi, J.R. Brahmer, S.N. Gettinger, D.C. Smith, and D.F. McDermott Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N Engl J Med 366 2012 2443 2454
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
-
51
-
-
84897890387
-
Immune checkpoint blockade in cancer treatment: A double-edged sword cross-targeting the host as an "innocent bystander"
-
L. Gelao, C. Criscitiello, A. Esposito, A. Goldhirsch, and G. Curigliano Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander" Toxins (Basel) 6 2014 914 933
-
(2014)
Toxins (Basel)
, vol.6
, pp. 914-933
-
-
Gelao, L.1
Criscitiello, C.2
Esposito, A.3
Goldhirsch, A.4
Curigliano, G.5
-
52
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
-
M.A. Curran, W. Montalvo, H. Yagita, and J.P. Allison PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors Proc Natl Acad Sci U S A 107 2010 4275 4280
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
53
-
-
84884569284
-
New combinations and immunotherapies for melanoma: Latest evidence and clinical utility
-
A.M. Menzies, and G.V. Long New combinations and immunotherapies for melanoma: latest evidence and clinical utility Ther Adv Med Oncol 5 2013 278 285
-
(2013)
Ther Adv Med Oncol
, vol.5
, pp. 278-285
-
-
Menzies, A.M.1
Long, G.V.2
-
54
-
-
84892365940
-
Checkpoint blocking antibodies in cancer immunotherapy
-
C. Kyi, and M.A. Postow Checkpoint blocking antibodies in cancer immunotherapy FEBS Lett 588 2014 368 376
-
(2014)
FEBS Lett
, vol.588
, pp. 368-376
-
-
Kyi, C.1
Postow, M.A.2
-
55
-
-
68549135290
-
Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
-
C.S. Higano, P.F. Schellhammer, E.J. Small, P.A. Burch, J. Nemunaitis, and L. Yuh Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer Cancer 115 2009 3670 3679
-
(2009)
Cancer
, vol.115
, pp. 3670-3679
-
-
Higano, C.S.1
Schellhammer, P.F.2
Small, E.J.3
Burch, P.A.4
Nemunaitis, J.5
Yuh, L.6
-
57
-
-
84861988397
-
Development of sipuleucel-T: Autologous cellular immunotherapy for the treatment of metastatic castrate resistant prostate cancer
-
R.B. Sims Development of sipuleucel-T: autologous cellular immunotherapy for the treatment of metastatic castrate resistant prostate cancer Vaccine 30 2012 4394 4397
-
(2012)
Vaccine
, vol.30
, pp. 4394-4397
-
-
Sims, R.B.1
-
58
-
-
33746012881
-
Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
-
E.J. Small, P.F. Schellhammer, C.S. Higano, C.H. Redfern, J.J. Nemunaitis, and F.H. Valone Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer J Clin Oncol 24 2006 3089 3094
-
(2006)
J Clin Oncol
, vol.24
, pp. 3089-3094
-
-
Small, E.J.1
Schellhammer, P.F.2
Higano, C.S.3
Redfern, C.H.4
Nemunaitis, J.J.5
Valone, F.H.6
-
59
-
-
77955066199
-
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
-
P.W. Kantoff, C.S. Higano, N.D. Shore, E.R. Berger, E.J. Small, and D.F. Penson Sipuleucel-T immunotherapy for castration-resistant prostate cancer N Engl J Med 363 2010 411 422
-
(2010)
N Engl J Med
, vol.363
, pp. 411-422
-
-
Kantoff, P.W.1
Higano, C.S.2
Shore, N.D.3
Berger, E.R.4
Small, E.J.5
Penson, D.F.6
-
60
-
-
80051548463
-
Integrated safety data from 4 randomized, double-blind, controlled trials of autologous cellular immunotherapy with sipuleucel-T in patients with prostate cancer
-
S.J. Hall, L. Klotz, A.J. Pantuck, D.J. George, J.B. Whitmore, and M.W. Frohlich Integrated safety data from 4 randomized, double-blind, controlled trials of autologous cellular immunotherapy with sipuleucel-T in patients with prostate cancer J Urol 186 2011 877 881
-
(2011)
J Urol
, vol.186
, pp. 877-881
-
-
Hall, S.J.1
Klotz, L.2
Pantuck, A.J.3
George, D.J.4
Whitmore, J.B.5
Frohlich, M.W.6
-
61
-
-
84885659813
-
Prostate cancer vaccines: Update on clinical development
-
S.M. Geary, and A.K. Salem Prostate cancer vaccines: update on clinical development Oncoimmunology 2 2013 e24523
-
(2013)
Oncoimmunology
, vol.2
, pp. 24523
-
-
Geary, S.M.1
Salem, A.K.2
-
63
-
-
84899496281
-
PROSTVACR targeted immunotherapy candidate for prostate cancer
-
N.D. Shore PROSTVACR targeted immunotherapy candidate for prostate cancer Immunotherapy 6 2014 235 247
-
(2014)
Immunotherapy
, vol.6
, pp. 235-247
-
-
Shore, N.D.1
-
64
-
-
77949895922
-
Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
-
P.W. Kantoff, T.J. Schuetz, B.A. Blumenstein, L.M. Glode, D.L. Bilhartz, and M. Wyand Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer J Clin Oncol 28 2010 1099 1105
-
(2010)
J Clin Oncol
, vol.28
, pp. 1099-1105
-
-
Kantoff, P.W.1
Schuetz, T.J.2
Blumenstein, B.A.3
Glode, L.M.4
Bilhartz, D.L.5
Wyand, M.6
-
65
-
-
77950473925
-
Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer
-
J.L. Gulley, P.M. Arlen, R.A. Madan, K.Y. Tsang, M.P. Pazdur, and L. Skarupa Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer Cancer Immunol Immunother 59 2010 663 674
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 663-674
-
-
Gulley, J.L.1
Arlen, P.M.2
Madan, R.A.3
Tsang, K.Y.4
Pazdur, M.P.5
Skarupa, L.6
-
66
-
-
84877913638
-
Immunotherapy updates in pancreatic cancer: Are we there yet?
-
K.S. Gunturu, G.R. Rossi, and M.W. Saif Immunotherapy updates in pancreatic cancer: are we there yet? Ther Adv Med Oncol 5 2013 81 89
-
(2013)
Ther Adv Med Oncol
, vol.5
, pp. 81-89
-
-
Gunturu, K.S.1
Rossi, G.R.2
Saif, M.W.3
-
67
-
-
84871991189
-
Addition of algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: A phase 2 study
-
discussion p. 100-1
-
J.M. Hardacre, M. Mulcahy, W. Small, M. Talamonti, J. Obel, and S. Krishnamurthi Addition of algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: a phase 2 study J Gastrointest Surg 17 1 2013 94 100 discussion p. 100-1
-
(2013)
J Gastrointest Surg
, vol.17
, Issue.1
, pp. 94-100
-
-
Hardacre, J.M.1
Mulcahy, M.2
Small, W.3
Talamonti, M.4
Obel, J.5
Krishnamurthi, S.6
-
68
-
-
84890238900
-
Effect of algenpantucel-L immunotherapy for pancreatic cancer on anti-mesothelin antibody (Ab) titers and correlation with improved overall survival [abstract]
-
G.R. Rossi, J.M. Hardacre, M.F. Mulcahy, M.S. Talamonti, J.C. Obel, and C.R. Lima Effect of algenpantucel-L immunotherapy for pancreatic cancer on anti-mesothelin antibody (Ab) titers and correlation with improved overall survival [abstract] J Clin Oncol (Meeting Abstracts) 31 2013 3007
-
(2013)
J Clin Oncol (Meeting Abstracts)
, vol.31
, pp. 3007
-
-
Rossi, G.R.1
Hardacre, J.M.2
Mulcahy, M.F.3
Talamonti, M.S.4
Obel, J.C.5
Lima, C.R.6
-
69
-
-
0031701743
-
Rapid induction of primary human CD4+and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes
-
B. Agrawal, M.J. Krantz, M.A. Reddish, and B.M. Longenecker Rapid induction of primary human CD4+and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes Int Immunol 10 1998 1907 1916
-
(1998)
Int Immunol
, vol.10
, pp. 1907-1916
-
-
Agrawal, B.1
Krantz, M.J.2
Reddish, M.A.3
Longenecker, B.M.4
-
70
-
-
34547661985
-
L-BLP25: A peptide vaccine strategy in non small cell lung cancer
-
R. Sangha, and C. Butts L-BLP25: a peptide vaccine strategy in non small cell lung cancer Clin Cancer Res 13 2007 s4652 s4654
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4652-s4654
-
-
Sangha, R.1
Butts, C.2
-
71
-
-
84891373760
-
Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): A randomised, double-blind, phase 3 trial
-
C. Butts, M.A. Socinski, P.L. Mitchell, N. Thatcher, L. Havel, and M. Krzakowski Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial Lancet Oncol 15 2014 59 68
-
(2014)
Lancet Oncol
, vol.15
, pp. 59-68
-
-
Butts, C.1
Socinski, M.A.2
Mitchell, P.L.3
Thatcher, N.4
Havel, L.5
Krzakowski, M.6
-
72
-
-
27244449289
-
Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
-
C. Butts, N. Murray, A. Maksymiuk, G. Goss, E. Marshall, and D. Soulières Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer J Clin Oncol 23 2005 6674 6681
-
(2005)
J Clin Oncol
, vol.23
, pp. 6674-6681
-
-
Butts, C.1
Murray, N.2
Maksymiuk, A.3
Goss, G.4
Marshall, E.5
Soulières, D.6
-
73
-
-
84880755387
-
Adjuvant MAGE-A3 immunotherapy in resected non-small-cell lung cancer: Phase II randomized study results
-
J. Vansteenkiste, Zielinski, A. Linder, J. Dahabreh, E.E. Gonzalez, and W. Malinowski Adjuvant MAGE-A3 immunotherapy in resected non-small-cell lung cancer: phase II randomized study results J Clin Oncol 31 2013 2396 2403
-
(2013)
J Clin Oncol
, vol.31
, pp. 2396-2403
-
-
Vansteenkiste, J.1
Zielinski2
Linder, A.3
Dahabreh, J.4
Gonzalez, E.E.5
Malinowski, W.6
-
74
-
-
84873204700
-
Rindopepimut: An evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma
-
R. Babu, and D.C. Adamson Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma Core Evid 7 2012 93 103
-
(2012)
Core Evid
, vol.7
, pp. 93-103
-
-
Babu, R.1
Adamson, D.C.2
-
75
-
-
34250189213
-
Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma
-
C.E. Pelloski, K.V. Ballman, A.F. Furth, L. Zhang, E. Lin, and E.P. Sulman Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma J Clin Oncol 25 2007 2288 2294
-
(2007)
J Clin Oncol
, vol.25
, pp. 2288-2294
-
-
Pelloski, C.E.1
Ballman, K.V.2
Furth, A.F.3
Zhang, L.4
Lin, E.5
Sulman, E.P.6
-
76
-
-
0034214087
-
Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer
-
C.K. Tang, X.Q. Gong, D.K. Moscatello, A.J. Wong, and M.E. Lippman Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer Cancer Res 60 2000 3081 3087
-
(2000)
Cancer Res
, vol.60
, pp. 3081-3087
-
-
Tang, C.K.1
Gong, X.Q.2
Moscatello, D.K.3
Wong, A.J.4
Lippman, M.E.5
-
77
-
-
84908273592
-
Long-term follow-up of ACT III: A Phase II trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma [abstract]
-
(IM-03)
-
R.K. Lai, L.D. Recht, D.A. Reardon, N. Paleologos, M. Groves, and M.R. Rosenfeld Long-term follow-up of ACT III: A Phase II trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma [abstract] Neuro Oncol (Meeting Abstracts) 13 Suppl 3 2011 (IM-03)
-
(2011)
Neuro Oncol (Meeting Abstracts)
, vol.13
-
-
Lai, R.K.1
Recht, L.D.2
Reardon, D.A.3
Paleologos, N.4
Groves, M.5
Rosenfeld, M.R.6
-
78
-
-
79955784386
-
Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma
-
J.H. Sampson, K.D. Aldape, G.E. Archer, A. Coan, A. Desjardins, and A.H. Friedman Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma Neuro Oncol 13 2011 324 333
-
(2011)
Neuro Oncol
, vol.13
, pp. 324-333
-
-
Sampson, J.H.1
Aldape, K.D.2
Archer, G.E.3
Coan, A.4
Desjardins, A.5
Friedman, A.H.6
-
79
-
-
78149254368
-
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
-
J.H. Sampson, A.B. Heimberger, G.E. Archer, K.D. Aldape, A.H. Friedman, and H.S. Friedman Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma J Clin Oncol 28 2010 4722 4729
-
(2010)
J Clin Oncol
, vol.28
, pp. 4722-4729
-
-
Sampson, J.H.1
Heimberger, A.B.2
Archer, G.E.3
Aldape, K.D.4
Friedman, A.H.5
Friedman, H.S.6
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