Characterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogs

Molecular and Biochemical Parasitology

Volumn 196, Issue 2, 2014, Pages 90-99

  Bibis, Stergios S ^a   Dahlstrom, Kelly ^b   Zhu, Tongtong ^a   Zufferey, Rachel ^a,b  

^a ST JOHN'S UNIVERSITY   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

Choline analogs; Leishmania major; Phosphatidylcholine biosynthesis; Phosphatidylethanolaminemethyltransferase

Indexed keywords

CETRIMIDE; CHOLINE DERIVATIVE; DIGITONIN; LMJ PEM1 METHYLTRANSFERASE; LMJ PEM2 METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; MILTEFOSINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; UNCLASSIFIED DRUG; CHOLINE; PHOSPHATIDYLETHANOLAMINE; PROTOZOAL PROTEIN;

AMASTIGOTE; ARTICLE; AUXOTROPHY; BIOSYNTHESIS; CELL DIVISION; CELL FRACTIONATION; ENDOPLASMIC RETICULUM MEMBRANE; ENZYME INHIBITION; ENZYME LOCALIZATION; HETEROLOGOUS EXPRESSION; IMMUNOFLUORESCENCE; LEISHMANIA MAJOR; LIPID ANALYSIS; MOLECULAR BIOLOGY; NONHUMAN; PHOSPHOLIPID METHYLATION; PROMASTIGOTE; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; METHYLATION; MOUSE; PARASITOLOGY; SKIN LEISHMANIASIS;

ANIMALS; CHOLINE; HUMANS; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; METHYLATION; MICE; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; PHOSPHATIDYLETHANOLAMINES; PROTOZOAN PROTEINS;

EID: 84908265929     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2014.08.005     Document Type: Article

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