Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia

Science Translational Medicine

Volumn 6, Issue 258, 2014, Pages 258ra140-

  Bochner, David N ^a   Sapp, Richard W ^a   Adelson, Jaimie D ^a   Zhang, Siyu ^b   Lee, Hanmi ^a   Djurisic, Maja ^a   Syken, Josh ^c   Dan, Yang ^b   Shatz, Carla J ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PAIRED IMMUNOGLOBULIN LIKE RECEPTOR B; REGULATOR PROTEIN; UNCLASSIFIED DRUG; CRE RECOMBINASE; IMMUNOGLOBULIN RECEPTOR; INTEGRASE; LIGAND; PIRB PROTEIN, MOUSE; TAMOXIFEN;

AMBLYOPIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ASSAY; CELL DENSITY; CELL FUNCTION; CONTROLLED STUDY; DENDRITIC SPINE; EXCITATORY POSTSYNAPTIC POTENTIAL; EYE DOMINANCE; GENE DELETION; MOLECULAR DYNAMICS; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; UPREGULATION; VISUAL ACUITY; VISUAL CORTEX; ANIMAL; CONVALESCENCE; DRUG EFFECTS; GENOTYPE; METABOLISM; NEWBORN; PATHOPHYSIOLOGY; SYNAPSE;

AMBLYOPIA; ANIMALS; ANIMALS, NEWBORN; DENDRITIC SPINES; DOMINANCE, OCULAR; GENE DELETION; GENOTYPE; INTEGRASES; LIGANDS; MICE; NEURONAL PLASTICITY; PYRAMIDAL CELLS; RECEPTORS, IMMUNOLOGIC; RECOVERY OF FUNCTION; SYNAPSES; TAMOXIFEN; UP-REGULATION; VISUAL ACUITY; VISUAL CORTEX;

EID: 84908258946     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3010157     Document Type: Article

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