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Volumn 3, Issue 8, 2014, Pages 794-802

The Polycomb protein, Bmi1, regulates insulin sensitivity

Author keywords

Hepatic glucose production; Insulin signaling; Muscle glucose uptake; Polycomb Repressive Complex

Indexed keywords

BMI1 PROTEIN; GLUCOSE; INSULIN; INSULIN RECEPTOR; PROTEIN KINASE B;

EID: 84908243888     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.08.002     Document Type: Article
Times cited : (9)

References (21)
  • 2
    • 2342475666 scopus 로고    scopus 로고
    • Polycomb complexes and silencing mechanisms
    • Lund A.H., van Lohuizen M. Polycomb complexes and silencing mechanisms. Current Opinion in Cell Biology 2004, 16:239-246. 10.1016/j.ceb.2004.03.010.
    • (2004) Current Opinion in Cell Biology , vol.16 , pp. 239-246
    • Lund, A.H.1    van Lohuizen, M.2
  • 3
    • 29144487990 scopus 로고    scopus 로고
    • Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing
    • Cao R., Tsukada Y.-I., Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Molecular Cell 2005, 20:845-854. 10.1016/j.molcel.2005.12.002.
    • (2005) Molecular Cell , vol.20 , pp. 845-854
    • Cao, R.1    Tsukada, Y.-I.2    Zhang, Y.3
  • 4
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs J.J., Kieboom K., Marino S., DePinho R.A., van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999, 397:164-168. 10.1038/16476.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    van Lohuizen, M.5
  • 7
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J., Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003, 423:255-260. 10.1038/nature01572.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 8
    • 0028201742 scopus 로고
    • Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
    • van der Lugt N.M., Domen J., Linders K., van Roon M., Robanus-Maandag E., te Riele H., et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes & Development 1994, 8:757-769.
    • (1994) Genes & Development , vol.8 , pp. 757-769
    • van der Lugt, N.M.1    Domen, J.2    Linders, K.3    van Roon, M.4    Robanus-Maandag, E.5    te Riele, H.6
  • 9
    • 22344449361 scopus 로고    scopus 로고
    • Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways
    • Molofsky A.V., He S., Bydon M., Morrison S.J., Pardal R. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes & Development 2005, 19:1432-1437. 10.1101/gad.1299505.
    • (2005) Genes & Development , vol.19 , pp. 1432-1437
    • Molofsky, A.V.1    He, S.2    Bydon, M.3    Morrison, S.J.4    Pardal, R.5
  • 10
    • 65249121864 scopus 로고    scopus 로고
    • Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation
    • Dhawan S., Tschen S.-I., Bhushan A. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes & Development 2009, 23:906-911. 10.1101/gad.1742609.
    • (2009) Genes & Development , vol.23 , pp. 906-911
    • Dhawan, S.1    Tschen, S.-I.2    Bhushan, A.3
  • 12
    • 84873910684 scopus 로고    scopus 로고
    • Polycomb group response elements in drosophila and vertebrates
    • Kassis J.A., Brown J.L. Polycomb group response elements in drosophila and vertebrates. Advances in Genetics 2013, 81:83-118. 10.1016/B978-0-12-407677-8.00003-8.
    • (2013) Advances in Genetics , vol.81 , pp. 83-118
    • Kassis, J.A.1    Brown, J.L.2
  • 13
    • 84879222559 scopus 로고    scopus 로고
    • Embracing change to remain the same: conservation of polycomb functions despite divergence of binding motifs among species
    • Sharif J., Endo T.A., Ito S., Ohara O., Koseki H. Embracing change to remain the same: conservation of polycomb functions despite divergence of binding motifs among species. Current Opinion in Cell Biology 2013, 25:305-313. 10.1016/j.ceb.2013.02.009.
    • (2013) Current Opinion in Cell Biology , vol.25 , pp. 305-313
    • Sharif, J.1    Endo, T.A.2    Ito, S.3    Ohara, O.4    Koseki, H.5
  • 14
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael M.D., Kulkarni R.N., Postic C., Previs S.F., Shulman G.I., Magnuson M.A., et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Molecular Cell 2000, 6:87-97.
    • (2000) Molecular Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3    Previs, S.F.4    Shulman, G.I.5    Magnuson, M.A.6
  • 16
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • Lamming D.W., Ye L., Katajisto P., Goncalves M.D., Saitoh M., Stevens D.M., et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012, 335:1638-1643. 10.1126/science.1215135.
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1    Ye, L.2    Katajisto, P.3    Goncalves, M.D.4    Saitoh, M.5    Stevens, D.M.6
  • 17
    • 84862025421 scopus 로고    scopus 로고
    • Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
    • Sun Z., Miller R.A., Patel R.T., Chen J., Dhir R., Wang H., et al. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Medicine 2012, 18:934-942. 10.1038/nm.2744.
    • (2012) Nature Medicine , vol.18 , pp. 934-942
    • Sun, Z.1    Miller, R.A.2    Patel, R.T.3    Chen, J.4    Dhir, R.5    Wang, H.6
  • 18
    • 79957902675 scopus 로고    scopus 로고
    • Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling
    • Miller R.A., Chu Q., Le Lay J., Scherer P.E., Ahima R.S., Kaestner K.H., et al. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. Journal of Clinical Investigation 2011, 121:2518-2528. 10.1172/JCI45942.
    • (2011) Journal of Clinical Investigation , vol.121 , pp. 2518-2528
    • Miller, R.A.1    Chu, Q.2    Le Lay, J.3    Scherer, P.E.4    Ahima, R.S.5    Kaestner, K.H.6
  • 19
    • 66649084335 scopus 로고    scopus 로고
    • Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice
    • Tschen S.-I., Dhawan S., Gurlo T., Bhushan A. Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes 2009, 58:1312-1320. 10.2337/db08-1651.
    • (2009) Diabetes , vol.58 , pp. 1312-1320
    • Tschen, S.-I.1    Dhawan, S.2    Gurlo, T.3    Bhushan, A.4
  • 20
    • 84866981249 scopus 로고    scopus 로고
    • Bmi1 is required for hepatic progenitor cell expansion and liver tumor development
    • Fan L., Xu C., Wang C., Tao J., Ho C., Jiang L., et al. Bmi1 is required for hepatic progenitor cell expansion and liver tumor development. PLoS One 2012, 7:e46472. 10.1371/journal.pone.0046472.
    • (2012) PLoS One , vol.7 , pp. e46472
    • Fan, L.1    Xu, C.2    Wang, C.3    Tao, J.4    Ho, C.5    Jiang, L.6
  • 21
    • 84877836210 scopus 로고    scopus 로고
    • Vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis
    • Gargiulo G., Cesaroni M., Serresi M., de Vries N., Hulsman D., Bruggeman S.W., et al. Vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell 2013, 23:660-676. 10.1016/j.ccr.2013.03.030.
    • (2013) Cancer Cell , vol.23 , pp. 660-676
    • Gargiulo, G.1    Cesaroni, M.2    Serresi, M.3    de Vries, N.4    Hulsman, D.5    Bruggeman, S.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.