A psycho-genetic study of hedonic responsiveness in relation to “food addiction”

Nutrients

Volumn 6, Issue 10, 2014, Pages 4338-4353

  Davis, Caroline ^a   Loxton, Natalie J ^b  

^a YORK UNIVERSITY   (Canada)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

A118G; Food addiction; Hedonic responsiveness; mu opioid receptor

Indexed keywords

MU OPIATE RECEPTOR;

ADULT; ALLELE; AMYGDALOID NUCLEUS; ARTICLE; BINDING AFFINITY; BODY MASS; BULIMIA; CAUDATE NUCLEUS; DOPAMINERGIC SYSTEM; DOWN REGULATION; EATING HABIT; FEMALE; FOOD ADDICTION; FOOD CRAVING QUESTIONNAIRE; FOOD INTAKE; FOOD PREFERENCE QUESTIONNAIRE; FOOD REWARD; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HEDONIC EATING; HUMAN; LIKERT SCALE; LIPID DIET; LOGISTIC REGRESSION ANALYSIS; MALE; PRINCIPAL COMPONENT ANALYSIS; QUESTIONNAIRE; REWARD; SEX; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT GAIN; ADDICTION; EATING; FEEDING BEHAVIOR; FOOD; GENETICS; METABOLISM; MIDDLE AGED; NERVE CELL NETWORK; PSYCHOLOGY;

ADULT; BEHAVIOR, ADDICTIVE; EATING; FEEDING BEHAVIOR; FEMALE; FOOD; HUMANS; MALE; MIDDLE AGED; NERVE NET; RECEPTORS, OPIOID, MU;

EID: 84908217421     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6104338     Document Type: Article

References (64)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed.; American Psychiatric Association Press: Washington, WA, USA, 2013.
2. Potenza, M.N. Non-substance addictive behaviors in the context of DSM-5. Addict. Behav. 2014, 39, 1-2.
3. Davis, C.; Carter, J.C. If certain foods are addictive, how might this change the treatment of compulsive overeating and obesity? Curr. Addict. Rep. 2014, 1, 89-95.
4. Gearhardt, A.N.; Davis, C.; Kushner, R.; Brownell, K. The addiction potential of hyperpalatable foods. Curr. Drug Abuse Rev. 2011, 4, 140-145.
5. De Pierre, J.A.; Puhl, R.M.; Luedicke, J. Public perceptions of food addiction: A comparison with alcohol and tobacco. J. Subst. Use 2014, 19, 1-6.
6. Latner, J.D.; Puhl, R.M.; Murakami, J.M.; O'Brien, K.S. Food addiction as a causal model of obesity. Effects on stigma, blame, and perceived psychopathology. Appetite 2014, 77C, 77-82.
7. Meinzer, M.C.; Pettit, J.W.; Leventhal, A.M.; Hill, R.M. Explaining the covariance between attention-deficit hyperactivity disorder and depressive symptoms: The role of hedonic responsivity. J. Clin. Psychol. 2012, 68, 1111-1121.
8. Leventhal, A.M.; Chasson, G.S.; Tapia, E.; Miller, E.K.; Pettit, J.W. Measuring hedonic capacity in depression: A psychometric analysis of three anhedonia scales. J. Clin. Psychol. 2006, 62, 1545-1558.
9. Davis, C. From passive overeating to "food addiction": A spectrum of compulsion and severity. ISRN Obes. 2013, 2013, doi:10.1155/2013/435027.
10. George, O.; Koob, G.F. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci. Biobehav. Rev. 2010, 2, 232-247.
11. Davis, C.; Levitan, R.D.; Kaplan, A.S.; Carter, J.C.; Reid, C.; Curtis, C.; Patte, K.; Hwang, R.; Kennedy, J.L. Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2008, 32, 620-628.
12. Davis, C.; Levitan, R.D.; Yilmaz, Z.; Kaplan, A.S.; Carter, J.C.; Kennedy, J.L. Binge eating disorder and the dopamine D2 receptor: Genotypes and sub-phenotypes. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2012, 38, 328-335.
13. Schienle, A.; Schafer, A.; Hermann, A.; Vaitl, D. Binge-eating disorder: Reward sensitivity and brain activation to images of food. Biol. Psychiatry 2009, 65, 654-661.
14. Curtis, C.; Davis, C. A qualitative study of binge eating disorder and obesity from an addiction perspective. Eat. Disord. 2014, 22, 19-32.
15. Lowe, M.R.; Butryn, M.L.; Didie, E.R.; Annunziato, R.A.; Thomas, J.G.; Crerand, C.E.; Ochner, C.N.; Coletta, M.C.; Bellace, D.; Wallaert, M.; et al. The Power of Food Scale: A new measure of the psychological influence of the food environment. Appetite 2009, 53, 114-118.
16. Davis, C.; Loxton, N.J.; Levitan, R.D.; Kaplan, A.S.; Carter, J.C.; Kennedy, J.L. "Food addiction" and its associations with a dopaminergic multilocus genetic profile. Physiol. Behav. 2013, 118, 63-69.
17. Gearhardt, A.N.; Yokum, S.; Orr, P.T.; Stice, E.; Corbin, W.R.; Brownell, K.D. Neural correlates of food addiction. Arch. Gen. Psychiatry 2011, 32, E1-E9.
18. Davis, C.; Curtis, C.; Levitan, R.D.; Carter, J.C.; Kaplan, A.S.; Kennedy, J.L. Evidence that "food addiction" is a valid phenotype of obesity. Appetite 2011, 57, 711-717.
19. Davis, C. Compulsive overeating as an addictive behaviour: Overlap between food addiction and binge eating disorder. Curr. Obes. Rep. 2013, 2, 171-178.
20. Gearhardt, A.N.; Boswell, R.G.; White, M.A. The association of "food addiction" with disordered eating and body mass index. Eat. Behav. 2014, 15, 427-433.
21. Gearhardt, A.N.; White, M.A.; Masheb, R.M.; Morgan, P.T.; Crosby, R.D.; Grilo, C.M. An examination of the food addiction construct in patients with binge eating disorder. Int. J. Eat. Disord. 2012, 45, 657-663.
22. Berridge, K.C. "Liking" and "wanting" food rewards: Brain substrates and roles in eating disorders. Physiol. Behav. 2009, 97, 537-550.
23. Kelley, A.E.; Bakshi, V.P.; Haber, S.N.; Steininger, T.L.; Will, M.J.; Zhang, M. Opioid modulation of taste hedonics within the ventral striatum. Physiol. Behav. 2002, 76, 365-377.
24. Katsuura, Y.; Taha, S.A. Mu opioid receptor antagonism in the nucleus accumbens shell blocks consumption of a preferred sucrose solution in an anticipatory contrast paradigm. Neuroscience 2014, 261, 144-152.
25. Cambridge, V.C.; Ziauddeen, H.; Nathan, P.J.; Subramaniam, N.; Dodds, C.; Chamberlain, S.R.; Koch, A.; Maltby, K.; Skeggs, A.L.; Napolitano, A.; et al. Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people. Biol. Psychiatry 2013, 73, 887-894.
26. Kelley, A.E.; Will, M.J.; Steininger, T.L.; Zhang, M.; Haber, S.N. Restricted daily consumption of a highly palatable food (chocolate Ensure®) alters striatal encephalin gene expression. Eur. J. Neurosci. 2003, 18, 2592-2598.
27. Daubenmier, J.; Lustig, R.H.; Hecht, F.M.; Kristeller, J.; Woolley, J.; Adam, T.; Dallman, M.; Epel, E. A new biomarker of hedonic eating? Appetite 2014, 74, 92-100.
28. Bond, C.; LaForge, K.S.; Tian, M.; Melia, D.; Zhang, S.; Borg, L.; Gong, J.; Schluger, J.; Strong, J.A.; Leal, S.M.; et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opioid addiction. Proc. Natl. Acad. Sci. USA 1998, 95, 9608-9613.
29. Barr, C.S.; Schwandt, M.L.; Lindell, S.G.; Higley, J.D.; Maestropien, D.; Goldman, D.; Suomi, S.J.; Heilig, M. Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc. Natl. Acad. Sci. USA 2008, 105, 5277-5281.
30. Deb, I.; Chakraborty, J.; Gangopadhyay, P.K.; Choudhury, S.R.; Das, S. Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signalling by mu-opioid receptor and may contribute to the genetic risk for addiction. J. Neurochem. 2010, 112, 486-496.
31. Bart, G.; Kreek, M.J.; Ott, J.; LaForge, K.S.; Proudnikov, D.; Pollak, L.; Heilig, M. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology 2005, 30, 417-422.
32. Ray, L.A.; Bujarski, S.; MacKillop, J.; Courtney, K.E.; Monti, P.M.; Miotto, K. Subjective response to alcohol among alcohol-dependent individuals: Effects of the mu-opioid receptor (OPRM1) gene and alcoholism severity. Alcohol. Clin. Exp. Res. 2013, 37, E116-E124.
33. Kim, S.A.; Kim, J.W.; Song, J.Y.; Park, S.; Lee, H.J.; Chung, J.H. Association of polymorphisms in nicotinic acetylcholine receptor α4 subunit gene (CHRNA4), μ-opioid receptor gene (OPRM1), and ethanol-matabolizing enzyme genes with alcoholism in Korean patients. Alcohol 2004, 34, 115-120.
34. Zhang, H.; Luo, X.; Kranzler, H.R.; Lappalainen, J.; Yang, B.-Z.; Krupitsky, E.; Zvartau, E.; Gelernter, J. Association between two μ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum. Mol. Genet. 2006, 15, 807-819.
35. Miranda, R.; Ray, L.; Justus, A.; Meyerson, L.A.; Knopik, V.S.; McGeary, J.; Monti, P.M. Initial evidence of an association between OPRM1 and adolescent alcohol misuse. Alcohol. Clin. Exp. Res. 2010, 34, 112-122.
36. Ray, L.A.; Hutchinson, K.E. A polymorphism of the mu opioid receptor gene and sensitivity to the effects of alcohol in humans. Alcohol. Clin. Exp. Res. 2004, 28, 1789-1795.
37. Filbey, F.M.; Ray, L.; Smolen, A.; Claus, E.D.; Audette, A.; Hutchison, K.E. Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes. Alcohol. Clin. Exp. Res. 2008, 32, 1-11.
38. Troisi, A.; Frazzetto, G.; Carola, V.; di Lorenzo, G.; Coviello, M.; D'Amato, F.R.; Moles, A.; Siracusano, A.; Gross, C. Social hedonic capacity is associated with the A118G polymorphism of the μ-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients. Soc. Neurosci. 2011, 6, 88-97.
39. Gearhardt, A.N.; Corbin, W.R.; Brownell, K.D. Preliminary Validation of the Yale Food Addiction Scale. Appetite 2009, 52, 430-436.
40. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed.; American Psychiatric Association Press: Washington, WA, USA, 1994.
41. Lahiri, D.K.; Nurnburger, J.I., Jr. A rapid non-enzymatic method for the preparation of HMV DNA from blood for RFLP analysis. Nucleic Acids Res. 1991, 19, 5444.
42. Lotsch, J.; Geisslinger, G. Are μ-opioid receptor polymorphisms important for clinical opioid therapy? Trends Mol. Med. 2005, 11, 82-89.
43. Barrett, J.C.; Fry, B.; Maller, J.; Daly, M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21, 263-265.
44. Geiselman, P.J.; Anderson, A.M.; Dowdy, M.L.; West, D.B.; Redmann, S.M.; Smith, S.R. Reliability and validity of a macronutrient self-selection paradigm and a food preference questionnaire. Physiol. Behav. 1998, 63, 919-928.
45. Cappelleri, J.C.; Bushmakin, A.G.; Gerber, R.A.; Leidy, N.K.; Sexton, C.C.; Karlsson, J.; Lowe, M.R. Evaluating the Power of Food Scale in obese subjects and a general sample of individuals: Development and measurement properties. Int. J. Obes. 2009, 33, 913-922.
46. Cepeda-Benito, A.; Gleaves, D.H.; Williams, T.L.; Erath, S.A. The development and validation of the state and trait food-cravings questionnaires. Behav. Ther. 2000, 31, 151-173.
47. Hayes, A.F.; Preacher, K.J. Statistical mediation analysis with a multicategorical independent variable. Br. J. Math. Stat. Psychol. 2014, 67, 451-470.
48. Hair, J.F.; Black, B.; Babin, B.; Anderson, R.E.; Tatham, R.L. Multivariate Data Analysis; Pearson Education Inc.: Saddle River, NJ, USA, 2009.
49. Shrout, P.E.; Bolger, N. Mediation in experimental and nonexperimental studies: New procedures and recommendations. Psychol. Meth. 2002, 7, 422-445.
50. Hayes, A.F. Introduction to mediation, moderation, and conditional process analysis. In A Regression-Based Approach; Guilford Press: New York, NY, USA, 2013.
51. Hansson, B.; Westerberg, L. On the correlation between heterozygosity and fitness in natural populations. Mol. Ecol. 2002, 11, 2467-2474.
52. Ray, L.A.; Courtney, K.E.; Hutchison, K.E.; MacKillop, J.; Galvan, A.; Ghahremari, D.G. Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues. Am. Clin. Exp. Res. 2014, 38, 78-89.
53. Domino, E.F.; Evans, C.L.; Ni, L.S.; Guthrie, S.K.; Koeppe, R.A. Tobacco smoking produces greater striatal dopamine release in G-allele carriers with mu opioid receptor A118G polymorphism. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 38, 236-240.
54. Haerian, B.S.; Haerian, M.S. OPRM1 rs1799971 polymorphism and opioid dependence evidence from a meta-analysis. Pharmacogenomics 2013, 14, 813-824.
55. Berthoud, H.R.; Lenard, N.R.; Shin, A.C. Food reward, hyperphagia, and obesity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 300, 1266-1277.
56. Johnson, P.M.; Kenny, P.J. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat. Neurosci. 2010, 13, 635-641.
57. Martine, S.I.; Maniam, J.; South, T.; Holmes, N.; Westbrook, R.F.; Morris, M.J. Extended exposure to a palatable cafeteria diet alters gene expression in brain regions implicated in reward, and withdrawal from this diet alters gene expression in brain regions associated with stress. Behav. Brain Res. 2014, 265, 132-141.
58. Blum, K.; Chen, A.L.C.; Giordano, J.; Borsten, J.; Chen, T.J.H.; Hauser, M.; Simpatico, T.; Femino, J.; Braverman, E.R.; Debmayla, B. The addictive brain: All roads lead to dopamine. J. Psychoact. Drugs 2012, 44, 134-143.
59. Heber, D.; Carpenter, C.L. Addictive genes and the relationship to obesity and inflammation. Mol. Neurobiol. 2011, 44, 160-165.
60. Lavi-Avnon, Y.; Yadid, G.; Overstreet, D.H.; Weller, A. Abnormal patterns of maternal behavior in a genetic animal model of depression. Physiol. Behav. 2005, 84, 607-615.
61. Padrao, G.; Mallorqui, A.; Cucurell, D.; Marco-Pallares, J.; Rodriguez-Fornellis, A. Neurophysiological differences in reward processing in anhedonics. Cog. Affect. Behav. Neurosci. 2013, 13, 102-115.
62. Davis, C.; Fox, J. Sensitivity to reward and body mass index (BMI): Evidence for a non-linear relationship. Appetite 2008, 50, 43-49.
63. Hommer, D.W.; Bjork, J.M.; Gilman, J.M. Imaging brain response to reward in addictive behaviors. Ann. N. Y. Acad. Sci. 2011, 1216, 50-61.
64. Yilmaz, Z.; Davis, C.; Loxton, N.J.; Kaplan, A.S.; Levitan, R.D.; Carter, J.C.; Kennedy, J.L. Association between MC4R rs17882313 polymorphism and overeating behaviors. Int. J. Obes. 2014, doi:10.1038/ijo.2014.79.