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Volumn 42, Issue , 2014, Pages S393-S400

White Matter Hyperintensities as Early and Independent Predictors of Alzheimer's Disease Risk

Author keywords

Alzheimer's disease; biomarker; cerebrovascular disease; magnetic resonance imaging; white matter hyperintensities

Indexed keywords

AMYLOID BETA PROTEIN; BIOLOGICAL MARKER;

EID: 84908216330     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-141473     Document Type: Review
Times cited : (51)

References (88)
  • 1
    • 0031593785 scopus 로고    scopus 로고
    • Neuropathological and neuropsychological changes in "normal" aging: Evidence fo r preclinical alzheimer disease in cognitively normal individuals
    • Hulette CM,Welsh-Bohmer KA, Murray MG, Saunders AM, Mash DC, McIntyre LM (1998) Neuropathological and neuropsychological changes in "normal" aging: Evidence fo r preclinical Alzheimer disease in cognitively normal individuals. J Neuropathol Exp Neurol 57, 1168-1174.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 1168-1174
    • Hulette, C.M.1    Welsh-Bohmer, K.A.2    Murray, M.G.3    Saunders, A.M.4    Mash, D.C.5    McIntyre, L.M.6
  • 2
    • 0035168927 scopus 로고    scopus 로고
    • Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage alzheimer's disease
    • Morris JC, Price JL (2001) Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease. J Mol Neurosci 17, 101-118.
    • (2001) J Mol Neurosci , vol.17 , pp. 101-118
    • Morris, J.C.1    Price, J.L.2
  • 5
    • 13444293174 scopus 로고    scopus 로고
    • Defining molecular targets to prevent alzheimer disease
    • Selkoe DJ (2005) Defining molecular targets to prevent Alzheimer disease. Arch Neurol 62, 192-195.
    • (2005) Arch Neurol , vol.62 , pp. 192-195
    • Selkoe, D.J.1
  • 8
    • 0036218738 scopus 로고    scopus 로고
    • Alzheimer disease as a vascular disorder: Nosological evidence
    • de laTorre JC (2002) Alzheimer disease as a vascular disorder: Nosological evidence. Stroke 33, 1152-1162.
    • (2002) Stroke , vol.33 , pp. 1152-1162
    • De Latorre, J.C.1
  • 10
    • 13244274911 scopus 로고    scopus 로고
    • Atherosclerosis and ad: Analysis of data from theusnational alzheimer's coordinating center
    • Honig L S, Kukull W, Mayeux R (2005) Atherosclerosis and AD: Analysis of data from theUSNational Alzheimer's Coordinating Center. Neurology 64, 494-500.
    • (2005) Neurology , vol.64 , pp. 494-500
    • Honig, L.S.1    Kukull, W.2    Mayeux, R.3
  • 13
    • 84870922252 scopus 로고    scopus 로고
    • Midlife vascular risk factors and alzheimer's disease: Evidence from epidemiological studies
    • Tolppanen AM, Solomon A, Soininen H, KivipeltoM(2012) Midlife vascular risk factors and Alzheimer's disease: Evidence from epidemiological studies. J Alzheimers Dis 32, 531-540.
    • (2012) J Alzheimers Dis , vol.32 , pp. 531-540
    • Tolppanen, A.M.1    Solomon, A.2    Soininen, H.3    Kivipelto, M.4
  • 16
    • 0030660722 scopus 로고    scopus 로고
    • Cerebrovascular pathology in alzheimer's disease: Cause effect or epiphenomenon?
    • Hachinski V, Munoz DG (1997) Cerebrovascular pathology in Alzheimer's disease: Cause, effect or epiphenomenon? Ann N Y Acad Sci 826, 1-6.
    • (1997) Ann N y Acad Sci , vol.826 , pp. 1-6
    • Hachinski, V.1    Munoz, D.G.2
  • 17
    • 58149373440 scopus 로고    scopus 로고
    • Cerebrovascular dysfunction in amyloid precursor protein tr ansgenic mice: Contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition
    • Han BH, Zhou ML, Abousaleh F, Brendza RP, Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel GJ (2008) Cerebrovascular dysfunction in amyloid precursor protein tr ansgenic mice: Contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition. J Neurosci 28, 13542-13550.
    • (2008) J Neurosci , vol.28 , pp. 13542-13550
    • Han, B.H.1    Zhou, M.L.2    Abousaleh, F.3    Brendza, R.P.4    Dietrich, H.H.5    Koenigsknecht-Talboo, J.6    Cirrito, J.R.7    Milner, E.8    Holtzman, D.M.9    Zipfel, G.J.10
  • 18
    • 84872248937 scopus 로고    scopus 로고
    • Are vascular factors linked to the development of hippocampal atrophy in alzheimer's disease?
    • Dhikav V, Anand KS (2012) Are vascular factors linked to the development of hippocampal atrophy in Alzheimer's disease? J Alzheimers Dis 32, 711-718.
    • (2012) J Alzheimers Dis , vol.32 , pp. 711-718
    • Dhikav, V.1    Anand, K.S.2
  • 19
    • 0033546881 scopus 로고    scopus 로고
    • Cerebrovascular disease and threshold for dementia in the early stages of alzheimer's disease
    • Esiri MM, Nagy Z, Smith MZ, Barnetson L, SmithAD(1999) Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease. Lancet 354, 919-920.
    • (1999) Lancet , vol.354 , pp. 919-920
    • Esiri, M.M.1    Nagy, Z.2    Smith, M.Z.3    Barnetson, L.4    Smith, A.D.5
  • 21
    • 84905483332 scopus 로고    scopus 로고
    • Predicting aggressive decline in mild cognitive impairment: The importance of white matter hyperintensities
    • Tosto G, Zimmerman ME, Carmichael OT, Brickman AM (2014) Predicting aggressive decline in mild cognitive impairment: The importance of white matter hyperintensities. JAMA Neurol 71, 872-877.
    • (2014) JAMA Neurol , vol.71 , pp. 872-877
    • Tosto, G.1    Zimmerman, M.E.2    Carmichael, O.T.3    Brickman, A.M.4
  • 22
    • 84860307697 scopus 로고    scopus 로고
    • Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention
    • Valenzuela M, Esler M, Ritchie K, Brodaty H (2012) Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention. Transl Psychiatry 2, e107.
    • (2012) Transl Psychiatry , vol.2 , pp. e107
    • Valenzuela, M.1    Esler, M.2    Ritchie, K.3    Brodaty, H.4
  • 23
    • 0030937940 scopus 로고    scopus 로고
    • Pathogenesis of leukoaraiosis: A review
    • Pantoni L, Garcia JH (1997) Pathogenesis of leukoaraiosis: A review. Stroke 28, 652-659.
    • (1997) Stroke , vol.28 , pp. 652-659
    • Pantoni, L.1    Garcia, J.H.2
  • 27
    • 0029034159 scopus 로고
    • White matter hyperinten sities on mri in the neurologically nondiseased elderly analysis of cohorts of consecutive subjects aged 55 to 85 years living at home
    • Ylikoski A, Erkinjuntti T, Raininko R, Sarna S, Sulkava R, Tilvis R (1995) White matter hyperinten sities on MRI in the neurologically nondiseased elderly. Analysis of cohorts of consecutive subjects aged 55 to 85 years living at home. Stroke 26, 1171-1177.
    • (1995) Stroke , vol.26 , pp. 1171-1177
    • Ylikoski, A.1    Erkinjuntti, T.2    Raininko, R.3    Sarna, S.4    Sulkava, R.5    Tilvis, R.6
  • 31
    • 84892766695 scopus 로고    scopus 로고
    • Cerebral white matter hyperintensities in the prediction of cognitive decline and incident dementia
    • Mortamais M, Artero S, RitchieK(2013) Cerebral white matter hyperintensities in the prediction of cognitive decline and incident dementia. Int Rev Psychiatry 25, 686-698.
    • (2013) Int Rev Psychiatry , vol.25 , pp. 686-698
    • Mortamais, M.1    Artero, S.2    Ritchie, K.3
  • 32
    • 77955360281 scopus 로고    scopus 로고
    • The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-Analysis
    • Debette S, Markus HS (2010) The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-Analysis. BMJ 341, c3666.
    • (2010) BMJ , vol.341 , pp. c3666
    • Debette, S.1    Markus, H.S.2
  • 34
    • 77950271941 scopus 로고    scopus 로고
    • Association of mri markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: The framingham offspring study
    • Debette S, Beiser A, DeCarli C, Au R, Himali JJ,Kel ly-Hayes M, Romero JR, Kase CS, Wolf PA, Seshadri S (2010) Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: The Framingham Offspring Study. Stroke 41, 600-606.
    • (2010) Stroke , vol.41 , pp. 600-606
    • Debette, S.1    Beiser, A.2    Decarli, C.3    Au, R.4    Himali, J.J.5    Kelly-Hayes, M.6    Romero, J.R.7    Kase, C.S.8    Wolf, P.A.9    Seshadri, S.10
  • 39
    • 80051791388 scopus 로고    scopus 로고
    • White matter lesions on brain magnetic resonance imaging scan and 5-year cognitive decline: The honolulu-Asia aging study
    • Inaba M, White L, Bell C, Chen R, Petrovitch H, Launer L, Abbott RD, Ross GW,Masaki K (2011) White matter lesions on brain magnetic resonance imaging scan and 5-year cognitive decline: The Honolulu-Asia aging study. J Am Geriatr Soc 59, 1484-1489.
    • (2011) J Am Geriatr Soc , vol.59 , pp. 1484-1489
    • Inaba, M.1    White, L.2    Bell, C.3    Chen, R.4    Petrovitch, H.5    Launer, L.6    Abbott, R.D.7    Ross, G.W.8    Masaki, K.9
  • 42
    • 68149174856 scopus 로고    scopus 로고
    • Cognitive impairment risk: White matter hyperintensity progression matters
    • Silbert LC, Howieson DB, Dodge H, Kaye JA (2009) Cognitive impairment risk: White matter hyperintensity progression matters. Neurology 73, 120-125.
    • (2009) Neurology , vol.73 , pp. 120-125
    • Silbert, L.C.1    Howieson, D.B.2    Dodge, H.3    Kaye, J.A.4
  • 44
    • 0038516524 scopus 로고    scopus 로고
    • Progression of cerebral whi te matter lesions: 6-year results of the austrian stroke prevention study
    • Schmidt R, Enzinger C, Ropele S, Schmidt H, Fazekas F (2003) Progression of cerebral whi te matter lesions: 6-year results of the Austrian Stroke Prevention Study. Lancet 361, 2046-2048.
    • (2003) Lancet , vol.361 , pp. 2046-2048
    • Schmidt, R.1    Enzinger, C.2    Ropele, S.3    Schmidt, H.4    Fazekas, F.5
  • 45
    • 11144223888 scopus 로고    scopus 로고
    • Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: The cardiovascular health study
    • Longstreth WT, Jr., Arnold AM, Beauchamp NJ, Jr., Manolio TA, Lefkowitz D, Jungreis C, Hirsch CH, O'Leary DH, Furberg CD (2005) Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: The Cardiovascular Health Study. Stroke 36, 56-61.
    • (2005) Stroke , vol.36 , pp. 56-61
    • Longstreth, W.T.1    Arnold, A.M.2    Beauchamp, N.J.3    Manolio, T.A.4    Lefkowitz, D.5    Jungreis, C.6    Hirsch, C.H.7    O'Leary, D.H.8    Furberg, C.D.9
  • 48
    • 54049142899 scopus 로고    scopus 로고
    • Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam scan study
    • van Dijk EJ, Prins ND, Vrooman HA, Hofman A, Koudstaal PJ, Breteler MM (2008) Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study. Stroke 39, 2712-2719.
    • (2008) Stroke , vol.39 , pp. 2712-2719
    • Van Dijk, E.J.1    Prins, N.D.2    Vrooman, H.A.3    Hofman, A.4    Koudstaal, P.J.5    Breteler, M.M.6
  • 50
    • 47649083124 scopus 로고    scopus 로고
    • Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in mci patients
    • Bombois S, Debette S, Bruandet A, Delbeuck X, Delmaire C, Leys D, Pasquier F (2008) Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients. Stroke 39, 2046-2051.
    • (2008) Stroke , vol.39 , pp. 2046-2051
    • Bombois, S.1    Debette, S.2    Bruandet, A.3    Delbeuck, X.4    Delmaire, C.5    Leys, D.6    Pasquier, F.7
  • 52
    • 3242784764 scopus 로고    scopus 로고
    • Memory impairment, but not cerebrovascular disease, predicts progression o f mci to dementia
    • DeCarli C, Mungas D, Harvey D, Reed B, Weiner M, Chui H, Jagust W (2004) Memory impairment, but not cerebrovascular disease, predicts progression o f MCI to dementia. Neurology 63, 220-227.
    • (2004) Neurology , vol.63 , pp. 220-227
    • Decarli, C.1    Mungas, D.2    Harvey, D.3    Reed, B.4    Weiner, M.5    Chui, H.6    Jagust, W.7
  • 53
    • 84876401318 scopus 로고    scopus 로고
    • Impact of white matter lesions and cognitive deficits on conversion from mild cognitive impairment to alzheimer's disease
    • Defrancesco M, Marksteiner J, Deisenhammer E, Kemmler G, Djurdjevic T, Schocke M (2013) Impact of white matter lesions and cognitive deficits on conversion from mild cognitive impairment to Alzheimer's disease. J Alzheimers Dis 34, 665-672.
    • (2013) J Alzheimers Dis , vol.34 , pp. 665-672
    • Defrancesco, M.1    Marksteiner, J.2    Deisenhammer, E.3    Kemmler, G.4    Djurdjevic, T.5    Schocke, M.6
  • 54
    • 84873021863 scopus 로고    scopus 로고
    • Do cerebral white matter lesions influence the rate of progression from mild cognitive impairment to dementia?
    • Devine ME, Fonseca JA, Walker Z (2013) Do cerebral white matter lesions influence the rate of progression from mild cognitive impairment to dementia? Int Psychogeriatr 25, 120-127.
    • (2013) Int Psychogeriatr , vol.25 , pp. 120-127
    • Devine, M.E.1    Fonseca, J.A.2    Walker, Z.3
  • 57
    • 3142539896 scopus 로고    scopus 로고
    • Medial temporal lobe atrophy on mri predicts dementia in patients with mild cognitive impairment
    • Korf ES, Wahlund LO, Visser PJ, Scheltens P (2004) Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology 63, 94-100.
    • (2004) Neurology , vol.63 , pp. 94-100
    • Korf, E.S.1    Wahlund, L.O.2    Visser, P.J.3    Scheltens, P.4
  • 60
    • 65249160528 scopus 로고    scopus 로고
    • Progression of mild cognitive impairment to dementia: Contribution of cerebrovascular disease compared with medial temporal lobe atrophy
    • Staekenborg SS, Koedam EL, Henneman WJ, Stokman P, Barkhof F, Scheltens P, van der Flier WM (2009) Progression of mild cognitive impairment to dementia: Contribution of cerebrovascular disease compared with medial temporal lobe atrophy. Stroke 40, 1269-1274.
    • (2009) Stroke , vol.40 , pp. 1269-1274
    • Staekenborg, S.S.1    Koedam, E.L.2    Henneman, W.J.3    Stokman, P.4    Barkhof, F.5    Scheltens, P.6    Van Der Flier, W.M.7
  • 62
    • 55149090311 scopus 로고    scopus 로고
    • Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia
    • van Straaten EC, Harvey D, Scheltens P, Barkhof F, Petersen RC, Thal LJ, Jack CR, Jr., DeCarli C (2008) Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia. J Neurol 255, 1302-1308.
    • (2008) J Neurol , vol.255 , pp. 1302-1308
    • Van Straaten, E.C.1    Harvey, D.2    Scheltens, P.3    Barkhof, F.4    Petersen, R.C.5    Thal, L.J.6    Jack, C.R.7    Decarli, C.8
  • 63
    • 84882395407 scopus 로고    scopus 로고
    • Dissociable effects of alzheimer disease and white matter hyperintensities on brain metabolism
    • Haight TJ, Landau SM, Carmichael O, Schwarz C, DeCarli C, Jagust WJ (2013) Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism. JAMA Neurol 70, 1039-1045.
    • (2013) JAMA Neurol , vol.70 , pp. 1039-1045
    • Haight, T.J.1    Landau, S.M.2    Carmichael, O.3    Schwarz, C.4    Decarli, C.5    Jagust, W.J.6
  • 71
    • 79953050635 scopus 로고    scopus 로고
    • White matter lesion load increases the risk of low csf abeta42 in apolipoprotein e-varepsilon4 carriers attending a memory clinic
    • Stenset V, Hofoss D, J ohnsen L, Berstad AE, Negaard A, Skinningsrud A, Gjerstad L, Fladby T (2011) White matter lesion load increases the risk of low CSF Abeta42 in apolipoprotein E-varepsilon4 carriers attending a memory clinic. J Neuroimagi ng 21, e78-82.
    • (2011) J Neuroimaging , vol.21 , pp. e78-82
    • Stenset, V.1    Hofoss, D.2    Johnsen, L.3    Berstad, A.E.4    Negaard, A.5    Skinningsrud, A.6    Gjerstad, L.7    Fladby, T.8
  • 73
    • 84867559655 scopus 로고    scopus 로고
    • Vascular burden and alzheimer disease pathologic progression
    • Lo RY, Jagust WJ (2012) Vascular burden and Alzheimer disease pathologic progression. Neurology 79, 1349-1355.
    • (2012) Neurology , vol.79 , pp. 1349-1355
    • Lo, R.Y.1    Jagust, W.J.2
  • 80
    • 84875423094 scopus 로고    scopus 로고
    • Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-Amyloid in cognitively normal older individuals
    • Wirth M, Madison CM, Rabinovici GD, Oh H, Landau SM, Jagust WJ ( 2013) Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-Amyloid in cognitively normal older individuals. J Neurosci 33, 5553-5563.
    • (2013) J Neurosci , vol.33 , pp. 5553-5563
    • Wirth, M.1    Madison, C.M.2    Rabinovici, G.D.3    Oh, H.4    Landau, S.M.5    Jagust, W.J.6
  • 82
  • 84
    • 84885619924 scopus 로고    scopus 로고
    • White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume am ong individuals with mild cognitive impairment
    • Guzman VA,Carmichael OT,Schwarz C,Tosto G,Zimmerman ME,Brickman AM(2013 White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume am ong individuals with mild cognitive impairment Alzheimers Dement 9, S124-131
    • (2013) Alzheimers Dement , vol.9 , pp. S124-131
    • Guzman, V.A.1    Carmichael, O.T.2    Schwarz, C.3    Tosto, G.4    Zimmerman, M.E.5    Brickman, A.M.6
  • 85
    • 72249102169 scopus 로고    scopus 로고
    • Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: The atherosclerosis risk in communities (aric) study
    • Alonso A, Mosley TH, Jr., GottesmanRF, Catellier D, Sharrett AR, Coresh J (2009) Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: The Atherosclerosis Risk in Communities (ARIC) study. J Neurol Neurosurg Psychiatry 80, 1194-1201.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 1194-1201
    • Alonso, A.1    Mosley, T.H.2    Gottesman, R.F.3    Catellier, D.4    Sharrett, A.R.5    Coresh, J.6
  • 86
    • 0025863618 scopus 로고
    • Neuropathological stageing of alzheimer-related changes
    • Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82, 239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2


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