RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia

Epigenetics

Volumn 9, Issue 9, 2014, Pages 1252-1260

  Poetsch, Anna R ^a   Lipka, Daniel B ^a   Witte, Tania ^a   Claus, Rainer ^a   Nöllke, Peter ^b   Zucknick, Manuela ^a   Olk Batz, Christiane ^b   Fluhr, Silvia ^b   Dworzak, Michael ^c   De Moerloose, Barbara ^d   Starý, Jan ^e,f   Zecca, Marco ^g   Hasle, Henrik ^h   Schmugge, Markus ⁱ   van den Heuvel Eibrink, Marry M ^j,k   Locatelli, Franco ^l,m   Niemeyer, Charlotte M ^a,b   Flotho, Christian ^a,b   Plass, Christoph ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

^e UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^f Czech Pediatric Hematology Working Group (CPH)   (Czech Republic)

^g FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^h AARHUS UNIVERSITY HOSPITAL   (Denmark)

ⁱ UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^j ERASMUS MEDICAL CENTER   (Netherlands)

^k Dutch Child Oncology Group   (Netherlands)

^l BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^m UNIVERSITY OF PAVIA   (Italy)

more..

Author keywords

DNA methylation; Epigenetics; JMML; juvenile myelomonocytic leukemia; RASA4

Indexed keywords

GENOMIC DNA; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; ISOPROTEIN; PROTEIN TYROSINE PHOSPHATASE SHP 2; PTPN11 PROTEIN, HUMAN; RASA4 PROTEIN, HUMAN;

ARTICLE; CANCER PROGNOSIS; CANCER SPECIFIC SURVIVAL; CANCER STAGING; CHILD; CONTROLLED STUDY; DNA EXTRACTION; DNA ISOLATION; DNA METHYLATION; DNA MICROARRAY; EPIGENETICS; FEMALE; GENE; GENE AMPLIFICATION; GENE MUTATION; GENE SILENCING; GENETIC ANALYSIS; HUMAN; JUVENILE MYELOMONOCYTIC LEUKEMIA; MAJOR CLINICAL STUDY; MALE; NEWBORN; NUCLEOTIDE SEQUENCE; PATHOLOGY; QUANTITATIVE ASSAY; RASA4 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; ADOLESCENT; CHROMOSOME 7; CPG ISLAND; DRUG RESISTANCE; GENETICS; INFANT; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; METABOLISM; MONOSOMY; MUTATION; PRESCHOOL CHILD; PROGNOSIS; PROMOTER REGION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 7; CPG ISLANDS; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE SILENCING; HUMANS; INFANT; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; MALE; MONOSOMY; MUTATION; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RAS GTPASE-ACTIVATING PROTEINS;

EID: 84908215285     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.29941     Document Type: Article

References (23)

1. Niemeyer CM, Aricò M, Basso G, Biondi A, Cantù Rajnoldi A, Creutzig U, Haas O, Harbott J, Hasle H, Kerndrup G, et al.; European Working Group on Myelodysplastic Syndromes in Childhood (EWOGMDS). Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. Blood 1997; 89:3534-43; PMID:9160658
2. Locatelli F, Nöllke P, Zecca M, Korthof E, Lanino E, Peters C, Pession A, Kabisch H, Uderzo C, Bonfim CS, et al.; European Working Group on Childhood MDS; European Blood and Marrow Transplantation Group. Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. Blood 2005; 105:410- 9; PMID:15353481; http://dx.doi.org/10.1182/ blood-2004-05-1944
3. Niemeyer CM, Locatelli F. Chronic myeloproliferative disorders. In: Pui CH, ed. Childhood Leukemias. 3rd Edition. New York: Cambridge University Press; 2012:444-502.
4. Olk-Batz C, Poetsch AR, Nöllke P, Claus R, Zucknick M, Sandrock I, Witte T, Strahm B, Hasle H, Zecca M, et al.; European Working Group of Myelodysplastic Syndromes in Childhood (EWOG-MDS). Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome. Blood 2011; 117:4871-80; PMID:21406719; http://dx.doi. org/10.1182/blood-2010-08-298968
5. Flotho C, Valcamonica S, Mach-Pascual S, Schmahl G, Corral L, Ritterbach J, Hasle H, Aricò M, Biondi A, Niemeyer CM. RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). Leukemia 1999; 13:32-7; PMID:10049057; http://dx.doi.org/10.1038/ sj.leu.2401240
6. Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, Hählen K, Hasle H, Licht JD, Gelb BD. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003; 34:148-50; PMID:12717436; http://dx.doi. org/10.1038/ng1156
7. Flotho C, Steinemann D, Mullighan CG, Neale G, Mayer K, Kratz CP, Schlegelberger B, Downing JR, Niemeyer CM. Genome-wide singlenucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. Oncogene 2007; 26:5816-21; PMID:17353900; http://dx.doi.org/10.1038/ sj.onc.1210361
8. Loh ML, Sakai DS, Flotho C, Kang M, Fliegauf M, Archambeault S, Mullighan CG, Chen L, Bergstraesser E, Bueso-Ramos CE, et al. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood 2009; 114:1859- 63; PMID:19571318; http://dx.doi.org/10.1182/ blood-2009-01-198416
9. Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, et al. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet 2010; 42:794-800; PMID:20694012; http:// dx.doi.org/10.1038/ng.641
10. Flotho C, Kratz CP, Bergsträsser E, Hasle H, Starý J, Trebo M, van den Heuvel-Eibrink MM, Wójcik D, Zecca M, Locatelli F, et al.; European Working Group of Myelodysplastic Syndromes in Childhood. Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations. Blood 2008; 111:966-7, author reply 967-8; PMID:18182584; http://dx.doi.org/10.1182/ blood-2007-09-111831
11. Yoshida N, Yagasaki H, Xu Y, Matsuda K, Yoshimi A, Takahashi Y, Hama A, Nishio N, Muramatsu H, Watanabe N, et al. Correlation of clinical features with the mutational status of GM-CSF signaling pathwayrelated genes in juvenile myelomonocytic leukemia. Pediatr Res 2009; 65:334-40; PMID:19047918; http://dx.doi.org/10.1203/PDR.0b013e3181961d2a
12. Niemeyer CM, Strahm B, Dworzak M, de Moerloose B, Hasle H, Stary J, et al. JMML revisited: role and outcome of hematopoietic stem cell transplantation in subtypes of juvenile myelomonocytic leukemia. Blood 2012; 120:955
13. Luna-Fineman S, Shannon KM, Atwater SK, Davis J, Masterson M, Ortega J, Sanders J, Steinherz P, Weinberg V, Lange BJ. Myelodysplastic and myeloproliferative disorders of childhood: a study of 167 patients. Blood 1999; 93:459-66; PMID:9885207
14. Lockyer PJ, Kupzig S, Cullen PJ. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. Curr Biol 2001; 11:981-6; PMID:11448776; http://dx.doi.org/10.1016/S0960-9822(01)00261-5
15. Zhang J, Guo J, Dzhagalov I, He YW. An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. Nat Immunol 2005; 6:911-9; PMID:16041389; http:// dx.doi.org/10.1038/ni1232
16. Kupzig S, Deaconescu D, Bouyoucef D, Walker SA, Liu Q, Polte CL, Daumke O, Ishizaki T, Lockyer PJ, Wittinghofer A, et al. GAP1 family members constitute bifunctional Ras and Rap GTPaseactivating proteins. J Biol Chem 2006; 281:9891- 900; PMID:16431904; http://dx.doi.org/10.1074/ jbc.M512802200
17. Yarwood S, Bouyoucef-Cherchalli D, Cullen PJ, Kupzig S. The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling. Biochem Soc Trans 2006; 34:846-50; PMID:17052212; http://dx.doi. org/10.1042/BST0340846
18. Dai Y, Walker SA, de Vet E, Cook S, Welch HC, Lockyer PJ. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities. J Biol Chem 2011; 286:19905-16; PMID:21460216; http://dx.doi.org/10.1074/jbc. M110.201301
19. Ehrich M, Nelson MR, Stanssens P, Zabeau M, Liloglou T, Xinarianos G, Cantor CR, Field JK, van den Boom D. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci U S A 2005; 102:15785-90; PMID:16243968; http:// dx.doi.org/10.1073/pnas.0507816102
20. Sakaguchi H, Okuno Y, Muramatsu H, Yoshida K, Shiraishi Y, Takahashi M, Kon A, Sanada M, Chiba K, Tanaka H, et al. Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet 2013; 45:937- 41; PMID:23832011; http://dx.doi.org/10.1038/ ng.2698
21. Batz C, Sandrock I, Niemeyer CM, Flotho C. Methylation of the PTEN gene CpG island is infrequent in juvenile myelomonocytic leukemia: Comments on "PTEN deficiency is a common defect in juvenile myelomonocytic leukemia" [Leuk. Res. 2009;33:671-677 (Epub 2008 November 17)]. Leuk Res 2009; 33:1578-9, author reply 1580; PMID:19487024; http://dx.doi.org/10.1016/j. leukres.2009.04.040
22. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A 2004; 101:6062-7; PMID:15075390; http:// dx.doi.org/10.1073/pnas.0400782101
23. Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, et al. Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia. Br J Haematol 2005; 128:805-12; PMID:15755284; http://dx.doi. org/10.1111/j.1365-2141.2005.05392.x