Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia

British Journal of Haematology

Volumn 128, Issue 6, 2005, Pages 805-812

  Hasegawa, Daisuke ^a,b   Manabe, Atsushi ^a,c   Kubota, Takeo ^d,e   Kawasaki, Hirohide ^a   Hirose, Imiko ^a   Ohtsuka, Yoshitoshi ^a   Tsuruta, Toshihisa ^a   Ebihara, Yasuhiro ^a   Goto, Yu Ichi ^d   Zhao, Xiao Yan ^f   Sakashita, Kazuo ^f   Koike, Kenichi ^f   Isomura, Mariko ^g   Kojima, Seiji ^g   Hoshika, Akinori ^b   Tsuji, Kohichiro ^a   Nakahata, Tatsutoshi ^h  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c ST LUKE'S INTERNATIONAL HOSPITAL   (Japan)

^d NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^e UNIVERSITY OF YAMANASHI   (Japan)

^f SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h KYOTO UNIVERSITY   (Japan)

Author keywords

Aberrant methylation; Childhood; Juvenile myelomonocytic leukaemia; Myelodysplastic syndrome; p15

Indexed keywords

PROTEIN P15; PROTEIN P16;

ADOLESCENT; ARTICLE; BLAST CELL CRISIS; CANCER GROWTH; CELL COUNT; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CLINICAL EXAMINATION; COLONY FORMATION; CONTROLLED STUDY; DNA METHYLATION; DRUG EFFICACY; FEMALE; GENE; GENE MUTATION; HUMAN; HUMAN CELL; INFANT; JUVENILE MYELOMONOCYTIC LEUKEMIA; LABORATORY TEST; MALE; MYELODYSPLASTIC SYNDROME; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PTPN11 GENE;

ADOLESCENT; ADULT; AGED; CELL CYCLE PROTEINS; CHILD; CHILD, PRESCHOOL; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DNA METHYLATION; FEMALE; GENES, P16; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MALE; MIDDLE AGED; MUTATION; MYELODYSPLASTIC SYNDROMES; PROSPECTIVE STUDIES; PROTEIN-TYROSINE-PHOSPHATASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 20144388129     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05392.x     Document Type: Article

References (48)

1. Aoki, E., Ohashi, H., Uchida, T., Murate, T., Saito, H. & Kinoshita, T. (2003) Expression levels of DNA methyltransferase genes do not correlate with p15INK4B gene methylation in myelodysplastic syndromes. Leukemia, 17, 1903-1904 [Letter].
2. Arico, M., Biondi, A. & Pui, C.H. (1997) Juvenile myelomonocytic leukemia. Blood, 90, 479-488.
3. Au, W.Y., Fung, A., Man, C., Ma, S.K., Wan, T.S., Liang, R. & Kwong, Y.L. (2003) Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations. British Journal of Haematology, 120, 1062-1065.
4. Cameron, E.E., Baylin, S.B. & Herman, J.G. (1999) p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood, 94, 2445-2451.
5. Christiansen, D.H., Andersen, M.K. & Pedersen-Bjergaard, J. (2003) Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia. Leukemia, 17, 1813-1819.
6. Daskalakis, M., Nguyen, T.T., Nguyen, C., Guldberg, P., Kohler, G., Wijermans, P., Jones, P.A. & Lubbert, M. (2002) Demethylation of a hypermethylation p15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment. Blood, 100, 2957-2964.
7. Ebihara, Y., Wada, M., Ueda, T., Xu, M.J., Manabe, A., Tanaka, R., Ito, M., Mugishima, H., Asano, S., Nakahata, T. & Tsuji, K. (2002) Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34+ CD38- cells expressing Flk2/Flt3. British Journal of Haematology, 119, 525-534.
8. Emanuel, P.D. (1999) Myelodysplasia and myeloproliferative disorders in childhood: an update. British Journal of Haematology, 105, 852-863.
9. Emanuel, P.D., Bates, L.J., Castleberry, R.P., Gualtieri, R.J. & Zuckerman, S. (1991) Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood, 77, 925-929.
10. Emanuel, P.D., Snyder, R.C., Wiley, T., Gopurala, B. & Castleberry, R.P. (2000) Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors. Blood, 95, 639-645.
11. Garcia-Manero, G., Daniel, J., Smith, T.L., Kornblau, S.M., Lee, M.S., Kantarjian, H.M. & Issa, J.P.J. (2002) DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. Clinical Cancer Research, 8, 2217-2224.
12. Garcia-Manero, G., Jeha, S., Daniel, J., Williamson, J., Albitar, M., Kantarjian, H.M. & Issa, J.P.J. (2003) Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia. Cancer, 97, 695-702.
13. Guo, S.X., Taki, T., Ohnishi, H., Piao, H.Y., Tabuchi, K., Bessho, F., Hanada, R., Yanagisawa, M. & Hayashi, Y. (2000) Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia. Leukemia Research, 24, 39-46.
14. Gutierrez, M.I., Siraj, A.K., Bhargava, M., Ozbek, U., Banavali, S., Chaudhary, M.A., Solh, H.E.I. & Bhatia, K. (2003) Concurrent methylation of multiple genes in childhood ALL: correlation with phenotype and molecular subgroup. Leukemia, 17, 1845-1850.
15. Hasle, H., Niemeyer, C.M., Chessells, J.M., Baumann, I., Bennett, J.M., Kerndrup, G. & Head, D.R. (2003) A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases. Leukemia, 17, 277-282.
16. Herman, J.G. & Baylin, S.B. (2003) Gene silencing in cancer in association with promoter hypermethylation. New England Journal of Medicine, 349, 2042-2054.
17. Herman, J.G., Graff, J.R., Myohanen, S., Nelkin, B.D. & Baylin, S.B. (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proceedings of the National Academy of Sciences of the United States of America, 93, 9821-9826.
18. Herman, J.G., Civin, C.I., Issa, J.P.J., Collector, M.I., Sharkis, S.J. & Baylin, S.B. (1997) Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major type of hematological malignancies. Cancer Research, 57, 837-841.
19. Isomura, M., Kamachi, Y., Kudo, K., Watanabe, N., Nakamura, Y., Yamamoto, T., Ken, R., Kojima, S. & Yamamoto, K. (2003) Somatic mutations in PTPN11 in the Japanese patients with juvenile myelomonocytic leukemia. Blood, 102, 366a-367a [Abstract].
20. Issa, J.P., Garcia-Manero, G., Giles, F.J., Mannari, R., Thomas, D., Faderl, S., Bayar, E., Lyons, J., Rosenfeld, C.S., Cortes, J. & Kantarjian, H.M. (2004) Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies. Blood, 103, 1635-1640.
21. Jones, P.A. & Laird, P.W. (1999) Cancer epigenetics comes of age. Nature Genetics, 21, 163-167.
22. Kosaki, K., Suzuki, T., Muroya, K., Hasegawa, T., Sato, S., Matsuo, N., Kosaki, R., Nagai, T., Hasegawa, Y. & Ogata, T. (2002) PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome. Journal of Clinical Endocrinology and Metabolism, 87, 3529-3533.
23. Kubota, T., Das, S., Christian, S.L., Baylin, S.B., Herman, J.G. & Ledbetter, D.H. (1997) Methylation-specific PCR simplifies imprinting analysis. Nature Genetics, 16, 16-17.
24. Locatelli, F., Niemeyer, C., Angelucci, E., Bender-Gotze, C., Burdach, S., Ebell, W., Friedrich, W., Hasle, H., Hermann, J., Jacobsen, N., Klingebiel, T., Kremens, B., Mann, G., Pession, A., Peters, C., Schmid, H.J., Stary, J., Suttorp, M., Uderzo, C., vanÕt Veer-Korthof, E.T., Vossen, J., Zecca, M. & Zimmermann, M. (1997) Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood. Journal of Clinical Oncology, 15, 566-573.
25. Loh, M.L., Vattikuti, S., Schubbert, S., Reynolds, M.G., Carlson, E., Lieuw, K.H., Cheng, J.W., Lee, C.M., Stokoe, D., Bonifas, J.M., Curtiss, N.P., Gotlib, J., Meshinchi, S., Le Beau, M.M., Emanuel, P.D. & Shannon, K.M. (2004) Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood, 103, 2325-2331
26. Manabe, A. & Nakahata, T. (2003) Experiences on MDS and JMML from Japan. In: Myelodysplastic and Myeloproliferative Disorders in Children (ed. by L.F. Lopes & H. Hasle), pp. 317-324, Lemar Livraria, Sao Paulo, Brazil.
27. Manabe, A., Okamura, J., Yumura-Yagi, K., Akiyama, Y., Sako, M., Uchiyama, H., Kojima, S., Koike, K., Saito, T. & Nakahata, T., MDS Committee of the Japanese Society of Pediatric Hematology (2002) Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the International JMML Working Group. Leukemia, 16, 645-649.
28. Manabe, A., Zaike, Y., Sugahara, S., Tsuchida, M., Masunaga, A., Kikuchi, A., Kojima, S., Oda, M., Ikuta, K., Kato, K., Tsurusawa, M., Akiyama, Y., Hara, J., Ikushima, S. & Nakahata, T. (2003) Pediatric RAEB-M6a syndrome: a proposal of a unique entity. Blood, 102, 329b [Abstract].
29. Miyauchi, J., Asada, M., Sasaki, M., Tsunematsu, Y., Kojima, S. & Mizutani, S. (1994) Mutations of the N-ras gene in juvenile chronic myelogeneous leukemia. Blood, 83, 2248-2254.
30. Niemeyer, C.M., Arico, M., Basso, G., Cantu-Rajnoldi, A., Creutzig, U., Haas, O.A., Harbott, J., Hasle, H., Kerndrup, G., Locatelli, F., Mann, G., Stollmann-Gibbels, B., van't Veer Korthof, E.T., van Wering, E.R., Zimmermann, M. & Members of the European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS) (1997) Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. Blood, 89, 3534-3543.
31. Niemeyer, C.M., Fenu, S., Hasle, H., Mann, G., Stary, J. & van Wering, E. (1998) Differentiating juvenile myelomonocytic leukemia from infectious disease. Blood, 91, 365-367 [Letter].
32. Preisler, H.D., Li, B., Chen, H., Fisher, L., Nayini, J., Raza, A., Creech, S. & Venugopal, P. (2001) P15INK4B gene methylation and expression in normal, myelodysplastic, and acute myelogenous leukemia cells and in the marrow cells of cured lymphoma patients. Leukemia, 15, 1589-1595.
33. Quesnel, B., Guilerm, G., Vereecque, R., Wattel, E., Preudhomme, C., Bauters, F., Vanrumbeke, M. & Fenaux, P. (1998) Methylation of the p15INK4b gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood, 91, 2985-2990.
34. Sakashita, K., Koike, K., Kinoshita, T., Shiohara, M., Kamijo, T., Taniguchi, S. & Kubota, T. (2001) Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development. Journal of Clinical Investigation, 108, 1195-1204.
35. Sasaki, H., Manabe, A., Kojima, S., Tsuchida, M., Hayashi, Y., Ikuta, K., Okamura, I., Koike, K., Ohara, A., Ishii, E., Komada, Y., Hibi, S. & Nakahata, T. & MDS Committee of the Japanese Society of Pediatric Hematology (2001) Myelodysplastic syndrome in childhood: a retrospective study of 189 patients in Japan. Leukemia, 11, 1713-1720.
36. Shimizu, F., Nakayama, J., Ishizone, S., Zhang, M.X., Kawakubo, M., Ota, H., Sugiyama, A., Kawasaki, S., Fukuda, M. & Katsuyama, T. (2003) Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer. Laboratory Investigation, 83, 187-197.
37. Silverman, L.R., Demakos, E.P., Peterson, B.L., Kornblith, A.B., Holland, J.C., Odchimar-Reissig, R., Stone, R.M., Nelson, D., Powell, B.L., DeCastro, C.M., Ellerton, J., Larson, R.A., Schiffer, C.A. & Holland, J.F. (2002) Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. Journal of Clinical Oncology, 20, 2429-2440.
38. Tartaglia, M., Niemeyer, C.M., Fragale, A., Song, X., Buechner, J., Jung, A., Hahlen, K., Hasle, H., Licht, J.D. & Gelb, B.D. (2003) Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndrome and acute myeloid leukemia. Nature Genetics, 34, 148-150.
39. Teofili, L., Rutella, S., Chiusolo, P., La Barbera, E.O., Rumi, C., Ranelletti, F.O., Maggiano, N., Leone, G. & Larocca, L.M. (1998) Expression of p15INK4B in normal hematopoiesis. Experimental Hematology, 26, 1133-1139.
40. Teofili, L., Morosetti, R., Martini, M., Urbano, R., Putzulu, R., Rutella, S., Pierelli, L., Leone, G. & Larocca, L.M. (2000) Expression of cyclin-dependent kinase inhibitor p15INK4B during normal and leukemic myeloid differentiation. Experimental Hematology, 28, 519-526.
41. Teofili, L., Martini, M., Di Mario, A., Rutella, S., Urbano, R., Luongo, M., Leone, G. & Larocca, L.M. (2001) Expression of p15ink4b gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors. Blood, 98, 495-497.
42. Teofili, L., Martini, M., Luongo, M., Diverio, D., Capelli, G., Breccia, M., Lo Coco, F., Leone, G. & Larocca, L.M. (2003) Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis. Leukemia, 17, 919-924
43. Tessema, M., Langer, F., Dingemann, J., Ganser, A., Kreipe, H. & Lehmann, U. (2003) Aberrant methylation and impaired expression of the p15 INK4b cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). Leukemia, 17, 910-918.
44. Toyota, M., Kopecky, K.J., Toyota, M.O., Jair, K.W., Willman, C.L. & Issa, J.P.J. (2001) Methylation profiling in acute myeloid leukemia. Blood, 97, 2823-2829.
45. Tsuzaka, K., Fukuhara, I., Setoyama, Y., Yoshimoto, K., Suzuki, K., Abe, T. & Takeuchi, T. (2003) TCR zeta mRNA with an alternatively spliced 3′-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex. Journal of Immunology, 171, 2496-2503.
46. Uchida, T., Kinoshita, T., Nagai, H., Nakahara, Y., Saito, H. & Hotta, T. (1997) Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. Blood, 90, 1403-1409.
47. Vardiman, J.W., Pierre, R., Imbert, M., Bain, B., Brunning, R.D. & Flandrin, G. (2001) Juvenile myelomonocytic leukaemia. In: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (ed. by E.S. Jaffe, N.L. Harris, H. Stein & J.W. Vardiman), pp. 55-57, IARC Press, Lyon, France.
48. Wong, I.H.N., Ng, M.H.L., Huang, D.P. & Lee, J.C.K. (2000) Aberrant p15 promoter methylation in adult and childhood leukemias of nearly all morphologic subtypes: potential prognostic implications. Blood, 95, 1942-1949.