Insufficient interleukin-12 signalling favours differentiation of human CD4+ and CD8+ T cells into GATA-3+ and GATA-3+ T-bet+ subsets in humanized mice

Immunology

Volumn 143, Issue 2, 2014, Pages 202-218

  Billerbeck, Eva ^a   Labitt, Rachael N ^a   Vega, Kevin ^a   Frias Staheli, Natalia ^a   Dorner, Marcus ^a,b   Xiao, Jing W ^a   Rice, Charles M ^a   Ploss, Alexander ^a,c  

^a ROCKEFELLER UNIVERSITY   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

Humanized mice; Interleukin 12; T cell plasticity

Indexed keywords

GAMMA INTERFERON; GATA3 PROTEIN, HUMAN; IFNG PROTEIN, HUMAN; IL4 PROTEIN, HUMAN; INTERLEUKIN 12; INTERLEUKIN 4; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR TBX21; T-BOX TRANSCRIPTION FACTOR TBX21; TRANSCRIPTION FACTOR GATA 3;

ADENOVIRUS; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C57BL MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; DENDRITIC CELL; DRUG EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOST PATHOGEN INTERACTION; HUMAN; HUMANIZED MICE; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; KINETICS; LIVER; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PATHOGENICITY; PHENOTYPE; SCID MOUSE; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; T-CELL PLASTICITY; TRANSGENIC MOUSE; VIROLOGY; VIRUS LOAD; XENOGRAFT;

HUMANIZED MICE; INTERLEUKIN-12; T-CELL PLASTICITY;

ADENOVIRIDAE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; DENDRITIC CELLS; GATA3 TRANSCRIPTION FACTOR; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOST-PATHOGEN INTERACTIONS; HUMANS; INJECTIONS, INTRAPERITONEAL; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-4; KINETICS; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; PHENOTYPE; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION, HETEROLOGOUS; VIRAL LOAD;

EID: 84908209406     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12304     Document Type: Article

References (41)

1. Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol 2010; 28:445-89.
2. H2 effector cells made? Curr Opin Immunol 2009; 21:153-60.
3. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7:145-73.
4. Pulendran B, Artis D. New paradigms in type 2 immunity. Science 2012; 337:431-5.
5. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:655-69.
6. Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89:587-96.
7. H2-type immune responses initiated and amplified? Nat Rev Immunol 2010; 10:225-35.
8. Vignali DA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol 2012; 13:722-8.
9. + T cells. Curr Opin Immunol 2003; 15:336-42.
10. + T cell skewing in allergic lung disease. Proc Natl Acad Sci USA 2013; 110:8152-7.
11. + T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production. Arthritis Rheum 2011; 63:1738-47.
12. + T cell transcription factors. Nat Rev Immunol 2012; 12:799-804.
13. Nakayamada S, Takahashi H, Kanno Y, O'Shea JJ. Helper T cell diversity and plasticity. Curr Opin Immunol 2012; 24:297-302.
14. + cell subset with combined Th2 and Th1 cell functions. Immunity 2010; 32:116-28.
15. Fang M, Xie H, Dougan SK, Ploegh H, van Oudenaarden A. Stochastic cytokine expression induces mixed T helper cell States. PLoS Biol 2013; 11:e1001618.
16. + Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol 2013; 11:e1001633.
17. Antebi YE, Reich-Zeliger S, Hart Y et al. Mapping differentiation under mixed culture conditions reveals a tunable continuum of T cell fates. PLoS Biol 2013; 11:e1001616.
18. Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG. Human hemato-lymphoid system mice: current use and future potential for medicine. Annu Rev Immunol 2013; 31:635-74.
19. Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL. Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol 2012; 12:786-98.
20. Huntington ND, Alves NL, Legrand N et al. IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proc Natl Acad Sci U S A 2011; 108:6217-22.
21. Billerbeck E, Horwitz JA, Labitt RN et al. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol 2013; 191:1753-64.
22. null humanized mice. Blood 2011; 117:3076-86.
23. Shultz LD, Lyons BL, Burzenski LM et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2Rγ null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005; 174:6477-89.
24. null mice. Blood 2005; 106:1565-73.
25. null mutation. Clin Immunol 2010; 135:84-98.
26. Melkus MW, Estes JD, Padgett-Thomas A et al. Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat Med 2006; 12:1316-22.
27. null humanized mice. Proc Natl Acad Sci U S A 2010; 107:13022-7.
28. Strowig T, Gurer C, Ploss A et al. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med 2009; 206:1423-34.
29. + T cells infiltrate the target tissue in experimental autoimmunity. J Immunol 2010; 185:7467-73.
30. + regulatory T cell fate during inflammation in mice. J Clin Invest 2011; 121:4503-15.
31. + dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice. Blood 2013; 121:5034-44.
32. Tanaka S, Saito Y, Kunisawa J et al. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice. J Immunol 2012; 188:6145-55.
33. Willinger T, Rongvaux A, Strowig T, Manz MG, Flavell RA. Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. Trends Immunol 2011; 32:321-7.
34. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3:133-46.
35. Chen Q, Khoury M, Chen J. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A 2009; 106:21783-8.
36. + dendritic cells in vivo. J Immunol 2014; 192:1982-9.
37. Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buch DW, Schmitz J. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol 2000; 165:6037-46.
38. Guermonprez P, Helft J, Claser C et al. Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat Med 2013; 19:730-8.
39. - (NRG) mice is similar to but not identical to the original stem cell donor. Clin Exp Immunol 2013; 174:402-13.
40. Bossini-Castillo L, Martin JE, Broen J et al. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Hum Mol Genet 2012; 21:926-33.
41. Carreno BM, Becker-Hapak M, Huang A et al. IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity. J Clin Investig 2013; 123:3383-94.