메뉴 건너뛰기




Volumn 3, Issue 7, 2014, Pages 705-716

CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin

Author keywords

CB1 receptor; Endocannabinoid; Hypothalamus; Leptin; Obesity; Ventromedial nucleus

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; STAT3 PROTEIN; STEROIDOGENIC FACTOR 1; TRIACYLGLYCEROL LIPASE;

EID: 84908208686     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.07.004     Document Type: Article
Times cited : (68)

References (52)
  • 1
    • 33845891613 scopus 로고    scopus 로고
    • Understanding global nutrition dynamics as a step towards controlling cancer incidence
    • Popkin B.M. Understanding global nutrition dynamics as a step towards controlling cancer incidence. Nature Reviews Cancer 2007, 7(1):61-67.
    • (2007) Nature Reviews Cancer , vol.7 , Issue.1 , pp. 61-67
    • Popkin, B.M.1
  • 2
    • 84856961540 scopus 로고    scopus 로고
    • Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity
    • Ryan K.K., Woods S.C., Seeley R.J. Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metabolism 2012, 15(2):137-149.
    • (2012) Cell Metabolism , vol.15 , Issue.2 , pp. 137-149
    • Ryan, K.K.1    Woods, S.C.2    Seeley, R.J.3
  • 3
    • 34247886103 scopus 로고    scopus 로고
    • The role of CNS fuel sensing in energy and glucose regulation
    • Cota D., Proulx K., Seeley R.J. The role of CNS fuel sensing in energy and glucose regulation. Gastroenterology 2007, 132(6):2158-2168.
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2158-2168
    • Cota, D.1    Proulx, K.2    Seeley, R.J.3
  • 4
    • 84874135468 scopus 로고    scopus 로고
    • Physiology. Food as a hormone
    • Ryan K.K., Seeley R.J. Physiology. Food as a hormone. Science 2013, 339(6122):918-919.
    • (2013) Science , vol.339 , Issue.6122 , pp. 918-919
    • Ryan, K.K.1    Seeley, R.J.2
  • 5
    • 84856481281 scopus 로고    scopus 로고
    • The role of the endocannabinoid system in the neuroendocrine regulation of energy balance
    • Bermudez-Silva F.J., Cardinal P., Cota D. The role of the endocannabinoid system in the neuroendocrine regulation of energy balance. Journal of Psychopharmacology 2012, 26(1):114-124.
    • (2012) Journal of Psychopharmacology , vol.26 , Issue.1 , pp. 114-124
    • Bermudez-Silva, F.J.1    Cardinal, P.2    Cota, D.3
  • 6
    • 80052035103 scopus 로고    scopus 로고
    • Energy balance regulation by endocannabinoids at central and peripheral levels
    • Quarta C., Mazza R., Obici S., Pasquali R., Pagotto U. Energy balance regulation by endocannabinoids at central and peripheral levels. Trends in Molecular Medicine 2011, 17(9):518-526.
    • (2011) Trends in Molecular Medicine , vol.17 , Issue.9 , pp. 518-526
    • Quarta, C.1    Mazza, R.2    Obici, S.3    Pasquali, R.4    Pagotto, U.5
  • 8
    • 79951979686 scopus 로고    scopus 로고
    • Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
    • Lafourcade M., Larrieu T., Mato S., Duffaud A., Sepers M., Matias I., et al. Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nature Neuroscience 2011, 14(3):345-350.
    • (2011) Nature Neuroscience , vol.14 , Issue.3 , pp. 345-350
    • Lafourcade, M.1    Larrieu, T.2    Mato, S.3    Duffaud, A.4    Sepers, M.5    Matias, I.6
  • 9
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
    • Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. Journal of Neuroscience 1991, 11(2):563-583.
    • (1991) Journal of Neuroscience , vol.11 , Issue.2 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    de Costa, B.R.5    Rice, K.C.6
  • 10
    • 0033452718 scopus 로고    scopus 로고
    • Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain
    • Marsicano G., Lutz B. Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. European Journal of Neuroscience 1999, 11(12):4213-4225.
    • (1999) European Journal of Neuroscience , vol.11 , Issue.12 , pp. 4213-4225
    • Marsicano, G.1    Lutz, B.2
  • 11
    • 31944452253 scopus 로고    scopus 로고
    • The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
    • King B.M. The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiology & Behavior 2006, 87(2):221-244.
    • (2006) Physiology & Behavior , vol.87 , Issue.2 , pp. 221-244
    • King, B.M.1
  • 12
    • 0028276035 scopus 로고
    • Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases
    • Ikeda Y., Shen W.H., Ingraham H.A., Parker K.L. Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. Molecular Endocrinology 1994, 8(5):654-662.
    • (1994) Molecular Endocrinology , vol.8 , Issue.5 , pp. 654-662
    • Ikeda, Y.1    Shen, W.H.2    Ingraham, H.A.3    Parker, K.L.4
  • 13
    • 0028959656 scopus 로고
    • The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus
    • Ikeda Y., Luo X., Abbud R., Nilson J.H., Parker K.L. The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Molecular Endocrinology 1995, 9(4):478-486.
    • (1995) Molecular Endocrinology , vol.9 , Issue.4 , pp. 478-486
    • Ikeda, Y.1    Luo, X.2    Abbud, R.3    Nilson, J.H.4    Parker, K.L.5
  • 14
    • 0036153668 scopus 로고    scopus 로고
    • Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity
    • Majdic G., Young M., Gomez-Sanchez E., Anderson P., Szczepaniak L.S., Dobbins R.L., et al. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 2002, 143(2):607-614.
    • (2002) Endocrinology , vol.143 , Issue.2 , pp. 607-614
    • Majdic, G.1    Young, M.2    Gomez-Sanchez, E.3    Anderson, P.4    Szczepaniak, L.S.5    Dobbins, R.L.6
  • 15
    • 84881257127 scopus 로고    scopus 로고
    • Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain
    • Lindberg D., Chen P., Li C. Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain. Journal of Comparative Neurology 2013, 521(14):3167-3190.
    • (2013) Journal of Comparative Neurology , vol.521 , Issue.14 , pp. 3167-3190
    • Lindberg, D.1    Chen, P.2    Li, C.3
  • 16
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • Dhillon H., Zigman J.M., Ye C., Lee C.E., McGovern R.A., Tang V., et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006, 49(2):191-203.
    • (2006) Neuron , vol.49 , Issue.2 , pp. 191-203
    • Dhillon, H.1    Zigman, J.M.2    Ye, C.3    Lee, C.E.4    McGovern, R.A.5    Tang, V.6
  • 17
    • 77956627976 scopus 로고    scopus 로고
    • PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis
    • Xu Y., Hill J.W., Fukuda M., Gautron L., Sohn J.W., Kim K.W., et al. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metabolism 2010, 12(1):88-95.
    • (2010) Cell Metabolism , vol.12 , Issue.1 , pp. 88-95
    • Xu, Y.1    Hill, J.W.2    Fukuda, M.3    Gautron, L.4    Sohn, J.W.5    Kim, K.W.6
  • 18
    • 54349113070 scopus 로고    scopus 로고
    • Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
    • Zhang R., Dhillon H., Yin H., Yoshimura A., Lowell B.B., Maratos-Flier E., et al. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology 2008, 149(11):5654-5661.
    • (2008) Endocrinology , vol.149 , Issue.11 , pp. 5654-5661
    • Zhang, R.1    Dhillon, H.2    Yin, H.3    Yoshimura, A.4    Lowell, B.B.5    Maratos-Flier, E.6
  • 19
    • 0035185205 scopus 로고    scopus 로고
    • Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats
    • Jamshidi N., Taylor D.A. Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. British Journal of Pharmacology 2001, 134(6):1151-1154.
    • (2001) British Journal of Pharmacology , vol.134 , Issue.6 , pp. 1151-1154
    • Jamshidi, N.1    Taylor, D.A.2
  • 20
    • 48249113421 scopus 로고    scopus 로고
    • Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus
    • Kim K.W., Jo Y.H., Zhao L., Stallings N.R., Chua S.C., Parker K.L. Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Molecular Endocrinology 2008, 22(8):1950-1961.
    • (2008) Molecular Endocrinology , vol.22 , Issue.8 , pp. 1950-1961
    • Kim, K.W.1    Jo, Y.H.2    Zhao, L.3    Stallings, N.R.4    Chua, S.C.5    Parker, K.L.6
  • 22
    • 84865421329 scopus 로고    scopus 로고
    • Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice
    • Cardinal P., Bellocchio L., Clark S., Cannich A., Klugmann M., Lutz B., et al. Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice. Endocrinology 2012, 153(9):4136-4143.
    • (2012) Endocrinology , vol.153 , Issue.9 , pp. 4136-4143
    • Cardinal, P.1    Bellocchio, L.2    Clark, S.3    Cannich, A.4    Klugmann, M.5    Lutz, B.6
  • 23
    • 49049114337 scopus 로고    scopus 로고
    • The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    • Cota D., Matter E.K., Woods S.C., Seeley R.J. The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. Journal of Neuroscience 2008, 28(28):7202-7208.
    • (2008) Journal of Neuroscience , vol.28 , Issue.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 24
    • 36048988035 scopus 로고    scopus 로고
    • Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism
    • Galie M., Farace P., Nanni C., Spinelli A., Nicolato E., Boschi F., et al. Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism. Neoplasia 2007, 9(11):900-908.
    • (2007) Neoplasia , vol.9 , Issue.11 , pp. 900-908
    • Galie, M.1    Farace, P.2    Nanni, C.3    Spinelli, A.4    Nicolato, E.5    Boschi, F.6
  • 25
    • 84895821132 scopus 로고    scopus 로고
    • Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice
    • Binder E., Bermúdez-Silva F.J., Elie M., Leste-Lasserre T., Belluomo I., Clark S., et al. Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice. Obesity (Silver Spring) 2013, 22(3):713-720.
    • (2013) Obesity (Silver Spring) , vol.22 , Issue.3 , pp. 713-720
    • Binder, E.1    Bermúdez-Silva, F.J.2    Elie, M.3    Leste-Lasserre, T.4    Belluomo, I.5    Clark, S.6
  • 26
    • 58149330247 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system
    • Proulx K., Cota D., Woods S.C., Seeley R.J. Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system. Diabetes 2008, 57(12):3231-3238.
    • (2008) Diabetes , vol.57 , Issue.12 , pp. 3231-3238
    • Proulx, K.1    Cota, D.2    Woods, S.C.3    Seeley, R.J.4
  • 28
    • 0035156262 scopus 로고    scopus 로고
    • Obesity, body fat distribution, insulin sensitivity and Islet beta-cell function as explanations for metabolic diversity
    • Kahn S.E., Prigeon R.L., Schwartz R.S., Fujimoto W.Y., Knopp R.H., Brunzell J.D., et al. Obesity, body fat distribution, insulin sensitivity and Islet beta-cell function as explanations for metabolic diversity. Journal of Nutrition 2001, 131(2):354S-360S.
    • (2001) Journal of Nutrition , vol.131 , Issue.2 , pp. 354S-360S
    • Kahn, S.E.1    Prigeon, R.L.2    Schwartz, R.S.3    Fujimoto, W.Y.4    Knopp, R.H.5    Brunzell, J.D.6
  • 30
    • 77649092148 scopus 로고    scopus 로고
    • Regulation of lipid metabolism by energy availability: a role for the central nervous system
    • Nogueiras R., Lopez M., Dieguez C. Regulation of lipid metabolism by energy availability: a role for the central nervous system. Obesity Reviews 2010, 11(3):185-201.
    • (2010) Obesity Reviews , vol.11 , Issue.3 , pp. 185-201
    • Nogueiras, R.1    Lopez, M.2    Dieguez, C.3
  • 31
    • 77950199353 scopus 로고    scopus 로고
    • CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance
    • Quarta C., Bellocchio L., Mancini G., Mazza R., Cervino C., Braulke L.J., et al. CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metabolism 2010, 11(4):273-285.
    • (2010) Cell Metabolism , vol.11 , Issue.4 , pp. 273-285
    • Quarta, C.1    Bellocchio, L.2    Mancini, G.3    Mazza, R.4    Cervino, C.5    Braulke, L.J.6
  • 32
    • 0032844158 scopus 로고    scopus 로고
    • Electrical stimulation of the ventromedial hypothalamus enhances both fat utilization and metabolic rate that precede and parallel the inhibition of feeding behavior
    • Ruffin M., Nicolaidis S. Electrical stimulation of the ventromedial hypothalamus enhances both fat utilization and metabolic rate that precede and parallel the inhibition of feeding behavior. Brain Research 1999, 846(1):23-29.
    • (1999) Brain Research , vol.846 , Issue.1 , pp. 23-29
    • Ruffin, M.1    Nicolaidis, S.2
  • 33
    • 2642614548 scopus 로고    scopus 로고
    • Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
    • Anthonsen M.W., Rönnstrand L., Wernstedt C., Degerman E., Holm C. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. The Journal of Biological Chemistry 1998, 273(1):215-221.
    • (1998) The Journal of Biological Chemistry , vol.273 , Issue.1 , pp. 215-221
    • Anthonsen, M.W.1    Rönnstrand, L.2    Wernstedt, C.3    Degerman, E.4    Holm, C.5
  • 36
    • 44949163013 scopus 로고    scopus 로고
    • Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
    • Buettner C., Muse E.D., Cheng A., Chen L., Scherer T., Pocai A., et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nature Medicine 2008, 14(6):667-675.
    • (2008) Nature Medicine , vol.14 , Issue.6 , pp. 667-675
    • Buettner, C.1    Muse, E.D.2    Cheng, A.3    Chen, L.4    Scherer, T.5    Pocai, A.6
  • 37
    • 80054850926 scopus 로고    scopus 로고
    • Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism
    • Scherer T., Buettner C. Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism. Reviews in Endocrine and Metabolic Disorders 2011, 12(3):235-243.
    • (2011) Reviews in Endocrine and Metabolic Disorders , vol.12 , Issue.3 , pp. 235-243
    • Scherer, T.1    Buettner, C.2
  • 42
    • 0024158305 scopus 로고
    • Sympathetic activity following paraventricular or ventromedial hypothalamic lesions in rats
    • Sakaguchi T., Bray G.A., Eddlestone G. Sympathetic activity following paraventricular or ventromedial hypothalamic lesions in rats. Brain Research Bulletin 1988, 20(4):461-465.
    • (1988) Brain Research Bulletin , vol.20 , Issue.4 , pp. 461-465
    • Sakaguchi, T.1    Bray, G.A.2    Eddlestone, G.3
  • 43
    • 0020083243 scopus 로고
    • Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions
    • Vander Tuig J.G., Knehans A.W., Romsos D.R. Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions. Life Sciences 1982, 30(11):913-920.
    • (1982) Life Sciences , vol.30 , Issue.11 , pp. 913-920
    • Vander Tuig, J.G.1    Knehans, A.W.2    Romsos, D.R.3
  • 44
    • 0032833029 scopus 로고    scopus 로고
    • Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion
    • Satoh N., Ogawa Y., Katsuura G., Numata Y., Tsuji T., Hayase M., et al. Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes 1999, 48(9):1787-1793.
    • (1999) Diabetes , vol.48 , Issue.9 , pp. 1787-1793
    • Satoh, N.1    Ogawa, Y.2    Katsuura, G.3    Numata, Y.4    Tsuji, T.5    Hayase, M.6
  • 45
    • 0035848818 scopus 로고    scopus 로고
    • Leptin-regulated endocannabinoids are involved in maintaining food intake
    • Di Marzo V., Goparaju S.K., Wang L., Liu J., Bátkai S., Járai Z., et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 2001, 410(6830):822-825.
    • (2001) Nature , vol.410 , Issue.6830 , pp. 822-825
    • Di Marzo, V.1    Goparaju, S.K.2    Wang, L.3    Liu, J.4    Bátkai, S.5    Járai, Z.6
  • 46
    • 29144464338 scopus 로고    scopus 로고
    • Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit
    • Jo Y.H., Chen Y.J., Chua S.C., Talmage D.A., Role L.W. Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 2005, 48(6):1055-1066.
    • (2005) Neuron , vol.48 , Issue.6 , pp. 1055-1066
    • Jo, Y.H.1    Chen, Y.J.2    Chua, S.C.3    Talmage, D.A.4    Role, L.W.5
  • 47
    • 33745768460 scopus 로고    scopus 로고
    • Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release
    • Malcher-Lopes R., Di S., Marcheselli V.S., Weng F.J., Stuart C.T., Bazan N.G., et al. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. Journal of Neuroscience 2006, 26(24):6643-6650.
    • (2006) Journal of Neuroscience , vol.26 , Issue.24 , pp. 6643-6650
    • Malcher-Lopes, R.1    Di, S.2    Marcheselli, V.S.3    Weng, F.J.4    Stuart, C.T.5    Bazan, N.G.6
  • 48
    • 27744457512 scopus 로고    scopus 로고
    • Topographic mapping of VMH→ arcuate nucleus microcircuits and their reorganization by fasting
    • Sternson S.M., Shepherd G.M., Friedman J.M. Topographic mapping of VMH→ arcuate nucleus microcircuits and their reorganization by fasting. Nature Neuroscience 2005, 8(10):1356-1363.
    • (2005) Nature Neuroscience , vol.8 , Issue.10 , pp. 1356-1363
    • Sternson, S.M.1    Shepherd, G.M.2    Friedman, J.M.3
  • 52
    • 21644453934 scopus 로고    scopus 로고
    • Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase
    • Kola B., Hubina E., Tucci S.A., Kirkham T.C., Garcia E.A., Mitchell S.E., et al. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. The Journal of Biological Chemistry 2005, 280(26):25196-25201.
    • (2005) The Journal of Biological Chemistry , vol.280 , Issue.26 , pp. 25196-25201
    • Kola, B.1    Hubina, E.2    Tucci, S.A.3    Kirkham, T.C.4    Garcia, E.A.5    Mitchell, S.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.