Cold atmospheric pressure plasma and decontamination. Can it contribute to preventing hospital-acquired infections?

Journal of Hospital Infection

Volumn 88, Issue 2, 2014, Pages 59-65

  O'Connor, N ^a,b   Cahill, O ^a   Daniels, S ^a,b   Galvin, S ^c   Humphreys, H ^c,d  

^a National Centre for Plasma Science and Technology (NCPST)   (Ireland)

^b DUBLIN CITY UNIVERSITY   (Ireland)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^d BEAUMONT HOSPITAL   (Ireland)

Author keywords

Cold atmospheric pressure plasma (CAPP); Decontamination; Disinfection; Healthcare associated infections

Indexed keywords

DISINFECTANT AGENT; NITROGEN DERIVATIVE; REACTIVE OXYGEN METABOLITE; PLASMA GAS;

ANTIBACTERIAL ACTIVITY; BACTERIAL CELL; BACTERICIDAL ACTIVITY; BIOFILM; BLOOD CLOTTING; CANCER THERAPY; CLINICAL MEDICINE; COLD ATMOSPHERIC PRESSURE PLASMA SYSTEM; DERMATITIS; DISINFECTION; ELECTRIC FIELD; HEALTH CARE FACILITY; HEALTHCARE ASSOCIATED INFECTION; HOSPITAL EQUIPMENT; HOSPITAL INFECTION; HOSPITAL MANAGEMENT; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; NONHUMAN; REVIEW; SKIN DECONTAMINATION; ULTRAVIOLET RADIATION; WOUND HEALING; CROSS INFECTION; DEVICES; MICROBIAL VIABILITY; MICROBIOLOGY; PHARMACOLOGY; PLASMA GAS; PROCEDURES; WASTE MANAGEMENT;

CROSS INFECTION; DECONTAMINATION; HUMANS; MICROBIAL VIABILITY; PLASMA GASES;

EID: 84908200805     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2014.06.015     Document Type: Review

References (88)

1. Flanagan M.E., Welsh C.A., Kiess C., et al. Anational collaborative for reducing health care associated infections: current initiatives, challenges, and opportunities. Am J Infect Control 2011, 39:685-689.
2. Otter J.A., Yezli S., French G.L. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol 2011, 32:687-699.
3. Kramer A., Schwebke I., Kampf G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis 2006, 6:130.
4. Lu P.-L., Siu L.K., Chen T.-C., et al. Methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii on computer interface surfaces of hospital wards and association with clinical isolates. BMC Infect Dis 2009, 9:164.
5. Carducci A., Verani M., Lombardi R., Casini B., Privitera G. Environmental survey to assess viral contamination of air and surfaces in hospital settings. JHosp Infect 2011, 77:242-247.
6. Cheng K.L., Boost M.V., Chung J.W.Y. Study on the effectiveness of disinfection with wipes against methicillin-resistant Staphylococcus aureus and implications for hospital hygiene. Am J Infect Control 2011, 39:577-580.
7. Hooker E.A., Allen S.D., Gray L.D. Terminal cleaning of hospital bed mattresses and bed decks does not eliminate bacterial contamination. Am J Infect Control 2011, 39:E23-E24.
8. Creamer E., Humphreys H. The contribution of beds to healthcare-associated infection: the importance of adequate decontamination. JHosp Infect 2008, 69:8-23.
9. Morgan D.J., Liang S.Y., Smith C.L., et al. Frequent multidrug-resistant Acinetobacter baumannii contamination of gloves, gowns, and hands of healthcare workers. Infect Control Hosp Epidemiol 2010, 31:716-721.
10. Eibicht S.J., Vogel U. Meticillin-resistant Staphylococcus aureus (MRSA) contamination of ambulance cars after short term transport of MRSA-colonised patients is restricted to the stretcher. JHosp Infect 2011, 78:221-225.
11. Allegranzi B., Pittet D. Role of hand hygiene in healthcare-associated infection prevention. JHosp Infect 2009, 73:305-315.
12. Steed C., Kelly J.W., Blackhurst D., et al. Hospital hand hygiene opportunities: where and when (HOW2)? The HOW2 Benchmark Study. Am J Infect Control 2011, 39:19-26.
13. Yam R., Yuen P.L., Yung R., Choy T. Rethinking hospital general ward ventilation design using computational fluid dynamics. JHosp Infect 2011, 77:31-36.
14. Borkow G., Gabbay J. Biocidal textiles can help fight nosocomial infections. Med Hypotheses 2008, 70:990-994.
15. Guilhermetti M., Marques Wiirzler L.A., Castanheira Facio B., et al. Antimicrobial efficacy of alcohol-based hand gels. JHosp Infect 2010, 74:219-224.
16. Dixon J.M., Carver R.L. Daily chlorohexidine gluconate bathing with impregnated cloths results in statistically significant reduction in central line associated bloodstream infections. Am J Infect Control 2010, 38:817-821.
17. Diab-Elschahawi M., Blacky A., Bachhofner N., Koller W. Lumen claims of the STERRAD 100NX sterilizer: testing performance limits when processing equipment containing long, narrow lumens. Am J Infect Control 2011, 39:770-774.
18. Berrington A.W., Pedler S.J. Investigation of gaseous ozone for MRSA decontamination of hospital side-rooms. JHosp Infect 1998, 40:61-65.
19. Saito R., Uetera Y., Saito Y., Okamura N., Moriya K., Koike K. Evaluation of the efficacy of a low temperature steam and formaldehyde steriliser by using biological indicators. JHosp Infect 2009, 73:179-180.
20. Svrcek J., Marhoul A., Kacer P., Kuzma M., Panek L., Lerveny C. The influence of operating conditions on the efficiency of vapor phase hydrogen peroxide in the degradation of 4-(dimethylamino) benzaldehyde. Chemosphere 2010, 81:617.
21. Beattie C., Harry L.E., Hamilton S.A., Burke D. Cardiac arrest following hydrogen peroxide irrigation of a breast wound. JPlast Reconstr Aesthet Surg 2010, 63:e253-e254.
22. Davies A., Pottage T., Bennett A., Walker J. Gaseous and air decontamination technologies for Clostridium difficile in the healthcare environment. JHosp Infect 2010, 77:199-203.
23. Kogelschatz U. Atmospheric-pressure plasma technology. Plasma Phys Cont Fus 2004, 46:B63-B75.
24. Fridman A.A., Kennedy L.A. Plasma physics and engineering 2004, CRC Press, Boca Raton.
25. Roth J.R. Industrial plasma engineering: applications to non-thermal plasma processing 2001, CRC Press, Boca Raton.
26. Raizer Y. Gas discharge physics 1991, Springer-Verlag, Berlin.
27. Fridman G., Friedman G., Gutsol A., Shekhter A.B., Vasilets V.N., Fridman A. Applied plasma medicine. Plasma Process Polym 2008, 5:503-533.
28. Kogelschatz U., Eliasson B., Egli W. From ozone generators to flat television screens: history and future potential of dielectric-barrier discharges. Pure Appl Chem 1999, 71:1819-1828.
29. Shenton M.J., Stevens G.C. Surface modification of polymer surfaces: atmospheric plasma versus vacuum plasma treatments. JPhys D: Appl Phys 2001, 34:2761-2768.
30. Schutze A., Jeong J., Babayan S., Park J., Selwyn G., Hicks R. The atmospheric pressure plasma jet: a review and comparison to other plasma sources. IEEE Trans Plasma Sci 1998, 26:1685-1694.
31. Jeong J.Y., Babayan S.E., Tu V.J., et al. Etching materials with an atmospheric pressure plasma jet. Plasma Sources Sci Technol 1998, 7:282-285.
32. Stoffels E., Flikweert A.J., Stoffels W.W., Kroesen G.M.W. Plasma needle: a non-destructive atmospheric plasma source for fine surface treatment of (bio)materials. Plasma Sources Sci Technol 2002, 11:383-388.
33. Shashurin A., Keidar M., Bronnikov S., Jurjus R.A., Stepp M.A. Living tissue under treatment of cold plasma atmospheric jet. Appl Phys Lett 2008, 93:181501.
34. Fridman G., Peddinghaus M., Balasubramanian M., et al. Blood coagulation and living tissue sterilization by floating-electrode dielectric barrier discharge in air. Plasma Chem Plasma Processing 2006, 26:425-442.
35. Stoffels E. "Tissue processing" with atmospheric plasmas. Contrib Plasma Phys 2007, 47:40-48.
36. Laroussi M. Nonthermal decontamination of biological media by atmospheric pressure plasmas: review, analysis, and prospects. IEEE Trans Plasma Sci 2002, 30:1409-1415.
37. Laroussi M. Sterilization of contaminated matter with an atmospheric pressure plasma. IEEE Trans Plasma Sci 1996, 24:1188-1191.
38. Herrmann H.W., Henins I., Park J., Selwyn G.S. Decontamination of chemical and biological warfare (CBW) agents using an atmospheric pressure plasma jet (APPJ). Phys Plasmas 1999, 6:2284.
39. Stoffels E., Sakiyama Y., Graves D. Cold atmospheric plasma: charged species and their interactions with cells and tissues. IEEE Trans Plasma Sci 2008, 36:1441-1457.
40. Kong M.G., Kroesen G., Morfill G., et al. Plasma medicine: an introductory review. New J Phys 2009, 11:115012.
41. Laroussi M. Low-temperature plasmas for medicine?. IEEE Trans Plasma Sci 2009, 37:714-725.
42. Goosen N., Moolenaar G.F. Repair of UV damage in bacteria. DNA Repair 2008, 7:353-379.
43. Stalder K.R., Vidmar R.J., Nersisyan G., Graham W.G. Modeling the chemical kinetics of high-pressure glow discharges in mixtures of helium with real air. JAppl Phys 2006, 99:093301.
44. 2 plasmas. Plasma Process Polym 2010, 7:846-865.
45. Fridman G., Brooks A.D., Balasubramanian M., et al. Comparison of direct and indirect effects of non-thermal atmospheric-pressure plasma on bacteria. Plasma Process Polym 2007, 4:370-375.
46. Laroussi M., Mendis D.A., Rosenberg M. Plasma interaction with microbes. New J Phys 2003, 5:41.
47. Pompl P., Jamitzky F., Shimizu T., et al. The effect of low-temperature plasma on bacteria as observed by repeated AFM imaging. New J Phys 2009, 11:115023.
48. Xu L., Tu Y., Yu Y., Tan M., Li J., Chen H. Augmented survival of Neisseria gonorrhoeae within biofilms: exposure to atmospheric pressure non-thermal plasmas. Eur J Clin Microbiol Infect Dis 2011, 30:25-31.
49. Li Y.F., Taylor D., Zimmermann J.L., et al. Invivo skin treatment using two portable plasma devices: comparison of a direct and an indirect cold atmospheric plasma treatment. Clin Plasma Med 2013, 1:35-39.
50. Emmert S., Brehmer F., Hänßle H., et al. Atmospheric pressure plasma in dermatology: ulcus treatment and much more. Clin Plasma Med 2013, 1:24-29.
51. Daeschlein G., Scholz S., Ahmed R., et al. Skin decontamination by low temperature atmospheric pressure plasma jet and dielectric barrier discharge plasma. JHosp Infect 2012, 81:177-183.
52. Maisch T., Shimizu T., Isbary G., et al. Contact-free inactivation of Candida albicans biofilms by cold atmospheric air plasma. Appl Environ Microbiol 2012, 78:4242-4247.
53. Isbary G., Morfill G., Schmidt H.U., et al. Afirst prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. Br J Dermatol 2010, 163:78-82.
54. Isbary G., Morfill G., Zimmermann J., Shimizu T., Stolz W. Cold atmospheric plasma: a successful treatment of lesions in Hailey-Hailey disease. Arch Dermatol 2011, 147:388-390.
55. Isbary G., Heinlin J., Shimizu T., et al. Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial. Br J Dermatol 2012, 167:404-410.
56. Isbary G., Shimizu T., Zimmermann J.L., Thomas H.M., Morfill G.E., Stolz W. Cold atmospheric plasma for local infection control and subsequent pain reduction in a patient with chronic post-operative ear infection. New Micro New Infect 2013, 1:41-43.
57. Tipa R.S., Kroesen G.M.W. Plasma-stimulated wound healing. IEEE Trans Plasma Sci 2011, 39:2978-2979.
58. Kalghatgi S.U., Fridman G., Cooper M., et al. Mechanism of blood coagulation by nonthermal atmospheric pressure dielectric barrier discharge plasma. IEEE Trans Plasma Sci 2007, 35:1559-1566.
59. Welz C., Becker S., Li Y.-F., et al. Effects of cold atmospheric plasma on mucosal tissue culture. JPhys D: Appl Phys 2013, 46:045401.
60. Klämpfl T.G., Isbary G., Shimizu T., et al. Cold atmospheric air plasma sterilization against spores and other microorganisms of clinical interest. Appl Environ Microbiol 2012, 78:5077-5082.
61. Zimmermann J.L., Dumler K., Shimizu T., et al. Effects of cold atmospheric plasmas on adenoviruses in solution. JPhys D: Appl Phys 2011, 44:505201.
62. Cahill O.J., Claro T., O'Connor N., et al. Cold air plasma to decontaminate inanimate surfaces of the hospital environment. Appl Environ Microbiol 2014, 80:2004-2010.
63. Burts M.L., Alexeff I., Meek E.T., McCullers J.A. Use of atmospheric non-thermal plasma as a disinfectant for objects contaminated with methicillin-resistant Staphylococcus aureus. Am J Infect Control 2009, 37:729-733.
64. Hoffmann C., Berganza C., Zhang J. Cold atmospheric plasma: methods of production and application in dentistry and oncology. Med Gas Res 2013, 3:21.
65. Sung S.-J., Huh J.-B., Yun M.-J., Chang B.M.W., Jeong C.-M., Jeon Y.-C. Sterilization effect of atmospheric pressure non-thermal air plasma on dental instruments. JAdv Prosthodont 2013, 5:2-8.
66. Martines E., Brun P., Brun P., et al. Towards a plasma treatment of corneal infections. Clin Plasma Med 2013, 1:17-24.
67. Brun P., Vono M., Venier P., et al. Disinfection of ocular cells and tissues by atmospheric-pressure cold plasma. PLoS One 2012, 7:e33245.
68. Pan J., Sun K., Liang Y., et al. Cold plasma therapy of a tooth root canal infected with Enterococcus faecalis biofilms invitro. JEndod 2013, 39:105-110.
69. Idlibi A.N., Al-Marrawi F., Hannig M., et al. Destruction of oral biofilms formed in situ on machined titanium (Ti) surfaces by cold atmospheric plasma. Biofouling 2013, 29:369-379.
70. Gorynia S., Koban I., Matthes R., et al. Invitro efficacy of cold atmospheric pressure plasma on S.sanguinis biofilms in comparison of two test models. GMS Hyg Infect Control 2013, 8(1):01.
71. Gadri R.B., Roth J.R., Montie T.C., et al. Sterilization and plasma processing of room temperature surfaces with a one atmosphere uniform glow discharge plasma (OAUGDP). Surf Coat Technol 2000, 131:528-541.
72. Kelly-Wintenberg K., Montie T.C., Brickman C., et al. Room temperature sterilization of surfaces and fabrics with a one atmosphere uniform glow discharge plasma. JInd Microbiol Biotechnol 1998, 20:69-74.
73. Oehmigen K., Hähnel M., Brandenburg R., Wilke C., Weltmann K.D., von Woedtke T. The role of acidification for antimicrobial activity of atmospheric pressure plasma in liquids. Plasma Process Polym 2010, 7:250-257.
74. Weng C.-C., Wu Y.-T., Liao J.-D., et al. Inactivation of bacteria by a mixed argon and oxygen micro-plasma as a function of exposure time. Int J Radiat Biol 2009, 85:362-368.
75. Brandenburg R., Ehlbeck J., Stieber M., et al. Antimicrobial treatment of heat sensitive products by miniaturized atmospheric pressure plasma jets (APPJs). JPhys D: Appl Phys 2008, 41:194008.
76. Kim G.J., Chung T.H., Bae S.H., Leem S.H. Bacterial inactivation using atmospheric pressure single pin electrode microplasma jet with a ground ring. Appl Phys Lett 2009, 94:141502.
77. Sato T., Urayama T., Nakatani T., Miyahara T. Inactivation of Escherichia coli by a coaxial microwave plasma flow. IEEE Trans Plasma Sci 2007, 43:1159-1163.
78. Laroussi M., Tendero C., Lu X., Alla S., Hynes W.L. Inactivation of bacteria by the plasma pencil. Plasma Process Polym 2006, 3:470-473.
79. Ikawa S., Kitano K., Hamaguchi S. Effects of pH on bacterial inactivation in aqueous solutions due to low-temperature atmospheric pressure plasma application. Plasma Process Polym 2010, 7:33-42.
80. Yu Q.S., Huang C., Hsieh F.H., Huff H., Duan Y. Bacterial inactivation using a low-temperature atmospheric plasma brush sustained with argon gas. JBiomed Mats Res B 2007, 80:211-219.
81. Cotter J.J., Maguire P., Soberon F., Daniels S., O' Gara J.P., Casey E. Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma. JHosp Infect 2011, 78:204-207.
82. Lim J., Uhm H., Li S.Z. Influence of oxygen in atmospheric-pressure argon plasma jet on sterilization of Bacillus atrophaeus spores. Phys Plasma 2007, 14:093504.
83. Daeschlein G., von Woedtke T., Kindel E., Brandenburg R., Weltmann K.-D., Jünger M. Antibacterial activity of an atmospheric pressure plasma jet against relevant wound pathogens invitro on a simulated wound environment. Plasma Process Polym 2010, 7:224-230.
84. Sohbatzadeh F., Hosseinzadeh Colagar A., Mirzanejhad S., Mahmodi S. E.coli, P.aeruginosa, and B.cereus bacteria sterilization using afterglow of nonthermal plasma at atmospheric pressure. Appl Biochem Biotechnol 2010, 160:1978-1984.
85. Cooper M, Vaze N, Anderson S, etal. Spacecraft sterilization using nonequilibrium atmospheric pressure plasma. Presented at: 18th International Symposium on Plasma Chemistry, Kyoto, Japan, 26-31 August, 2007.
86. Perni S., Shama G., Kong M.G. Cold atmospheric plasma disinfection of cut fruit surfaces contaminated with migrating microorganisms. JFood Prot 2008, 71:1619-1625.
87. Galvin S., Cahill O., O'Connor N., Cafolla A.A., Daniels S., Humphreys H. The antimicrobial effects of helium and helium-air plasma on Staphylococcus aureus and Clostridium difficile. Lett Appl Microbiol 2013, 57:83-90.
88. McDonald L.C., Arduino M. Editorial commentary: climbing the evidentiary hierarchy for environmental infection control. Clin Infect Dis 2013, 56:36-39.