메뉴 건너뛰기




Volumn 7, Issue 5, 2014, Pages 329-338

Structural and metabolic effects of obesity on the myocardium and the aorta

Author keywords

Cardiac imaging techniques; Cardiovascular diseases; Obesity

Indexed keywords

ADENOSINE TRIPHOSPHATE; LEPTIN; LEPTIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

EID: 84908192220     PISSN: 16624025     EISSN: 16624033     Source Type: Journal    
DOI: 10.1159/000368429     Document Type: Review
Times cited : (20)

References (106)
  • 2
    • 0035064965 scopus 로고    scopus 로고
    • Obesity cardiomyopathy: Pathophysiology and evolution of the clinical syndrome
    • Alpert MA: Obesity cardiomyopathy: Pathophysiology and evolution of the clinical syndrome. Am J Med Sci 2001; 321: 225-236.
    • (2001) Am J Med Sci , vol.321 , pp. 225-236
    • Alpert, M.A.1
  • 4
    • 0023879355 scopus 로고
    • Echocardiographically detected left ventricular hypertrophy: Prevalence and risk factors. The Framingham Heart Study
    • Levy D, Anderson KM, Savage DD, Kannel WB, Christiansen JC, Castelli WP: Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. The Framingham Heart Study. Ann Intern Med 1988; 108:7-13.
    • (1988) Ann Intern Med , vol.108 , pp. 7-13
    • Levy, D.1    Anderson, K.M.2    Savage, D.D.3    Kannel, W.B.4    Christiansen, J.C.5    Castelli, W.P.6
  • 5
    • 0035089266 scopus 로고    scopus 로고
    • Prognostic implications of left ventricular hypertrophy
    • Vakili BA, Okin PM, Devereux RB: Prognostic implications of left ventricular hypertrophy. Am Heart J 2001; 141:334-341.
    • (2001) Am Heart J , vol.141 , pp. 334-341
    • Vakili, B.A.1    Okin, P.M.2    Devereux, R.B.3
  • 8
    • 0027305107 scopus 로고
    • Obesity and the heart
    • Alexander JK: Obesity and the heart. Heart Dis Stroke 1993; 2: 317-321.
    • (1993) Heart Dis Stroke , vol.2 , pp. 317-321
    • Alexander, J.K.1
  • 9
    • 0026512403 scopus 로고
    • Separate and joint influences of obesity and mild hypertension on left ventricular mass and geometry: The Framingham Heart Study
    • Lauer MS, Anderson KM, Levy D: Separate and joint influences of obesity and mild hypertension on left ventricular mass and geometry: the Framingham Heart Study. J Am Coll Cardiol 1992; 19: 130-134.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 130-134
    • Lauer, M.S.1    Anderson, K.M.2    Levy, D.3
  • 11
    • 0028326266 scopus 로고
    • Left ventricular filling in young normotensive obese adults
    • Ku CS, Lin SL, Wang DJ, Chang SK, Lee WJ: Left ventricular filling in young normotensive obese adults. Am J Cardiol 1994; 73: 613-615.
    • (1994) Am J Cardiol , vol.73 , pp. 613-615
    • Ku, C.S.1    Lin, S.L.2    Wang, D.J.3    Chang, S.K.4    Lee, W.J.5
  • 12
    • 0022652560 scopus 로고
    • Cardiopathy of obesity - A not-so-Victorian disease
    • Messerli FH: Cardiopathy of obesity - a not-so-Victorian disease. N Engl J Med 1986; 314: 378-380.
    • (1986) N Engl J Med , vol.314 , pp. 378-380
    • Messerli, F.H.1
  • 13
    • 67549148805 scopus 로고    scopus 로고
    • Disparate effects of obesity and left ventricular geometry on mortality in 8088 elderly patients with preserved systolic function
    • Lavie CJ, Milani RV, Patel D, Artham SM, Ventura HO: Disparate effects of obesity and left ventricular geometry on mortality in 8088 elderly patients with preserved systolic function. Postgrad Med 2009; 121: 119-125.
    • (2009) Postgrad Med , vol.121 , pp. 119-125
    • Lavie, C.J.1    Milani, R.V.2    Patel, D.3    Artham, S.M.4    Ventura, H.O.5
  • 19
    • 31344444358 scopus 로고    scopus 로고
    • Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes
    • Madani S, De Girolamo S, Munoz DM, Li RK, Sweeney G: Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc Res 2006; 69: 716-725.
    • (2006) Cardiovasc Res , vol.69 , pp. 716-725
    • Madani, S.1    De Girolamo, S.2    Munoz, D.M.3    Li, R.K.4    Sweeney, G.5
  • 20
    • 0041857804 scopus 로고    scopus 로고
    • The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes
    • Rajapurohitam V, Gan XT, Kirshenbaum LA, Karmazyn M: The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ Res 2003; 93: 277-279.
    • (2003) Circ Res , vol.93 , pp. 277-279
    • Rajapurohitam, V.1    Gan, X.T.2    Kirshenbaum, L.A.3    Karmazyn, M.4
  • 21
    • 1642464978 scopus 로고    scopus 로고
    • Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways
    • Tajmir P, Ceddia RB, Li RK, Coe IR, Sweeney G: Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways. Endocrinology 2004; 145: 1550-1555.
    • (2004) Endocrinology , vol.145 , pp. 1550-1555
    • Tajmir, P.1    Ceddia, R.B.2    Li, R.K.3    Coe, I.R.4    Sweeney, G.5
  • 23
    • 33748130863 scopus 로고    scopus 로고
    • Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes
    • Zeidan A, Javadov S, Karmazyn M: Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes. Cardiovasc Res 2006; 72: 101-111.
    • (2006) Cardiovasc Res , vol.72 , pp. 101-111
    • Zeidan, A.1    Javadov, S.2    Karmazyn, M.3
  • 24
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks AS, Davis SM, Bates SH, Myers MG, Jr.: Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000; 275: 14563-14572.
    • (2000) J Biol Chem , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers, M.G.4
  • 25
    • 0030956390 scopus 로고    scopus 로고
    • The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
    • Ghilardi N, Skoda RC: The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol 1997; 11: 393-399.
    • (1997) Mol Endocrinol , vol.11 , pp. 393-399
    • Ghilardi, N.1    Skoda, R.C.2
  • 26
    • 23044463589 scopus 로고    scopus 로고
    • Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: A potential role for leptin in mediating human left ventricular hypertrophy
    • Perego L, Pizzocri P, Corradi D, Maisano F, Paganelli M, Fiorina P, Barbieri M, Morabito A, Paolisso G, Folli F, Pontiroli AE: Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. J Clin Endocrinol Metab 2005; 90: 4087-4093.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4087-4093
    • Perego, L.1    Pizzocri, P.2    Corradi, D.3    Maisano, F.4    Paganelli, M.5    Fiorina, P.6    Barbieri, M.7    Morabito, A.8    Paolisso, G.9    Folli, F.10    Pontiroli, A.E.11
  • 27
    • 0030069728 scopus 로고    scopus 로고
    • Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation
    • Cittadini A, Stromer H, Katz SE, Clark R, Moses AC, Morgan JP, Douglas PS: Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. Circulation 1996; 93: 800-809.
    • (1996) Circulation , vol.93 , pp. 800-809
    • Cittadini, A.1    Stromer, H.2    Katz, S.E.3    Clark, R.4    Moses, A.C.5    Morgan, J.P.6    Douglas, P.S.7
  • 28
    • 31544480404 scopus 로고    scopus 로고
    • Cardiovascular mortality in overweight subjects: The key role of associated risk factors
    • Thomas F, Bean K, Pannier B, Oppert JM, Guize L, Benetos A: Cardiovascular mortality in overweight subjects: the key role of associated risk factors. Hypertension 2005; 46: 654-659.
    • (2005) Hypertension , vol.46 , pp. 654-659
    • Thomas, F.1    Bean, K.2    Pannier, B.3    Oppert, J.M.4    Guize, L.5    Benetos, A.6
  • 30
    • 84855838162 scopus 로고    scopus 로고
    • Prevalence of obesity and the relationship between the body mass index and body fat: Cross-sectional, population-based data
    • Pasco JA, Nicholson GC, Brennan SL, Kotowicz MA: Prevalence of obesity and the relationship between the body mass index and body fat: cross-sectional, population-based data. PLoS One 2012; 7:e29580.
    • (2012) PLoS One , vol.7
    • Pasco, J.A.1    Nicholson, G.C.2    Brennan, S.L.3    Kotowicz, M.A.4
  • 32
    • 54949108283 scopus 로고    scopus 로고
    • Impact of left ventricular geometry on prognosis in hypertensive patients with left ventricular hypertrophy (the Life Study)
    • Gerdts E, Cramariuc D, de Simone G, Wachtell K, Dahlof B, Devereux RB: Impact of left ventricular geometry on prognosis in hypertensive patients with left ventricular hypertrophy (the Life Study). Eur J Echocardiogr 2008; 9: 809-815.
    • (2008) Eur J Echocardiogr , vol.9 , pp. 809-815
    • Gerdts, E.1    Cramariuc, D.2    De Simone, G.3    Wachtell, K.4    Dahlof, B.5    Devereux, R.B.6
  • 33
    • 0028904509 scopus 로고
    • Prognosis of left ventricular geometric patterns in the Framingham Heart Study
    • Krumholz HM, Larson M, Levy D: Prognosis of left ventricular geometric patterns in the Framingham Heart Study. J Am Coll Cardiol 1995; 25: 879-884.
    • (1995) J Am Coll Cardiol , vol.25 , pp. 879-884
    • Krumholz, H.M.1    Larson, M.2    Levy, D.3
  • 34
    • 0029147359 scopus 로고
    • Left ventricular hypertrophy has a greater impact on survival in women than in men
    • Liao Y, Cooper RS, Mensah GA, McGee DL: Left ventricular hypertrophy has a greater impact on survival in women than in men. Circulation 1995; 92: 805-810.
    • (1995) Circulation , vol.92 , pp. 805-810
    • Liao, Y.1    Cooper, R.S.2    Mensah, G.A.3    McGee, D.L.4
  • 35
    • 33745148603 scopus 로고    scopus 로고
    • Association of obesity with left ventricular remodeling and diastolic dysfunction in patients without coronary artery disease
    • Powell BD, Redfield MM, Bybee KA, Freeman WK, Rihal CS: Association of obesity with left ventricular remodeling and diastolic dysfunction in patients without coronary artery disease. Am J Cardiol 2006; 98: 116-120.
    • (2006) Am J Cardiol , vol.98 , pp. 116-120
    • Powell, B.D.1    Redfield, M.M.2    Bybee, K.A.3    Freeman, W.K.4    Rihal, C.S.5
  • 40
    • 66149192687 scopus 로고    scopus 로고
    • Perils of weight loss: The advantage of being obese in patients with heart failure
    • Kydd A, Pugh PJ: Perils of weight loss: the advantage of being obese in patients with heart failure. Expert Rev Cardiovasc Ther 2009; 7: 263-267.
    • (2009) Expert Rev Cardiovasc Ther , vol.7 , pp. 263-267
    • Kydd, A.1    Pugh, P.J.2
  • 42
    • 0037161363 scopus 로고    scopus 로고
    • Mitral ratio of peak early to late diastolic filling velocity as a predictor of mortality in middle-aged and elderly adults: The Strong Heart Study
    • Bella JN, Palmieri V, Roman MJ, Liu JE, Welty TK, Lee ET, Fabsitz RR, Howard BV, Devereux RB: Mitral ratio of peak early to late diastolic filling velocity as a predictor of mortality in middle-aged and elderly adults: the Strong Heart Study. Circulation 2002; 105: 1928-1933.
    • (2002) Circulation , vol.105 , pp. 1928-1933
    • Bella, J.N.1    Palmieri, V.2    Roman, M.J.3    Liu, J.E.4    Welty, T.K.5    Lee, E.T.6    Fabsitz, R.R.7    Howard, B.V.8    Devereux, R.B.9
  • 45
    • 1942420839 scopus 로고    scopus 로고
    • Alterations in left ventricular structure and function in young healthy obese women: Assessment by echocardiography and tissue doppler imaging
    • Peterson LR, Waggoner AD, Schechtman KB, Meyer T, Gropler RJ, Barzilai B, Davila-Roman VG: Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue doppler imaging. J Am Coll Cardiol 2004; 43: 1399-1404.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1399-1404
    • Peterson, L.R.1    Waggoner, A.D.2    Schechtman, K.B.3    Meyer, T.4    Gropler, R.J.5    Barzilai, B.6    Davila-Roman, V.G.7
  • 47
    • 79952674321 scopus 로고    scopus 로고
    • Effect of obesity and overweight on left ventricular diastolic function: A community-based study in an elderly cohort
    • Russo C, Jin Z, Homma S, Rundek T, Elkind MS, Sacco RL, Di Tullio MR: Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort. J Am Coll Cardiol 2011; 57: 1368-1374.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 1368-1374
    • Russo, C.1    Jin, Z.2    Homma, S.3    Rundek, T.4    Elkind, M.S.5    Sacco, R.L.6    Di Tullio, M.R.7
  • 49
    • 33646231760 scopus 로고    scopus 로고
    • Current perspectives in diastolic dysfunction and diastolic heart failure
    • Leite-Moreira AF: Current perspectives in diastolic dysfunction and diastolic heart failure. Heart 2006; 92: 712-718.
    • (2006) Heart , vol.92 , pp. 712-718
    • Leite-Moreira, A.F.1
  • 50
    • 34548848059 scopus 로고    scopus 로고
    • Mito-chondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    • Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED: Mito-chondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 2007; 56: 2457-2466.
    • (2007) Diabetes , vol.56 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3    Sheng, X.4    Wright, J.J.5    Hu, X.X.6    Aziz, S.7    Johnson, J.I.8    Bugger, H.9    Zaha, V.G.10    Abel, E.D.11
  • 51
    • 27444441492 scopus 로고    scopus 로고
    • Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity
    • Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED: Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation 2005; 112: 2686-2695.
    • (2005) Circulation , vol.112 , pp. 2686-2695
    • Boudina, S.1    Sena, S.2    O'Neill, B.T.3    Tathireddy, P.4    Young, M.E.5    Abel, E.D.6
  • 54
    • 0038488294 scopus 로고    scopus 로고
    • Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus
    • Diamant M, Lamb HJ, Groeneveld Y, Endert EL, Smit JW, Bax JJ, Romijn JA, de Roos A, Radder JK: Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol 2003; 42: 328-335.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 328-335
    • Diamant, M.1    Lamb, H.J.2    Groeneveld, Y.3    Endert, E.L.4    Smit, J.W.5    Bax, J.J.6    Romijn, J.A.7    De Roos, A.8    Radder, J.K.9
  • 55
    • 77749264608 scopus 로고    scopus 로고
    • ATP consumption by sarcoplasmic reticulum Ca2+ pumps accounts for 50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle
    • Norris SM, Bombardier E, Smith IC, Vigna C, Tupling AR: ATP consumption by sarcoplasmic reticulum Ca2+ pumps accounts for 50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle. Am J Physiol Cell Physiol 2010; 298:C521-529.
    • (2010) Am J Physiol Cell Physiol , vol.298 , pp. C521-529
    • Norris, S.M.1    Bombardier, E.2    Smith, I.C.3    Vigna, C.4    Tupling, A.R.5
  • 56
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart - An engine out of fuel
    • Neubauer S: The failing heart - an engine out of fuel. N Engl J Med 2007; 356: 1140-1151.
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 59
    • 0015191784 scopus 로고
    • Substrate utilization and glycolysis in the heart
    • Opie LH: Substrate utilization and glycolysis in the heart. Cardiology 1971; 56: 2-21.
    • (1971) Cardiology , vol.56 , pp. 2-21
    • Opie, L.H.1
  • 60
    • 0034625061 scopus 로고    scopus 로고
    • Increased diastolic chamber stiffness during demand ischemia: Response to quick length change differentiates rigor-activated from calcium-activated tension
    • Varma N, Eberli FR, Apstein CS: Increased diastolic chamber stiffness during demand ischemia: response to quick length change differentiates rigor-activated from calcium-activated tension. Circulation 2000; 101: 2185-2192.
    • (2000) Circulation , vol.101 , pp. 2185-2192
    • Varma, N.1    Eberli, F.R.2    Apstein, C.S.3
  • 61
    • 0031036553 scopus 로고    scopus 로고
    • Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions
    • Stanley WC, Lopaschuk GD, Hall JL, McCormack JG: Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res 1997; 33: 243-257.
    • (1997) Cardiovasc Res , vol.33 , pp. 243-257
    • Stanley, W.C.1    Lopaschuk, G.D.2    Hall, J.L.3    McCormack, J.G.4
  • 62
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD: Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005; 85: 1093-1129.
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 63
    • 0025312933 scopus 로고
    • Effects of acute hyperglycemia on myocardial glycolytic activity in humans
    • Wisneski JA, Stanley WC, Neese RA, Gertz EW: Effects of acute hyperglycemia on myocardial glycolytic activity in humans. J Clin Invest 1990; 85: 1648-1656.
    • (1990) J Clin Invest , vol.85 , pp. 1648-1656
    • Wisneski, J.A.1    Stanley, W.C.2    Neese, R.A.3    Gertz, E.W.4
  • 64
    • 3042711537 scopus 로고    scopus 로고
    • Linking gene expression to function: Metabolic flexibility in the normal and diseased heart
    • Taegtmeyer H, Golfman L, Sharma S, Razeghi P, van Arsdall M: Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann N Y Acad Sci 2004; 1015: 202-213.
    • (2004) Ann N y Acad Sci , vol.1015 , pp. 202-213
    • Taegtmeyer, H.1    Golfman, L.2    Sharma, S.3    Razeghi, P.4    Van Arsdall, M.5
  • 65
    • 0024342002 scopus 로고
    • Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats
    • Wall SR, Lopaschuk GD: Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats. Biochim Biophys Acta 1989; 1006: 97-103.
    • (1989) Biochim Biophys Acta , vol.1006 , pp. 97-103
    • Wall, S.R.1    Lopaschuk, G.D.2
  • 67
    • 50449119332 scopus 로고
    • Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism
    • Bing RJ, Siegel A, Ungar I, Gilbert M: Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism. Am J Med 1954; 16: 504-515.
    • (1954) Am J Med , vol.16 , pp. 504-515
    • Bing, R.J.1    Siegel, A.2    Ungar, I.3    Gilbert, M.4
  • 68
    • 33745784213 scopus 로고    scopus 로고
    • Thematic review series: Patient-oriented research. Free fatty acid metabolism in human obesity
    • Koutsari C, Jensen MD: Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity. J Lipid Res 2006; 47: 1643-1650.
    • (2006) J Lipid Res , vol.47 , pp. 1643-1650
    • Koutsari, C.1    Jensen, M.D.2
  • 70
    • 0026076713 scopus 로고
    • Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat
    • Lopaschuk GD, Russell JC: Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat. J Appl Physiol 1991; 71: 1302-1308.
    • (1991) J Appl Physiol , vol.71 , pp. 1302-1308
    • Lopaschuk, G.D.1    Russell, J.C.2
  • 71
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech RL: The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostag Leukotr Ess 2004; 70: 309-319.
    • (2004) Prostag Leukotr Ess , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 73
    • 0036879012 scopus 로고    scopus 로고
    • The energetics of ion distribution: The origin of the resting electric potential of cells
    • Veech RL, Kashiwaya Y, Gates DN, King MT, Clarke K: The energetics of ion distribution: The origin of the resting electric potential of cells. IUBMB Life 2002; 54: 241-252.
    • (2002) IUBMB Life , vol.54 , pp. 241-252
    • Veech, R.L.1    Kashiwaya, Y.2    Gates, D.N.3    King, M.T.4    Clarke, K.5
  • 74
    • 0034095332 scopus 로고    scopus 로고
    • Myocardial substrate metabolism influences left ventricular energetics in vivo
    • Korvald C, Elvenes OP, Myrmel T: Myocardial substrate metabolism influences left ventricular energetics in vivo. Am J Physiol Heart C 2000; 278:H1345-H1351.
    • (2000) Am J Physiol Heart C , vol.278 , pp. H1345-H1351
    • Korvald, C.1    Elvenes, O.P.2    Myrmel, T.3
  • 78
    • 34147136152 scopus 로고    scopus 로고
    • Relationship of mitochondrial DNA depletion and respiratory chain activity in preadipocytes treated with nucleoside reverse transcriptase inhibitors
    • Stankov MV, Lucke T, Das AM, Schmidt RE, Behrens GM: Relationship of mitochondrial DNA depletion and respiratory chain activity in preadipocytes treated with nucleoside reverse transcriptase inhibitors. Antivir Ther 2007; 12: 205-216.
    • (2007) Antivir Ther , vol.12 , pp. 205-216
    • Stankov, M.V.1    Lucke, T.2    Das, A.M.3    Schmidt, R.E.4    Behrens, G.M.5
  • 79
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger J, Moller DE: The mechanisms of action of PPARs. Annu Rev Med 2002; 53: 409-435.
    • (2002) Annu Rev Med , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 81
    • 0034467428 scopus 로고    scopus 로고
    • PPAR signaling in the control of cardiac energy metabolism
    • Barger PM, Kelly DP: PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med 2000; 10: 238-245.
    • (2000) Trends Cardiovasc Med , vol.10 , pp. 238-245
    • Barger, P.M.1    Kelly, D.P.2
  • 82
    • 0032479423 scopus 로고    scopus 로고
    • Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
    • Motojima K, Passilly P, Peters JM, Gonzalez FJ, Latruffe N: Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem 1998; 273: 16710-16714.
    • (1998) J Biol Chem , vol.273 , pp. 16710-16714
    • Motojima, K.1    Passilly, P.2    Peters, J.M.3    Gonzalez, F.J.4    Latruffe, N.5
  • 88
    • 0037117651 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part II: Potential mechanisms
    • Young ME, McNulty P, Taegtmeyer H: Adaptation and maladaptation of the heart in diabetes: part II: potential mechanisms. Circulation 2002; 105: 1861-1870.
    • (2002) Circulation , vol.105 , pp. 1861-1870
    • Young, M.E.1    McNulty, P.2    Taegtmeyer, H.3
  • 89
    • 0037046203 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part I: General concepts
    • Taegtmeyer H, McNulty P, Young ME: Adaptation and maladaptation of the heart in diabetes: part I: general concepts. Circulation 2002; 105: 1727-1733.
    • (2002) Circulation , vol.105 , pp. 1727-1733
    • Taegtmeyer, H.1    McNulty, P.2    Young, M.E.3
  • 90
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
    • Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW, Kelly DP: A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A 2003; 100: 1226-1231.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3    Aimond, F.4    Nerbonne, J.M.5    Kovacs, A.6    Gross, R.W.7    Kelly, D.P.8
  • 91
    • 77950788493 scopus 로고    scopus 로고
    • Shedding light on the enigma of myocardial lipotox-icity: The involvement of known and putative regulators of fatty acid storage and mobilization
    • Brindley DN, Kok BP, Kienesberger PC, Lehner R, Dyck JR: Shedding light on the enigma of myocardial lipotox-icity: the involvement of known and putative regulators of fatty acid storage and mobilization. Am J Physiol Endocrinol Metab 2010; 298:E897-908.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E897-908
    • Brindley, D.N.1    Kok, B.P.2    Kienesberger, P.C.3    Lehner, R.4    Dyck, J.R.5
  • 95
    • 0037298589 scopus 로고    scopus 로고
    • Comparison of aortic elasticity determined by cardiovascular magnetic resonance imaging in obese versus lean adults
    • Danias PG, Tritos NA, Stuber M, Botnar RM, Kissinger KV, Manning WJ: Comparison of aortic elasticity determined by cardiovascular magnetic resonance imaging in obese versus lean adults. Am J Cardiol 2003; 91: 195-199.
    • (2003) Am J Cardiol , vol.91 , pp. 195-199
    • Danias, P.G.1    Tritos, N.A.2    Stuber, M.3    Botnar, R.M.4    Kissinger, K.V.5    Manning, W.J.6
  • 97
    • 33747135139 scopus 로고    scopus 로고
    • Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta
    • Edirisinghe I, McCormick Hallam K, Kappagoda CT: Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta. Clin Sci (Lond) 2006; 111: 145-151.
    • (2006) Clin Sci (Lond) , vol.111 , pp. 145-151
    • Edirisinghe, I.1    McCormick Hallam, K.2    Kappagoda, C.T.3
  • 98
    • 84863636004 scopus 로고    scopus 로고
    • Increasing plasma free fatty acids in healthy subjects induces aortic distensibility changes seen in obesity
    • Rider OJ, Holloway CJ, Emmanuel Y, Bloch E, Clarke K, Neubauer S: Increasing plasma free fatty acids in healthy subjects induces aortic distensibility changes seen in obesity. Circ Cardiovasc Imaging 2012; 5: 367-375.
    • (2012) Circ Cardiovasc Imaging , vol.5 , pp. 367-375
    • Rider, O.J.1    Holloway, C.J.2    Emmanuel, Y.3    Bloch, E.4    Clarke, K.5    Neubauer, S.6
  • 100
    • 4143075821 scopus 로고    scopus 로고
    • The impact of weight reduction surgery on health-care costs in morbidly obese patients
    • Sampalis JS, Liberman M, Auger S, Christou NV: The impact of weight reduction surgery on health-care costs in morbidly obese patients. Obes Surg 2004;14: 939-947.
    • (2004) Obes Surg , vol.14 , pp. 939-947
    • Sampalis, J.S.1    Liberman, M.2    Auger, S.3    Christou, N.V.4
  • 102
    • 77955351686 scopus 로고    scopus 로고
    • Effects of weight loss on ventricular systolic and diastolic functions and left ventricular mass assessed by tissue doppler imaging in obese geriatric women: Preliminary report
    • Varli M, Turhan S, Aras S, Atli T, Erdogan G: Effects of weight loss on ventricular systolic and diastolic functions and left ventricular mass assessed by tissue doppler imaging in obese geriatric women: preliminary report. Aging Clin Exp Res 2010; 22: 206-211.
    • (2010) Aging Clin Exp Res , vol.22 , pp. 206-211
    • Varli, M.1    Turhan, S.2    Aras, S.3    Atli, T.4    Erdogan, G.5
  • 104
    • 70349880708 scopus 로고    scopus 로고
    • Improvement of left ventricular function by lifestyle intervention in obesity: Contributions of weight loss and reduced insulin resistance
    • Kosmala W, O'Moore-Sullivan T, Plaksej R, Przewlocka-Kosmala M, Marwick TH: Improvement of left ventricular function by lifestyle intervention in obesity: Contributions of weight loss and reduced insulin resistance. Diabetologia 2009; 52: 2306-2316.
    • (2009) Diabetologia , vol.52 , pp. 2306-2316
    • Kosmala, W.1    O'Moore-Sullivan, T.2    Plaksej, R.3    Przewlocka-Kosmala, M.4    Marwick, T.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.