Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat: A combined in vivo and in vitro evaluation

Circulation

Volumn 93, Issue 4, 1996, Pages 800-809

  Cittadini, Antonio ^a   Strömer, Hinrik ^a   Katz, Sarah E ^a   Clark, Ross ^b   Moses, Alan C ^a   Morgan, James P ^a   Douglas, Pamela S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b GENENTECH INC   (United States)

Author keywords

cardiac function; growth factors; ventricular hypertrophy

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HEART FUNCTION; HEART HYPERTROPHY; HEART PERFORMANCE; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030069728     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.93.4.800     Document Type: Article

References (53)

1. Thornar MO, Vance ML, Horvath E, Kovacs K. The anterior pituitary. In: Wilson JD, Foster DW, eds. Williams' Textbook of Endocrinology. 8th ed. Philadelphia, Pa: WB Saunders; 1992: 221-310.
2. Rosen T, Bengtsson B-A. Premature cardiovascular mortality in hypopituitarism: a study of 333 consecutive patients. Lancet. 1990; 336:285-288.
3. Fazio S, Cittadini A, Sabatini D, Merola B, Colao AM, Biondi B, Lombardi G, Saccà L. Evidence for biventricular involvement in acromegaly: a Doppler echocardiographic study. Eur Heart J. 1993; 14:26-33.
4. Fazio S, Cittadini A, Cuocolo A, Merola B, Sabatini D, Colao A, Biondi B, Lombardi G, Saccà L. Impaired cardiac performance is a distinct feature of uncomplicated acromegaly. J Clin Endocrinol Metab. 1994;79:441-446.
5. Cittadini A, Cuocolo A, Merola B, Fazio S, Sabatini D, Nicolai E, Colao A, Longobardi S, Lombardi G, Saccà L. Impairment of cardiac performance in adult growth-hormone deficiency. Am J Physiol. 1994;267:E219-E225.
6. Merola B, Cittadini A, Colao A, Fazio S, Longobardi S, Sabatini D, Saccà L, Lombardi G. Cardiac structural and functional abnormalities in GH-deficient adults. J Clin Endocrinol Metab. 1993;77: 1658-1661.
7. Merola B, Cittadini A, Colao A, Ferone D, Fazio S, Sabatini D, Biondi B, Saccà L, Lombardi G. Chronic treatment with the somatostatin analog octreotide improves cardiac abnormalities in patients with acromegaly. J Clin Endocrinol Metab. 1993;77:790-793.
8. Amato G, Carella C, Fazio S, La Montagna G, Cittadini A, Sabatini D, Marciano-Moni L, Saccà L, Bellastella A. Body composition, bone metabolism, heart structure and function in growth hormone deficient adults before and after growth hormone replacement therapy at low doses. J Clin Endocrinol Metab. 1993;77:1671-1676.
9. Penney DG, Dunbar JC, Baylerian MS. Cardiomegaly and hemodynamics in rats with a transplantable growth hormone-secreting tumor. Cardiovasc Res. 1985;19:270-277.
10. Rubin SA, Buttrick P, Malhotra A, Melmed S, Fishbein MC. Cardiac physiology, biochemistry and morphology in response to excess growth hormone in the rat. J Mol Cell Cardiol. 1990;22: 429-438.
11. Ito H, Hiroe M, Hirata Y, Tsujino M, Adachi S, Schichiri M, Koike A, Nogami A, Marumo F. Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes. Circulation. 1993;87:1715-1721.
12. Hanson MC, Kenneth AF, Alexander RW, DeLafontaine P. Induction of cardiac insulin-like growth factor I gene expression in pressure overload hypertrophy. Am J Med Sci. 1993;306:69-74.
13. Donohue TJ, Lance DD, Lango MN, Fliegner K, Lango RP, Benstein JA, Slater WR, Catanese VM. Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy. Circulation. 1994;89:799-809.
14. Isgaard J, Wählander H, Adams MA, Friberg P. Increased expression of growth receptor mRNA and insulin-like growth factor-I mRNA in volume overloaded hearts. Hypertension. 1994;23(pt 2):884-888.
15. Bondy CA, Underwood LE, Clemmons DR, Guler H-P, Bach MA, Skarulis M. Clinical uses of insulin-like growth factor-I. Ann Intern Med. 1994;120:593-601.
16. Litwin SE, Katz SE, Morgan JP, Douglas PS. Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat. Circulation. 1994;89:345-354.
17. Sahn DJ, DeMaria A, Kisslo J, Weyman A, the Committee on M-Mode Standardization of the American Society of Echocardiography. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58:1072-1083.
18. Devereux RB. Detection of left ventricular hypertrophy by M-mode echocardiography: anatomic validation, standardization, and comparison to other methods. Hypertension. 1987;9:19-26.
19. Weyman AE. Cross-Sectional Echocardiography. Philadelphia, Pa: Lea & Febiger; 1982:283-297.
20. de Simone G, Wallerson DC, Volpe M, Devereux RB. Echocardiographic measurements of left ventricular mass and volume in normotensive and hypertensive rats: necropsy validation. Am J Hypertens. 1990;3:688-696.
21. Grossman W. Evaluation of systolic and diastolic function of the myocardium. In: Grossman W, Baim DS, eds. Cardiac Catheterization, Angiography and Intervention. Ed. 4. Philadelphia, Pa/London, UK: Lea & Febiger; 1991:319-339.
22. Douglas PS, Reichek N. Estimation of wall stress and left ventricular mass by noninvasive techniques and clinical implications. Cardiovasc Clin. 1986;17:103-128.
23. 2+ modulation during postischemic reperfusion in rat heart. Am J Physiol. 1995;268:H100-H111.
24. Apstein CS, Deckelbaum L, Mueller M, Hagopian L, Hood WB. Graded global ischemia and reperfusion: cardiac function and lactate metabolism. Circulation. 1977;55:864-872.
25. Feldman AM, Weinberg EO, Ray PE, Lorell BH. Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding. Circ Res. 1993;73:184-]92.
26. Albini CH, Sotos J, Sherman B, Johanson A, Celniker A, Hopwood N, Quattrin T, Mills BJ, MacGillivray M. Diagnostic significance of urinary growth hormone measurements in children with growth failure: correlation between serum and urine growth hormone. Pediatr Res. 1991;29:619-622.
27. Lieberman SA, Bukar J, Chen SA, Celniker AC, Compton PG, Cook J, Albu J, Perlman AJ, Hoffman AR. Effects of recombinant human insulin-like growth factor-1 (rhIGF-1) on total free IGF-1 concentrations, IGF-binding proteins, and glycemic response in humans. J Clin Endocrinol Metab. 1992;75:30-36.
28. Douglas PS, Tallant B. Hypertrophy, fibrosis and diastolic dysfunction in early canine experimental hypertension. J Am Coll Cardiol. 1991;17:530-536.
29. Yin RC, Spurgeon HA, Rakusan K, Weisfeldt ML, Lakatta EG. Use of tibial length to quantify cardiac hypertrophy: application in the aging rat. Am J Physiol. 1982;243:H941-H947.
30. Saccà L, Cittadini A, Fazio S. Growth hormone and the heart. Endocr Rev. 1994;15:555-573.
31. Karmazyn M, Daly MJ, Moffat MP, Dhalla NS. A possible mechanism of inotropic action of prolactin on rat heart. Am J Physiol. 1982;243:E458-E463.
32. Caidahl K, Eden S, Bengtsson B-A. Cardiovascular and renal effects of growth hormone. Clin Endocrinol. 1994;40:393-400.
33. Thuesen L, Christiansen JS, Sorensen KE, Jorgensen JOL, Orskov H, Henningsen P. Increased myocardial contractility following growth hormone administration in normal man. Danish Med Bull. 1988;35:193-196.
34. Kiowski W, Stochitzky K, Kim JH, Hussain MA, Froesch ER. Insulin-like growth factor-I causes endothelium-dependent arterial vasodilation. Circulation. 1994;90(suppl I):I-242. Abstract.
35. Jabri N, Scalch DS, Schwartz SL, Fischer JS, Kipnes MS, Radnik BJ, Turman NJ, Marcsisin VS, Guler H-S. Adverse effects of recombinant human insulin-like growth factor I in obese insulin-resistant type II diabetic patients. Diabetes. 1994;43:369-374.
36. Rosen HN, Chen V, Cittadini A, Moses AC, Greenspan SL, Douglas PS, Beamer WG. Treatment with GH and IGF-1 in growing rats increases bone mineral content but not bone mineral density. J Bone Miner Res. 1995;10:1352-1358.
37. Fong Y, Rosenbaum M, Tracey KJ, Raman G, Hesse DG, Matthews DE, Leibel RL, Gertner JM, Fischman DA, Lowry SF. Recombinant growth hormone enhances muscle myosin heavy-chain mRNA accumulation and amino acid accrual in humans. Proc Natl Acad Sci U S A. 1989;86:3371-3374.
38. Hjalmarson A, Isaksson O, Ahren K. Effects of growth hormone and insulin on amino acid transport in perfused heart rat. Am J Physiol. 1969;217:1795-1802.
39. Mathews LS, Enberg B, Norstedt G. Regulation of rat growth hormone receptor gene expression. J Biol Chem. 1989;17: 9905-9910.
40. Shahi M, Beshyah SA, Hackett D, Sharp PS, Johnston DG, Foale RA. Myocardial dysfunction in treated hypopitutarism: a possible explanation for increased cardiovascular mortality. Br Heart J. 1992; 67:92-96.
41. Engelmann GL, Boehm KD, Haskell JF, Khairallah PA, Ilan J. Insulin-like growth factors and neonatal cardiomyocyte development: ventricular gene expression and membrane receptor variations in normotensive and hypertensive rats. Mol Cell Endocrinol. 1989;63:1-14.
42. Scheuer J, Buttrick P. The cardiac hypertrophic response to pathologic and physiologic loads. Circulation. 1987;75(suppl I):I-63-I-68.
43. Gilbert PL, Siegel RJ, Melmed S, Sherman CT, Fishbein MC. Cardiac morphology in rats with growth hormone-producing tumors. J Mol Cell Cardiol. 1985;17:805-811.
44. + current in ventricular myocytes from acromegalic rats. Am J Physiol. 1991;260: H935-H942.
45. Mayoux E, Ventura-Clapier R, Timsit J, Bèhar-Cohen Hoffmann C, Mercadier J-J. Mechanical properties of rat cardiac skinned fibers are altered by chronic growth hormone hypersecretion. Circ Res. 1993;72:57-64.
46. Strömer H, Cittadini A, Douglas PS, Morgan JP. Exogeneously administered growth hormone and IGF-1 alter intracellular calcium handling and enhance cardiac performance. J Am Coll Cardiol. 1995;February special issue:282A. Abstract.
47. Timsit J, Riou B, Bertherat J, Wisnewsky C, Kato NS, Weisberg AS, Lubetzki J, Lecarpentier Y, Winegrad S, Mercadier JJ. Effect of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle. J Clin Invest. 1990;86:507-515.
48. Sasson Z, Rasooly Y, Blesania T, Rasooly I. Insulin resistance is an important determinant of left ventricular mass in the obese. Circulation. 1993;88:1431-1436.
49. Sechen SJ, Dunshea FR, Bauman DE. Somatotropin in lactating cows: effect on response to epinephrine and insulin. Am J Physiol. 1990;258:E582-E588.
50. Beauville M, Harant I, Crampes F, Riviere D, Tauber MT, Gariigues M. Effect of long-term rhGH administration in GH-deficient adults on fat cell epinephrine response. Am J Physiol. 1992;263:E467-E472.
51. Castagnino HE, Toranzos FA, Milei J, Weiss V, Beigelman R, Sarchi MI, Bordaneve CA, Azcoaga R. Preservation of the myocardial collagen framework by human growth hormone in experimental infarctions and reduction in the incidence of ventricular aneurysms. Int J Cardiol. 1992;35:101-114.
52. Ambler GR, Johnston BM, Maxwell L, Gavin JB, Gluckman PD. Improvement of doxorubicin induced cardiomyopathy in rats treated with insulin-like growth factor I. Cardiovasc Res. 1993;27: 1368-1373.
53. Duerr RL, Huang S, Miraliakbar HR, Clark R, Chien KR, Ross J Jr. Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J Clin Invest. 1995;95:619-627.