X-Linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Jain, Neeraj ^a   Tan, Jun Hou ^a   Feng, Shijin ^a   George, Bhawana ^a   Thanabalu, Thirumaran ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Actin cytoskeleton; Cell migration; Cell polarity; Hematopoietic cell kinase; Proteosome

Indexed keywords

CALPAIN; SHORT HAIRPIN RNA; STROMAL CELL DERIVED FACTOR 1ALPHA; WISKOTT ALDRICH SYNDROME PROTEIN; CXCL12 PROTEIN, HUMAN; STROMAL CELL DERIVED FACTOR 1; WAS PROTEIN, HUMAN;

ARTICLE; CHEMOTAXIS; GENE EXPRESSION; GENE SILENCING; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; JURKAT CELL LINE; LYMPHOCYTE MIGRATION; MISSENSE MUTATION; MUTANT; MUTATIONAL ANALYSIS; POLARIZATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; T LYMPHOCYTE; THROMBOCYTOPENIA; X CHROMOSOME LINKED DISORDER; X LINKED THROMBOCYTOPENIA; AMINO ACID SUBSTITUTION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

AMINO ACID SUBSTITUTION; CHEMOKINE CXCL12; CHEMOTAXIS; GENETIC DISEASES, X-LINKED; HUMANS; JURKAT CELLS; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEOLYSIS; T-LYMPHOCYTES; THROMBOCYTOPENIA; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 84908177569     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-014-0091-1     Document Type: Article

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