α-Melanocyte-stimulating hormone: A protective peptide against chemotherapy-induced hair follicle damage?

British Journal of Dermatology

Volumn 170, Issue 4, 2014, Pages 956-960

  Bohm M ^a   Bodo E ^b,c   Funk, W ^d   Paus, R ^b,e  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c Department of Agricultural Sciences and Environmental Management   (Hungary)

^d Klinik Dr Kozlowski   (Germany)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; HEME OXYGENASE 1; MELANIN; PERFOSFAMIDE; 4-HYDROPEROXYDECHLOROCYCLOPHOSPHAMIDE; ALKYLATING AGENT; CYCLOPHOSPHAMIDE; HORMONE;

ADULT; ALOPECIA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMOTHERAPY INDUCED ALOPECIA; CONTROLLED STUDY; EXPLORATORY RESEARCH; FEMALE; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; KERATINOCYTE; NORMAL HUMAN; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCALP; ANALOGS AND DERIVATIVES; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MIDDLE AGED;

ALOPECIA; ALPHA-MSH; ANTINEOPLASTIC AGENTS, ALKYLATING; CELLS, CULTURED; CYCLOPHOSPHAMIDE; FEMALE; HAIR FOLLICLE; HEME OXYGENASE-1; HORMONES; HUMANS; MIDDLE AGED;

EID: 84908172859     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.12759     Document Type: Article

References (25)

1. McGarvey EL, Pinkerton RC, Rogers LM, et al,. Psychological sequelae and alopecia among women with cancer. Cancer Pract 2001; 9: 283-9.
2. Trueb RM,. Chemotherapy-induced alopecia. Semin Cutan Med Surg 2009; 28: 11-14.
3. Chon SY, Champion RW, Geddes ER, et al,. Chemotherapy-induced alopecia. J Am Acad Dermatol 2012; 67: 37-47.
4. Bodo E, Tobin DJ, Kamenisch Y, et al,. Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. Am J Pathol 2007; 171: 1153-67.
5. Bodo E, Kromminga A, Biro T, et al,. Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone. J Invest Dermatol 2009; 129: 1126-39.
6. Ito N, Ito T, Kromminga A, et al,. Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J 2005; 19: 1332-4.
7. Tobin DJ,. The cell biology of human hair follicle pigmentation. Pigment Cell Melanoma Res 2011; 24: 75-88.
8. Paus R,. A neuroendocrinological perspective on human hair follicle pigmentation. Pigment Cell Melanoma Res 2011; 24: 89-106.
9. Böhm M, Metze D, Schulte U, et al,. Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ. Exp Dermatol 1999; 8: 453-61.
10. Böhm M, Eickelmann M, Li Z, et al,. Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cells. Endocrinology 2005; 146: 4635-46.
11. Kauser S, Thody AJ, Schallreuter KU, et al,. A fully functional proopiomelano-cortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes. Endocrinology 2005; 146: 532-43.
12. Slominski A, Wortsman J,. Neuroendocrinology of the skin. Endocrine Rev 2000; 21: 457-87.
13. Böhm M, Wolff I, Scholzen TE, et al,. Alpha-melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. J Biol Chem 2005; 280: 5795-802.
14. Kokot A, Metze D, Mouchet N, et al,. Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin. Endocrinology 2009; 150: 3197-206.
15. Spencer JD, Gibbons NC, Rokos H, et al,. Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo. J Invest Dermatol 2007; 127: 411-20.
16. Harms J, Minder CE, Minder EI,. An alpha-melanocyte-stimulating analogue in erythropoietic protoporphyria. N Engl J Med 2009; 360: 306-7.
17. Haylett AK, Nie Z, Brownrigg M, et al,. Systemic photoprotection in solar urticaria with α-melanocyte-stimulating hormone analogue [Nle4-D-Phe7]-α-MSH. Br J Dermatol 2011; 164: 407-14.
18. Böhm M, Ehrchen J, Luger TA,. Beneficial effects of the melanocortin analogue Nle(4-) -D-Phe(7)-α-MSH in acne vulgaris. J Eur Acad Dermatol Venereol 2014; 28: 108-11.
19. Hendrix S, Handjiski B, Peters EM, et al,. A guide to assessing damage response pathways of the hair follicle: lessons from cyclophosphamide-induced alopecia in mice. J Invest Dermatol 2005; 125: 42-51.
20. Takahashi T, Shimizu H, Morimatsu H, et al,. Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation. Mini Rev Med Chem 2007; 7: 745-53.
21. Dessinioti C, Antoniou C, Katsambas A, et al,. Melanocortin 1 receptor variants: functional role and pigmentary associations. Photochem Photobiol 2011; 87: 978-87.
22. Rousseau K, Kauser S, Pritchard LE, et al,. Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J 2007; 21: 1844-56.
23. Brzoska T, Luger TA, Maaser C, et al,. α-Melanocyte-stimulating hormone and related tripeptides. Biochemistry, anti-inflammatory effects in vitro and in vivo and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocrine Rev 2008; 29: 561-602.
24. Meyer KC, Bodo E, Brzoska T, et al,. Immunomodulatory effects of the alpha-melanocyte-stimulating hormone-related tripeptide K(D)PT on human scalp hair follicles under proinflammatory conditions. Br J Dermatol 2009; 161: 1400-3.
25. Mastrofrancesco A, Kokot A, Eberle A, et al,. KdPT, a tripeptide derivative of alpha-melanocyte-stimulating hormone, suppresses IL-1 beta-mediated cytokine expression and signaling in human sebocytes. J Immunol 2010; 185: 1903-11.