Chemotherapy-induced alopecia

Journal of the American Academy of Dermatology

Volumn 67, Issue 1, 2012, Pages

  Chon, Susan Y ^a   Champion, Rachel W ^b   Geddes, Elizabeth R ^c   Rashid, Rashid M ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

alopecia; chemotherapy; chemotherapy induced alopecia; clinical; treatment

Indexed keywords

AMMONIUM TRICHLORO(DIOXYETHYLENE O,O')TELLURATE; BLEOMYCIN; CALCITRIOL; CARBOPLATIN; CHLORMETHINE; COLECALCIFEROL; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DASATINIB; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR; ETOPOSIDE; FIBROBLAST GROWTH FACTOR 1; FLUOROURACIL; HYDROXYUREA; IFOSFAMIDE; IMUVERT; INTERLEUKIN 1; M 50054; METHOTREXATE; MINOXIDIL; PACLITAXEL; PAZOPANIB; RECOMBINANT INTERLEUKIN 1BETA; SUNITINIB; THIOTEPA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

ALOPECIA; APOPTOSIS; BREAST CANCER; BREAST CARCINOMA; CANCER PATIENT; CHEMOTHERAPY INDUCED ALOPECIA; CLINICAL FEATURE; DISEASE SEVERITY; ENDOMETRIUM CARCINOMA; GYNECOLOGIC CANCER; HAIR FOLLICLE; HAIR GROWTH; HAIR LOSS; HUMAN; LUNG CANCER; MASCULINITY; MENTAL STRESS; NONHUMAN; PATHOGENESIS; PATIENT EDUCATION; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SELF ESTEEM; SOFT TISSUE SARCOMA;

ALOPECIA; ANIMALS; ANTINEOPLASTIC AGENTS; HAIR; HUMANS;

EID: 84860013066     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2011.02.026     Document Type: Review

References (71)

1. T.F. Cash The psychology of hair loss and its implications for patient care Clin Dermatol 19 2001 161 166 (Pubitemid 32492958)
2. G. Cotsarelis, and S.E. Millar Towards a molecular understanding of hair loss and its treatment Trends Mol Med 7 2001 293 301 (Pubitemid 32606568)
3. G. Cotsarelis Gene expression profiling gets to the root of human hair follicle stem cells J Clin Invest 116 2006 19 22 (Pubitemid 43121784)
4. R. Paus Principles of hair cycle control J Dermatol 25 1998 793 802 (Pubitemid 29078758)
5. R. Paus, and G. Cotsarelis The biology of hair follicles N Engl J Med 341 1999 491 497 (Pubitemid 29372890)
6. R. Paus, B. Handjiski, S. Eichmuller, and B.M. Czarnetzki Chemotherapy-induced alopecia in mice: induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone Am J Pathol 144 1994 719 734 (Pubitemid 24172061)
7. S. Hendrix, B. Handjiski, E.M. Peters, and R. Paus A guide to assessing damage response pathways of the hair follicle: lessons from cyclophosphamide- induced alopecia in mice J Invest Dermatol 125 2005 42 51 (Pubitemid 40981422)
8. R. Paus, M.B. Schilli, B. Handjiski, A. Menrad, B.M. Henz, and P. Plonka Topical calcitriol enhances normal hair regrowth but does not prevent chemotherapy-induced alopecia in mice Cancer Res 56 1996 4438 4443 (Pubitemid 26330452)
9. A. Shirai, H. Tsunoda, T. Tamaoki, and T. Kamiya Topical application of cyclosporin A induces rapid-remodeling of damaged anagen hair follicles produced in cyclophosphamide administered mice J Dermatol Sci 27 2001 7 13 (Pubitemid 32655422)
10. M. Maurer, B. Handjiski, and R. Paus Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia Am J Pathol 150 1997 1433 1441 (Pubitemid 27152660)
11. V.A. Botchkarev Molecular mechanisms of chemotherapy-induced hair loss J Investig Dermatol Symp Proc 8 2003 72 75 (Pubitemid 36900494)
12. G. Lindner, V.A. Botchkarev, N.V. Botchkareva, G. Ling, C. van der Veen, and R. Paus Analysis of apoptosis during hair follicle regression (catagen) Am J Pathol 151 1997 1601 1617 (Pubitemid 27527923)
13. V.A. Botchkarev, E.A. Komarova, F. Siebenhaar, N.V. Botchkareva, P.G. Komarov, and M. Maurer p53 Is essential for chemotherapy-induced hair loss Cancer Res 60 2000 5002 5006
14. A.A. Sharov, F. Siebenhaar, T.Y. Sharova, N.V. Botchkareva, B.A. Gilchrest, and V.A. Botchkarev Fas signaling is involved in the control of hair follicle response to chemotherapy Cancer Res 64 2004 6266 6270 (Pubitemid 39129430)
15. A.A. Sharov, G.Z. Li, T.N. Palkina, T.Y. Sharova, B.A. Gilchrest, and V.A. Botchkarev Fas and c-kit are involved in the control of hair follicle melanocyte apoptosis and migration in chemotherapy-induced hair loss J Invest Dermatol 120 2003 27 35 (Pubitemid 36120969)
16. N. Nakashima-Kamimura, K. Nishimaki, T. Mori, S. Asoh, and S. Ohta Prevention of chemotherapy-induced alopecia by the anti-death FNK protein Life Sci 82 2008 218 225
17. D.M. Reeves Alopecia C.H. Yarbro, M.H. Frogge, M. Goodman, Cancer symptom management 3rd ed 2004 Jones and Bartlett Publishers Sudbury, MA 275 281
18. D. Batchelor Hair and cancer chemotherapy: consequences and nursing care-a literature study Eur J Cancer Care (Engl) 10 2001 147 163 (Pubitemid 33699419)
19. S.J. Yun, and S.J. Kim Hair loss pattern due to chemotherapy-induced anagen effluvium: a cross-sectional observation Dermatology 215 2007 36 40 (Pubitemid 46976012)
20. B. Tallon, E. Blanchard, and L.J. Goldberg Permanent chemotherapy-induced alopecia: case report and review of the literature J Am Acad Dermatol 63 2010 333 336
21. P. Ljungman, M. Hassan, A.N. Bekassy, O. Ringden, and G. Oberg Busulfan concentration in relation to permanent alopecia in recipients of bone marrow transplants Bone Marrow Transplant 15 1995 869 871
22. D. Tran, R.D. Sinclair, A.P. Schwarer, and C.W. Chow Permanent alopecia following chemotherapy and bone marrow transplantation Australas J Dermatol 41 2000 106 108 (Pubitemid 30304005)
23. M. Machado, J.S. Moreb, and S.A. Khan Six cases of permanent alopecia after various conditioning regimens commonly used in hematopoietic stem cell transplantation Bone Marrow Transplant 40 2007 979 982 (Pubitemid 350048197)
24. A. Tosti, B.M. Piraccini, C. Vincenzi, and C. Misciali Permanent alopecia after busulfan chemotherapy Br J Dermatol 152 2005 1056 1058 (Pubitemid 40704954)
25. M.E. de Jonge, R.A. Mathot, O. Dalesio, A.D. Huitema, S. Rodenhuis, and J.H. Beijnen Relationship between irreversible alopecia and exposure to cyclophosphamide, thiotepa and carboplatin (CTC) in high-dose chemotherapy Bone Marrow Transplant 30 2002 593 597 (Pubitemid 35414809)
26. B.W. Baker, C.L. Wilson, A.L. Davis, R.L. Spearing, D.N. Hart, and D.C. Heaton Busulphan/cyclophosphamide conditioning for bone marrow transplantation may lead to failure of hair regrowth Bone Marrow Transplant 7 1991 43 47
27. M. Vowels, L.L. Chan, N. Giri, S. Russell, and R. Lam-Po-Tang Factors affecting hair regrowth after bone marrow transplantation Bone Marrow Transplant 12 1993 347 350 (Pubitemid 23295517)
28. C. Prevezas, B. Matard, L. Pinquier, and P. Reygagne Irreversible and severe alopecia following docetaxel or paclitaxel cytotoxic therapy for breast cancer Br J Dermatol 160 2009 883 885
29. J.C. Donovan, D.M. Ghazarian, and J.C. Shaw Scarring alopecia associated with use of the epidermal growth factor receptor inhibitor gefitinib Arch Dermatol 144 2008 1524 1525
30. J.E. Graves, B.F. Jones, A.C. Lind, and M.P. Heffernan Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib J Am Acad Dermatol 55 2006 349 353 (Pubitemid 44038007)
31. M. Pongpudpunth, M.F. Demierre, and L.J. Goldberg A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib J Cutan Pathol 36 2009 1303 1307
32. C. Robert, J.C. Soria, A. Spatz, A. Le Cesne, D. Malka, and P. Pautier Cutaneous side-effects of kinase inhibitors and blocking antibodies Lancet Oncol 6 2005 491 500 (Pubitemid 40903630)
33. S. Routhouska, A.C. Gilliam, and P. Mirmirani Hair depigmentation during chemotherapy with a class III/V receptor tyrosine kinase inhibitor Arch Dermatol 142 2006 1477 1479 (Pubitemid 44790642)
34. J.T. Hartmann, and L. Kanz Sunitinib and periodic hair depigmentation due to temporary c-KIT inhibition Arch Dermatol 144 2008 1525 1526
35. A. Sun, R.S. Akin, E. Cobos, and J. Smith Hair depigmentation during chemotherapy with dasatinib, a dual Bcr-Abl/Src family tyrosine kinase inhibitor J Drugs Dermatol 8 2009 395 398
36. K. Munstedt, N. Manthey, S. Sachsse, and H. Vahrson Changes in self-concept and body image during alopecia induced cancer chemotherapy Support Care Cancer 5 1997 139 143 (Pubitemid 27163456)
37. J. Lemieux, E. Maunsell, and L. Provencher Chemotherapy-induced alopecia and effects on quality of life among women with breast cancer: a literature review Psychooncology 17 2008 317 328 (Pubitemid 351513680)
38. G.M. Kiebert, J. Hanneke, C.J. de Haes, J. Kievit, and C.J. van de Velde Effect of peri-operative chemotherapy on the quality of life of patients with early breast cancer Eur J Cancer 26 1990 1038 1042
39. T.G. Freedman Social and cultural dimensions of hair loss in women treated for breast cancer Cancer Nurs 17 1994 334 341 (Pubitemid 24255423)
40. E.L. McGarvey, L.D. Baum, R.C. Pinkerton, and L.M. Rogers Psychological sequelae and alopecia among women with cancer Cancer Pract 9 2001 283 289 (Pubitemid 33032427)
41. A.J. Tierney, J. Taylor, and S.J. Closs Knowledge, expectations and experiences of patients receiving chemotherapy for breast cancer Scand J Caring Sci 6 1992 75 80
42. S. Rosman Cancer and stigma: experience of patients with chemotherapy-induced alopecia Patient Educ Couns 52 2004 333 339 (Pubitemid 38283905)
43. S. Hilton, K. Hunt, C. Emslie, M. Salinas, and S. Ziebland Have men been overlooked? A comparison of young men and women's experiences of chemotherapy-induced alopecia Psychooncology 17 2008 577 583
44. S. Nolte, J. Donnelly, S. Kelly, P. Conley, and R. Cobb A randomized clinical trial of a videotape intervention for women with chemotherapy-induced alopecia: a gynecologic oncology group study Oncol Nurs Forum 33 2006 305 311 (Pubitemid 43672484)
45. P. Katsimbri, A. Bamias, and N. Pavlidis Prevention of chemotherapy-induced alopecia using an effective scalp cooling system Eur J Cancer 36 2000 766 771 (Pubitemid 30179749)
46. E. Alley, R. Green, and L. Schuchter Cutaneous toxicities of cancer therapy Curr Opin Oncol 14 2002 212 216 (Pubitemid 34235056)
47. F. Mols, C.J. van den Hurk, A.J. Vingerhoets, and W.P. Breed Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical considerations Support Care Cancer 17 2009 181 189
48. E.G. Grevelman, and W.P.M. Breed Prevention of chemotherapy-induced hair loss by scalp cooling Ann Oncol 16 2005 352 358 (Pubitemid 40458310)
49. G. Witman, E. Cadman, and M. Chen Misuse of scalp hypothermia Cancer Treat Rep 65 1981 507 508 (Pubitemid 11075016)
50. S.A. Forsberg Scalp cooling therapy and cytotoxic treatment Lancet 357 2001 1134 (Pubitemid 32322562)
51. J. Lemieux, C. Amireault, L. Provencher, and E. Maunsell Incidence of scalp metastases in breast cancer: a retrospective cohort study in women who were offered scalp cooling Breast Cancer Res Treat 118 2009 547 552
52. M. Duvic, N.A. Lemak, V. Valero, S.R. Hymes, K.L. Farmer, and G.N. Hortobagyi A randomized trial of minoxidil in chemotherapy-induced alopecia J Am Acad Dermatol 35 1996 74 78 (Pubitemid 26231327)
53. C.O. Granai, H. Frederickson, W. Gajewski, A. Goodman, A. Goldstein, and H. Baden The use of minoxidil to attempt to prevent alopecia during chemotherapy for gynecologic malignancies Eur J Gynaecol Oncol 12 1991 129 132
54. R. Rodriguez, M. Machiavelli, B. Leone, A. Romero, M.A. Cuevas, and M. Langhi Minoxidil (Mx) as a prophylaxis of doxorubicin-induced alopecia Ann Oncol 5 1994 769 770 (Pubitemid 24302698)
55. B. Sredni, R.-H. Xu, M. Albeck, U. Gafter, R. Gal, and A. Shani The protective role of the immunomodulator AS101 against chemotherapy-induced alopecia studies on human and animal models Int J Cancer 65 1996 97 103
56. M. Hidalgo, D. Rinaldi, G. Medina, T. Griffin, J. Turner, and D.D. Von Hoff A phase I trial of topical topitriol (calcitriol, 1,25-dihydroxyvitamin D3) to prevent chemotherapy-induced alopecia Anticancer Drugs 10 1999 393 395
57. A.E. Buhl Minoxidil's action in hair follicles J Invest Dermatol 96 Suppl5 1991 73 74S
58. B. Sredni, R.R. Caspi, A. Klein, Y. Kalechman, Y. Danziger, and M. BenYa'akov A new immunomodulating compound (AS-101) with potential therapeutic application Nature 330 1987 173 176 (Pubitemid 17158547)
59. M. Shohat, D. Mimouni, D. Ben-Amitai, B. Sredni, D. Sredni, and B. Shohat In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101 Clin Exp Dermatol 30 2005 432 434 (Pubitemid 40835349)
60. J. Wang, Z. Lu, and J.L. Au Protection against chemotherapy-induced alopecia Pharm Res 23 2006 2505 2514
61. J.J. Jimenez, E. Alvarez, C.D. Bustamante, and A.A. Yunis Pretreatment with 1,25(OH)2D3 protects from Cytoxan-induced alopecia without protecting the leukemic cells from Cytoxan Am J Med Sci 310 1995 43 47
62. A.L. Balsari, D. Morelli, S. Menard, U. Veronesi, and M.I. Colnaghi Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies FASEB J 8 1994 226 230
63. A.M. Hussein, A. Stuart, and W.P. Peters Protection against chemotherapy-induced alopecia by cyclosporin A in the newborn rat animal model Dermatology 190 1995 192 196
64. A.M. Hussein, J.J. Jimenez, C.A. McCall, and A.A. Yunis Protection from chemotherapy-induced alopecia in a rat model Science 249 1990 1564 1566
65. A.M. Hussein Chemotherapy-induced alopecia: new developments South Med J 86 1993 489 496 (Pubitemid 23150687)
66. J.J. Jimenez, and A.A. Yunis Protection from 1-beta-D- arabinofuranosylcytosine-induced alopecia by epidermal growth factor and fibroblast growth factor in the rat model Cancer Res 52 1992 413 415
67. D.M. Danilenko, B.D. Ring, D. Yanagihara, W. Benson, B. Wiemann, and C.O. Starnes Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation: normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia Am J Pathol 147 1995 145 154
68. F. D'Agostini, M. Bagnasco, D. Giunciuglio, A. Albini, and S. De Flora Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice Int J Oncol 13 1998 217 224 (Pubitemid 28329207)
69. J.J. Jimenez, H.S. Huang, and A.A. Yunis Treatment with ImuVert/N-acetylcysteine protects rats from cyclophosphamide/cytarabine-induced alopecia Cancer Invest 10 1992 271 276
70. E.M. Peters, K. Foitzik, R. Paus, S. Ray, and M.F. Holick A new strategy for modulating chemotherapy-induced alopecia, using PTH/PTHrP receptor agonist and antagonist J Invest Dermatol 117 2001 173 178 (Pubitemid 34205698)
71. T. Tsuda, Y. Ohmori, H. Muramatsu, Y. Hosaka, K. Takiguchi, and F. Saitoh Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia Eur J Pharmacol 433 2001 37 45 (Pubitemid 34038080)