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Volumn 27, Issue 10, 2014, Pages 1871-1876

Flavokawains A and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHALCONE DERIVATIVE; DIHYDROMETHYSTICIN; FLAVOKAWAIN A; FLAVOKAWAIN B; KAVA; PARACETAMOL; UNCLASSIFIED DRUG; 7,8-DIHYDROMETHYSTICIN; CHALCONE; FLAVONOID; PYRONE DERIVATIVE;

EID: 84908145863     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx5003194     Document Type: Article
Times cited : (34)

References (30)
  • 1
    • 39549097791 scopus 로고    scopus 로고
    • Kava consumption and its health effects
    • Gounder, R. (2006) Kava consumption and its health effects. Pacific Health Dialogue 13, 131-135.
    • (2006) Pacific Health Dialogue , vol.13 , pp. 131-135
    • Gounder, R.1
  • 2
    • 79956264661 scopus 로고    scopus 로고
    • Neurocognitive effects of kava (Piper methysticum): A systematic review
    • LaPorte, E., Sarris, J., Stough, C., and Scholey, A. (2011) Neurocognitive effects of kava (Piper methysticum): a systematic review. Hum. Psychopharmacol. 26, 102-111.
    • (2011) Hum. Psychopharmacol. , vol.26 , pp. 102-111
    • LaPorte, E.1    Sarris, J.2    Stough, C.3    Scholey, A.4
  • 3
    • 60549099731 scopus 로고    scopus 로고
    • St. John's wort and Kava in treating major depressive disorder with comorbid anxiety: A randomised double-blind placebo-controlled pilot trial
    • Sarris, J., Kavanagh, D. J., Deed, G., and Bone, K. M. (2009) St. John's wort and Kava in treating major depressive disorder with comorbid anxiety: a randomised double-blind placebo-controlled pilot trial. Hum. Psychopharmacol. 24, 41-48.
    • (2009) Hum. Psychopharmacol. , vol.24 , pp. 41-48
    • Sarris, J.1    Kavanagh, D.J.2    Deed, G.3    Bone, K.M.4
  • 4
    • 67651005824 scopus 로고    scopus 로고
    • The Kava Anxiety Depression Spectrum Study (KADSS): A randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum
    • Sarris, J., Kavanagh, D. J., Byrne, G., Bone, K. M., Adams, J., and Deed, G. (2009) The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology (Berl.) 205, 399-407.
    • (2009) Psychopharmacology (Berl.) , vol.205 , pp. 399-407
    • Sarris, J.1    Kavanagh, D.J.2    Byrne, G.3    Bone, K.M.4    Adams, J.5    Deed, G.6
  • 5
    • 0033971030 scopus 로고    scopus 로고
    • Efficacy of kava extract for treating anxiety: Systematic review and meta-analysis
    • Pittler, M. H., and Ernst, E. (2000) Efficacy of kava extract for treating anxiety: systematic review and meta-analysis. J. Clin. Psychopharmacol. 20, 84-89.
    • (2000) J. Clin. Psychopharmacol. , vol.20 , pp. 84-89
    • Pittler, M.H.1    Ernst, E.2
  • 6
    • 70350766713 scopus 로고    scopus 로고
    • Kava hepatotoxicity: Regulatory data selection and causality assessment
    • Teschke, R., and Wolff, A. (2009) Kava hepatotoxicity: regulatory data selection and causality assessment. Dig. Liver Dis. 41, 891-901.
    • (2009) Dig. Liver Dis. , vol.41 , pp. 891-901
    • Teschke, R.1    Wolff, A.2
  • 7
    • 84874931332 scopus 로고    scopus 로고
    • Contaminant hepatotoxins as culprits for kava hepatotoxicity-fact or fiction?
    • Teschke, R., Sarris, J., and Lebot, V. (2013) Contaminant hepatotoxins as culprits for kava hepatotoxicity-fact or fiction? Phytother. Res. 27, 472-474.
    • (2013) Phytother. Res. , vol.27 , pp. 472-474
    • Teschke, R.1    Sarris, J.2    Lebot, V.3
  • 8
    • 84908129229 scopus 로고    scopus 로고
    • German court repeals the withdrawal of marketing authorisation of kava-containing medicinal products
    • Carreño, I., Laurenza, E., Martelloni, A., Salas, B., Simões, B. G., and Vergona, P. R. (2014) German court repeals the withdrawal of marketing authorisation of kava-containing medicinal products. Trade Perspectives 13, 2-5.
    • (2014) Trade Perspectives , vol.13 , pp. 2-5
    • Carreño, I.1    Laurenza, E.2    Martelloni, A.3    Salas, B.4    Simões, B.G.5    Vergona, P.R.6
  • 9
    • 0038249051 scopus 로고    scopus 로고
    • Toxicity of kava pyrones, drug safety and precautions - A case study
    • Schulze, J., Raasch, W., and Siegers, C. P. (2003) Toxicity of kava pyrones, drug safety and precautions - a case study. Phytomedicine 10, 68-73.
    • (2003) Phytomedicine , vol.10 , pp. 68-73
    • Schulze, J.1    Raasch, W.2    Siegers, C.P.3
  • 10
    • 1842431946 scopus 로고    scopus 로고
    • Kava Hepatotoxicity: Are we any closer to the truth?
    • Anke, J., and Ramzan, I. (2004) Kava Hepatotoxicity: Are we any closer to the truth? Planta Med. 70, 193-196.
    • (2004) Planta Med. , vol.70 , pp. 193-196
    • Anke, J.1    Ramzan, I.2
  • 11
    • 84890482601 scopus 로고    scopus 로고
    • Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC)
    • Lebot, V., Do, T. K., and Legendre, L. (2014) Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC). Food Chem. 151, 554-560.
    • (2014) Food Chem. , vol.151 , pp. 554-560
    • Lebot, V.1    Do, T.K.2    Legendre, L.3
  • 12
    • 69949109902 scopus 로고    scopus 로고
    • Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity
    • Shaik, A. A., Hermanson, D. L., and Xing, C. (2009) Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. Bioorg. Med. Chem. Lett. 19, 5732-5736.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5732-5736
    • Shaik, A.A.1    Hermanson, D.L.2    Xing, C.3
  • 15
    • 56349138698 scopus 로고    scopus 로고
    • Kava hepatotoxicity: A clinical survey and critical analysis of 26 suspected cases
    • Teschke, R., Schwarzenboeck, A., and Hennermann, K. H. (2008) Kava hepatotoxicity: a clinical survey and critical analysis of 26 suspected cases. Eur. J. Gastroenterol. Hepatol. 20, 1182-1193.
    • (2008) Eur. J. Gastroenterol. Hepatol. , vol.20 , pp. 1182-1193
    • Teschke, R.1    Schwarzenboeck, A.2    Hennermann, K.H.3
  • 16
    • 0034327338 scopus 로고    scopus 로고
    • The correlation between cancer incidence and kava consumption
    • Steiner, G. G. (2000) The correlation between cancer incidence and kava consumption. Hawaii Med. J. 59, 420-422.
    • (2000) Hawaii Med. J. , vol.59 , pp. 420-422
    • Steiner, G.G.1
  • 19
    • 84865248458 scopus 로고    scopus 로고
    • Reduction in colon cancer risk by consumption of kava or kava fractions in carcinogen-treated rats
    • Triolet, J., Shaik, A. A., Gallaher, D. D., O'Sullivan, M. G., and Xing, C. (2012) Reduction in colon cancer risk by consumption of kava or kava fractions in carcinogen-treated rats. Nutr. Cancer 64, 838-846.
    • (2012) Nutr. Cancer , vol.64 , pp. 838-846
    • Triolet, J.1    Shaik, A.A.2    Gallaher, D.D.3    O'Sullivan, M.G.4    Xing, C.5
  • 20
    • 17144400791 scopus 로고    scopus 로고
    • Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein-Dependent and Mitochondria-Dependent Apoptotic Pathway and Suppresses Tumor Growth in Mice
    • Zi, X., and Simoneau, A. R. (2005) Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein-Dependent and Mitochondria-Dependent Apoptotic Pathway and Suppresses Tumor Growth in Mice. Cancer Res. 65, 3479-3486.
    • (2005) Cancer Res. , vol.65 , pp. 3479-3486
    • Zi, X.1    Simoneau, A.R.2
  • 22
    • 84909619250 scopus 로고    scopus 로고
    • Measuring the chemical and cytotoxic variability of commercially available kava
    • Martin, A. C. J. E., Xing, C., and Hegeman, A. D. (2014) Measuring the chemical and cytotoxic variability of commercially available kava. PLoS One,.
    • (2014) PLoS One
    • Martin, A.C.J.E.1    Xing, C.2    Hegeman, A.D.3
  • 23
    • 84863617682 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of kava kava extract (CAS No. 9000-38-8) in F344/N rats and B6C3F1 mice (Gavage Studies)
    • National Toxicology Program. (2012) Toxicology and carcinogenesis studies of kava kava extract (CAS No. 9000-38-8) in F344/N rats and B6C3F1 mice (Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser., 1-186.
    • (2012) Natl. Toxicol. Program Tech. Rep. Ser. , pp. 1-186
    • National Toxicology Program1
  • 24
    • 79955701682 scopus 로고    scopus 로고
    • Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells
    • Yang, X., and Salminen, W. F. (2011) Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells. Phytomedicine 18, 592-600.
    • (2011) Phytomedicine , vol.18 , pp. 592-600
    • Yang, X.1    Salminen, W.F.2
  • 26
    • 34247135372 scopus 로고    scopus 로고
    • Kava feeding in rats does not cause liver injury nor enhance galactosamineinduced hepatitis
    • DiSilvestro, R. A., Zhang, W., and DiSilvestro, D. J. (2007) Kava feeding in rats does not cause liver injury nor enhance galactosamineinduced hepatitis. Food Chem. Toxicol. 45, 1293-1300.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1293-1300
    • DiSilvestro, R.A.1    Zhang, W.2    DiSilvestro, D.J.3
  • 27
    • 58149512737 scopus 로고    scopus 로고
    • Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract
    • Guo, L., Li, Q., Xia, Q., Dial, S., Chan, P. C., and Fu, P. (2009) Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract. Food Chem. Toxicol. 47, 433-442.
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 433-442
    • Guo, L.1    Li, Q.2    Xia, Q.3    Dial, S.4    Chan, P.C.5    Fu, P.6
  • 28
    • 74649085160 scopus 로고    scopus 로고
    • Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies - Changes in drug metabolizing genes and potential mechanisms linked to kava toxicity
    • Guo, L., Shi, Q., Dial, S., Xia, Q., Mei, N., Li, Q. Z., Chan, P. C., and Fu, P. (2010) Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies - changes in drug metabolizing genes and potential mechanisms linked to kava toxicity. Food Chem. Toxicol. 48, 686-696.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 686-696
    • Guo, L.1    Shi, Q.2    Dial, S.3    Xia, Q.4    Mei, N.5    Li, Q.Z.6    Chan, P.C.7    Fu, P.8
  • 29
    • 33747131402 scopus 로고    scopus 로고
    • Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats
    • Sorrentino, L., Capasso, A., and Schmidt, M. (2006) Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats. Phytomedicine 13, 542-549.
    • (2006) Phytomedicine , vol.13 , pp. 542-549
    • Sorrentino, L.1    Capasso, A.2    Schmidt, M.3
  • 30
    • 78349302551 scopus 로고    scopus 로고
    • Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappa B and MAPK signaling pathways
    • Zhou, P., Gross, S., Liu, J. H., Yu, B. Y., Feng, L. L., Nolta, J., Sharma, V., Piwnica-Worms, D., and Qiu, S. X. (2010) Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappa B and MAPK signaling pathways. FASEB J. 24, 4722-4732.
    • (2010) FASEB J. , vol.24 , pp. 4722-4732
    • Zhou, P.1    Gross, S.2    Liu, J.H.3    Yu, B.Y.4    Feng, L.L.5    Nolta, J.6    Sharma, V.7    Piwnica-Worms, D.8    Qiu, S.X.9


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