Reduction in colon cancer risk by consumption of kava or kava fractions in carcinogen-treated rats

Nutrition and Cancer

Volumn 64, Issue 6, 2012, Pages 838-846

  Triolet, Julie ^a   Shaik, Ahmad Ali ^a   Gallaher, Daniel D ^a   Osullivan, Michael G ^a   Xing, Chengguo ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; DIMETHYLHYDRAZINE; KAVA; KAVA EXTRACT; MUCIN; SIALOMUCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER PREVENTION; CANCER RISK; CARCINOGENICITY; COLON CANCER; CONTROLLED STUDY; CRYPT CELL; DIET; DIET THERAPY; DRUG SAFETY; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; RAT; STAINING; TOXICITY TESTING;

1,2-DIMETHYLHYDRAZINE; ANIMALS; ANTICARCINOGENIC AGENTS; BODY WEIGHT; CARCINOGENS; COLONIC NEOPLASMS; EATING; KAVA; LIVER; MALE; ORGAN SIZE; PLANT EXTRACTS; PLANTS, MEDICINAL; PRECANCEROUS CONDITIONS; RATS; RATS, WISTAR;

EID: 84865248458     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2012.689917     Document Type: Article

References (50)

1. 2010. Cancer Facts and Figures,. Accessed October 15, 2010 at http://www.cancer.org/Research/CancerFactsFigures/CancerFactsFigures/ most-requested-tables-figures-2010
2. Henderson, B E, Kolonel, L N, Dworsky, R, and, Al, E. 1984. Cancer incidence in the islands of the Pacific. Fourth Symposium on Epidemiology and Cancer Registries in the Pacific Basin, 69: 73-81. (Pubitemid 16158039)
3. Tuomilehto, J, Zimmet, P, Taylor, R, Bennet, P, Wolf, E. 1986. Smoking rates in Pacific islands. Bull World Health Org, 64: 447-456. (Pubitemid 16020991)
4. Le Marchand, L, Hankin, J H, Bach, F, Kolonel, L N, Wilkens, L R. 1995. An ecological study of diet and lung cancer in the South Pacific. Int J Cancer, 63: 18-23.
5. Steiner, G G. 2000. The correlation between cancer incidence and kava consumption. Hawaii Med J, 59: 420-422.
6. Mathews, J M, Etheridge, A S, and, Black, S R. 2002. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos, 30: 1153-1157. (Pubitemid 35265819)
7. Anke, J, and, Ramzan, I. 2004. Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.). J Ethnopharmacol, 93: 153-160. (Pubitemid 38962400)
8. Russmann, S, Lauterburg, B H, Barguil, Y, Choblet, E, Cabalion, P. 2005. Traditional aqueous kava extracts inhibit cytochrome P450 1A2 in humans: protective effect against environmental carcinogens?. Clin Pharmacol Ther, 77: 453-454. (Pubitemid 40719274)
9. Wu, D, Nair, M G, and, DeWitt, D L. 2002. Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme. J Agric Food Chem, 50: 701-705. (Pubitemid 34163609)
10. Hashimoto, T, Suganuma, M, Fujiki, H, Yamada, M, Kohno, T. 2003. Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum). Phytomedicine, 10: 309-317. (Pubitemid 36597167)
11. Folmer, F, Blasius, R, Morceau, F, Tabudravu, J, Dicato, M. 2006. Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives. Biochem Pharmacol, 71: 1206-1218. (Pubitemid 43357901)
12. Brown, J R, and, DuBois, R N. 2005. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol, 23: 2840-2855. (Pubitemid 46179475)
13. Sinicrope, F A. 2006. Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. Mol Carcinog, 45: 447-454. (Pubitemid 43865854)
14. Stevinson, C, Huntley, A, and, Ernst, E. 2002. A systematic review of the safety of kava extract in the treatment of anxiety. Drug Saf, 25: 251-261. (Pubitemid 34569359)
15. Pittler, M H, and, Ernst, E. 2003. Kava extract for treating anxiety. Cochrane Database Syst Rev,: CD003383
16. Russmann, S, Barguil, Y, Cabalion, P, Kritsanida, M, Duhet, D. 2003. Hepatic injury due to traditional aqueous extracts of kava root in New Caledonia. Eur J Gastroenterol Hepatol, 15: 1033-1036. (Pubitemid 37094305)
17. U.S. Food and Drug Administration. Consumer Advisory: Kava-Containing Dietary Supplements May Be Associated With Severe Liver Injury. Accessed February 19, 2012 from http://www.fda.gov/Food/ResourcesForYou/Consumers/ ucm085482.htm
18. Hapke, H J, Sterner, W, Heisler, E, and, Brauer, H. 1971. Toxicological studies with Kavaform. Farmaco Prat, 26: 692-720.
19. Sorrentino, L, Capasso, A, and, Schmidt, M. 2006. Safety of ethanolic kava extract: results of a study of chronic toxicity in rats. Phytomedicine, 13: 542-549. (Pubitemid 44224050)
20. Behl, M, Nyska, A, Chhabra, R S, Travlos, G S, Fomby, L M. 2011. Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava. Food Chem Toxicol, 49: 2820-2829.
21. Reeves, P G, Nielsen, F H, and, Fahey, G C Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr, 123: 1939-1951. (Pubitemid 23342492)
22. Kulea Farm Kava Co. Traditional Kava Kava. Accessed February 23 2006, http://www.kickbackwithkava.com/kava-recipes.htm
23. Bird, R P. 1987. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett, 37: 147-151. (Pubitemid 17157833)
24. Caderni, G, Giannini, A, Lancioni, L, Luceri, C, Biggeri, A. 1995. Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis. Br J Cancer, 71: 763-769.
25. Filipe, M I. 1975. Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine: a morphological and histochemical study. Br J Cancer, 32: 60-77.
26. Jenab, M, Chen, J, and, Thompson, L U. 2001. Sialomucin production in aberrant crypt foci relates to degree of dysplasia and rate of cell proliferation. Cancer Lett, 165: 19-25. (Pubitemid 32206653)
27. Uchida, K, Kado, S, Ando, M, Nagata, Y, Takagi, A. 2001. A mucinous histochemical study on malignancy of aberrant crypt foci (ACF) in rat colon. J Vet Med Sci, 63: 145-149. (Pubitemid 33674504)
28. Shaik, A A, Hermanson, D L, and, Xing, C. 2009. Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. Bioorg Med Chem Lett, 19: 5732-5736.
29. Johnson, T E, Kassie, F, OSullivan, M G, Negia, M, Hanson, T E. 2008. Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Cancer Prev Res, 1: 430-438.
30. Carter, J W, Lancaster, H K, Hardman, W E, and, Cameron, I L. 1994. Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2-dimethylhydrazine-treated mice. Cancer Res, 54: 4304-4307. (Pubitemid 24273139)
31. Raju, J. 2008. Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer. World J Gastroenterol, 14: 6632-6635.
32. Papanikolaou, A, Wang, Q S, Papanikolaou, D, Whiteley, H E, and, Rosenberg, D W. 2000. Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane-induced colon carcinogenesis. Carcinogenesis, 21: 1567-1572. (Pubitemid 30601647)
33. Takayama, T, Ohi, M, Hayashi, T, Miyanishi, K, Nobuoka, A. 2001. Analysis of K-ras, APC, and-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology, 121: 599-611. (Pubitemid 32822575)
34. Filipe, M I. 1975. Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine: a morphological and histochemical study. Br J Cancer, 32: 60-77.
35. Klurfeld, D M, Weber, M M, and, Kritchevsky, D. 1987. Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat. Cancer Res, 47: 2759-2762. (Pubitemid 17113410)
36. Lasko, C M, and, Bird, R P. 1995. Modulation of aberrant crypt foci by dietary fat and caloric restriction: the effects of delayed intervention. Cancer Epidemiol Biomarkers Prev, 4: 49-55.
37. Lasko, C M, Good, C K, Adam, J, and, Bird, R P. 1999. Energy restriction modulates the development of advanced preneoplastic lesions depending on the level of fat in the diet. Nutr Cancer, 33: 69-75. (Pubitemid 29196125)
38. Yoshimi, N, Morioka, T, Kinjo, T, Inamine, M, Kaneshiro, T. 2004. Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride. Cancer Sci, 95: 792-797. (Pubitemid 39545584)
39. Rao, C V, Indranie, C, Simi, B, Manning, P T, Connor, J R. 2002. Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res, 62: 165-170. (Pubitemid 34074001)
40. Kirana, C, McIntosh, G H, Record, I R, and, Jones, G P. 2003. Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutr Cancer, 45: 218-225. (Pubitemid 37022796)
41. Li, W, Wanibuchi, H, Salim, E I, Wei, M, Yamamoto, S. 2000. Inhibition by ginseng of 1,2-dimethylhydrazine induction of aberrant crypt foci in the rat colon. Nutr Cancer, 36: 66-73. (Pubitemid 30317837)
42. Roncucci, L, Pedroni, M, Vaccina, F, Benatti, P, Marzona, L. 2000. Aberrant crypt foci in colorectal carcinogenesis: cell and crypt dynamics. Cell Prolif, 33: 1-18. (Pubitemid 30162619)
43. Caderni, G, Femia, A P, Giannini, A, Favuzza, A, Luceri, C. 2003. Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis. Cancer Res, 63: 2388-2392. (Pubitemid 36605173)
44. Femia, A P, Bendinelli, B, Giannini, A, Salvadori, M, Pinzani, P. 2005. Mucin-depleted foci have beta-catenin gene mutations, altered expression of its protein, and are dose-and time-dependent in the colon of 1,2-dimethylhydrazine- treated rats. Int J Cancer, 116: 9-15. (Pubitemid 40827749)
45. Arikawa, A Y, and, Gallaher, D D. 2008. Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated rats. J Nutr, 138: 526-532. (Pubitemid 351355252)
46. Pierre, F, Freeman, A, Tache, S, Van der Meer, R, and, Corpet, D E. 2004. Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons. J Nutr, 134: 2711-2716. (Pubitemid 39315277)
47. Sakano, K, Takahashi, M, Kitano, M, Sugimura, T, and, Wakabayashi, K. 2006. Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats. Asian Pac J Cancer Prev, 7: 599-603.
48. Sohn, O S, Ishizaki, H, Yang, C S, and, Fiala, E S. 1991. Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis, 12: 127-131.
49. Sohn, O S, Fiala, E S, Requeijo, S P, Weisburger, J H, and, Gonzalez, F J. 2001. Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol. Cancer Res, 61: 8435-8440. (Pubitemid 33131121)
50. Rizzo, A, Pallone, F, Monteleone, G, and, Fantini, M C. 2011. Intestinal inflammation and colorectal cancer: a double-edged sword?. World J Gastroenterol, 17: 3092-3100.