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Volumn 9, Issue 11, 2014, Pages

Measuring the chemical and cytotoxic variability of commercially available kava (Piper methysticum G. Forster)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; DIHYDROKAWAIN; DIHYDROMETHYSTICIN; FLAVOKAWAIN A; FLAVOKAWAIN B; KAVA EXTRACT; KAWAIN; METHYSTICIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; WATER; KAVA; PLANT EXTRACT;

EID: 84909619250     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111572     Document Type: Article
Times cited : (36)

References (48)
  • 1
    • 84909582420 scopus 로고    scopus 로고
    • Introduction, Hawaiian Cultivars, and Non-Hawaiian Cultivars Grown in Hawai'i Today
    • In: E Johnston, H Rogers, editors. Hilo, Hawaii: Association for Hawaiian 'Awa, 30-63
    • E Johnston, H Rogers (2006) Introduction, Hawaiian Cultivars, and Non-Hawaiian Cultivars Grown in Hawai'i Today. In: E Johnston, H Rogers, editors. Hawaiian 'Awa: Views of an ethnobotanical treasure. Hilo, Hawaii: Association for Hawaiian 'Awa, pp. 1-7, 30-63.
    • (2006) Hawaiian 'Awa: Views of An Ethnobotanical Treasure , pp. 1-7
    • Johnston, E.1    Rogers, H.2
  • 2
    • 0031047217 scopus 로고    scopus 로고
    • Electrospray high performance liquid chromatography-mass-spectrometry in phytochemical analysis of kava (Piper methysticum) extract
    • He X, Lin L, Lian L (1997) Electrospray high performance liquid chromatography-mass-spectrometry in phytochemical analysis of kava (Piper methysticum) extract. Planta Med 63: 70-74.
    • (1997) Planta Med , vol.63 , pp. 70-74
    • He, X.1    Lin, L.2    Lian, L.3
  • 3
    • 78651302770 scopus 로고    scopus 로고
    • Re-introduction of kava (Piper methysticum) to the EU: Is there a way forward?
    • Sarris J, Teschke R, Stough C, Scholey A, Schweltzer I (2011) Re-introduction of kava (Piper methysticum) to the EU: Is there a way forward? Planta Med 77: 107-110.
    • (2011) Planta Med , vol.77 , pp. 107-110
    • Sarris, J.1    Teschke, R.2    Stough, C.3    Scholey, A.4    Schweltzer, I.5
  • 4
    • 0034327338 scopus 로고    scopus 로고
    • The correlation between cancer incidence and kava consumption
    • Steiner G (2000) The correlation between cancer incidence and kava consumption. Hawaii Med J 59: 420-422.
    • (2000) Hawaii Med J , vol.59 , pp. 420-422
    • Steiner, G.1
  • 5
    • 61749084029 scopus 로고    scopus 로고
    • Johnson, Chemopreventive effect of kava on 4-(Methylnitrosamino)-1-(3-pryridyl)-1-butanone plus Benzo[a]pyrene-induced lung tumorigenesis in A/J mice
    • Johnson TE, Kassie F, O'Sullivan MG, Negia M, Hanson TE, et al. (2008) Johnson, Chemopreventive effect of kava on 4-(Methylnitrosamino)-1-(3-pryridyl)-1-butanone plus Benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Can Prev Res 1: 430-438.
    • (2008) Can Prev Res , vol.1 , pp. 430-438
    • Johnson, T.E.1    Kassie, F.2    O'sullivan, M.G.3    Negia, M.4    Hanson, T.E.5
  • 6
    • 79959950118 scopus 로고    scopus 로고
    • Lung tumorigenesis suppressing effects of commercial kava extract and its selected compounds in A/J mice
    • Johnson TE, Hermanson D, Wang L, Kassie F, Upadhyaya P, et al. (2011) Lung tumorigenesis suppressing effects of commercial kava extract and its selected compounds in A/J mice. Am J Chinese Med 39: 727-742.
    • (2011) Am J Chinese Med , vol.39 , pp. 727-742
    • Johnson, T.E.1    Hermanson, D.2    Wang, L.3    Kassie, F.4    Upadhyaya, P.5
  • 7
    • 84892385065 scopus 로고    scopus 로고
    • Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J Mice
    • Leitzman P, Narayanapillai SC, Balbo S, Zhou B, Upadhyaya P, et al. (2014) Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J Mice. Cancer Prev Res 7: 86-96.
    • (2014) Cancer Prev Res , vol.7 , pp. 86-96
    • Leitzman, P.1    Narayanapillai, S.C.2    Balbo, S.3    Zhou, B.4    Upadhyaya, P.5
  • 8
    • 17144400791 scopus 로고    scopus 로고
    • Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of bax proteindependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice
    • Zi X, Simoneau AR (2005) Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of bax proteindependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res, 65: 3479-3486.
    • (2005) Cancer Res , vol.65 , pp. 3479-3486
    • Zi, X.1    Simoneau, A.R.2
  • 10
    • 0034949915 scopus 로고    scopus 로고
    • Interaction of various Piper methysticum cultivars with CNS receptors in vitro
    • Dinh LD, Simmen U, Bueter KB, Bueter B, Lundstrom K, et al. (2001) Interaction of various Piper methysticum cultivars with CNS receptors in vitro. Planta Medica 67: 306-311.
    • (2001) Planta Medica , vol.67 , pp. 306-311
    • Dinh, L.D.1    Simmen, U.2    Bueter, K.B.3    Bueter, B.4    Lundstrom, K.5
  • 11
    • 84887627178 scopus 로고    scopus 로고
    • Genetic fingerprinting of Fijian kava
    • Jokhan AD and McLenachan PA (2004) Genetic fingerprinting of Fijian kava. S Pac J Nat Sci 22: 43-45.
    • (2004) S Pac J Nat Sci , vol.22 , pp. 43-45
    • Jokhan, A.D.1    McLenachan, P.A.2
  • 12
    • 79958772932 scopus 로고    scopus 로고
    • Is the quality of kava (Piper methysticum Forst f.) responsible for different geographical patterns
    • Lebot V, Siméoni P (2004) Is the quality of kava (Piper methysticum Forst f.) responsible for different geographical patterns. Ethnobotany Res App 2: 19-28.
    • (2004) Ethnobotany Res App , vol.2 , pp. 19-28
    • Lebot, V.1    Siméoni, P.2
  • 13
    • 0033385371 scopus 로고    scopus 로고
    • Morphological, phytochemical, and genetic variation in Hawaiian cultivars of 'awa (Kava, Piper methysticum, Piperaceae)
    • Lebot V, Johnston E, Zheng QZ, McKern D, McKenna DJ (1999) Morphological, phytochemical, and genetic variation in Hawaiian cultivars of 'awa (Kava, Piper methysticum, Piperaceae). Econ Bot 53: 407-418.
    • (1999) Econ Bot , vol.53 , pp. 407-418
    • Lebot, V.1    Johnston, E.2    Zheng, Q.Z.3    McKern, D.4    McKenna, D.J.5
  • 15
    • 0031792331 scopus 로고    scopus 로고
    • Reversed-phase high-performance liquid chromatographic method for quantitative analysis of the six major kavalactones in Piper methysticum
    • Shao Y, He K, Zheng B, Zheng Q (1998) Reversed-phase high-performance liquid chromatographic method for quantitative analysis of the six major kavalactones in Piper methysticum. J Chromatogr A 825: 1-8.
    • (1998) J Chromatogr A , vol.825 , pp. 1-8
    • Shao, Y.1    He, K.2    Zheng, B.3    Zheng, Q.4
  • 16
    • 0036100226 scopus 로고    scopus 로고
    • Identification of factors determining kavalactone content and chemotype in kava (Piper methysticum Forst.F.)
    • Siméoni P, Lebot V (2002) Identification of factors determining kavalactone content and chemotype in kava (Piper methysticum Forst. F.). Biochem Syst Ecol 30: 413-424.
    • (2002) Biochem Syst Ecol , vol.30 , pp. 413-424
    • Siméoni, P.1    Lebot, V.2
  • 17
    • 78651346028 scopus 로고    scopus 로고
    • Kava hepatotoxicity solution: A six-point plan for new kava standardization
    • Teschke R, Sarris J, Lebot V (2011) Kava hepatotoxicity solution: A six-point plan for new kava standardization. Phytomedicine; 18: 96-103.
    • (2011) Phytomedicine; , vol.18 , pp. 96-103
    • Teschke, R.1    Sarris, J.2    Lebot, V.3
  • 18
    • 84890482601 scopus 로고    scopus 로고
    • Detection of Flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC)
    • Lebot V, Do TKT, Legendre L (2014) Detection of Flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC). Food Chem 151: 554-560.
    • (2014) Food Chem , vol.151 , pp. 554-560
    • Lebot, V.1    Do, T.K.T.2    Legendre, L.3
  • 19
    • 38849103386 scopus 로고    scopus 로고
    • The quality of kava consumed in the South Pacific
    • Lebot V (2006) The quality of kava consumed in the South Pacific. HerbalGram. 71: 34-37.
    • (2006) HerbalGram. , vol.71 , pp. 34-37
    • Lebot, V.1
  • 20
    • 67349168679 scopus 로고    scopus 로고
    • Kava hepatotoxicity: Comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixtures
    • Teschke R, Genthner A, Wolff A (2009) Kava hepatotoxicity: Comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixtures. J Ethnopharmacol 123: 378-384.
    • (2009) J Ethnopharmacol , vol.123 , pp. 378-384
    • Teschke, R.1    Genthner, A.2    Wolff, A.3
  • 21
    • 33646500546 scopus 로고    scopus 로고
    • In vitro cytotoxicity of nonpolar constituents from different parts of kavaplant (Piper methysticum)
    • Jhoo JW, Freeman JP, Heinze TM, Moody JD, Schnackenberg LK, et al. (2006) In vitro cytotoxicity of nonpolar constituents from different parts of kavaplant (Piper methysticum). J Agr Food Chem 54: 3157-3162.
    • (2006) J Agr Food Chem , vol.54 , pp. 3157-3162
    • Jhoo, J.W.1    Freeman, J.P.2    Heinze, T.M.3    Moody, J.D.4    Schnackenberg, L.K.5
  • 22
    • 2842561704 scopus 로고    scopus 로고
    • Influence of extraction solvent and temperature on the quantitative determination of oligosaccharides from plant materials by high-performance liquid chromatography
    • Johansen NH, Glitse V, Knudsen KEB (1996) Influence of extraction solvent and temperature on the quantitative determination of oligosaccharides from plant materials by high-performance liquid chromatography. J Agric Food Chem 44: 1470-1474.
    • (1996) J Agric Food Chem , vol.44 , pp. 1470-1474
    • Johansen, N.H.1    Glitse, V.2    Knudsen, K.E.B.3
  • 23
    • 19944364891 scopus 로고    scopus 로고
    • Comparison of extracts prepared from plant by-products using different solvents and extraction time
    • Lapornik B, Prosek M, Wondra G A (2005) Comparison of extracts prepared from plant by-products using different solvents and extraction time, J Food Eng 71: 214-222.
    • (2005) J Food Eng , vol.71 , pp. 214-222
    • Lapornik, B.1    Prosek, M.2    Wondra, G.A.3
  • 24
    • 69949109902 scopus 로고    scopus 로고
    • Identification of methysticin as a potent and non-toxic NF-kB inhibitor from kava, potentially responsible for kava's chemopreventive actvity
    • Shaik AA, Hermanson DL, Xing C (2009) Identification of methysticin as a potent and non-toxic NF-kB inhibitor from kava, potentially responsible for kava's chemopreventive actvity. Bioorg. Med Chem Lett 19: 5732-5736.
    • (2009) Bioorg. Med Chem Lett , vol.19 , pp. 5732-5736
    • Shaik, A.A.1    Hermanson, D.L.2    Xing, C.3
  • 25
    • 78349302551 scopus 로고    scopus 로고
    • Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kB and MAPK signaling pathways
    • Zhou P, Gross S, Liu J, Yu B, Feng L, et al, (2010) Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kB and MAPK signaling pathways. FASEB J 24: 4722-4732.
    • (2010) FASEB J , vol.24 , pp. 4722-4732
    • Zhou, P.1    Gross, S.2    Liu, J.3    Yu, B.4    Feng, L.5
  • 26
    • 80052301875 scopus 로고    scopus 로고
    • Kava and kava hepatotoxicity: Requirements for novel experimental, ethnobotanical, and clinical studies based on a review of the evidence
    • Teschke R, Qiu SX, Xuan TD, Lebot V (2011) Kava and kava hepatotoxicity: Requirements for novel experimental, ethnobotanical, and clinical studies based on a review of the evidence. Phytother Res, 25: 1263-1274.
    • (2011) Phytother Res , vol.25 , pp. 1263-1274
    • Teschke, R.1    Qiu, S.X.2    Xuan, T.D.3    Lebot, V.4
  • 27
    • 79961127236 scopus 로고    scopus 로고
    • Herbal hepatotoxicity by kava: Update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits
    • Teschke R, Qiu SX, Lebot V (2011) Herbal hepatotoxicity by kava: Update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. Digestive and Liver Disease, 43: 676-681.
    • (2011) Digestive and Liver Disease , vol.43 , pp. 676-681
    • Teschke, R.1    Qiu, S.X.2    Lebot, V.3
  • 28
    • 80051895129 scopus 로고    scopus 로고
    • Proposal for a kava quality standard code
    • Teschke R, Lebot V (2011) Proposal for a kava quality standard code. Food and Chem Toxicol. 49: 2503-2516.
    • (2011) Food and Chem Toxicol. , vol.49 , pp. 2503-2516
    • Teschke, R.1    Lebot, V.2
  • 29
    • 84909641457 scopus 로고    scopus 로고
    • Kava and the risk of liver toxicity: Past, current, and future
    • Teschke R (2011) Kava and the risk of liver toxicity: past, current, and future. Am Herb Prod Assoc Rep 26: 8-17.
    • (2011) Am Herb Prod Assoc Rep , vol.26 , pp. 8-17
    • Teschke, R.1
  • 30
    • 0037532579 scopus 로고    scopus 로고
    • Kava extracts: Safety and risks including rare hepatotoxicity
    • Teschke R, Gaus W, Loew D (2003) Kava extracts: Safety and risks including rare hepatotoxicity. Phytomedicine 10: 440-446.
    • (2003) Phytomedicine , vol.10 , pp. 440-446
    • Teschke, R.1    Gaus, W.2    Loew, D.3
  • 32
    • 79953204321 scopus 로고    scopus 로고
    • Does inflammation play a role in kava hepatotoxicity
    • Zhang LY, Rowe A, Ramzan I (2011) Does inflammation play a role in kava hepatotoxicity. Phytother Res 25: 629-630.
    • (2011) Phytother Res , vol.25 , pp. 629-630
    • Zhang, L.Y.1    Rowe, A.2    Ramzan, I.3
  • 33
    • 84909616140 scopus 로고    scopus 로고
    • Fiji Bureau of Statistics Fiji Bureau of Statistics Publicatio. Accessed: March 18, 2014
    • Fiji Bureau of Statistics (2013) 2011 Export Statistics. Fiji Bureau of Statistics Publicatio. Available: http://www.statsfiji.gov.fj/index.php/document-library/ cat-view/12-economic-statistics/17-international-trade?start=25. Accessed: March 18, 2014.
    • (2013) 2011 Export Statistics
  • 34
    • 84909616139 scopus 로고    scopus 로고
    • Tonga Statistics Department . Nuku'alofa Statistics Department Publication. Accessed: March 18, 2014
    • Tonga Statistics Department (2008-2012) Kingdom of Tonga annual foreign trade report. Nuku'alofa Statistics Department Publication. Available: www.spc. int/prism/tonga/index.php/economic/merchandise-trade/export. Accessed: March 18, 2014.
    • (2008) Kingdom of Tonga Annual Foreign Trade Report
  • 35
    • 84909616138 scopus 로고    scopus 로고
    • Vanuatu National Statistics Office, Vanuatu National Statistics Office Publication. Accessed: March 18, 2014
    • Vanuatu National Statistics Office (2013) Statistics Update: Overseas Trade, August 2013 Highlights. Vanuatu National Statistics Office Publication. Available: http://www.vnso.gov.vu/index.php/economic-statistics/economicsummary. Accessed: March 18, 2014.
    • (2013) Statistics Update: Overseas Trade, August 2013 Highlights
  • 37
    • 0037974273 scopus 로고    scopus 로고
    • Identification of novel electrophilic metabolites of Piper methysticum Forst. (Kava)
    • Johnson BM, Qiu S, Zhang S, Burdette JE, Yu L, et al. (2003) Identification of novel electrophilic metabolites of Piper methysticum Forst. (Kava). Chem Res Toxicol 16: 733-740.
    • (2003) Chem Res Toxicol , vol.16 , pp. 733-740
    • Johnson, B.M.1    Qiu, S.2    Zhang, S.3    Burdette, J.E.4    Yu, L.5
  • 39
    • 79960475169 scopus 로고    scopus 로고
    • Constituents in kava extracts potentially involved in hepatotoxicity: A Review
    • Olsen LR, Grillo MP, Skonberg C (2011) Constituents in kava extracts potentially involved in hepatotoxicity: A Review. Chem Res Toxicol 24: 992-2002.
    • (2011) Chem Res Toxicol , vol.24 , pp. 992-2002
    • Olsen, L.R.1    Grillo, M.P.2    Skonberg, C.3
  • 40
    • 3242677212 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. F.)
    • Anke J, Ramzan I (2004) Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.). J Ethnopharmacol 93: 153-160.
    • (2004) J Ethnopharmacol , vol.93 , pp. 153-160
    • Anke, J.1    Ramzan, I.2
  • 41
    • 80052866052 scopus 로고    scopus 로고
    • Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava
    • Behl M, Nyska A, Chhabra RS, Travlos GS, Fomby LM, et al. (2011) Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava. Food Chem Toxicol 49: 2820-2829.
    • (2011) Food Chem Toxicol , vol.49 , pp. 2820-2829
    • Behl, M.1    Nyska, A.2    Chhabra, R.S.3    Travlos, G.S.4    Fomby, L.M.5
  • 42
    • 2442706282 scopus 로고    scopus 로고
    • Effects of kava (Kavakava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes
    • Zou L, Henderson GL, Harkey MR, Sakai Y, Li A (2004) Effects of kava (Kavakava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. Phytomedicine 11: 285-294.
    • (2004) Phytomedicine , vol.11 , pp. 285-294
    • Zou, L.1    Henderson, G.L.2    Harkey, M.R.3    Sakai, Y.4    Li, A.5
  • 43
    • 79955701682 scopus 로고    scopus 로고
    • Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells
    • Yang X, Salminen W F (2011) Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells. Phytomedicine 18: 592-600.
    • (2011) Phytomedicine , vol.18 , pp. 592-600
    • Yang, X.1    Salminen, W.F.2
  • 44
    • 33750933267 scopus 로고
    • High-performance liquid chromatography of kava lactones from Piper methysticum
    • Smith RM, Thakrar H, Arowolo TA, Shafi AA (1984) High-performance liquid chromatography of kava lactones from Piper methysticum. J Chromatogr 283: 303-308.
    • (1984) J Chromatogr , vol.283 , pp. 303-308
    • Smith, R.M.1    Thakrar, H.2    Arowolo, T.A.3    Shafi, A.A.4
  • 45
    • 26844542538 scopus 로고    scopus 로고
    • HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst
    • Meissmer O and Haberlein H (2005) HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst. Journal of Chromatography B, 826: 46-49.
    • (2005) Journal of Chromatography B , vol.826 , pp. 46-49
    • Meissmer, O.1    Haberlein, H.2
  • 46
    • 77951996135 scopus 로고    scopus 로고
    • Plant metabolomics-meetings the analytical challenges of comprehensive metabolite analysis
    • Hegeman AD (2010) Plant metabolomics-meetings the analytical challenges of comprehensive metabolite analysis. Brief Funct Gen 9: 139-148.
    • (2010) Brief Funct Gen , vol.9 , pp. 139-148
    • Hegeman, A.D.1
  • 47
    • 0037989908 scopus 로고    scopus 로고
    • Piperidine alkaloids from Piper methysticum
    • Dragull K, Yoshida WY, Tang C (2003) Piperidine alkaloids from Piper methysticum. Phytochemistry 63: 193-198.
    • (2003) Phytochemistry , vol.63 , pp. 193-198
    • Dragull, K.1    Yoshida, W.Y.2    Tang, C.3
  • 48
    • 84864763405 scopus 로고    scopus 로고
    • Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog
    • Warmka JK, Solberg EL, Zeliadt NA, Srinivasan B, Charlson AT, et al. (2012) Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog. Biochem Biophys Res Comm 424: 488-492.
    • (2012) Biochem Biophys Res Comm , vol.424 , pp. 488-492
    • Warmka, J.K.1    Solberg, E.L.2    Zeliadt, N.A.3    Srinivasan, B.4    Charlson, A.T.5


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