Identification of methysticin as a potent and non-toxic NF-κB inhibitor from kava, potentially responsible for kava's chemopreventive activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5732-5736

  Shaik, Ahmad Ali ^a   Hermanson, David Lee ^a   Xing, Chengguo ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cancer; Kava; Methysticin; Nuclear factor B

Indexed keywords

CYCLOOXYGENASE 2; DESMETHYOXYYANGONIN; DIHYDROKAWAIN; DIHYDROMETHYSTICIN; FLAVOKAWAIN A; FLAVOKAWAIN B; FLAVOKAWAIN C; I KAPPA B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAVA; KAWAIN; LACTONE DERIVATIVE; METHYSTICIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; LIVER TOXICITY; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; HUMANS; KAVA; NF-KAPPA B; PYRANS;

PIPER METHYSTICUM;

EID: 69949109902     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.003     Document Type: Article

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