메뉴 건너뛰기




Volumn 1, Issue 1, 2014, Pages 75-82

Genetics and Smoking

Author keywords

Addiction; Genes; Genome wide association; Nicotine; Nicotine metabolism; Nicotinic receptors; Tobacco

Indexed keywords


EID: 84908143243     PISSN: None     EISSN: 21962952     Source Type: Journal    
DOI: 10.1007/s40429-013-0006-3     Document Type: Review
Times cited : (45)

References (83)
  • 1
    • 84857363499 scopus 로고    scopus 로고
    • Atlanta, GA. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health
    • USDHHS. How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General. Atlanta, GA. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2010.
    • (2010) The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General
  • 2
    • 14144253640 scopus 로고    scopus 로고
    • Metabolism and disposition kinetics of nicotine
    • COI: 1:CAS:528:DC%2BD2MXis1Gmtro%3D, PID: 15734728
    • Hukkanen J, Jacob 3rd P, Benowitz NL. Metabolism and disposition kinetics of nicotine. Pharmacol Rev. 2005;57:79–115.
    • (2005) Pharmacol Rev , vol.57 , pp. 79-115
    • Hukkanen, J.1    Jacob, P.2    Benowitz, N.L.3
  • 4
    • 0036499938 scopus 로고    scopus 로고
    • Nicotine addiction: the possible role of functional upregulation
    • COI: 1:CAS:528:DC%2BD38XhsFCmsLs%3D, PID: 11879680
    • Buisson B, Bertrand D. Nicotine addiction: the possible role of functional upregulation. Trends Pharmacol Sci. 2002;23:130–6.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 130-136
    • Buisson, B.1    Bertrand, D.2
  • 7
    • 77951711343 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify multiple loci associated with smoking behavior
    • Papers 7–9, published back-to-back Nature Genetics 2010, jointly looked at four smoking behavior phenotypes a GWAS meta-analysis comprising approximately 140 0000 subjects
    • Tobacco and Genetics Consortium. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet. 2010;42:441–7. Papers 7–9, published back-to-back in Nature Genetics in 2010, jointly looked at four smoking behavior phenotypes in a GWAS meta-analysis comprising approximately 140 0000 subjects.
    • (2010) Nat Genet , vol.42 , pp. 441-447
  • 8
    • 77951751034 scopus 로고    scopus 로고
    • Meta-analysis and imputation refines the association of 15q25 with smoking quantity
    • COI: 1:CAS:528:DC%2BC3cXltFKlsro%3D, PID: 20418889, Papers 7–9, published back-to-back Nature Genetics 2010, jointly looked at four smoking behavior phenotypes a GWAS meta-analysis comprising approximately 140 0000 subjects
    • Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet. 2010;42:436–40. Papers 7–9, published back-to-back in Nature Genetics in 2010, jointly looked at four smoking behavior phenotypes in a GWAS meta-analysis comprising approximately 140 0000 subjects.
    • (2010) Nat Genet , vol.42 , pp. 436-440
    • Liu, J.Z.1    Tozzi, F.2    Waterworth, D.M.3    Pillai, S.G.4    Muglia, P.5    Middleton, L.6
  • 9
    • 77951748276 scopus 로고    scopus 로고
    • Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
    • COI: 1:CAS:528:DC%2BC3cXltFKltr4%3D, PID: 20418888, Papers 7–9, published back-to-back Nature Genetics 2010, jointly looked at four smoking behavior phenotypes a GWAS meta-analysis comprising approximately 140 0000 subjects
    • Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet. 2010;42:448–53. Papers 7–9, published back-to-back in Nature Genetics in 2010, jointly looked at four smoking behavior phenotypes in a GWAS meta-analysis comprising approximately 140 0000 subjects.
    • (2010) Nat Genet , vol.42 , pp. 448-453
    • Thorgeirsson, T.E.1    Gudbjartsson, D.F.2    Surakka, I.3    Vink, J.M.4    Amin, N.5    Geller, F.6
  • 10
    • 0038112088 scopus 로고    scopus 로고
    • Structure and gating mechanism of the acetylcholine receptor pore
    • COI: 1:CAS:528:DC%2BD3sXkvVKmsrY%3D, PID: 12827192
    • Miyazawa A, Fujiyoshi Y, Unwin N. Structure and gating mechanism of the acetylcholine receptor pore. Nature. 2003;423:949–55.
    • (2003) Nature , vol.423 , pp. 949-955
    • Miyazawa, A.1    Fujiyoshi, Y.2    Unwin, N.3
  • 11
    • 2542486433 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors and the regulation of neuronal signalling
    • COI: 1:CAS:528:DC%2BD2cXksVelsLs%3D, PID: 15165747
    • Dajas-Bailador F, Wonnacott S. Nicotinic acetylcholine receptors and the regulation of neuronal signalling. Trends Pharmacol Sci. 2004;25:317–24.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 317-324
    • Dajas-Bailador, F.1    Wonnacott, S.2
  • 12
    • 0031032949 scopus 로고    scopus 로고
    • Presynaptic nicotinic ACh receptors
    • COI: 1:CAS:528:DyaK2sXhtFajtrk%3D, PID: 9023878
    • Wonnacott S. Presynaptic nicotinic ACh receptors. Trends Neurosci. 1997;20:92–8.
    • (1997) Trends Neurosci , vol.20 , pp. 92-98
    • Wonnacott, S.1
  • 13
    • 27644454004 scopus 로고    scopus 로고
    • Is there a common molecular pathway for addiction?
    • COI: 1:CAS:528:DC%2BD2MXhtFCrurbP, PID: 16251986
    • Nestler EJ. Is there a common molecular pathway for addiction? Nat Neurosci. 2005;8:1445–9.
    • (2005) Nat Neurosci , vol.8 , pp. 1445-1449
    • Nestler, E.J.1
  • 14
    • 0034672822 scopus 로고    scopus 로고
    • Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area
    • COI: 1:CAS:528:DC%2BD3cXotV2msL4%3D, PID: 11044884
    • Schilstrom B, Fagerquist MV, Zhang X, Hertel P, Panagis G, Nomikos GG, et al. Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area. Synapse. 2000;38:375–83.
    • (2000) Synapse , vol.38 , pp. 375-383
    • Schilstrom, B.1    Fagerquist, M.V.2    Zhang, X.3    Hertel, P.4    Panagis, G.5    Nomikos, G.G.6
  • 15
    • 0037452854 scopus 로고    scopus 로고
    • Glutamate receptor function in learning and memory
    • COI: 1:CAS:528:DC%2BD3sXitV2ht70%3D, PID: 12644276
    • Riedel G, Platt B, Micheau J. Glutamate receptor function in learning and memory. Behav Brain Res. 2003;140:1–47.
    • (2003) Behav Brain Res , vol.140 , pp. 1-47
    • Riedel, G.1    Platt, B.2    Micheau, J.3
  • 16
    • 0025828670 scopus 로고
    • Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor
    • COI: 1:CAS:528:DyaK3MXisVejsbY%3D, PID: 2005979
    • Cooper E, Couturier S, Ballivet M. Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature. 1991;350:235–8.
    • (1991) Nature , vol.350 , pp. 235-238
    • Cooper, E.1    Couturier, S.2    Ballivet, M.3
  • 17
    • 63849308882 scopus 로고    scopus 로고
    • The road to discovery of neuronal nicotinic cholinergic receptor subtypes
    • COI: 1:CAS:528:DC%2BC3cXhtVKlurbE, PID: 19184647
    • Collins AC, Salminen O, Marks MJ, Whiteaker P, Grady SR. The road to discovery of neuronal nicotinic cholinergic receptor subtypes. Handb Exp Pharmacol. 2009;192:85–112.
    • (2009) Handb Exp Pharmacol , vol.192 , pp. 85-112
    • Collins, A.C.1    Salminen, O.2    Marks, M.J.3    Whiteaker, P.4    Grady, S.R.5
  • 18
    • 41649103052 scopus 로고    scopus 로고
    • A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    • COI: 1:CAS:528:DC%2BD1cXktFCgsbg%3D, PID: 18385739
    • Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 2008;452:638–42.
    • (2008) Nature , vol.452 , pp. 638-642
    • Thorgeirsson, T.E.1    Geller, F.2    Sulem, P.3    Rafnar, T.4    Wiste, A.5    Magnusson, K.P.6
  • 20
    • 84862643496 scopus 로고    scopus 로고
    • Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence
    • PID: 22006218
    • Yoon D, Kim YJ, Cui WY, Van der Vaart A, Cho YS, Lee JY, et al. Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. Hum Genet. 2012;131:1009–21.
    • (2012) Hum Genet , vol.131 , pp. 1009-1021
    • Yoon, D.1    Kim, Y.J.2    Cui, W.Y.3    Van der Vaart, A.4    Cho, Y.S.5    Lee, J.Y.6
  • 21
    • 77957366301 scopus 로고    scopus 로고
    • Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD
    • PID: 20700436, this paper the authors diligently scrutinized the 15q25 smoking locus, and dissected several independent loci contributing to smoking behavior, suggesting a high level of genetic complexities within this locus
    • Saccone NL, Culverhouse RC, Schwantes-An TH, Cannon DS, Chen X, Cichon S, et al. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet. 2010;6:e1001053. In this paper the authors diligently scrutinized the 15q25 smoking locus, and dissected several independent loci contributing to smoking behavior, suggesting a high level of genetic complexities within this locus.
    • (2010) PLoS Genet , vol.6
    • Saccone, N.L.1    Culverhouse, R.C.2    Schwantes-An, T.H.3    Cannon, D.S.4    Chen, X.5    Cichon, S.6
  • 22
    • 79951694140 scopus 로고    scopus 로고
    • Genetic vulnerability and susceptibility to substance dependence
    • COI: 1:CAS:528:DC%2BC3MXit1Kntb4%3D, PID: 21338875
    • Bierut LJ. Genetic vulnerability and susceptibility to substance dependence. Neuron. 2011;69(4):618–27.
    • (2011) Neuron , vol.69 , Issue.4 , pp. 618-627
    • Bierut, L.J.1
  • 23
    • 79953246461 scopus 로고    scopus 로고
    • Habenular alpha5 nicotinic receptor subunit signalling controls nicotine intake
    • COI: 1:CAS:528:DC%2BC3MXht12msr0%3D, PID: 21278726, This sophisticated paper reveals that, at least rodents, CHRNA5 is crucial inducing an inhibitory motivational signal that acts to limit nicotine intake
    • Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ. Habenular alpha5 nicotinic receptor subunit signalling controls nicotine intake. Nature. 2011;471:597–601. This sophisticated paper reveals that, at least in rodents, CHRNA5 is crucial in inducing an inhibitory motivational signal that acts to limit nicotine intake.
    • (2011) Nature , vol.471 , pp. 597-601
    • Fowler, C.D.1    Lu, Q.2    Johnson, P.M.3    Marks, M.J.4    Kenny, P.J.5
  • 24
    • 70149090145 scopus 로고    scopus 로고
    • The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    • COI: 1:CAS:528:DC%2BD1MXhtVOmtL7N, PID: 19706762
    • Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res. 2009;69:6848–56.
    • (2009) Cancer Res , vol.69 , pp. 6848-6856
    • Saccone, N.L.1    Wang, J.C.2    Breslau, N.3    Johnson, E.O.4    Hatsukami, D.5    Saccone, S.F.6
  • 25
    • 77957862820 scopus 로고    scopus 로고
    • Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population
    • PID: 20808433
    • Li MD, Yoon D, Lee JY, Han BG, Niu T, Payne TJ, et al. Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. PLoS One. 2010;5:e12183.
    • (2010) PLoS One , vol.5
    • Li, M.D.1    Yoon, D.2    Lee, J.Y.3    Han, B.G.4    Niu, T.5    Payne, T.J.6
  • 26
    • 84879988890 scopus 로고    scopus 로고
    • Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study
    • COI: 1:CAS:528:DC%2BC3sXhsV2gs7%2FE, PID: 23875064
    • Hallfors J, Loukola A, Pitkaniemi J, Broms U, Mannisto S, Salomaa V, et al. Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study. Int J Mol Epidemiol Genet. 2013;4:109–19.
    • (2013) Int J Mol Epidemiol Genet , vol.4 , pp. 109-119
    • Hallfors, J.1    Loukola, A.2    Pitkaniemi, J.3    Broms, U.4    Mannisto, S.5    Salomaa, V.6
  • 27
    • 84861549512 scopus 로고    scopus 로고
    • Analysis of detailed phenotype profiles reveals CHRNA-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits
    • Broms U, Wedenoja J, Largeau MR, Korhonen T, Pitkaniemi J, Keskitalo-Vuokko K, et al. Analysis of detailed phenotype profiles reveals CHRNA-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. Nicotine Tob Res. 2012;14:720–33. doi:10.1093/ntr/ntr283.
    • (2012) Nicotine Tob Res , vol.14 , pp. 720-733
    • Broms, U.1    Wedenoja, J.2    Largeau, M.R.3    Korhonen, T.4    Pitkaniemi, J.5    Keskitalo-Vuokko, K.6
  • 28
    • 84885935952 scopus 로고    scopus 로고
    • Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway
    • COI: 1:CAS:528:DC%2BC3sXhs1CltLbM, PID: 23443019
    • Gabrielsen ME, Romundstad P, Langhammer A, Krokan HE, Skorpen F. Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway. Eur J Hum Genet. 2013;21:1293–9.
    • (2013) Eur J Hum Genet , vol.21 , pp. 1293-1299
    • Gabrielsen, M.E.1    Romundstad, P.2    Langhammer, A.3    Krokan, H.E.4    Skorpen, F.5
  • 29
    • 77951766653 scopus 로고    scopus 로고
    • Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
    • PID: 19776245
    • Lips EH, Gaborieau V, McKay JD, Chabrier A, Hung RJ, Boffetta P, et al. Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. Int J Epidemiol. 2010;39:563–77.
    • (2010) Int J Epidemiol , vol.39 , pp. 563-577
    • Lips, E.H.1    Gaborieau, V.2    McKay, J.D.3    Chabrier, A.4    Hung, R.J.5    Boffetta, P.6
  • 30
    • 84872788481 scopus 로고    scopus 로고
    • Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans
    • PID: 23232035
    • Walsh KM, Amos CI, Wenzlaff AS, Gorlov IP, Sison JD, Wu X, et al. Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans. Oncotarget. 2012;3:1428–38.
    • (2012) Oncotarget , vol.3 , pp. 1428-1438
    • Walsh, K.M.1    Amos, C.I.2    Wenzlaff, A.S.3    Gorlov, I.P.4    Sison, J.D.5    Wu, X.6
  • 31
    • 84873326172 scopus 로고    scopus 로고
    • Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans
    • COI: 1:CAS:528:DC%2BC3sXitVOisrY%3D, PID: 23221128
    • Walsh KM, Gorlov IP, Hansen HM, Wu X, Spitz MR, Zhang H, et al. Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev. 2013;22:251–60.
    • (2013) Cancer Epidemiol Biomarkers Prev , vol.22 , pp. 251-260
    • Walsh, K.M.1    Gorlov, I.P.2    Hansen, H.M.3    Wu, X.4    Spitz, M.R.5    Zhang, H.6
  • 32
    • 84863349878 scopus 로고    scopus 로고
    • Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking
    • COI: 1:CAS:528:DC%2BC38XkvVOqt70%3D, PID: 22438940
    • Kapoor M, Wang JC, Bertelsen S, Bucholz K, Budde JP, Hinrichs A, et al. Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. PLoS One. 2012;7:e33513.
    • (2012) PLoS One , vol.7
    • Kapoor, M.1    Wang, J.C.2    Bertelsen, S.3    Bucholz, K.4    Budde, J.P.5    Hinrichs, A.6
  • 33
    • 84887606484 scopus 로고    scopus 로고
    • Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking
    • PID: 24186853
    • Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, et al. Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. Genet Epidemiol. 2013;37:846–59.
    • (2013) Genet Epidemiol , vol.37 , pp. 846-859
    • Stephens, S.H.1    Hartz, S.M.2    Hoft, N.R.3    Saccone, N.L.4    Corley, R.C.5    Hewitt, J.K.6
  • 34
    • 84865562672 scopus 로고    scopus 로고
    • Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
    • PID: 22868939, A large meta-analysis presenting evidence for a gene by environment (G × E) interaction at the 15q25 locus
    • Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, et al. Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry. 2012;69:854–60. A large meta-analysis presenting evidence for a gene by environment (G × E) interaction at the 15q25 locus.
    • (2012) Arch Gen Psychiatry , vol.69 , pp. 854-860
    • Hartz, S.M.1    Short, S.E.2    Saccone, N.L.3    Culverhouse, R.4    Chen, L.5    Schwantes-An, T.H.6
  • 35
    • 77954761157 scopus 로고    scopus 로고
    • Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes
    • COI: 1:CAS:528:DC%2BC3cXovFKmtr4%3D, PID: 20485328
    • Sherva R, Kranzler HR, Yu Y, Logue MW, Poling J, Arias AJ, et al. Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology. 2010;35:1921–31.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1921-1931
    • Sherva, R.1    Kranzler, H.R.2    Yu, Y.3    Logue, M.W.4    Poling, J.5    Arias, A.J.6
  • 36
    • 2642529861 scopus 로고    scopus 로고
    • Effect of smokeless tobacco (snus) on smoking and public health in Sweden
    • COI: 1:STN:280:DC%2BD2c%2Flslemsw%3D%3D, PID: 14660766
    • Foulds J, Ramstrom L, Burke M, Fagerström K. Effect of smokeless tobacco (snus) on smoking and public health in Sweden. Tob Control. 2003;12:349–59.
    • (2003) Tob Control , vol.12 , pp. 349-359
    • Foulds, J.1    Ramstrom, L.2    Burke, M.3    Fagerström, K.4
  • 37
    • 0025923219 scopus 로고
    • The fagerström test for nicotine dependence: a revision of the fagerström tolerance questionnaire
    • COI: 1:STN:280:DyaK38%2Fjtlejtg%3D%3D, PID: 1932883
    • Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO. The fagerström test for nicotine dependence: a revision of the fagerström tolerance questionnaire. Br J Addict. 1991;86:1119–27.
    • (1991) Br J Addict , vol.86 , pp. 1119-1127
    • Heatherton, T.F.1    Kozlowski, L.T.2    Frecker, R.C.3    Fagerström, K.O.4
  • 38
    • 84867209234 scopus 로고    scopus 로고
    • CHRNB3 is more strongly associated with fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results
    • PID: 22524403
    • Rice JP, Hartz SM, Agrawal A, Almasy L, Bennett S, Breslau N, et al. CHRNB3 is more strongly associated with fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results. Addiction. 2012;107:2019–28.
    • (2012) Addiction , vol.107 , pp. 2019-2028
    • Rice, J.P.1    Hartz, S.M.2    Agrawal, A.3    Almasy, L.4    Bennett, S.5    Breslau, N.6
  • 39
    • 84888298016 scopus 로고    scopus 로고
    • Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations
    • COI: 1:CAS:528:DC%2BC3sXhs1yhs7fF, PID: 23319001
    • Cui WY, Wang S, Yang J, Yi SG, Yoon D, Kim YJ, et al. Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations. Mol Psychiatry. 2013;18:1149–51.
    • (2013) Mol Psychiatry , vol.18 , pp. 1149-1151
    • Cui, W.Y.1    Wang, S.2    Yang, J.3    Yi, S.G.4    Yoon, D.5    Kim, Y.J.6
  • 40
    • 71349087317 scopus 로고    scopus 로고
    • Meta-analysis of 15 genome-wide linkage scans of smoking behavior
    • COI: 1:CAS:528:DC%2BD1MXhsFGrsbjF, PID: 19819424, This paper summarizes the linkage analysis literature, which may be of relevance when searching for rare variants families
    • Han S, Gelernter J, Luo X, Yang BZ. Meta-analysis of 15 genome-wide linkage scans of smoking behavior. Biol Psychiatry. 2010;67:12–9. This paper summarizes the linkage analysis literature, which may be of relevance when searching for rare variants in families.
    • (2010) Biol Psychiatry , vol.67 , pp. 12-19
    • Han, S.1    Gelernter, J.2    Luo, X.3    Yang, B.Z.4
  • 41
    • 80051998030 scopus 로고    scopus 로고
    • Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence
    • COI: 1:CAS:528:DC%2BC3MXhtVOjsrnK, PID: 21683344
    • Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, et al. Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biol Psychiatry. 2011;70:528–36.
    • (2011) Biol Psychiatry , vol.70 , pp. 528-536
    • Xie, P.1    Kranzler, H.R.2    Krauthammer, M.3    Cosgrove, K.P.4    Oslin, D.5    Anton, R.F.6
  • 42
    • 84856079279 scopus 로고    scopus 로고
    • Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence
    • COI: 1:CAS:528:DC%2BC38XhtV2is7g%3D, PID: 22042774
    • Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, et al. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Hum Mol Genet. 2012;21:647–55.
    • (2012) Hum Mol Genet , vol.21 , pp. 647-655
    • Haller, G.1    Druley, T.2    Vallania, F.L.3    Mitra, R.D.4    Li, P.5    Akk, G.6
  • 43
    • 75749124555 scopus 로고    scopus 로고
    • Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation
    • COI: 1:CAS:528:DC%2BC3cXhtlCrurg%3D, PID: 19890259
    • Wang J, Li MD. Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. Neuropsychopharmacology. 2010;35:702–19.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 702-719
    • Wang, J.1    Li, M.D.2
  • 44
    • 77952420982 scopus 로고    scopus 로고
    • Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    • COI: 1:CAS:528:DC%2BC3cXmtVSnt7c%3D, PID: 20393456
    • Petrovsky N, Quednow BB, Ettinger U, Schmechtig A, Mossner R, Collier DA, et al. Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers. Neuropsychopharmacology. 2010;35:1429–39.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1429-1439
    • Petrovsky, N.1    Quednow, B.B.2    Ettinger, U.3    Schmechtig, A.4    Mossner, R.5    Collier, D.A.6
  • 45
  • 46
    • 84897467984 scopus 로고    scopus 로고
    • Association of the nicotinic receptor alpha7 subunit gene (CHRNA7) with schizophrenia and visual backward masking
    • PID: 24155726
    • Bakanidze G, Roinishvili M, Chkonia E, Kitzrow W, Richter S, Neumann K, et al. Association of the nicotinic receptor alpha7 subunit gene (CHRNA7) with schizophrenia and visual backward masking. Front Psychiatry. 2013;4:133.
    • (2013) Front Psychiatry , vol.4 , pp. 133
    • Bakanidze, G.1    Roinishvili, M.2    Chkonia, E.3    Kitzrow, W.4    Richter, S.5    Neumann, K.6
  • 47
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
    • Cross-Disorder Group of the Psychiatric Genomics Consortium, Genetic Risk Outcome of Psychosis (GROPU) Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet. 2013;381:1371–79.
    • (2013) The Lancet , vol.381 , pp. 1371-1379
  • 49
    • 84899481501 scopus 로고    scopus 로고
    • Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample
    • This is the first paper to present data supporting the involvement of the neuregulin signaling pathway nicotine dependence. The association between nicotine dependence and a neuregulin receptor, ERBB4, is supported by convergent evidence from linkage studies and by replication an independent sample. Future support comes from behavioral mouse models (see Ref. [50], below
    • Loukola A, Wedenoja J, Keskitalo-Vuokko K, Broms U, Korhonen T, Ripatti S, et al. Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample. Mol Psychiatry. 2013. doi:10.1038/mp.2013.72. This is the first paper to present data supporting the involvement of the neuregulin signaling pathway in nicotine dependence. The association between nicotine dependence and a neuregulin receptor, ERBB4, is supported by convergent evidence from linkage studies and by replication in an independent sample. Future support comes from behavioral mouse models (see Ref. [50], below).
    • (2013) Mol Psychiatry
    • Loukola, A.1    Wedenoja, J.2    Keskitalo-Vuokko, K.3    Broms, U.4    Korhonen, T.5    Ripatti, S.6
  • 50
    • 84903596923 scopus 로고    scopus 로고
    • Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence
    • This paper nicely demonstrates that both ErbB4 and NRG3 (Neuregulin 3) expression increases during nicotine exposure and withdrawal a mouse model. Further, withdrawal-induced anxiety is abolished both mice with a knock-down mutation Nrg3, and mice treated with an ErbB4 inhibitor, suggesting that the neuregulin signaling pathway is essential the anxiety effects of nicotine withdrawal. The authors also show that NRG3 SNPs associate with smoking cessation success a clinical trial
    • Turner JR, Ray R, Lee B, Everett L, Xiang J, Jepson C, et al. Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence. Mol Psychiatry. 2013. doi:10.1038/mp.2013.104. This paper nicely demonstrates that both ErbB4 and NRG3 (Neuregulin 3) expression increases during nicotine exposure and withdrawal in a mouse model. Further, withdrawal-induced anxiety is abolished both in mice with a knock-down mutation in Nrg3, and in mice treated with an ErbB4 inhibitor, suggesting that the neuregulin signaling pathway is essential in the anxiety effects of nicotine withdrawal. The authors also show that NRG3 SNPs associate with smoking cessation success in a clinical trial.
    • (2013) Mol Psychiatry
    • Turner, J.R.1    Ray, R.2    Lee, B.3    Everett, L.4    Xiang, J.5    Jepson, C.6
  • 51
    • 0037429649 scopus 로고    scopus 로고
    • Neuregulins: functions, forms, and signaling strategies
    • COI: 1:CAS:528:DC%2BD3sXitVyltr8%3D, PID: 12648463
    • Falls DL. Neuregulins: functions, forms, and signaling strategies. Exp Cell Res. 2003;284:14–30.
    • (2003) Exp Cell Res , vol.284 , pp. 14-30
    • Falls, D.L.1
  • 52
    • 43949084738 scopus 로고    scopus 로고
    • Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
    • COI: 1:CAS:528:DC%2BD1cXmtVahur0%3D, PID: 18478032
    • Mei L, Xiong WC. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci. 2008;9:437–52.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 437-452
    • Mei, L.1    Xiong, W.C.2
  • 54
    • 0037221589 scopus 로고    scopus 로고
    • Association of neuregulin 1 with schizophrenia confirmed in a Scottish population
    • COI: 1:CAS:528:DC%2BD3sXis1ygsw%3D%3D, PID: 12478479
    • Stefansson H, Sarginson J, Kong A, Yates P, Steinthorsdottir V, Gudfinnsson E, et al. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet. 2003;72:83–7.
    • (2003) Am J Hum Genet , vol.72 , pp. 83-87
    • Stefansson, H.1    Sarginson, J.2    Kong, A.3    Yates, P.4    Steinthorsdottir, V.5    Gudfinnsson, E.6
  • 55
    • 33745684066 scopus 로고    scopus 로고
    • Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology
    • COI: 1:CAS:528:DC%2BD28Xmsl2jur8%3D, PID: 16442083
    • Harrison PJ, Law AJ. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry. 2006;60:132–40.
    • (2006) Biol Psychiatry , vol.60 , pp. 132-140
    • Harrison, P.J.1    Law, A.J.2
  • 56
    • 58049209657 scopus 로고    scopus 로고
    • Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia
    • COI: 1:CAS:528:DC%2BD1MXpsFaktQ%3D%3D, PID: 19118813
    • Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, et al. Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia. Am J Hum Genet. 2009;84:21–34.
    • (2009) Am J Hum Genet , vol.84 , pp. 21-34
    • Chen, P.L.1    Avramopoulos, D.2    Lasseter, V.K.3    McGrath, J.A.4    Fallin, M.D.5    Liang, K.Y.6
  • 57
    • 32244444322 scopus 로고    scopus 로고
    • The involvement of ErbB4 with schizophrenia: association and expression studies
    • COI: 1:CAS:528:DC%2BD2sXms1SrtL0%3D, PID: 16402353
    • Silberberg G, Darvasi A, Pinkas-Kramarski R, Navon R. The involvement of ErbB4 with schizophrenia: association and expression studies. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:142–8.
    • (2006) Am J Med Genet B Neuropsychiatr Genet , vol.141B , pp. 142-148
    • Silberberg, G.1    Darvasi, A.2    Pinkas-Kramarski, R.3    Navon, R.4
  • 58
    • 30344445643 scopus 로고    scopus 로고
    • Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    • COI: 1:CAS:528:DC%2BD2sXms1Srt7g%3D, PID: 16249994
    • Norton N, Moskvina V, Morris DW, Bray NJ, Zammit S, Williams NM, et al. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:96–101.
    • (2006) Am J Med Genet B Neuropsychiatr Genet , vol.141B , pp. 96-101
    • Norton, N.1    Moskvina, V.2    Morris, D.W.3    Bray, N.J.4    Zammit, S.5    Williams, N.M.6
  • 59
    • 33846589304 scopus 로고    scopus 로고
    • Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia
    • COI: 1:CAS:528:DC%2BD2sXhtVKktrs%3D, PID: 17164265
    • Law AJ, Kleinman JE, Weinberger DR, Weickert CS. Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet. 2007;16:129–41.
    • (2007) Hum Mol Genet , vol.16 , pp. 129-141
    • Law, A.J.1    Kleinman, J.E.2    Weinberger, D.R.3    Weickert, C.S.4
  • 60
    • 43949141596 scopus 로고    scopus 로고
    • Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
    • COI: 1:CAS:528:DC%2BD1cXkslSnt7w%3D, PID: 18385378
    • Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A. 2008;105:5585–90.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5585-5590
    • Savonenko, A.V.1    Melnikova, T.2    Laird, F.M.3    Stewart, K.A.4    Price, D.L.5    Wong, P.C.6
  • 61
    • 47749095968 scopus 로고    scopus 로고
    • Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment
    • COI: 1:STN:280:DC%2BD1cvlsFKhtg%3D%3D, PID: 18626010
    • Dejaegere T, Serneels L, Schafer MK, Van Biervliet J, Horre K, Depboylu C, et al. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proc Natl Acad Sci U S A. 2008;105:9775–80.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9775-9780
    • Dejaegere, T.1    Serneels, L.2    Schafer, M.K.3    Van Biervliet, J.4    Horre, K.5    Depboylu, C.6
  • 62
    • 85083227483 scopus 로고
    • DSM-IV (4th edition). American Psychiatric Association, Washington
    • Diagnostic and statistical manual of mental disorders: DSM-IV (4th edition). American Psychiatric Association: Washington, 1994.
    • (1994)
  • 63
    • 84878654809 scopus 로고    scopus 로고
    • Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients
    • COI: 1:CAS:528:DC%2BC3sXhtFSqt7rI, PID: 23715299
    • Hatzimanolis A, McGrath JA, Wang R, Li T, Wong PC, Nestadt G, et al. Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients. Transl Psychiatry. 2013;3:e264.
    • (2013) Transl Psychiatry , vol.3
    • Hatzimanolis, A.1    McGrath, J.A.2    Wang, R.3    Li, T.4    Wong, P.C.5    Nestadt, G.6
  • 64
    • 0030885491 scopus 로고    scopus 로고
    • A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
    • COI: 1:CAS:528:DyaK2sXmsVGlu7s%3D, PID: 9316878
    • Messina ES, Tyndale RF, Sellers EM. A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. J Pharmacol Exp Ther. 1997;282:1608–14.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 1608-1614
    • Messina, E.S.1    Tyndale, R.F.2    Sellers, E.M.3
  • 65
    • 36448929757 scopus 로고    scopus 로고
    • Genetic variability in CYP2A6 and the pharmacokinetics of nicotine
    • COI: 1:CAS:528:DC%2BD2sXht1Cku7rP, PID: 17979512
    • Mwenifumbo JC, Tyndale RF. Genetic variability in CYP2A6 and the pharmacokinetics of nicotine. Pharmacogenomics. 2007;8:1385–402.
    • (2007) Pharmacogenomics , vol.8 , pp. 1385-1402
    • Mwenifumbo, J.C.1    Tyndale, R.F.2
  • 66
    • 34147195806 scopus 로고    scopus 로고
    • Overview of the pharmacogenomics of cigarette smoking
    • COI: 1:CAS:528:DC%2BD2sXjvVaqs7g%3D, PID: 17224913
    • Ho MK, Tyndale RF. Overview of the pharmacogenomics of cigarette smoking. Pharmacogenomics J. 2007;7:81–98.
    • (2007) Pharmacogenomics J , vol.7 , pp. 81-98
    • Ho, M.K.1    Tyndale, R.F.2
  • 67
    • 84862685998 scopus 로고    scopus 로고
    • Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes
    • Gold AB, Lerman C. Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. Hum Genet 2012.
    • (2012) Hum Genet
    • Gold, A.B.1    Lerman, C.2
  • 68
    • 67149146254 scopus 로고    scopus 로고
    • Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine
    • COI: 1:CAS:528:DC%2BD1MXksVCls7c%3D, PID: 19300303
    • Swan GE, Lessov-Schlaggar CN, Bergen AW, He Y, Tyndale RF, Benowitz NL. Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine. Pharmacogenet Genomics. 2009;19:388–98.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 388-398
    • Swan, G.E.1    Lessov-Schlaggar, C.N.2    Bergen, A.W.3    He, Y.4    Tyndale, R.F.5    Benowitz, N.L.6
  • 69
    • 63849147368 scopus 로고    scopus 로고
    • Nicotine chemistry, metabolism, kinetics and biomarkers
    • COI: 1:CAS:528:DC%2BC3cXhtVKlurbK, PID: 19184645
    • Benowitz NL, Hukkanen J, Jacob 3rd P. Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol. 2009;192:29–60.
    • (2009) Handb Exp Pharmacol , vol.192 , pp. 29-60
    • Benowitz, N.L.1    Hukkanen, J.2    Jacob, P.3
  • 70
    • 84876565867 scopus 로고    scopus 로고
    • The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex
    • COI: 1:CAS:528:DC%2BC3sXltFCgu7g%3D, PID: 23371292
    • Zhu AZ, Renner CC, Hatsukami DK, Swan GE, Lerman C, Benowitz NL, et al. The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex. Cancer Epidemiol Biomarkers Prev. 2013;22:708–18.
    • (2013) Cancer Epidemiol Biomarkers Prev , vol.22 , pp. 708-718
    • Zhu, A.Z.1    Renner, C.C.2    Hatsukami, D.K.3    Swan, G.E.4    Lerman, C.5    Benowitz, N.L.6
  • 71
    • 3042563552 scopus 로고    scopus 로고
    • Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity
    • COI: 1:CAS:528:DC%2BD2cXlsVaqtrY%3D, PID: 15229465
    • Dempsey D, Tutka P, Jacob 3rd P, Allen F, Schoedel K, Tyndale RF, et al. Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity. Clin Pharmacol Ther. 2004;76:64–72.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 64-72
    • Dempsey, D.1    Tutka, P.2    Jacob, P.3    Allen, F.4    Schoedel, K.5    Tyndale, R.F.6
  • 72
    • 0038119910 scopus 로고    scopus 로고
    • Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
    • COI: 1:CAS:528:DC%2BD3sXks1als74%3D, PID: 12814665
    • Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Neuropharmacology. 2003;45:122–32.
    • (2003) Neuropharmacology , vol.45 , pp. 122-132
    • Miksys, S.1    Lerman, C.2    Shields, P.G.3    Mash, D.C.4    Tyndale, R.F.5
  • 73
    • 84895832391 scopus 로고    scopus 로고
    • Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms
    • Bloom AJ, Baker TB, Chen LS, Breslau N, Hatsukami D, Bierut LJ, et al. Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. Hum Mol Genet 2013.
    • (2013) Hum Mol Genet
    • Bloom, A.J.1    Baker, T.B.2    Chen, L.S.3    Breslau, N.4    Hatsukami, D.5    Bierut, L.J.6
  • 74
    • 84890136969 scopus 로고    scopus 로고
    • Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6)
    • Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, et al. Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction. 2013. doi:10.1111/add.12353.
    • (2013) Addiction
    • Chen, L.S.1    Bloom, A.J.2    Baker, T.B.3    Smith, S.S.4    Piper, M.E.5    Martinez, M.6
  • 75
    • 80052681515 scopus 로고    scopus 로고
    • Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk
    • COI: 1:CAS:528:DC%2BC3MXhtFKisbjM, PID: 21747048
    • Wassenaar CA, Dong Q, Wei Q, Amos CI, Spitz MR, Tyndale RF. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. J Natl Cancer Inst. 2011;103:1342–6.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1342-1346
    • Wassenaar, C.A.1    Dong, Q.2    Wei, Q.3    Amos, C.I.4    Spitz, M.R.5    Tyndale, R.F.6
  • 76
    • 70349573295 scopus 로고    scopus 로고
    • Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15
    • COI: 1:CAS:528:DC%2BD1MXhtFyhu77F, PID: 19628476
    • Keskitalo K, Broms U, Heliovaara M, Ripatti S, Surakka I, Perola M, et al. Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Hum Mol Genet. 2009;18:4007–12.
    • (2009) Hum Mol Genet , vol.18 , pp. 4007-4012
    • Keskitalo, K.1    Broms, U.2    Heliovaara, M.3    Ripatti, S.4    Surakka, I.5    Perola, M.6
  • 77
    • 84861325364 scopus 로고    scopus 로고
    • Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure
    • PID: 22534784
    • Munafò MR, Timofeeva MN, Morris RW, Prieto-Merino D, Sattar N, Brennan P, et al. Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst. 2012;104:740–8.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 740-748
    • Munafò, M.R.1    Timofeeva, M.N.2    Morris, R.W.3    Prieto-Merino, D.4    Sattar, N.5    Brennan, P.6
  • 79
    • 33847280943 scopus 로고    scopus 로고
    • Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking
    • PID: 17324032
    • Dick DM, Viken R, Purcell S, Kaprio J, Pulkkinen L, Rose RJ. Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking. J Abnorm Psychol. 2007;116:213–8.
    • (2007) J Abnorm Psychol , vol.116 , pp. 213-218
    • Dick, D.M.1    Viken, R.2    Purcell, S.3    Kaprio, J.4    Pulkkinen, L.5    Rose, R.J.6
  • 80
    • 33644596841 scopus 로고    scopus 로고
    • The moderating effects of religiosity on the genetic and environmental determinants of smoking initiation
    • PID: 16497606
    • Timberlake DS, Rhee SH, Haberstick BC, Hopfer C, Ehringer M, Lessem JM, et al. The moderating effects of religiosity on the genetic and environmental determinants of smoking initiation. Nicotine Tob Res. 2006;8:123–33.
    • (2006) Nicotine Tob Res , vol.8 , pp. 123-133
    • Timberlake, D.S.1    Rhee, S.H.2    Haberstick, B.C.3    Hopfer, C.4    Ehringer, M.5    Lessem, J.M.6
  • 81
    • 69949149819 scopus 로고    scopus 로고
    • Interplay of genetic risk factors and parent monitoring in risk for nicotine dependence
    • PID: 20871796
    • Chen LS, Johnson EO, Breslau N, Hatsukami D, Saccone NL, Grucza RA, et al. Interplay of genetic risk factors and parent monitoring in risk for nicotine dependence. Addiction. 2009;104:1731–40.
    • (2009) Addiction , vol.104 , pp. 1731-1740
    • Chen, L.S.1    Johnson, E.O.2    Breslau, N.3    Hatsukami, D.4    Saccone, N.L.5    Grucza, R.A.6
  • 82
    • 78649627016 scopus 로고    scopus 로고
    • Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence
    • PID: 20840187
    • Johnson EO, Chen LS, Breslau N, Hatsukami D, Robbins T, Saccone NL, et al. Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence. Addiction. 2010;105:2014–22.
    • (2010) Addiction , vol.105 , pp. 2014-2022
    • Johnson, E.O.1    Chen, L.S.2    Breslau, N.3    Hatsukami, D.4    Robbins, T.5    Saccone, N.L.6
  • 83
    • 50949084462 scopus 로고    scopus 로고
    • Mendelian randomisation and causal inference in observational epidemiology
    • PID: 18752343
    • Sheehan NA, Didelez V, Burton PR, Tobin MD. Mendelian randomisation and causal inference in observational epidemiology. PLoS Med. 2008;5:e177.
    • (2008) PLoS Med , vol.5
    • Sheehan, N.A.1    Didelez, V.2    Burton, P.R.3    Tobin, M.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.