Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway

European Journal of Human Genetics

Volumn 21, Issue 11, 2013, Pages 1293-1299

  Gabrielsen, Maiken E ^a   Romundstad, Pål ^b   Langhammer, Arnulf ^b   Krokan, Hans E ^a   Skorpen, Frank ^a,b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

COPD; enetic association; lung cancer; nicotine addiction; snus

Indexed keywords

NICOTINE;

ADULT; ARTICLE; CHROMOSOME; CHROMOSOME 15Q25; CHRONIC OBSTRUCTIVE LUNG DISEASE; FEMALE; GENE; GENE CLUSTER; GENETIC ASSOCIATION; GENOTYPE; HUMAN; LUNG CANCER; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; NORWAY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKELESS TOBACCO; SMOKING; SMOKING HABIT; TOBACCO DEPENDENCE;

NICOTIANA TABACUM;

ALLELES; CHROMOSOMES, HUMAN, PAIR 15; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; NORWAY; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; TOBACCO USE DISORDER; TOBACCO, SMOKELESS;

EID: 84885935952     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2013.26     Document Type: Article

References (52)

1. World Health Organization. WHO Report on the Global Tobacco Epidemic, 2008; The MPOWER package: Geneva, Switzerland.
2. Wasswa-Kintu S, Gan WQ, Man SFP, Pare PD, Sin DD: Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis. Thorax 2005; 60: 570-575. (Pubitemid 40966211)
3. Global Initiative for Chronic Obstructive Lung Disease: Global strategy for the diagnosis, management, and prevention of COPD: updated 2010. http://www.goldcopd. org/uploads/users/files/GOLDReport-April112011.pdf.
4. Lopez AD, Mathers CD: Measuring the global burden of disease and epidemiological transitions: 2002-2030. Ann Trop Med Parasitol 2006; 100: 481-499. (Pubitemid 47050869)
5. Amos CI, Wu X, Broderick P et al: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 2008; 40: 616-622. (Pubitemid 351601203)
6. Thorgeirsson TE, Geller F, Sulem P et al: A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 2008; 452: 638-642. (Pubitemid 351483366)
7. Wang Y, Broderick P, Webb E et al: Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet 2008; 40: 1407-1409.
8. Broderick P, Wang Y, Vijayakrishnan J et al: Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Cancer Res 2009; 69: 6633-6641.
9. Hung RJ, McKay JD, Gaborieau V et al: A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 2008; 452: 633-637. (Pubitemid 351483367)
10. Lips EH, Gaborieau V, McKay JD et al: Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. Int J Epidemiol 2010; 39: 563-577.
11. Spitz MR, Amos CI, Dong Q, Lin J, Wu X: The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst 2008; 100: 1552-1556.
12. Truong T, Hung RJ, Amos CI et al: Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst 2010; 102: 959-971.
13. Pillai SG, Ge D, Zhu G et al: A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 2009; 5: e1000421.
14. Bierut LJ, Madden PA, Breslau N et al: Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 2007; 16: 24-35. (Pubitemid 46152542)
15. Bierut LJ, Stitzel JA, Wang JC et al: Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 2008; 165: 1163-1171.
16. Saccone NL, Saccone SF, Hinrichs AL et al: Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 453-466.
17. Saccone NL, Schwantes-An TH, Wang JC et al: Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav 2010; 9: 741-750.
18. Saccone NL, Wang JC, Breslau N et al: The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res 2009; 69: 6848-6856.
19. Saccone SF, Hinrichs AL, Saccone NL et al: Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 2007; 16: 36-49. (Pubitemid 46152543)
20. Weiss RB, Baker TB, Cannon DS et al: A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet 2008; 4: e1000125.
21. Ware JJ, van den Bree MB, Munafo MR: Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. Nicotine Tob Res 2011; 13: 1167-1175.
22. Tobacco and Genetics Consortium; Furberg HKY, Dackor J, Boerwinkle E et al: Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 2010; 42: 441-447.
23. Liu JZ, Tozzi F, Waterworth DM et al: Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010; 42: 436-440.
24. Thorgeirsson TE, Gudbjartsson DF, Surakka I et al: Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 2010; 42: 448-453.
25. Saccone NL, Culverhouse RC, Schwantes-An TH et al: Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet 2010; 6: e1001053.
26. Improgo MR, Scofield MD, Tapper AR, Gardner PD: From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene 2010; 29: 4874-4884.
27. Dasgupta P, Chellappan SP: Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story. Cell Cycle 2006; 5: 2324-2328. (Pubitemid 44801377)
28. Maneckjee R, Minna JD: Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ 1994; 5: 1033-1040. (Pubitemid 24312278)
29. Wright SC, Zhong J, Zheng H, Larrick JW: Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB J 1993; 7: 1045-1051. (Pubitemid 23243447)
30. Foulds J, Ramstrom L, Burke M, Fagerstrom K: Effect of smokeless tobacco (snus) on smoking and public health in Sweden. Tob Control 2003; 12: 349-359. (Pubitemid 39452035)
31. Holmen J, Midthjell K, Krü ger et al: The Nord-Trøndelag Health Study 1995-97 (HUNT 2): objectives, contents, methods and participation. Norsk Epidemiol 2003; 13: 19-22.
32. Krokstad S, Langhammer A, Hveem K et al: Cohort Profile: The HUNT Study, Norway. Int J Epidemiol 2012; e-pub ahead of print 9 August 2012; doi:10.1093/ije/dys095.
33. Langhammer A, Johnsen R, Gulsvik A, Holmen TL, Bjermer L: Sex differences in lung vulnerability to tobacco smoking. Eur Respir J 2003; 21: 1017-1023. (Pubitemid 36675620)
34. Rostad H, Naalsund A, Norstein J, Jacobsen R, Aalokken TM: Is the treatment of lung cancer in Norway adequate? Tidsskr Nor Laegeforen 2002; 122: 2258-2262. (Pubitemid 35277619)
35. Langhammer A, Johnsen R, Gulsvik A, Holmen TL, Bjermer L: Forced spirometry reference values for Norwegian adults: the Bronchial Obstruction in Nord-Trondelag Study. Eur Respir J 2001; 18: 770-779. (Pubitemid 33076918)
36. Young RP, Hopkins RJ, Hay BA, Epton MJ, Black PN, Gamble GD: Lung cancer gene associated with COPD: triple whammy or possible confounding effect? Eur Respir J 2008; 32: 1158-1164.
37. Thorgeirsson TE, Stefansson K: Commentary: gene-environment interactions and smoking-related cancers. Int J Epidemiol 2010; 39: 577-579.
38. Lund KE, Scheffels J, McNeill A: The association between use of snus and quit rates for smoking: results from seven Norwegian cross-sectional studies. Addiction 2011; 106: 162-167.
39. Piper ME, McCarthy DE, Baker TB: Assessing tobacco dependence: a guide to measure evaluation and selection. Nicotine Tobacco Res 2006; 8: 339-351. (Pubitemid 43977036)
40. Baker TB, Weiss RB, Bolt D et al: Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Nicotine Tob Res 2009; 11: 785-796.
41. Berrettini W, Yuan X, Tozzi F et al: Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry 2008; 13: 368-373. (Pubitemid 351399826)
42. Hansen HM, Xiao Y, Rice T et al: Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. Hum Mol Genet 2010; 19: 3652-3661.
43. Wang Y, Broderick P, Matakidou A, Eisen T, Houlston RS: Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk. PLoS One 2011; 6: e19085.
44. Catassi A, Servent D, Paleari L, Cesario A, Russo P: Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: implications on lung carcinogenesis. Mutat Res 2008; 659: 221-231.
45. Egleton RD, Brown KC, Dasgupta P: Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis. Trends Pharmacol Sci 2008; 29: 151-158.
46. Improgo MR, Scofield MD, Tapper AR, Gardner PD: The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog Neurobiol 2010; 92: 212-226.
47. Improgo MR, Schlichting NA, Cortes RY, Zhao-Shea R, Tapper AR, Gardner PD: ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Mol Cancer Res 2010; 8: 194-203.
48. Improgo MR, Tapper AR, Gardner PD: Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer. Biochem Pharmacol 2011; 82: 1015-1021.
49. Schuller HM, Orloff M: Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells. Biochem Pharmacol 1998; 55: 1377-1384. (Pubitemid 28298517)
50. Schuller HM: Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat Rev Cancer 2009; 9: 195-205.
51. Tsurutani J, Castillo SS, Brognard J et al: Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. Carcinogenesis 2005; 26: 1182-1195. (Pubitemid 41417895)
52. West KA, Brognard J, Clark AS et al: Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest 2003; 111: 81-90. (Pubitemid 36134851)