Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli

Pain

Volumn 155, Issue 10, 2014, Pages 1962-1975

  Hockley, James R F ^a   Boundouki, George ^a   Cibert Goton, Vincent ^a   McGuire, Cian ^a   Yip, Ping K ^a   Chan, Christopher ^a   Tranter, Michael ^a   Wood, John N ^b   Nassar, Mohammed A ^c   Blackshaw, L Ashley ^a   Aziz, Qasim ^a   Michael, Gregory J ^a   Baker, Mark D ^a   Winchester, Wendy J ^d   Knowles, Charles H ^a   Bulmer, David C ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Distal colon; Inflammatory bowel disease; NaV1.9; Nociceptor sensitivity; Noxious distension; Supernatants; Visceral hypersensitivity; Visceral pain; Voltage gated sodium channel

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; SODIUM CHANNEL NAV1.9; TUMOR NECROSIS FACTOR ALPHA; ADENOSINE TRIPHOSPHATE; PROSTAGLANDIN E2; SCN11A PROTEIN, MOUSE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON RESECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DESCENDING COLON; ELECTROSTIMULATION; EVOKED RESPONSE; EXCITATION; FEMALE; GENE DELETION; HEMICOLECTOMY; HUMAN; HUMAN TISSUE; HYPERSENSITIVITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; MALE; MECHANICAL STIMULATION; MESENTERY; MOUSE; NOCICEPTION; NONHUMAN; PAIN RECEPTOR; PAIN THRESHOLD; POSTOPERATIVE ANALGESIA; PROCTOCOLECTOMY; PROTEIN EXPRESSION; RECEPTIVE FIELD; SENSITIZATION; SENSORY NERVE; SENSORY NERVE CELL; SENSORY SYSTEM ELECTROPHYSIOLOGY; SMALL INTESTINE RESECTION; SODIUM CURRENT; SPINAL GANGLION; SPLANCHNIC NERVE; STIMULUS RESPONSE; VISCERAL PAIN; ADOLESCENT; ADULT; AGED; ANIMAL; COLON; DRUG EFFECTS; GENETICS; HYPERALGESIA; INNERVATION; KNOCKOUT MOUSE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; STIMULATION; YOUNG ADULT;

ACTION POTENTIALS; ADENOSINE TRIPHOSPHATE; ADOLESCENT; ADULT; AGED; ANIMALS; COLON; DINOPROSTONE; FEMALE; GANGLIA, SPINAL; HUMANS; HYPERALGESIA; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; NAV1.9 VOLTAGE-GATED SODIUM CHANNEL; PHYSICAL STIMULATION; VISCERAL AFFERENTS; YOUNG ADULT;

EID: 84908137354     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2014.06.015     Document Type: Article

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