메뉴 건너뛰기




Volumn 74, Issue 20, 2014, Pages 5832-5845

Metabolic vulnerabilities in endometrial cancer

Author keywords

[No Author keywords available]

Indexed keywords

2 FUROIC ACID DERIVATIVE; 3 BROMOPYRUVATE; 5 (TETRADECYLOXY) 2 FUROIC ACID; 6 DIAZO 5 OXONORLEUCINE; DEOXYGLUCOSE; DICHLOROACETIC ACID; ETOMOXIR; METFORMIN; PHLORETIN; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BROMOPYRUVATE; COENZYME A; GLUCOSE TRANSPORTER; HEXOKINASE; PYRUVATE KINASE; REACTIVE OXYGEN METABOLITE; SLC2A9 PROTEIN, HUMAN;

EID: 84908125830     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-0254     Document Type: Article
Times cited : (85)

References (50)
  • 4
    • 84865464494 scopus 로고    scopus 로고
    • Molecular targets and targeted therapeutics in endometrial cancer
    • Weigelt B, Banerjee S. Molecular targets and targeted therapeutics in endometrial cancer. Curr Opin Oncol 2012;24:554-63.
    • (2012) Curr Opin Oncol , vol.24 , pp. 554-563
    • Weigelt, B.1    Banerjee, S.2
  • 5
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004;4:579-591.
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 6
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625-38.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 8
    • 82955233133 scopus 로고    scopus 로고
    • Impaired glucose metabolism and diabetes and the risk of breast, endometrial, and ovarian cancer
    • Lambe M, Wigertz A, Garmo H, Walldius G, Jungner I, Hammar N. Impaired glucose metabolism and diabetes and the risk of breast, endometrial, and ovarian cancer. Cancer Causes Control 2011;22:1163-1171.
    • (2011) Cancer Causes Control , vol.22 , pp. 1163-1171
    • Lambe, M.1    Wigertz, A.2    Garmo, H.3    Walldius, G.4    Jungner, I.5    Hammar, N.6
  • 9
    • 0346888536 scopus 로고    scopus 로고
    • Cancerincidence in patients with type 1 diabetes mellitus: A population-based cohort study in Sweden
    • Zendehdel K, Nyren O, Ostenson CG, Adami HO, Ekbom A, Ye W. Cancerincidence in patients with type 1 diabetes mellitus: a population-based cohort study in Sweden. J Natl Cancer Inst 2003;95:1797-800.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1797-1800
    • Zendehdel, K.1    Nyren, O.2    Ostenson, C.G.3    Adami, H.O.4    Ekbom, A.5    Ye, W.6
  • 10
    • 84856741601 scopus 로고    scopus 로고
    • Morbidly obese women with and without endometrial cancer: Are there differences in measured physical fitness, body composition, or hormones?
    • Modesitt SC, Geffel DL, Via J, Weltman LA. Morbidly obese women with and without endometrial cancer: are there differences in measured physical fitness, body composition, or hormones? Gynecol Oncol 2012;124:431-6.
    • (2012) Gynecol Oncol , vol.124 , pp. 431-436
    • Modesitt, S.C.1    Geffel, D.L.2    Via, J.3    Weltman, L.A.4
  • 13
    • 49849087494 scopus 로고    scopus 로고
    • Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    • Lu KH, Wu W, Dave B, Slomovitz BM, Burke TW, Munsell MF, et al. Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. Clin Cancer Res 2008;14:2543-50.
    • (2008) Clin Cancer Res , vol.14 , pp. 2543-2550
    • Lu, K.H.1    Wu, W.2    Dave, B.3    Slomovitz, B.M.4    Burke, T.W.5    Munsell, M.F.6
  • 14
    • 84863688356 scopus 로고    scopus 로고
    • Not all fat is equal: Differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer
    • Modesitt SC, Hsu JY, Chowbina SR, Lawrence RT, Hoehn KL. Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer. Int J Gynecol Cancer 2012;22:732-41.
    • (2012) Int J Gynecol Cancer , vol.22 , pp. 732-741
    • Modesitt, S.C.1    Hsu, J.Y.2    Chowbina, S.R.3    Lawrence, R.T.4    Hoehn, K.L.5
  • 15
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012;2:401-4.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3    Gross, B.E.4    Sumer, S.O.5    Aksoy, B.A.6
  • 16
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
    • Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013;6:pl1.
    • (2013) Sci Signal , vol.6 , pp. l1
    • Gao, J.1    Aksoy, B.A.2    Dogrusoz, U.3    Dresdner, G.4    Gross, B.5    Sumer, S.O.6
  • 18
    • 84908139636 scopus 로고    scopus 로고
    • [Internet]. Maryland: The Cancer Genome Atlas (TCGA) Research Network; [updated 2014; cited 2014 Jul 25]. Available from
    • cancergenome.nih.gov [Internet]. Maryland: The Cancer Genome Atlas (TCGA) Research Network; 2014 [updated 2014; cited 2014 Jul 25]. Available from http://cancergenome.nih.gov.
    • (2014)
  • 19
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
    • (2001) Nucleic Acids Res , vol.29 , pp. e45
    • Pfaffl, M.W.1
  • 21
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protocols 2008;4:44-57.
    • (2008) Nat Protocols , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 22
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang DW, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009;37:1-13.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 24
    • 0020985062 scopus 로고
    • Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture
    • Way DL, Grosso DS, Davis JR, Surwit EA, Christian CD. Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture. In Vitro 1983;19:147-58.
    • (1983) In Vitro , vol.19 , pp. 147-158
    • Way, D.L.1    Grosso, D.S.2    Davis, J.R.3    Surwit, E.A.4    Christian, C.D.5
  • 25
    • 0034664974 scopus 로고    scopus 로고
    • Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
    • Doege H, Bocianski A, Joost HG, Schurmann A. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. Biochem J 2000;350:771-6.
    • (2000) Biochem J , vol.350 , pp. 771-776
    • Doege, H.1    Bocianski, A.2    Joost, H.G.3    Schurmann, A.4
  • 26
    • 84871965497 scopus 로고    scopus 로고
    • MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
    • Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, et al. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nat Genet 2013;45:104-108.
    • (2013) Nat Genet , vol.45 , pp. 104-108
    • Birsoy, K.1    Wang, T.2    Possemato, R.3    Yilmaz, O.H.4    Koch, C.E.5    Chen, W.W.6
  • 27
    • 84873027161 scopus 로고    scopus 로고
    • Anticancer efficacy of the metabolic blocker 3-bromopyruvate: Specific molecular targeting
    • Ganapathy-Kanniappan S, Kunjithapatham R, Geschwind J-FH. Anticancer efficacy of the metabolic blocker 3-bromopyruvate: specific molecular targeting. Anticancer Res 2013;33:13-20.
    • (2013) Anticancer Res , vol.33 , pp. 13-20
    • Ganapathy-Kanniappan, S.1    Kunjithapatham, R.2    Geschwind, J.-F.H.3
  • 28
    • 84862809596 scopus 로고    scopus 로고
    • A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: From bench side to bedside
    • Ko YH, Verhoeven HA, Lee MJ, Corbin DJ, Vogl TJ, Pedersen PL. A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside. J Bioenerg Biomembr 2012;44:163-70.
    • (2012) J Bioenerg Biomembr , vol.44 , pp. 163-170
    • Ko, Y.H.1    Verhoeven, H.A.2    Lee, M.J.3    Corbin, D.J.4    Vogl, T.J.5    Pedersen, P.L.6
  • 30
    • 60849101819 scopus 로고    scopus 로고
    • Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells: ROS-mediated cell death by 3-BrPA
    • Kim JS, Ahn KJ, Kim JA, Kim HM, Lee JD, Lee JM, et al. Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells: ROS-mediated cell death by 3-BrPA. J Bioenerg Biomembr 2008;40:607-18.
    • (2008) J Bioenerg Biomembr , vol.40 , pp. 607-618
    • Kim, J.S.1    Ahn, K.J.2    Kim, J.A.3    Kim, H.M.4    Lee, J.D.5    Lee, J.M.6
  • 31
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007;7:763-777.
    • (2007) Nat Rev Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 32
    • 79960648977 scopus 로고    scopus 로고
    • Glucose transporters in the uterus: An analysis of tissue distribution and proposed physiological roles
    • Frolova AI, Moley KH. Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles. Reproduction 2011;142:211-20.
    • (2011) Reproduction , vol.142 , pp. 211-220
    • Frolova, A.I.1    Moley, K.H.2
  • 34
    • 84861652568 scopus 로고    scopus 로고
    • Reversed glucose and fatty acids transporter expression in human endometrial cancer
    • Knapp P, Chabowski A, Harasiuk D, Gorski J. Reversed glucose and fatty acids transporter expression in human endometrial cancer. Horm Metab Res 2012;44:436-41.
    • (2012) Horm Metab Res , vol.44 , pp. 436-441
    • Knapp, P.1    Chabowski, A.2    Harasiuk, D.3    Gorski, J.4
  • 36
    • 12944262229 scopus 로고    scopus 로고
    • Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
    • Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 2005;202:654-62.
    • (2005) J Cell Physiol , vol.202 , pp. 654-662
    • Macheda, M.L.1    Rogers, S.2    Best, J.D.3
  • 37
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the warburg effect: the metabolic requirements of cell proliferation. Science 2009;324:1029-33.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 38
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • Ward Patrick S, Thompson Craig B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012;21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward Patrick, S.1    Thompson Craig, B.2
  • 39
    • 84868528894 scopus 로고    scopus 로고
    • The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer
    • Slomovitz BM, Coleman RL. The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer. Clin Cancer Res 2012;18:5856-64.
    • (2012) Clin Cancer Res , vol.18 , pp. 5856-5864
    • Slomovitz, B.M.1    Coleman, R.L.2
  • 40
    • 84893048809 scopus 로고    scopus 로고
    • Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells. Energy depletion, oxidative stress, protein kinase activity modulation
    • Calvino E, Estan MC, Sanchez-Martin C, Brea R, de Blas E, Boyano-Adanez MC, et al. Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells. energy depletion, oxidative stress, protein kinase activity modulation. J Pharmacol Exp Ther 2013;348:324-35.
    • (2013) J Pharmacol Exp Ther , vol.348 , pp. 324-335
    • Calvino, E.1    Estan, M.C.2    Sanchez-Martin, C.3    Brea, R.4    De Blas, E.5    Boyano-Adanez, M.C.6
  • 41
    • 84865746708 scopus 로고    scopus 로고
    • Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1
    • Cardaci S, Rizza S, Filomeni G, Bernardini R, Bertocchi F, Mattei M, et al. Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1. Cancer Res 2012;72:4526-36.
    • (2012) Cancer Res , vol.72 , pp. 4526-4536
    • Cardaci, S.1    Rizza, S.2    Filomeni, G.3    Bernardini, R.4    Bertocchi, F.5    Mattei, M.6
  • 42
    • 34748922322 scopus 로고    scopus 로고
    • Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma
    • Kim W, Yoon J-H, Jeong J-M, Cheon G-J, Lee T-S, Yang J-I, et al. Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma. Mol Cancer Ther 2007;6:2554-62.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2554-2562
    • Kim, W.1    Yoon, J.-H.2    Jeong, J.-M.3    Cheon, G.-J.4    Lee, T.-S.5    Yang, J.-I.6
  • 43
    • 84862777922 scopus 로고    scopus 로고
    • Overexpression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester
    • Tang Z, Yuan S, Hu Y, Zhang H, Wu W, Zeng Z, et al. Overexpression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester. J Bioenerg Biomembr 2012;44:117-25.
    • (2012) J Bioenerg Biomembr , vol.44 , pp. 117-125
    • Tang, Z.1    Yuan, S.2    Hu, Y.3    Zhang, H.4    Wu, W.5    Zeng, Z.6
  • 44
    • 70350101307 scopus 로고    scopus 로고
    • Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate
    • Thangaraju M, Karunakaran SK, Itagaki S, Gopal E, Elangovan S, Prasad PD, et al. Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. Cancer 2009;115:4655-66.
    • (2009) Cancer , vol.115 , pp. 4655-4666
    • Thangaraju, M.1    Karunakaran, S.K.2    Itagaki, S.3    Gopal, E.4    Elangovan, S.5    Prasad, P.D.6
  • 45
    • 84866260153 scopus 로고    scopus 로고
    • Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity
    • Zhang Q, Pan J, North PE, Yang S, Lubet RA, Wang Y, et al. Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity. Cancer Prev Res 2012;5:717-25.
    • (2012) Cancer Prev Res , vol.5 , pp. 717-725
    • Zhang, Q.1    Pan, J.2    North, P.E.3    Yang, S.4    Lubet, R.A.5    Wang, Y.6
  • 46
    • 64949118623 scopus 로고    scopus 로고
    • Novel therapy for malignant pleural mesothelioma based on antienergetic effect: An experimental study using 3-Bromopyruvate on nude mice
    • Zhang X, Varin E, Briand M, Allouche S, Heutte N, Schwartz L, et al. Novel therapy for malignant pleural mesothelioma based on antienergetic effect: an experimental study using 3-Bromopyruvate on nude mice. Anticancer Res 2009;29:1443-8.
    • (2009) Anticancer Res , vol.29 , pp. 1443-1448
    • Zhang, X.1    Varin, E.2    Briand, M.3    Allouche, S.4    Heutte, N.5    Schwartz, L.6
  • 47
    • 0024444472 scopus 로고
    • Evidence for the regulatory function of synaptoplasmic acetyl-CoA in acetylcholine synthesis in nerve endings
    • Bielarczyk H, Szutowicz A. Evidence for the regulatory function of synaptoplasmic acetyl-CoA in acetylcholine synthesis in nerve endings. Biochem J 1989;262:377-80.
    • (1989) Biochem J , vol.262 , pp. 377-380
    • Bielarczyk, H.1    Szutowicz, A.2
  • 48
    • 0019888075 scopus 로고
    • Acetyl coenzyme A and acetylcholine in slices of rat caudate nuclei incubated in the presence of metabolic inhibitors
    • Ricny J, Tucek S. Acetyl coenzyme A and acetylcholine in slices of rat caudate nuclei incubated in the presence of metabolic inhibitors. J Biol Chem 1981;256:4919-23.
    • (1981) J Biol Chem , vol.256 , pp. 4919-4923
    • Ricny, J.1    Tucek, S.2
  • 50
    • 77952745676 scopus 로고    scopus 로고
    • 3-Bromopyruvate induces necrotic cell death in sensitive melanomacell lines
    • Qin JZ, Xin H, Nickoloff BJ. 3-Bromopyruvate induces necrotic cell death in sensitive melanomacell lines. Biochem Biophys Res Commun 2010;396:495-500.
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 495-500
    • Qin, J.Z.1    Xin, H.2    Nickoloff, B.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.