Morbidly obese women with and without endometrial cancer: Are there differences in measured physical fitness, body composition, or hormones?

Gynecologic Oncology

Volumn 124, Issue 3, 2012, Pages 431-436

  Modesitt, Susan C ^a   Geffel, Dyanna L ^b   Via, Jennifer ^a   L Weltman, Arthur ^a,c  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Endometrial cancer; Exercise; Obesity

Indexed keywords

ADIPONECTIN; ANDROSTENEDIONE; ESTRADIOL; ESTRONE; GLUCOSE; INSULIN; LEPTIN; PROGESTERONE; SEX HORMONE BINDING GLOBULIN;

ABDOMINAL HYSTERECTOMY; ADIPONECTIN BLOOD LEVEL; ADULT; AIR DISPLACEMENT PLETHYSMOGRAPHY; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; ENDOMETRIUM CANCER; ESTRADIOL BLOOD LEVEL; ESTRONE BLOOD LEVEL; FAT WEIGHT; FEMALE; FITNESS; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LEPTIN BLOOD LEVEL; MORBID OBESITY; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PILOT STUDY; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; QUALITY OF LIFE; TREADMILL; WAIST CIRCUMFERENCE;

BODY COMPOSITION; ENDOMETRIAL NEOPLASMS; FEMALE; HORMONES; HUMANS; MIDDLE AGED; OBESITY, MORBID; PHYSICAL FITNESS; PILOT PROJECTS; POSTMENOPAUSE;

EID: 84856741601     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.11.013     Document Type: Article

References (67)

1. A.A. Hedley, C.L. Ogden, C.L. Johnson, M.D. Carroll, L.R. Curtin, and K.M. Flegal Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002 JAMA 291 2004 2847 2850
2. H. Vaino, and F. Bianchini IARC handbooks of cancer prevention 1 ed. Weight control and physical activity Volume 6 2002 International Agency for Research on Cancer Lyon, France
3. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
4. A. Bergstrom, P. Pisani, V. Tenet, A. Wolk, and H.O. Adami Overweight as an avoidable cause of cancer in Europe Int J Cancer 91 2001 421 430
5. E.E. Calle, C. Rodriguez, K. Walker-Thurmond, and M.J. Thun Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 348 2003 1625 1638
6. A. Akhmedkhanov, A. Zeleniuch-Jacquotte, and P. Toniolo Role of exogenous and endogenous hormones in endometrial cancer: review of the evidence and research perspectives Ann N Y Acad Sci 943 2001 296 315
7. L.A. Brinton, M.L. Berman, R. Mortel, L.B. Twiggs, R.J. Barrett, and G.D. Wilbanks Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study Am J Obstet Gynecol 167 1992 1317 1325
8. M. Gangemi, G. Meneghetti, O. Predebon, R. Scappatura, and A. Rocco Obesity as a risk factor for endometrial cancer Clin Exp Obstet Gynecol 14 1987 119 122
9. R. Kaaks, A. Lukanova, and M.S. Kurzer Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review Cancer Epidemiol Biomarkers Prev 11 2002 1531 1543
10. E. Petridou, M. Belechri, N. Dessypris, P. Koukoulomatis, E. Diakomanolis, and E. Spanos Leptin and body mass index in relation to endometrial cancer risk Ann Nutr Metab 46 2002 147 151
11. S.A. Tornberg, and J.M. Carstensen Relationship between Quetelet's index and cancer of breast and female genital tract in 47,000 women followed for 25 years Br J Cancer 69 1994 358 361
12. A. Wolk, G. Gridley, M. Svensson, O. Nyren, J.K. McLaughlin, and J.F. Fraumeni A prospective study of obesity and cancer risk (Sweden) Cancer Causes Control 12 2001 13 21
13. S.C. Modesitt, and J.R. van Nagell Jr. The impact of obesity on the incidence and treatment of gynecologic cancers: a review Obstet Gynecol Surv 60 2005 683 692
14. E. Braunwald, A.S. Fauci, D.L. Kasper, S.L. Hauser, D.L. Longo, and J.L. Jameson Harrison's principles of internal medicine 15th ed. 2001 McGraw-Hill New York
15. C.L. Enriori, and J. Reforzo-Membrives Peripheral aromatization as a risk factor for breast and endometrial cancer in postmenopausal women: a review Gynecol Oncol 17 1984 1 21
16. J.M. Grodin, P.K. Siiteri, and P.C. MacDonald Source of estrogen production in postmenopausal women J Clin Endocrinol Metab 36 1973 207 214
17. R. Pettigrew, and D. Hamilton-Fairley Obesity and female reproductive function Br Med Bull 53 1997 341 358
18. P.K. Siiteri Steroid hormones and endometrial cancer Cancer Res 38 1978 4360 4366
19. A. Lucisano, M.G. Acampora, N. Russo, E. Maniccia, A. Montemurro, and S. Dell'Acqua Ovarian and peripheral plasma levels of progestogens, androgens and oestrogens in post-menopausal women Maturitas 6 1984 45 53
20. D.C. Anderson Sex-hormone-binding globulin Clin Endocrinol (Oxf) 3 1974 69 96
21. R.B. Greenblatt, R.D. Gambrell Jr., and L.D. Stoddard The protective role of progesterone in the prevention of endometrial cancer Pathol Res Pract 174 1982 297 318
22. R.D. Gambrell The role of hormones in the etiology of breast and endometrial cancer Acta Obstet Gynecol Scand Suppl 88 1979 73 81
23. T. You, R. Yang, M.F. Lyles, D. Gong, and B.J. Nicklas Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors Am J Physiol Endocrinol Metab 288 2005 E741 E747
24. M.T. Goodman, J.H. Hankin, L.R. Wilkens, L.C. Lyu, K. McDuffie, and L.Q. Liu Diet, body size, physical activity, and the risk of endometrial cancer Cancer Res 57 1997 5077 5085
25. X.O. Shu, M.C. Hatch, W. Zheng, Y.T. Gao, and L.A. Brinton Physical activity and risk of endometrial cancer Epidemiology 4 1993 342 349
26. A.S. Furberg, and I. Thune Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort Int J Cancer 104 2003 669 676
27. T. Moradi, O. Nyren, R. Bergstrom, G. Gridley, M. Linet, and A. Wolk Risk for endometrial cancer in relation to occupational physical activity: a nationwide cohort study in Sweden Int J Cancer 76 1998 665 670
28. S.R. Sturgeon, L.A. Brinton, M.L. Berman, R. Mortel, L.B. Twiggs, and R.J. Barrett Past and present physical activity and endometrial cancer risk Br J Cancer 68 1993 584 589
29. E. Salazar-Martinez, E.C. Lazcano-Ponce, G.G. Lira-Lira, P. Escudero-De los Rios, J. Salmeron-Castro, and F. Larrea Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women Cancer Causes Control 11 2000 707 711
30. L.J. Schouten, R.A. Goldbohm, and P.A. van den Brandt Anthropometry, physical activity, and endometrial cancer risk: results from the Netherlands Cohort Study J Natl Cancer Inst 96 2004 1635 1638
31. T. Moradi, E. Weiderpass, L.B. Signorello, I. Persson, O. Nyren, and H.O. Adami Physical activity and postmenopausal endometrial cancer risk (Sweden) Cancer Causes Control 11 2000 829 837
32. L.H. Colbert, J.V. Lacey Jr., C. Schairer, P. Albert, A. Schatzkin, and D. Albanes Physical activity and risk of endometrial cancer in a prospective cohort study (United States) Cancer Causes Control 14 2003 559 567
33. C.E. Matthews, W.H. Xu, W. Zheng, Y.T. Gao, Z.X. Ruan, and J.R. Cheng Physical activity and risk of endometrial cancer: a report from the Shanghai endometrial cancer study Cancer Epidemiol Biomarkers Prev 14 2005 779 785
34. A.J. Littman, L.F. Voigt, S.A. Beresford, and N.S. Weiss Recreational physical activity and endometrial cancer risk Am J Epidemiol 154 2001 924 933
35. R. Knols, N.K. Aaronson, D. Uebelhart, J. Fransen, and G. Aufdemkampe Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials J Clin Oncol 23 2005 3830 3842 10.1200/JCO.2005.02.148
36. K.H. Schmitz, J. Holtzman, K.S. Courneya, L.C. Masse, S. Duval, and R. Kane Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis Cancer Epidemiol Biomarkers Prev 14 2005 1588 1595 10.1158/1055-9965.EPI-04-0703
37. M.D. Holmes, W.Y. Chen, D. Feskanich, C.H. Kroenke, and G.A. Colditz Physical activity and survival after breast cancer diagnosis JAMA 293 2005 2479 2486
38. H.W. Kohl, S.N. Blair, R.S. Paffenbarger Jr., C.A. Macera, and J.J. Kronenfeld A mail survey of physical activity habits as related to measured physical fitness Am J Epidemiol 127 1988 1228 1239
39. J.F. Sallis, W.L. Haskell, P.D. Wood, S.P. Fortmann, T. Rogers, and S.N. Blair Physical activity assessment methodology in the Five-City Project Am J Epidemiol 121 1985 91 106
40. B.E. Ainsworth, W.L. Haskell, M.C. Whitt, M.L. Irwin, A.M. Swartz, and S.J. Strath Compendium of physical activities: an update of activity codes and MET intensities Med Sci Sports Exerc 32 2000 S498 S504
41. ACSM's guidelines for exercise testing and prescription 7th ed 2006 Lippincott, Williams and Wilkins Philadelphia, PA
42. E.M. Haskvitz, R.L. Seip, J.Y. Weltman, A.D. Rogol, and A. Weltman The effect of training intensity on ratings of perceived exertion Int J Sports Med 13 1992 377 383
43. T.G. Lohman, A.F. Roche, and R. Martorell Anthropometric standardization reference manual 1988 Human Kinetics Champaign
44. M.A. McCrory, T.D. Gomez, E.M. Bernauer, and P.A. Mole Evaluation of a new air displacement plethysmograph for measuring human body composition Med Sci Sports Exerc 27 1995 1686 1691
45. W.E. Siri Body composition from fluid spaces and density: analysis of methods J. Brozek, A. Henschel, Techniques for measuring body composition 1961 National Academy of Science Washington, D.C 223 244
46. Q. Zhang, Q. Shen, J. Celestino, M.R. Milam, S.N. Westin, and R.A. Lacour Enhanced estrogen-induced proliferation in obese rat endometrium Am J Obstet Gynecol 200 2009 186 e1-8
47. D. Schottenfeld Epidemiology of endometrial neoplasia J Cell Biochem Suppl 23 1995 151 159
48. N. Potischman, R.N. Hoover, L.A. Brinton, P. Siiteri, J.F. Dorgan, and C.A. Swanson Case-control study of endogenous steroid hormones and endometrial cancer J Natl Cancer Inst 88 1996 1127 1135
49. C.C.M. Thomas, P.A.P.M.S. Wingo, M.S.M.D.M.P.H. Dolan, N.C.M.D. Lee, and L.C.M.D.M.P.H. Richardson Endometrial cancer risk among younger, overweight women Obstet Gynecol 114 2009 22 27
50. A.E. Schindler Progestogen deficiency and endometrial cancer risk Maturitas 62 2009 334 337
51. S.C. Modesitt, B. Huang, B.J. Shelton, and S. Wyatt Endometrial cancer in Kentucky: the impact of age, smoking status, and rural residence Gynecol Oncol 103 2006 300 306
52. G.M. McCawley, J.S. Ferriss, D. Geffel, C.J. Northup, and S.C. Modesitt Cancer in obese women: potential protective impact of bariatric surgery J Am Coll Surg 208 2009 1093 1098
53. S.L. Park, M.T. Goodman, Z.F. Zhang, L.N. Kolonel, B.E. Henderson, and V.W. Setiawan Body size, adult BMI gain and endometrial cancer risk: the multiethnic cohort Int J Cancer 126 2010 490 499
54. A. Suzuki, H. Urushitani, H. Watanabe, T. Sato, T. Iguchi, and T. Kobayashi Comparison of estrogen responsive genes in the mouse uterus, vagina and mammary gland J Vet Med Sci 69 2007 725 731
55. I. Kelesidis, T. Kelesidis, and C.S. Mantzoros Adiponectin and cancer: a systematic review Br J Cancer 94 2006 1221 1225
56. L. Dal Maso, L.S. Augustin, A. Karalis, R. Talamini, S. Franceschi, and D. Trichopoulos Circulating adiponectin and endometrial cancer risk J Clin Endocrinol Metab 2004 1160 1163
57. E. Petridou, C. Mantzoros, N. Dessypris, P. Koukoulomatis, C. Addy, and Z. Voulgaris Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece J Clin Endocrinol Metab 88 2003 993 997
58. P.T. Soliman, D. Wu, G. Tortolero-Luna, K.M. Schmeler, B.M. Slomovitz, and M.S. Bray Association between adiponectin, insulin resistance, and endometrial cancer Cancer 106 2006 2376 2381
59. N. Ashizawa, T. Yahata, J. Quan, S. Adachi, K. Yoshihara, and K. Tanaka Serum leptin-adiponectin ratio and endometrial cancer risk in postmenopausal female subjects Gynecol Oncol 119 2010 65 69
60. D. Housa, J. Housova, Z. Vernerova, and M. Haluzik Adipocytokines and cancer Physiol Res 55 2005 233 244
61. S.S. Yuan, K.B. Tsai, Y.F. Chung, T.F. Chan, Y.T. Yeh, and L.Y. Tsai Aberrant expression and possible involvement of the leptin receptor in endometrial cancer Gynecol Oncol 92 2004 769 775
62. E. Friberg, A. Wallin, and A. Wolk Sucrose, high-sugar foods, and risk of endometrial cancer-a population-based cohort study Cancer Epidemiol Biomarkers Prev 20 2011 1831 1837
63. K.S. Courneya, K.H. Karvinen, K.L. Campbell, R.G. Pearcey, G. Dundas, and V. Capstick Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors Gynecol Oncol 97 2005 422 430
64. C.M. Friedenreich Physical activity and cancer prevention: from observational to intervention research Cancer Epidemiol Biomarkers Prev 10 2001 287 301
65. C.M. Friedenreich, L.S. Cook, A.M. Magliocco, M.A. Duggan, and K.S. Courneya Case-control study of lifetime total physical activity and endometrial cancer risk Cancer Causes Control 21 2010 1105 1116
66. C.M. Friedenreich, and M.R. Orenstein Physical activity and cancer prevention: etiologic evidence and biological mechanisms J Nutr 132 2002 3456S 3464S
67. D.M. Purdie, and A.C. Green Epidemiology of endometrial cancer Best Pract Res Clin Obstet Gynaecol 15 2001 341 354