Immunomodulatory activity and partial characterisation of polysaccharides from Momordica charantia

Molecules

Volumn 19, Issue 9, 2014, Pages 13432-13447

  Deng, Yuan Yuan ^a,b,c   Yi, Yang ^b   Zhang, Li Fang ^b   Zhang, Rui Fen ^b   Zhang, Yan ^b   Wei, Zhen Cheng ^b   Tang, Xiao Jun ^b   Zhang, Ming Wei ^b  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b INSTITUTE OF ANIMAL SCIENCE   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Immunomodulatory activity; Momordica charantia; Polysaccharide; Structure

Indexed keywords

HEMOLYSIN; IMMUNOLOGIC FACTOR; PLANT EXTRACT; POLYSACCHARIDE;

ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; CYTOTOXICITY; DRUG EFFECTS; FRUIT; IC50; INFRARED SPECTROSCOPY; ISOLATION AND PURIFICATION; MACROPHAGE; MALE; METABOLISM; MOMORDICA CHARANTIA; MOUSE; NATURAL KILLER CELL; PHAGOCYTOSIS; SPLEEN; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOTOXICITY, IMMUNOLOGIC; FRUIT; HEMOLYSIN PROTEINS; IMMUNOLOGIC FACTORS; INHIBITORY CONCENTRATION 50; KILLER CELLS, NATURAL; MACROPHAGES; MALE; MICE; MOMORDICA CHARANTIA; PHAGOCYTOSIS; PLANT EXTRACTS; POLYSACCHARIDES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPLEEN;

EID: 84908125319     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules190913432     Document Type: Article

References (51)

1. Paul, A.; Raychaudhuri, S. S. Medicinal uses and molecular identification of two Momordica charantia varieties-A review. Electron. J. Biol. 2010, 6, 43-51.
2. Ahmed, I.; Adeghate, E.; Cummings, E.; Sharma, A.; Singh, J. Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol. Cell. Biochem. 2004, 261, 63-70.
3. Popovich, D. G.; Li, L.; Zhang, W. Bitter melon (Momordica charantia) triterpenoid extract reduces preadipocyte viability, lipid accumulation and adiponectin expression in 3T3-L1 cells. Food Chem. Toxicol. 2010, 48, 1619-1626.
4. Umukoro, S.; Ashorobi, R. Evaluation of anti-inflammatory and membrane stabilizing property of aqueous leaf extract of Momordica charantia in rats. Afr. J. Biomed. Res. 2006, 9, 119-124.
5. Kubola, J.; Siriamornpun, S. Phenolic contents and antioxidant activities of bitter gourd (Momordica charantia L.) leaf, stem and fruit fraction extracts in vitro. Food Chem. 2008, 110, 881-890.
6. Akihisa, T.; Higo, N.; Tokuda, H.; Ukiya, M.; Akazawa, H.; Tochigi, Y.; Kimura, Y.; Suzuki, T.; Nishino, H. Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects. J. Nat. Prod. 2007, 70, 1233-1239.
7. Lee-Huang, S.; Huang, P. L.; Nara, P. L.; Chen, H.-C.; Kung, H.-F.; Huang, P.; Huang, H. I.; Huang, P. L. MAP 30: A new inhibitor of HIV-1 infection and replication. FEBS Lett. 1990, 272, 12-18.
8. Kobori, M.; Ohnishi-Kameyama, M.; Akimoto, Y.; Yukizaki, C.; Yoshida, M. Alpha eleostearic acid and its dihydroxy derivative are major apoptosis inducing components of bitter gourd. J. Agric. Food Chem. 2008, 56, 10515-10520.
9. Bian, X.; Shen, F.; Chen, Y.; Wang, B.; Deng, M.; Meng, Y. PEGylation of alpha-momorcharin: Synthesis and characterization of novel anti-tumor conjugates with therapeutic potential. Biotechnol. Lett. 2010, 32, 883-890.
10. Nerurkar, P.; Ray, R. B. Bitter melon: Antagonist to cancer. Pharm. Res. 2010, 27, 1049-1053.
11. Xu, B.; Dong, Y.; Zhang, H.-H.; Cui, H.-L.; Lu, Q. The antihyperglycemic effects of polysaccharide from Momordica charantia in STZ-induced diabetic mice. Acta Nutr. Sin. 2006, 28, 401-404.
12. Kalupahana, N. S.; Moustaid-Moussa, N.; Claycombe, K. J. Immunity as a link between obesity and insulin resistance. Mol. Aspects Med. 2012, 33, 26-34.
13. Zitvogel, L.; Apetoh, L.; Ghiringhelli, F.; Kroemer, G. Immunological aspects of cancer chemotherapy. Nat. Rev. Immunol. 2008, 8, 59-73.
14. Jin, M.; Zhao, K.; Huang, Q.; Xu, C.; Shang, P. Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis (Oliv.) Diels: A review. Carbohydr. Polym. 2012, 89, 713-722.
15. Zhu, X. L.; Chen, A. F.; Lin, Z. B. Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice. J. Ethnopharmacol. 2007, 111, 219-226.
16. Omarsdottir, S.; Freysdottir, J.; Olafsdottir, E. S. Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformis. Phytomedicine 2007, 14, 179-184.
17. Mizuno, M.; Shiomi, Y.; Minato, K.-I.; Kawakami, S.; Ashida, H.; Tsuchida, H. Fucogalactan isolated from Sarcodon aspratus elicits release of tumor necrosis factor-a and nitric oxide from murine macrophages. Immunopharmacology 2000, 46, 113-121.
18. Han, X.-Q.; Chan, B. C. L.; Yu, H.; Yang, Y.-H.; Hu, S.-Q.; Ko, C.-H.; Dong, C.-X.; Wong, C.-K.; Shaw, P.-C.; Fung, K.-P. Sttructural characterization and immuno-modulating activities of a polysaccharide from Ganoderma sinense. Int. J. Biol. Macromol. 2012, 51, 597-603.
19. Huang, Z.; Zhang, L.; Duan, X.; Liao, Z.; Ding, H.; Cheung, P. C. Novel highly branched water-soluble heteropolysaccharides as immunopotentiators to inhibit S-180 tumor cell growth in BALB/c mice. Carbohydr. Polym. 2012, 87, 427-434.
20. Ke, C.; Qiao, D.; Luo, J.; Li, Z.; Sun, Y.; Ye, H.; Zeng, X. Immunostimulatory activity and structure of polysaccharide from Streptococcus equi subsp. zooepidemicus. Int. J. Biol. Macromol. 2013, 57, 218-225.
21. Mizuno, T. Development of antitumor polysaccharides from mushroom fungi. Foods Food Ingred. J. Jpn. 1996, 167, 69-85.
22. Wan, Z.-X.; Zhang, F.; Geng, Q.; Wang, P.-Y.; Zhou, H.; Zhang, Y.-M. Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice. Int. Dairy J. 2010, 20, 522-527.
23. Yi, Y.; Liao, S.-T.; Zhang, M.-W.; Zhang, R.-F.; Deng, Y.-Y.; Yang, B.; Wei, Z.-C. Immunomodulatory activity of polysaccharide-protein complex of longan (Dimocarpus longan Lour.) pulp. Molecules 2011, 16, 10324-10336.
24. Chen, J. R.; Yang, Z. Q.; Hu, T. J.; Yan, Z. T.; Niu, T. X.; Wang, L.; Cui, D. A.; Wang, M. Immunomodulatory activity in vitro and in vivo of polysaccharide from Potentilla anserina. Fitoterapia 2010, 81, 1117-1124.
25. Bao, X.; Liu, C.; Fang, J.; Li, X. Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst. Carbohydr. Res. 2001, 332, 67-74.
26. Sun, Y.; Liang, H.; Cai, G.; Guan, S.; Tong, H.; Yang, X.; Liu, J. Sulfated modification of the water-soluble polysaccharides from Polyporus albicans mycelia and its potential biological activities. Int. J. Biol. Macromol. 2009, 44, 14-17.
27. Iribe, H.; Koga, T. Augmentation of the proliferative response of thymocytes to phytohemagglutinin by the muramyl dipeptide. Cell. Immunol. 1984, 88, 9-15.
28. Zhang, C.; Huang, K. Characteristic immunostimulation by MAP, a polysaccharide isolated from the mucus of the loach, Misgurnus anguillicaudatus. Carbohydr. Polym. 2005, 59, 75-82.
29. Sun, Y. X.; Liu, J. C. Purification, structure and immunobiological activity of a water-soluble polysaccharide from the fruiting body of Pleurotus ostreatus. Bioresour. Technol. 2009, 100, 983-986.
30. Sun, Y.; Liang, H.; Zhang, X.; Tong, H.; Liu, J. Structural elucidation and immunological activity of a polysaccharide from the fruiting body of Armillaria mellea. Bioresour. Technol. 2009, 100, 1860-1863.
31. Sun, Y. X.; Liu, J. C. Structural characterization of a water-soluble polysaccharide from the roots of Codonopsis pilosula and its immunity activity. Int. J. Biol. Macromol. 2008, 43, 279-282.
32. Yang, C.; He, N.; Ling, X.; Ye, M.; Zhang, C.; Shao, W.; Yao, C.; Wang, Z.; Li, Q. The isolation and characterization of polysaccharides from longan pulp. Sep. Purif. Technol. 2008, 63, 226-230.
33. Yi, Y.; Liao, S. T.; Zhang, M. W.; Shi, J.; Zhang, R. F.; Deng, Y. Y.; Wei, Z. C. Physicochemical characteristics and immunomodulatory activities of three polysaccharide-protein complexes of longan pulp. Molecules 2011, 16, 6148-6164.
34. Zhang, W. Biochemical Technology of Carbohydrate Complexes; Zhejiang University Press: Hangzhou, China, 1994.
35. Yi, Y.; Zhang, M.-W.; Liao, S.-T.; Zhang, R.-F.; Deng, Y.-Y.; Wei, Z.-C.; Tang, X.-J.; Zhang, Y. Structural features and immunomodulatory activities of polysaccharides of longan pulp. Carbohydr. Polym. 2012, 87, 636-643.
36. Xu, R.; Ye, H.; Sun, Y.; Tu, Y.; Zeng, X. Preparation, preliminary characterization, antioxidant, hepatoprotective and antitumor activities of polysaccharides from the flower of tea plant (Camellia sinensis). Food Chem. Toxicol. 2012, 50, 2473-2480.
37. Zhao, M.; Yang, N.; Yang, B.; Jiang, Y.; Zhang, G. Structural characterization of water-soluble polysaccharides from Opuntia monacantha cladodes in relation to their anti-glycated activities. Food Chem. 2007, 105, 1480-1486.
38. Yang, W.; Pei, F.; Shi, Y.; Zhao, L.; Fang, Y.; Hu, Q. Purification, characterization and anti-proliferation activity of polysaccharides from Flammulina velutipes. Carbohydr. Polym. 2012, 88, 474-480.
39. Guoling, L.; Zhengxiang, N.; Honghui, G. Isolation and Characterization of Polysaccharides from Momordica charantia L. Fruits. Food Sci. 2010, 31, 5.
40. Orlovskaya, T. Carbohydrates and lipids from Momordica charantia. Chem. Nat. Compd. 2008, 44, 227-228.
41. Thakur, M.; Weng, A.; Fuchs, H.; Sharma, V.; Bhargava, C. S.; Chauhan, N. S.; Dixit, V. K.; Bhargava, S. Rasayana properties of Ayurvedic herbs: Are polysaccharides a major contributor. Carbohydr. Polym. 2012, 87, 3-15.
42. Sekhon, B. K.; Sze, D. M.-Y.; Chan, W. K.; Fan, K.; Li, G. Q.; Moore, D. E.; Roubin, R. H. PSSod Chem. 2013,. 138, 2201-2209.
43. Leiro, J. M.; Castro, R.; Arranz, J. A.; Lamas, J. Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh. Int. Immunopharmacol. 2007, 7, 879-888.
44. Qiao, D.; Luo, J.; Ke, C.; Sun, Y.; Ye, H.; Zeng, X. Immunostimulatory activity of the polysaccharides from Hyriopsis cumingii. Int. J. Biol. Macromol. 2010, 47, 676-680.
45. Zhang, D.; Wang, C.; Wu, H.; Xie, J.; Du, L.; Xia, Z.; Cai, J.; Huang, Z.; Wei, D. Three sulphated polysaccharides isolated from the mucilage of mud snail, Bullacta exarata philippi: Characterization and antitumour activity. Food Chem. 2013, 138, 306-314.
46. Staub, A. Removeal of protein-Sevag method. Methods Carbohydr. Chem. 1956, 5, 5-6.
47. Dubois, M.; Gilles, K. A.; Hamilton, J. K.; Pebers, P. A.; Smith, F. Colorimetric method for determination of sugars and related substances. Anal. Chem. 1956, 28, 350-356.
48. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Annal. Biochem. 1976, 72, 248-254.
49. Xu, W. Q. Study on The Structure Feature, Biological Activity and Anti-tumor Mechanism of Polysaccharide from Spores of Tremella fuciformis Berk.. Ph. D. Thesis, Tianjin University, Tianjin, China, June 2006.
50. Kowalski, J. Effect of enkephalins and endorphins on cytotoxic activity of natural killer cells and macrophages/monocytes in mice. Eur. J. Pharmacol. 1997, 326, 251-255.
51. Chen, X.; Jin, J.; Tang, J.; Wang, Z.; Wang, J.; Jin, L.; Lu, J. Extraction, purification, characterization and hypoglycemic activity of a polysaccharide isolated from the root of Ophiopogon japonicus. Carbohydr. Polym. 2011, 83, 749-754.