Small molecule-directed specification of sclerotome-like chondroprogenitors and induction of a somitic chondrogenesis program from embryonic stem cells

Development (Cambridge)

Volumn 141, Issue 20, 2014, Pages 3848-3858

  Zhao, Jiangang ^a,d   Li, Songhui ^b,e   Trilok, Suprita ^a   Tanaka, Makoto ^b,g   Jokubaitis Jameson, Vanta ^b,f   Wang, Bei ^b   Niwa, Hitoshi ^c   Nakayama, Naoki ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b MONASH UNIVERSITY   (Australia)

^c RIKEN Center for Biosystems Dynamics Research   (Japan)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^e CSIRO   (Australia)

^f UNIVERSITY OF MELBOURNE   (Australia)

^g OSAKA POLICE HOSPITAL   (Japan)

Author keywords

Chondrogenesis; Mouse; Paraxial mesoderm; Pluripotent stem cells; Sclerotome

Indexed keywords

6 [4 (1 PIPERAZINYL)PHENYL] 3 (4 QUINOLINYL)PYRAZOLO[1,5 A]PYRIMIDINE; BONE MORPHOGENETIC PROTEIN; PEPTIDES AND PROTEINS; PROTEIN BAPX1; PROTEIN PAX1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; 6 [[2 [[4 (2,4 DICHLOROPHENYL) 5 (4 METHYL 1H IMIDAZOL 2 YL) 2 PYRIMIDINYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; BETA CATENIN; CULTURE MEDIUM; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CARTILAGE; CHONDROGENESIS; IN VITRO STUDY; IN VIVO STUDY; MESODERM; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; SCLEROTOME; ANIMAL; BONE MARROW CELL; CARTILAGE CELL; CELL DIFFERENTIATION; CELL SEPARATION; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; EMBRYONIC STEM CELL; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; METABOLISM; PHYSIOLOGY; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; CARTILAGE; CELL DIFFERENTIATION; CELL SEPARATION; CHONDROCYTES; CHONDROGENESIS; CULTURE MEDIA; EMBRYONIC STEM CELLS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; MESODERM; MICE; PLURIPOTENT STEM CELLS; PYRAZOLES; PYRIDINES; PYRIMIDINES; TRANSFORMING GROWTH FACTOR BETA; WNT SIGNALING PATHWAY;

EID: 84908106058     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.105981     Document Type: Article

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