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Volumn 116, Issue 10, 2003, Pages 2015-2028

Microscopic cartilage formation with embryonic stem-cell-derived mesodermal progenitor cells

Author keywords

BMP; Cartilage; Embryonic stem cells; PDGF; TGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; COLLAGEN TYPE 1; COLLAGEN TYPE 2; HYALIN; NOGGIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BB; RECEPTOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA3; VASCULOTROPIN RECEPTOR 2;

EID: 0038445467     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00417     Document Type: Article
Times cited : (135)

References (48)
  • 1
    • 0030027482 scopus 로고    scopus 로고
    • In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification
    • Alini, M., Kofsky, Y., Wu, W., Pidoux, I. and Poole, A. R. (1996). In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. J. Bone Miner. Res. 11, 105-113.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 105-113
    • Alini, M.1    Kofsky, Y.2    Wu, W.3    Pidoux, I.4    Poole, A.R.5
  • 2
    • 0034962273 scopus 로고    scopus 로고
    • The perichondrium1 plays an important role in mediating the effects of TGF-beta 1 on endochondral bone formation
    • Alvarez, J., Horton, J., Sohn, P. and Serra, R. (2001). The perichondrium1 plays an important role in mediating the effects of TGF-beta 1 on endochondral bone formation. Dev. Dyn. 221, 311-321.
    • (2001) Dev. Dyn. , vol.221 , pp. 311-321
    • Alvarez, J.1    Horton, J.2    Sohn, P.3    Serra, R.4
  • 3
    • 0033756493 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) localization in developing human and rat growth plate, metaphysis, epiphysis, and articular cartilage
    • Anderson, H. C., Hodges, P. T., Aguilera, X. M., Missana, L. and Moylan, P. E. (2000). Bone morphogenetic protein (BMP) localization in developing human and rat growth plate, metaphysis, epiphysis, and articular cartilage. J. Histochem. Cytochem. 48, 1493-1502.
    • (2000) J. Histochem. Cytochem. , vol.48 , pp. 1493-1502
    • Anderson, H.C.1    Hodges, P.T.2    Aguilera, X.M.3    Missana, L.4    Moylan, P.E.5
  • 4
    • 0027209267 scopus 로고
    • TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: Regulation of gene expression for cartilage matrix proteins and metalloproteases
    • Ballock, R. T., Heydemann, A., Wakefield, L. M., Flanders, K. C., Roberts, A. B. and Sporn, M. B. (1993). TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases. Dev. Biol. 158, 414-429.
    • (1993) Dev. Biol. , vol.158 , pp. 414-429
    • Ballock, R.T.1    Heydemann, A.2    Wakefield, L.M.3    Flanders, K.C.4    Roberts, A.B.5    Sporn, M.B.6
  • 5
    • 0023494086 scopus 로고
    • Effects of fixation and processing on the immunohistochemical visualization of type-I, -III and -IV collagen in paraffin-embedded liver tissue
    • Bedossa, P., Bacci, J., Lemaigre, G. and Martin, E. (1987). Effects of fixation and processing on the immunohistochemical visualization of type-I, -III and -IV collagen in paraffin-embedded liver tissue. Histochemistry 88, 85-89.
    • (1987) Histochemistry , vol.88 , pp. 85-89
    • Bedossa, P.1    Bacci, J.2    Lemaigre, G.3    Martin, E.4
  • 7
    • 0032524011 scopus 로고    scopus 로고
    • Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning
    • Capdevila, J. and Johnson, R. L. (1998). Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning. Dev. Biol. 197, 205-217.
    • (1998) Dev. Biol. , vol.197 , pp. 205-217
    • Capdevila, J.1    Johnson, R.L.2
  • 9
    • 0029015923 scopus 로고
    • Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
    • Dumont, D. J., Fong, G. H., Puri, M. C., Gradwohl, G., Alitalo, K. and Breitman, M. L. (1995). Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development. Dev. Dyn. 203, 80-92.
    • (1995) Dev. Dyn. , vol.203 , pp. 80-92
    • Dumont, D.J.1    Fong, G.H.2    Puri, M.C.3    Gradwohl, G.4    Alitalo, K.5    Breitman, M.L.6
  • 10
    • 0030200262 scopus 로고    scopus 로고
    • Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb
    • Duprez, D., Bell, E. J., Richardson, M. K., Archer, C. W., Wolpert, L., Brickell, P. M. and Francis-West, P. H. (1996). Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Mech. Dev. 57, 145-157.
    • (1996) Mech. Dev. , vol.57 , pp. 145-157
    • Duprez, D.1    Bell, E.J.2    Richardson, M.K.3    Archer, C.W.4    Wolpert, L.5    Brickell, P.M.6    Francis-West, P.H.7
  • 11
    • 0344689758 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes
    • Enomoto-Iwamoto, M., Iwamoto, M., Mukudai, Y., Kawakami, Y., Nohno, T., Higuchi, Y., Takemoto, S., Ohuchi, H., Noji, S. and Kurisu, K. (1998). Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J. Cell Biol. 140, 409-418.
    • (1998) J. Cell Biol. , vol.140 , pp. 409-418
    • Enomoto-Iwamoto, M.1    Iwamoto, M.2    Mukudai, Y.3    Kawakami, Y.4    Nohno, T.5    Higuchi, Y.6    Takemoto, S.7    Ohuchi, H.8    Noji, S.9    Kurisu, K.10
  • 12
    • 0034071346 scopus 로고    scopus 로고
    • Basic fibroblast growth factor positively regulates hematopoietic development
    • Faloon, P., Arentson, E., Kazarov, A., Deng, C. X., Porcher, C., Orkin, S. and Choi, K. (2000). Basic fibroblast growth factor positively regulates hematopoietic development. Development 127, 1931-1941.
    • (2000) Development , vol.127 , pp. 1931-1941
    • Faloon, P.1    Arentson, E.2    Kazarov, A.3    Deng, C.X.4    Porcher, C.5    Orkin, S.6    Choi, K.7
  • 13
    • 0033973655 scopus 로고    scopus 로고
    • All for one and one for all: Condensations and the initiation of skeletal development
    • Hall, B. K. and Miyake, T. (2000). All for one and one for all: condensations and the initiation of skeletal development. Bioessays 22, 138-147.
    • (2000) Bioessays , vol.22 , pp. 138-147
    • Hall, B.K.1    Miyake, T.2
  • 14
    • 0002966157 scopus 로고
    • In vitro clonal assays for murine multipotential and lineage restricted myeloid progenitor cells
    • (eds N. G. Testa and G. Molineux), New York: Oxford University Press
    • Heyworth, C. M. and Spooncer, E. (1993). In vitro clonal assays for murine multipotential and lineage restricted myeloid progenitor cells. In Haemopoiesis, a practical approach (eds N. G. Testa and G. Molineux), pp. 37-53. New York: Oxford University Press.
    • (1993) Haemopoiesis, A Practical Approach , pp. 37-53
    • Heyworth, C.M.1    Spooncer, E.2
  • 15
    • 0028970392 scopus 로고
    • Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development
    • Johansson, B. M. and Wiles, M. V. (1995). Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol. Cell. Biol. 15, 141-151.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 141-151
    • Johansson, B.M.1    Wiles, M.V.2
  • 16
    • 1842293350 scopus 로고    scopus 로고
    • Flk-1 expression defines a population of early embryonic hematopoietic precursors
    • Kabrun, N., Buehring, H. J., Choi, K., Ullrich, A., Risau, W. and Keller, G. (1997). Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development 124, 2039-2048.
    • (1997) Development , vol.124 , pp. 2039-2048
    • Kabrun, N.1    Buehring, H.J.2    Choi, K.3    Ullrich, A.4    Risau, W.5    Keller, G.6
  • 17
    • 0030734773 scopus 로고    scopus 로고
    • Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells
    • Kataoka, H., Takakura, N., Nishikawa, S., Tsuchida, K., Kodama, H., Kunisada, T., Risau, W., Kita, T. and Nishikawa, S. I. (1997). Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells. Dev. Growth Differ. 39, 729-740.
    • (1997) Dev. Growth Differ. , vol.39 , pp. 729-740
    • Kataoka, H.1    Takakura, N.2    Nishikawa, S.3    Tsuchida, K.4    Kodama, H.5    Kunisada, T.6    Risau, W.7    Kita, T.8    Nishikawa, S.I.9
  • 18
    • 0141979839 scopus 로고
    • Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: Regulation by transforming growth factor beta and serum factors
    • Kato, Y., Iwamoto, M., Koike, T., Suzuki, F. and Takano, Y. (1988). Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors. Proc. Natl. Acad. Sci. USA 85, 9552-9556.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9552-9556
    • Kato, Y.1    Iwamoto, M.2    Koike, T.3    Suzuki, F.4    Takano, Y.5
  • 19
    • 0034176844 scopus 로고    scopus 로고
    • Embryonic stem cell-derived chondrogenic differentiation in vitro: Activation by BMP-2 and BMP-4
    • Kramer, J., Hegert, C., Guan, K., Wobus, A. M., Mueller, P. K. and Rohwedel, J. (2000). Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4. Mech. Dev. 92, 193-205.
    • (2000) Mech. Dev. , vol.92 , pp. 193-205
    • Kramer, J.1    Hegert, C.2    Guan, K.3    Wobus, A.M.4    Mueller, P.K.5    Rohwedel, J.6
  • 20
    • 0024446721 scopus 로고
    • Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-beta
    • Kulyk, W. M., Rodgers, B. J., Greer, K. and Kosher, R. A. (1989). Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-beta. Dev. Biol. 135, 424-430.
    • (1989) Dev. Biol. , vol.135 , pp. 424-430
    • Kulyk, W.M.1    Rodgers, B.J.2    Greer, K.3    Kosher, R.A.4
  • 21
    • 0025732395 scopus 로고
    • Role of transforming growth factor-beta in chondrogenic pattern formation in the embryonic limb: Stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-beta and evidence for endogenous TGF-beta-like activity
    • Leonard, C. M., Fuld, H. M., Frenz, D. A., Downie, S. A., Massague, J. and Newman, S. A. (1991). Role of transforming growth factor-beta in chondrogenic pattern formation in the embryonic limb: stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-beta and evidence for endogenous TGF-beta-like activity. Dev. Biol. 145, 99-109.
    • (1991) Dev. Biol. , vol.145 , pp. 99-109
    • Leonard, C.M.1    Fuld, H.M.2    Frenz, D.A.3    Downie, S.A.4    Massague, J.5    Newman, S.A.6
  • 23
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina, E., Wenzel, H. M., Kreschel, C., Karp, S., Gaffield, W., McMahon, A. P. and Vortkamp, A. (2001). BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 128, 4523-4534.
    • (2001) Development , vol.128 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 24
    • 0033375411 scopus 로고    scopus 로고
    • Developmental tumours, early differentiation and the transforming growth factor beta superfamily
    • Mummery, C. L. and van den Eijnden-van Raaij, A. J. (1999). Developmental tumours, early differentiation and the transforming growth factor beta superfamily. Int. J. Dev. Biol. 43, 693-709.
    • (1999) Int. J. Dev. Biol. , vol.43 , pp. 693-709
    • Mummery, C.L.1    van den Eijnden-van Raaij, A.J.2
  • 25
    • 0032055461 scopus 로고    scopus 로고
    • Natural killer and B-lymphoid potential in CD34+ cells derived from embryonic stem cells differentiated in the presence of vascular endothelial growth factor
    • Nakayama, N., Fang, I. and Elliott, G. (1998). Natural killer and B-lymphoid potential in CD34+ cells derived from embryonic stem cells differentiated in the presence of vascular endothelial growth factor. Blood 91, 2283-2295.
    • (1998) Blood , vol.91 , pp. 2283-2295
    • Nakayama, N.1    Fang, I.2    Elliott, G.3
  • 26
    • 0034177522 scopus 로고    scopus 로고
    • Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro
    • Nakayama, N., Lee, J. and Chiu, L. (2000). Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro. Blood 95, 2275-2283.
    • (2000) Blood , vol.95 , pp. 2275-2283
    • Nakayama, N.1    Lee, J.2    Chiu, L.3
  • 27
    • 0035871537 scopus 로고    scopus 로고
    • A novel chordin-like protein inhibitor for bone morphogenetic proteins expressed preferentially in mesenchymal cell lineages
    • Nakayama, N., Han, C. E., Scully, S., Nishinakamura, R., He, C., Zeni, L., Yamane, H., Chang, D., Yu, D., Yokota, T. et al. (2001). A novel chordin-like protein inhibitor for bone morphogenetic proteins expressed preferentially in mesenchymal cell lineages. Dev. Biol. 232, 372-387.
    • (2001) Dev. Biol. , vol.232 , pp. 372-387
    • Nakayama, N.1    Han, C.E.2    Scully, S.3    Nishinakamura, R.4    He, C.5    Zeni, L.6    Yamane, H.7    Chang, D.8    Yu, D.9    Yokota, T.10
  • 28
    • 0031833476 scopus 로고    scopus 로고
    • Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages
    • Nishikawa, S. I., Nishikawa, S., Hirashima, M., Matsuyoshi, N. and Kodama, H. (1998a). Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. Development 125, 1747-1757.
    • (1998) Development , vol.125 , pp. 1747-1757
    • Nishikawa, S.I.1    Nishikawa, S.2    Hirashima, M.3    Matsuyoshi, N.4    Kodama, H.5
  • 29
    • 17744416048 scopus 로고    scopus 로고
    • In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos
    • Nishikawa, S.-I., Nishikawa, S., Kawamoto, H., Yoshida, H., Kizumoto, M., Kataoka, H. and Katsura, Y. (1998b). In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity 8, 761-769.
    • (1998) Immunity , vol.8 , pp. 761-769
    • Nishikawa, S.-I.1    Nishikawa, S.2    Kawamoto, H.3    Yoshida, H.4    Kizumoto, M.5    Kataoka, H.6    Katsura, Y.7
  • 30
    • 0033556697 scopus 로고    scopus 로고
    • Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells
    • Ogawa, M., Kizumoto, M., Nishikawa, S., Fujimoto, T., Kodama, H. and Nishikawa, S. I. (1999). Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells. Blood 93, 1168-1177.
    • (1999) Blood , vol.93 , pp. 1168-1177
    • Ogawa, M.1    Kizumoto, M.2    Nishikawa, S.3    Fujimoto, T.4    Kodama, H.5    Nishikawa, S.I.6
  • 31
    • 0026695298 scopus 로고
    • Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation
    • Orr-Urtreger, A., Bedford, M. T., Do, M. S., Eisenbach, L. and Lonai, P. (1992). Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Development 115, 289-303.
    • (1992) Development , vol.115 , pp. 289-303
    • Orr-Urtreger, A.1    Bedford, M.T.2    Do, M.S.3    Eisenbach, L.4    Lonai, P.5
  • 32
    • 0033562850 scopus 로고    scopus 로고
    • Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation
    • Pathi, S., Rutenberg, J. B., Johnson, R. L. and Vortkamp, A. (1999). Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation. Dev. Biol. 209, 239-253.
    • (1999) Dev. Biol. , vol.209 , pp. 239-253
    • Pathi, S.1    Rutenberg, J.B.2    Johnson, R.L.3    Vortkamp, A.4
  • 33
    • 0034643084 scopus 로고    scopus 로고
    • BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes
    • Pizette, S. and Niswander, L. (2000). BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes. Dev. Biol. 219, 237-249.
    • (2000) Dev. Biol. , vol.219 , pp. 237-249
    • Pizette, S.1    Niswander, L.2
  • 34
    • 0028179081 scopus 로고
    • Transforming growth factor-beta and bone morphogenetic protein-2 act by distinct mechanisms to promote chick limb cartilage differentiation in vitro
    • Roark, E. F. and Greer, K. (1994). Transforming growth factor-beta and bone morphogenetic protein-2 act by distinct mechanisms to promote chick limb cartilage differentiation in vitro. Dev. Dyn. 200, 103-116.
    • (1994) Dev. Dyn. , vol.200 , pp. 103-116
    • Roark, E.F.1    Greer, K.2
  • 36
    • 0030727351 scopus 로고    scopus 로고
    • Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    • Serra, R., Johnson, M., Filvaroff, E. H., LaBorde, J., Sheehan, D. M., Derynck, R. and Moses, H. L. (1997). Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J. Cell Biol. 139, 541-552.
    • (1997) J. Cell Biol. , vol.139 , pp. 541-552
    • Serra, R.1    Johnson, M.2    Filvaroff, E.H.3    LaBorde, J.4    Sheehan, D.M.5    Derynck, R.6    Moses, H.L.7
  • 40
    • 0030808324 scopus 로고    scopus 로고
    • The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites
    • Soriano, P. (1997). The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 124, 2691-2700.
    • (1997) Development , vol.124 , pp. 2691-2700
    • Soriano, P.1
  • 41
    • 0030926144 scopus 로고    scopus 로고
    • PDGFR alpha expression during mouse embryogenesis: Immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5
    • Takakura, N., Yoshida, H., Ogura, Y., Kataoka, H., Nishikawa, S. and Nishikawa, S. (1997). PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5. J. Histochem. Cytochem. 45, 883-893.
    • (1997) J. Histochem. Cytochem. , vol.45 , pp. 883-893
    • Takakura, N.1    Yoshida, H.2    Ogura, Y.3    Kataoka, H.4    Nishikawa, S.5    Nishikawa, S.6
  • 42
    • 0034535222 scopus 로고    scopus 로고
    • Early myotome specification regulates PDGFA expression and axial skeleton development
    • Tallquist, M. D., Weismann, K. E., Hellstroem, M. and Soriano, P. (2000). Early myotome specification regulates PDGFA expression and axial skeleton development. Development 127, 5059-5070.
    • (2000) Development , vol.127 , pp. 5059-5070
    • Tallquist, M.D.1    Weismann, K.E.2    Hellstroem, M.3    Soriano, P.4
  • 43
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • Winnier, G., Blessing, M., Labosky, P. A. and Hogan, B. L. (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9, 2105-2116.
    • (1995) Genes Dev. , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 44
    • 0027336995 scopus 로고
    • flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors
    • Yamaguchi, T. P., Dumont, D. J., Conlon, R. A., Breitman, M. L. and Rossant, J. (1993). flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development 118, 489-498.
    • (1993) Development , vol.118 , pp. 489-498
    • Yamaguchi, T.P.1    Dumont, D.J.2    Conlon, R.A.3    Breitman, M.L.4    Rossant, J.5
  • 46
    • 0035795409 scopus 로고    scopus 로고
    • TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • Yang, X., Chen, L., Xu, X., Li, C., Huang, C. and Deng, C. X. (2001). TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J. Cell Biol. 153, 35-46.
    • (2001) J. Cell Biol. , vol.153 , pp. 35-46
    • Yang, X.1    Chen, L.2    Xu, X.3    Li, C.4    Huang, C.5    Deng, C.X.6
  • 47
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman, L. B., de Jesus-Escobar, J. M. and Harland, R. M. (1996). The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86, 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    de Jesus-Escobar, J.M.2    Harland, R.M.3
  • 48
    • 0030955344 scopus 로고    scopus 로고
    • Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage
    • Zoo, H., Wieser, R., Massague, J. and Niswander, L. (1997). Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev. 11, 2191-2203.
    • (1997) Genes Dev. , vol.11 , pp. 2191-2203
    • Zoo, H.1    Wieser, R.2    Massague, J.3    Niswander, L.4


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